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1. 发明授权

US09694055B2 Renal tissue regeneration 有权
公开(公告)号：US09694055B2
公开(公告)日：2017-07-04
申请号：US12991811
申请日：2009-05-11
申请人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
发明人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
IPC分类号： A61K47/30 , A61K38/39 , A61K9/00 , A61K38/48 , A61L27/24 , A61L27/52 , A61L27/54
CPC分类号： A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

2. 发明申请

US20110097379A1 DIRECTED STEM CELL RECRUITMENT 有权
标题翻译：指导性干细胞募集
公开(公告)号：US20110097379A1
公开(公告)日：2011-04-28
申请号：US12991811
申请日：2009-05-11
申请人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
发明人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
IPC分类号： A61K9/00 , A61K38/39 , A61K38/43 , A61K38/18 , A61K38/48 , A61P13/12 , A61K47/30 , A61K31/573
CPC分类号： A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
摘要翻译：本发明涉及在受试者的靶位点诱导细胞募集和组织再生的方法。它也部分地基于发现一个受试者自己的生物资源和环境条件可用于原位组织再生，从而减少或消除对供体细胞采购和离体操作这种供体细胞的需要。公开了通过在目标部位（例如肾）处诱导持续的正压来将受试者自己的干细胞募集到靶区域的方法，从而增加能够分化以再生靶组织的多能细胞的数量。

3. 发明授权

US08728463B2 Production of tissue engineered digits and limbs 有权
标题翻译：组织工程数字和四肢的生产
公开(公告)号：US08728463B2
公开(公告)日：2014-05-20
申请号：US11373046
申请日：2006-03-10
申请人： Anthony Atala , James Yoo , Grace Lim , Sang Jin Lee
发明人： Anthony Atala , James Yoo , Grace Lim , Sang Jin Lee
IPC分类号： A01N63/00
CPC分类号： A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
摘要翻译：本发明涉及生产允许协调运动的人造复合组织结构的方法。使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协调运动的人造复合组织构建体。

4. 发明授权

US08491457B2 Tissue engineered blood vessels 有权
标题翻译：组织工程血管
公开(公告)号：US08491457B2
公开(公告)日：2013-07-23
申请号：US11372743
申请日：2006-03-10
申请人： Anthony Atala , Shay Soker , James Yoo
发明人： Anthony Atala , Shay Soker , James Yoo
IPC分类号： A61F2/06
CPC分类号： A61L27/3604 , A61F2/06 , A61F2/062 , A61K35/44 , A61L27/3808 , A61L27/50 , A61L27/507 , A61L2430/36 , B82Y5/00 , B82Y10/00
摘要： The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow.
摘要翻译：本发明涉及通过将接种有内皮细胞的基质预处理以模拟血液流动的流体流动条件来制备人造血管的方法。

5. 发明申请

US20060171902A1 Engineered oral tissue structural constructs 审中-公开
标题翻译：工程口腔组织结构构造
公开(公告)号：US20060171902A1
公开(公告)日：2006-08-03
申请号：US11048097
申请日：2005-02-01
申请人： Anthony Atala , Akira Joraku , Christopher Sullivan , James Yoo
发明人： Anthony Atala , Akira Joraku , Christopher Sullivan , James Yoo
IPC分类号： A61K8/96 , A61K35/12
CPC分类号： A61L27/3839 , A61L27/3804 , C12N5/0633 , C12N2500/84 , C12N2501/11 , C12N2533/40
摘要： The invention is directed to compositions and methods for preparing an artificial oral tissue. The artificial oral tissue is prepared using a biocompatible substrate seeded with salivary gland cells that develop to produce a salivary gland tissue layer with a prototypal salivary system and a prototypal secretory system. The salivary gland cells proliferate, mature and differentiate into a salivary gland structure that are analogous to its in vivo counterpart.
摘要翻译：本发明涉及用于制备人造口腔组织的组合物和方法。人造口腔组织使用种植有唾液腺细胞的生物相容性底物制备，所述唾液腺细胞通过原型唾液系统和原型分泌系统开发产生唾液腺组织层。唾液腺细胞增殖，成熟并分化成类似于其体内对应物的唾液腺结构。

