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1. 发明授权

US09192578B2 Hot-melt extrusion of modified release multi-particulates 有权
标题翻译：改性释放多颗粒的热熔挤出
公开(公告)号：US09192578B2
公开(公告)日：2015-11-24
申请号：US12544963
申请日：2009-08-20
申请人： James W. McGinity , Sandra U. Schilling
发明人： James W. McGinity , Sandra U. Schilling
IPC分类号： A61K9/16 , A61K9/20 , A61K31/522 , B29C47/00 , B29K105/00
CPC分类号： A61K9/2077 , A61K9/1641 , A61K9/1694 , A61K9/2081 , A61K31/522 , B29C47/00 , B29C47/0014 , B29K2105/0035
摘要： The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
摘要翻译：本发明包括制备改性释放药物制剂的组合物和方法以及将改性释放多颗粒包埋在聚合物或蜡状基质中的制备方法。改性释放多颗粒包含有效量的具有已知或期望的药物释放曲线的治疗化合物。改性释放多颗粒可以包括聚合物涂层或可以结合到颗粒或芯材料中。聚合物基质包括在高温下软化或熔化的热塑性聚合物或亲脂性载体或其混合物，并且允许在热加工期间将改性释放多颗粒分布在聚合物基质中。选择配制化合物和加工条件以保持原来的改性释放多颗粒的控制释放特性和/或药物保护性质。

2. 发明申请

US20100047340A1 HOT-MELT EXTRUSION OF MODIFIED RELEASE MULTI-PARTICULATES 有权
标题翻译：改性释放多颗粒的热熔胶挤出
公开(公告)号：US20100047340A1
公开(公告)日：2010-02-25
申请号：US12544963
申请日：2009-08-20
申请人： James W. McGinity , Sandra U. Schilling
发明人： James W. McGinity , Sandra U. Schilling
IPC分类号： A61K31/522 , A61K9/10 , A61K9/26 , A61K9/52 , A61K9/22 , B29C47/00 , B29C47/38 , B29C47/40 , B29B9/06 , A61P11/08 , G06F15/00
CPC分类号： A61K9/2077 , A61K9/1641 , A61K9/1694 , A61K9/2081 , A61K31/522 , B29C47/00 , B29C47/0014 , B29K2105/0035
摘要： The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
摘要翻译：本发明包括制备改性释放药物制剂的组合物和方法以及将改性释放多颗粒包埋在聚合物或蜡状基质中的制备方法。改性释放多颗粒包含有效量的具有已知或期望的药物释放曲线的治疗化合物。改性释放多颗粒可以包括聚合物涂层或可以结合到颗粒或芯材料中。聚合物基质包括在高温下软化或熔化的热塑性聚合物或亲脂性载体或其混合物，并且允许在热加工期间将改性释放多颗粒分布在聚合物基质中。选择配制化合物和加工条件以保持原来的改性释放多颗粒的控制释放特性和/或药物保护性质。

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