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1. 发明申请

US20100327858A1 Pipeline Inspection Tool with Double Spiral EMAT Sensor Array 有权
标题翻译：双螺旋EMAT传感器阵列管道检测工具
公开(公告)号：US20100327858A1
公开(公告)日：2010-12-30
申请号：US12642031
申请日：2009-12-18
申请人： James Simek , Jed Ludlow , John H. Flora , Syed M. Ali , Huidong Gao
发明人： James Simek , Jed Ludlow , John H. Flora , Syed M. Ali , Huidong Gao
IPC分类号： G01N27/82
CPC分类号： G01N27/87
摘要： A pipeline inspection tool includes two pole magnets oriented at an oblique angle relative to the central longitudinal axis of the tool body. An array of sensor coil sets is located between opposing edges of the two pole magnets and oriented perpendicular to the central longitudinal axis. Each sensor coil set includes a transmitter coil and two opposing pairs of receiver coils that are gated to receive reflections from the wall of a tubular member. Because the line of sensor coils is rotated relative to the magnetic bias field, the receiver coils are in-line with, and have the same angular orientation as, the transmitter coil. The tool provides improved sensitivity to small defects, substantial decrease in RF pulser power requirements, full circumferential coverage, self-calibration of the transmitted signals, and less interference between transmitter coils caused by acoustic ring around.
摘要翻译：管道检查工具包括相对于工具主体的中心纵向轴线倾斜定向的两个磁极。传感器线圈组的阵列位于两个极磁体的相对边缘之间并且垂直于中心纵向轴线定向。每个传感器线圈组包括发射器线圈和两个相对的接收器线圈对，其被门控以从管状构件的壁接收反射。因为传感器线圈的线相对于磁偏置场旋转，所以接收器线圈与发射器线圈成一直线并具有相同的角度定向。该工具提供对小缺陷的改进的灵敏度，RF脉冲发生器功率要求的显着降低，全周期覆盖，发射信号的自校准以及由环形周围引起的发射器线圈之间的较小干扰。

2. 发明授权

US08319494B2 Pipeline inspection tool with double spiral EMAT sensor array 有权
标题翻译：双螺旋EMAT传感器阵列管道检测工具
公开(公告)号：US08319494B2
公开(公告)日：2012-11-27
申请号：US12642031
申请日：2009-12-18
申请人： James Simek , Jed Ludlow , John H. Flora , Syed M. Ali , Huidong Gao
发明人： James Simek , Jed Ludlow , John H. Flora , Syed M. Ali , Huidong Gao
IPC分类号： G01R19/18 , G01R19/22
CPC分类号： G01N27/87
摘要： A pipeline inspection tool includes two pole magnets oriented at an oblique angle relative to the central longitudinal axis of the tool body. An array of sensor coil sets is located between opposing edges of the two pole magnets and oriented perpendicular to the central longitudinal axis. Each sensor coil set includes a transmitter coil and two opposing pairs of receiver coils that are gated to receive reflections from the wall of a tubular member. Because the line of sensor coils is rotated relative to the magnetic bias field, the receiver coils are in-line with, and have the same angular orientation as, the transmitter coil. The tool provides improved sensitivity to small defects, substantial decrease in RF pulser power requirements, full circumferential coverage, self-calibration of the transmitted signals, and less interference between transmitter coils caused by acoustic ring around.
摘要翻译：管道检查工具包括相对于工具主体的中心纵向轴线倾斜定向的两个磁极。传感器线圈组的阵列位于两个极磁体的相对边缘之间并且垂直于中心纵向轴线定向。每个传感器线圈组包括发射器线圈和两个相对的接收器线圈对，其被门控以从管状构件的壁接收反射。因为传感器线圈的线相对于磁偏置场旋转，所以接收器线圈与发射器线圈成一直线并具有相同的角度定向。该工具提供对小缺陷的改进的灵敏度，RF脉冲发生器功率要求的显着降低，全周期覆盖，发射信号的自校准以及由环形周围引起的发射器线圈之间的较小干扰。

3. 发明申请

US20090136499A1 RAF Inhibitors and Uses Thereof 审中-公开
标题翻译： RAF抑制剂及其用途
公开(公告)号：US20090136499A1
公开(公告)日：2009-05-28
申请号：US12356097
申请日：2009-01-20
申请人： Jean-Marc Lapierre , Nivedita D. Namdev , Mark A. Ashwell , Dennis S. France , Hui Wu , Patrick M. Hutchins , Manish Tandon , Yanbin Liu , Jeff S. Link , Syed M. Ali , Chris J. Brassard , Robb B. Nicewonger , Anton Filikov , Rebecca J. Carazza
发明人： Jean-Marc Lapierre , Nivedita D. Namdev , Mark A. Ashwell , Dennis S. France , Hui Wu , Patrick M. Hutchins , Manish Tandon , Yanbin Liu , Jeff S. Link , Syed M. Ali , Chris J. Brassard , Robb B. Nicewonger , Anton Filikov , Rebecca J. Carazza
IPC分类号： A61K39/395 , C07D513/04 , A61K31/506 , A61K31/5377 , C07D498/04 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
摘要翻译：本发明提供咪唑并恶唑和咪唑并噻唑化合物及其合成。本发明的化合物能够抑制RAF激酶如B-RAFV600E的活性。该化合物可用于治疗细胞增殖性疾病如癌症。

