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1. 发明授权

US5603331A Data logging system for implantable cardiac device 失效
标题翻译：可植入心脏装置的数据记录系统
公开(公告)号：US5603331A
公开(公告)日：1997-02-18
申请号：US600133
申请日：1996-02-12
申请人： Jan P. Heemels , Gerrard M. Carlson , Julio C. Spinelli
发明人： Jan P. Heemels , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/37 , A61N1/372 , G06F17/00 , A61B5/0452
CPC分类号： A61N1/3702 , A61B5/02405 , A61B5/7232 , A61N1/36592
摘要： An implantable cardiac rhythm management device (pacemaker or defibrillator) having circuitry for determining the interval between two successive natural ventricular depolarization signals, includes the capability of computing and storing histogram arrays of heart rate variability data over a prolonged period, such as 24 hours. By utilizing an algorithm for generating a histographic log and a time domain log wherein a logarithmic data compression technique is implemented, the volume of HRV data collected for later telemetered readout to an external device does not exceed the memory and power capabilities of the implanted device.
摘要翻译：具有用于确定两个连续的自然心室去极化信号之间的间隔的电路的可植入心律管理装置（起搏器或除颤器）包括在延长的时间段（例如24小时）上计算和存储心率变异性数据的直方图阵列的能力。通过利用用于生成组织学记录的算法和实现对数数据压缩技术的时域日志，收集用于稍后遥测读出到外部设备的HRV数据的量不超过植入设备的存储器和功率能力。

2. 发明授权

US5413593A Using sub-threshold unipolar pacing markers to improve the interpretation of surface EKG in pacemaker patients 失效
标题翻译：使用亚阈值单极起搏标记来改善起搏器患者表面EKG的解释
公开(公告)号：US5413593A
公开(公告)日：1995-05-09
申请号：US188821
申请日：1994-01-31
申请人： Julio C. Spinelli , Jesse Hartley , Jan P. Heemels
发明人： Julio C. Spinelli , Jesse Hartley , Jan P. Heemels
IPC分类号： A61B5/0402 , A61N1/362 , A61N1/37 , A61N1/372
CPC分类号： A61N1/3706 , A61N1/37247
摘要： A pacemaker including a marker code generator generating marker codes between an indifferent electrode disposed on the pacemaker housing and the pacemaker can serving as a reference electrode. Marker code signals are generated proximate the pacemaker rather than proximate cardiac tissue, and thus can be generated at a large potential for sensing by surface EKG, and can also be generated simultaneously while pacing the heart and not necessarily in the refractory period. The pacemaker facilitates the interpretation of surface EKG, and can be sensed and recorded by commercially available two-channel holter monitors which can be taken home with the patient. Thus, marker code signals can be sensed and recorded while at home and played back for the physician at a later time for analysis. The marker code generator can be selectively turned on by the external programmer such that battery life depreciation is not appreciable. The pacemaker can be adapted with either a unipolar or bipolar endocardial lead.
摘要翻译：包括标记码发生器的起搏器可以在布置在起搏器外壳上的无关电极与起搏器之间产生标记代码，其可以用作参考电极。在起搏器附近产生标记代码信号，而不是紧邻心脏组织，因此可以在用于通过表面EKG进行感测的大电位下产生，并且还可以同时产生心脏起搏而不一定在不应期。起搏器有助于表面EKG的解释，并且可以由可以与患者一起回家的市售双通道保持器监视器来感测和记录。因此，可以在家中感测和记录标记代码信号，并在以后再次为医师回放分析。标记码发生器可以被外部编程器选择性地打开，使得电池寿命贬值不明显。起搏器可以适应单极或双极心内膜导联。

3. 发明授权

US5466245A Method and apparatus to continuously optimize the A-V delay in a dual chamber pacemaker 失效
标题翻译：在双室起搏器中不断优化A-V延迟的方法和装置
公开(公告)号：US5466245A
公开(公告)日：1995-11-14
申请号：US339815
申请日：1994-11-15
申请人： Julio C. Spinelli , Jan P. Heemels
发明人： Julio C. Spinelli , Jan P. Heemels
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36592 , A61N1/3682
摘要： A DDD-type cardiac pacemaker having a microprocessor-based controller is programmed to automatically determine and utilize and optimize A-V delay for the patient in whom the device is implanted. The microprocessor-based controller periodically changes the A-V delay and then computes heart rate variability over an insuing predetermined period. The particular A-V delay value associated with the minimum heart rate variability index is determined to be the optimum. Heart rate variability may be determined by performing a power spectrum analysis on cyclic variations in R-R intervals, preferably using a FFT signal processing chip, or by a time domain analysis based upon the standard deviation of R-R intervals during a prescribed period of time and a calculated value of respiratory sinus arrhythmia. The apparatus is also operative to optimize the A-V delay interval following a change in the pacing mode of the DDD-type pacemaker.
摘要翻译：具有基于微处理器的控制器的DDD型心脏起搏器被编程以自动确定并利用并优化其中植入装置的患者的A-V延迟。基于微处理器的控制器周期性地改变A-V延迟，然后在保持的预定时间段内计算心率变异性。与最小心率变异指数相关联的特定A-V延迟值被确定为最佳值。可以通过对RR间期的循环变化进行功率谱分析来确定心率变异性，优选使用FFT信号处理芯片，或者通过基于在规定时间段内的RR间隔的标准偏差的时域分析，呼吸窦性心律失常的价值。该装置还用于在DDD型起搏器的起搏模式改变之后优化A-V延迟间隔。

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