6. 发明申请

US20050054893A1 Penile reconstruction 失效
标题翻译：阴茎重建
公开(公告)号：US20050054893A1
公开(公告)日：2005-03-10
申请号：US10396202
申请日：2003-03-25
申请人： Anthony Atala , James Yoo
发明人： Anthony Atala , James Yoo
IPC分类号： A61F2/26 , A61L27/18 , A61L27/38 , A61F5/00
CPC分类号： A61L27/3817 , A61F2/26 , A61L27/18 , A61L27/3852 , C08L67/04
摘要： A cartilaginous structural member (CSM) for use in penile reconstruction, for the correction of developmental defects, postoperative reconstruction, and for reconstructive preprosthetic surgery. The cartilaginous structural member (CSM) comprise of live cells seeded onto pre-formed shaped structure which may be biodegradable. The live cells may comprise chondrocyte and the cartilaginous structural member (CSM) for use in reconstructive surgery may be constructed of polyglycolic acid. The implant structure is applicable to use for the regeneration and reconstruction or augmentation of semirigid members of the body such as the penis, nose, ear and locations which naturally has cartilage. Further, the cartilaginous structural member (CSM) may be used in plastic surgery such as, for example, breast augmentation or pectoral augmentation. The cartilaginous structural member (CSM) may be a composite cartilaginous structural member (CSM) comprising additional anchoring and strengthening elements for anchoring or changing the structural strength of said composite cartilaginous structural member (CSM).
摘要翻译：用于阴茎重建的软骨结构构件（CSM），用于矫正发育缺陷，术后重建和重建假体外科手术。软骨结构构件（CSM）包括接种到预先形成的成形结构上的活细胞，其可生物降解。活细胞可以包括软骨细胞，并且用于重建手术的软骨结构构件（CSM）可以由聚乙醇酸构成。植入物结构适用于再生和重建或增加身体的半刚性成分，例如阴茎，鼻子，耳朵和自然具有软骨的位置。此外，软骨结构构件（CSM）可以用于整形手术，例如隆胸或胸部增大。软骨结构构件（CSM）可以是复合软骨结构构件（CSM），其包括用于锚固或改变所述复合软骨结构构件（CSM）的结构强度的附加锚定和加固元件。

7. 发明申请

US20090265005A1 BIOREACTOR SYSTEM AND METHOD OF ENHANCING FUNCTIONALITY OF MUSCLE CULTURED IN VITRO 审中-公开
标题翻译：生物反馈系统和增强体内培养的肌肉功能的方法
公开(公告)号：US20090265005A1
公开(公告)日：2009-10-22
申请号：US12429385
申请日：2009-04-24
申请人： James Yoo , Joel Stitzel , Anthony Atala , George Christ
发明人： James Yoo , Joel Stitzel , Anthony Atala , George Christ
IPC分类号： A61F2/08 , A01N1/02
CPC分类号： A61F2/08 , A61F2002/0894 , A61L27/3604 , A61L27/367 , A61L27/3683 , A61L27/3691 , A61L27/3826 , A61L27/3895 , A61L2430/30 , A61L2430/34 , C12M21/08 , C12M35/04 , C12N5/0658 , C12N2527/00 , C12N2539/00
摘要： A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.
摘要翻译：从前体肌细胞体外产生有组织的骨骼肌组织的方法包括：（a）在组织培养基中的支持体上提供前体肌细胞; 然后（b）在第一时间段期间沿着第一轴线循环地拉伸和松弛支撑件至少两次; 然后（c）任选地，但优选在第二时间段内将载体保持在基本上静止的位置; 然后（d）重复步骤（b）和（c）足以增强在载体上形成的组织的功能性和/或从前体肌细胞在固体支持物上产生有组织的骨骼肌组织的次数。

8. 发明授权

US07531503B2 Cell scaffold matrices with incorporated therapeutic agents 有权
标题翻译：具有掺入治疗剂的细胞支架基质
公开(公告)号：US07531503B2
公开(公告)日：2009-05-12
申请号：US11084350
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61K38/00 , A61K31/70 , A61K33/00 , A61K33/36 , A61K33/32 , A61K33/04
CPC分类号： A61K49/18 , A61K38/00 , A61K41/0042 , A61K47/6923 , A61L27/26 , A61L27/507 , A61L27/54 , A61L2400/12 , B82Y5/00 , B82Y10/00 , Y10S977/906 , C08L67/04
摘要： The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on the surface of the matrix.
摘要翻译：本发明涉及用于制备用于受控递送至少一种治疗或生物剂到受试者的靶位点的基质的方法和组合物。这是使用与治疗或生物试剂偶联的纳米颗粒完成的，所述纳米颗粒结合到基质中或在基质的表面上反应。

9. 发明申请

US20060204539A1 Electrospun cell matrices 审中-公开
公开(公告)号：US20060204539A1
公开(公告)日：2006-09-14
申请号：US11083853
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61F2/02
CPC分类号： D01D5/0007 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01F4/00 , D01F6/92
摘要： The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.

10. 发明申请

US20060204445A1 Cell scaffold matrices with image contrast agents 审中-公开
标题翻译：具有图像造影剂的细胞支架基质
公开(公告)号：US20060204445A1
公开(公告)日：2006-09-14
申请号：US11083602
申请日：2005-03-18
申请人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
发明人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
IPC分类号： A61K49/10 , A61F2/02
CPC分类号： A61L27/54 , A61K41/0042 , A61K47/6923 , A61K49/18 , A61L27/047 , A61L27/26 , A61L27/50 , A61L27/507 , A61L2300/44 , C08L89/06
摘要： The invention is directed to methods and compositions for monitoring remodeling of an artificial tissue construct using image or contrast enhancing agents. The invention allows the growth, development, and remodeling of the artificial tissue to be monitored.
摘要翻译：本发明涉及使用图像或对比度增强剂监测人造组织构建体的重塑的方法和组合物。本发明允许监测人造组织的生长，发育和重塑。

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