4. 发明申请

US20090130117A1 Substituted Tetrazole Compounds and Uses Thereof 有权
标题翻译：取代的四氮唑化合物及其用途
公开(公告)号：US20090130117A1
公开(公告)日：2009-05-21
申请号：US12251093
申请日：2008-10-14
申请人： Rui-Yang Yang , Syed M. Ali , Mark A. Ashwell , Eugene Kelleher , Rocio Palma , Neil Westlund
发明人： Rui-Yang Yang , Syed M. Ali , Mark A. Ashwell , Eugene Kelleher , Rocio Palma , Neil Westlund
IPC分类号： A61K31/41 , C07D257/04 , C07D403/04 , C07D401/04 , C07D401/14 , C07D403/10 , A61P35/00 , A61K31/4196 , A61K31/675 , A61K39/395 , A61K31/519 , A61K31/505 , A61K31/7068 , A61K33/24 , A61K31/4535 , C07D413/14 , C07D413/12 , A61K31/5377 , A61K31/496 , A61K31/454
CPC分类号： C07D257/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12
摘要： The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention.
摘要翻译：本发明提供了四唑化合物，以及这些化合物的制备方法。本发明还涉及包含四唑化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明化合物来治疗细胞增殖性疾病如癌症的方法。

5. 发明授权

US07062756B2 Dynamic object usage pattern learning and efficient caching 有权
公开(公告)号：US07062756B2
公开(公告)日：2006-06-13
申请号：US09998035
申请日：2001-11-30
申请人： Yury Kamen , Robert N. Goldberg , Bruce K. Daniels , Syed M. Ali , Peter A. Yared
发明人： Yury Kamen , Robert N. Goldberg , Bruce K. Daniels , Syed M. Ali , Peter A. Yared
IPC分类号： G06F9/44
CPC分类号： H04L67/2819 , G06F17/30902 , H04L29/06 , H04L67/10 , H04L67/2847 , H04L67/2852 , H04L67/289 , H04L69/329
摘要： A method for transparently optimizing data access. The method includes gathering information related to data usage when a system is processing and determining a usage pattern of the system using gathered information.

6. 发明授权

US08273754B2 Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds 有权
标题翻译：取代的1H-吡唑并[3,4-D]嘧啶-6-胺化合物
公开(公告)号：US08273754B2
公开(公告)日：2012-09-25
申请号：US12649721
申请日：2009-12-30
申请人： Syed M. Ali , Mark A. Ashwell , Jason Hill , Jean-Marc Lapierre , Magdi Moussa , Nivedita Namdev , Robert Nicewonger , Manish Tandon , Rui-Yang Yang
发明人： Syed M. Ali , Mark A. Ashwell , Jason Hill , Jean-Marc Lapierre , Magdi Moussa , Nivedita Namdev , Robert Nicewonger , Manish Tandon , Rui-Yang Yang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的1H-吡唑并[3,4-d]嘧啶-6-胺化合物及其合成方法。本发明还涉及含有取代的1H-吡唑并[3,4-d]嘧啶-6-胺化合物的药物组合物和通过将这些化合物和药物组合物给予需要的受试者来治疗细胞增殖性疾病如癌症的方法其中。

7. 发明授权

US08114873B2 1,4-disubstituted naphthalenes as inhibitors of p38 map kinase 有权
标题翻译： 1,4-二取代萘作为p38映射激酶的抑制剂
公开(公告)号：US08114873B2
公开(公告)日：2012-02-14
申请号：US12854687
申请日：2010-08-11
申请人： Mark A. Ashwell , Yanbin Liu , Syed M. Ali , Jason Hill , Woj Wrona
发明人： Mark A. Ashwell , Yanbin Liu , Syed M. Ali , Jason Hill , Woj Wrona
IPC分类号： A61K31/5355 , A61K31/5375 , C07D265/30 , A61P29/00
CPC分类号： C07D295/185 , C07D207/27 , C07D207/327 , C07D207/404 , C07D209/12 , C07D209/42 , C07D209/44 , C07D209/48 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/60 , C07D213/30 , C07D213/56 , C07D213/61 , C07D213/81 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/26 , C07D231/12 , C07D231/14 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D241/08 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/14 , C07D277/24 , C07D285/14 , C07D295/088 , C07D295/155 , C07D307/42 , C07D317/60 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D491/10
摘要： Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof
摘要翻译：具有能够抑制P38的连接的杂环和芳环的萘基化合物，体内或体外抑制P38的方法，用于确定治疗P38和/或细胞因子相关病症的活性的诊断和用于治疗与P38活性相关的病症的方法或细胞因子活性; 更具体地，具有吗啉杂环的式（I）的萘系化合物及其使用方法

8. 发明授权

US07703074B2 Method and apparatus for tracking changes in a system 有权
标题翻译：跟踪系统变化的方法和装置
公开(公告)号：US07703074B2
公开(公告)日：2010-04-20
申请号：US11133831
申请日：2005-05-20
申请人： Yury Kamen , Syed M. Ali , Deepak Alur , John P. Crupi , Daniel B. Malks
发明人： Yury Kamen , Syed M. Ali , Deepak Alur , John P. Crupi , Daniel B. Malks
IPC分类号： G06F9/44 , G06F9/45
CPC分类号： G06F8/60
摘要： A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store using a tracking mechanism, and analyzing the target system by issuing a query to the characteristics store to obtain an analysis result, wherein the query uses tracking information associated with the tracking mechanism.
摘要翻译：一种用于分析目标系统的方法，所述目标系统包括使用特征提取器从所述目标系统获得多个特征，其中所述多个特征与特征模型相关联，使用跟踪机制将所述多个特征中的每一个存储在特征存储器中并且通过向所述特征商店发出查询以获得分析结果来分析所述目标系统，其中所述查询使用跟踪机制相关联的跟踪信息。

9. 发明授权

US07660802B2 Method and apparatus for generating components for pattern-based system design analysis using a characteristics model 有权
标题翻译：使用特征模型生成基于模式的系统设计分析的组件的方法和装置
公开(公告)号：US07660802B2
公开(公告)日：2010-02-09
申请号：US11133717
申请日：2005-05-20
申请人： Syed M. Ali , Yury Kamen , Deepak Alur , John P. Crupi , Daniel B. Malks
发明人： Syed M. Ali , Yury Kamen , Deepak Alur , John P. Crupi , Daniel B. Malks
IPC分类号： G06F7/00 , G06F17/00 , G06F15/16
CPC分类号： G06F8/75
摘要： A method for analyzing a target system that includes obtaining a characteristics model, generating at least one selected from the group consisting of a schema, characteristics store API, and a characteristics extractor, using the characteristics model, obtaining a plurality of characteristics from the target system using characteristics extractor, wherein each of the plurality of characteristics is associated with the characteristics model, storing each of the plurality of characteristics in the characteristics store using the schema, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.
摘要翻译：一种用于分析目标系统的方法，所述目标系统包括获得特征模型，使用所述特征模型从所述特征模型生成从由模式，特征存储API和特征提取器组成的组中选择的至少一个，从所述目标系统获得多个特征使用特征提取器，其中所述多个特征中的每一个与所述特征模型相关联，使用所述模式将所述多个特征中的每一个存储在所述特征存储中，并且通过向所述特征库发出至少一个查询来分析所述目标系统以获得分析结果。

10. 发明授权

US07624108B1 Method and apparatus for formally specifying application-specific read/write consistency 有权
标题翻译：用于正式指定应用程序特定读/写一致性的方法和装置
公开(公告)号：US07624108B1
公开(公告)日：2009-11-24
申请号：US10603884
申请日：2003-06-25
申请人： Robert N. Goldberg , Bruce K. Daniels , Yury Kamen , Syed M. Ali
发明人： Robert N. Goldberg , Bruce K. Daniels , Yury Kamen , Syed M. Ali
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30 , Y10S707/99938
摘要： A system for specifying read/write consistency for an application including an application including at least one transaction, wherein the at least one transaction includes at least one of a plurality of states, at least one of a plurality of transitions, and at least one artifact; and a database operatively connected to the application, wherein the application accesses data associated with the at least one artifact using a read/write consistency specification; wherein the read/write consistency specification specifies at least one selected from the group consisting of a read consistency and a write consistency for the at least one artifact within the transaction.
摘要翻译：一种用于指定包括至少一个事务的应用的应用的读/写一致性的系统，其中所述至少一个事务包括多个状态，多个转换中的至少一个以及至少一个工件 ; 以及可操作地连接到所述应用的数据库，其中所述应用使用读/写一致性规范访问与所述至少一个伪像相关联的数据; 其中所述读取/写入一致性规范指定从由所述事务内的所述至少一个工件的读取一致性和写入一致性组成的组中选择的至少一个。

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