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1. 发明授权

US5509932A Fixed tissue medical devices comprising albumin-binding dyes 失效
标题翻译：包含白蛋白结合染料的固定组织医疗装置
公开(公告)号：US5509932A
公开(公告)日：1996-04-23
申请号：US044846
申请日：1993-04-08
申请人： James R. Keogh , David A. Pearson , John W. Eaton
发明人： James R. Keogh , David A. Pearson , John W. Eaton
IPC分类号： A61F2/24 , A61L27/28 , A61L27/34 , A61F2/02
CPC分类号： A61L27/28 , A61L27/34 , A61F2/2412
摘要： An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.
摘要翻译：提供了一种植入式医疗装置，其包括固定组织，当该装置与含有白蛋白的生理液体接触时，该固定组织掺入一定量的能够在所述装置上形成内源性白蛋白的涂层的白蛋白结合染料。已经发现这些白蛋白结合染料当结合到组织心脏瓣膜中时显着降低钙化。还提供了增加可植入医疗装置的白蛋白结合能力的方法。

2. 发明授权

US5545213A Method for administering a bioactive agent 失效
标题翻译：施用生物活性剂的方法
公开(公告)号：US5545213A
公开(公告)日：1996-08-13
申请号：US430063
申请日：1995-04-27
申请人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
发明人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
IPC分类号： A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/00 , A61L33/00 , A61F2/06
CPC分类号： A61L29/16 , A61L27/54 , A61L33/0029 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/442 , A61L2300/602 , Y10S623/901 , Y10S623/921
摘要： Articles having a graft polymer with a net ionic charge bonded to a polymeric substrate surface provide an improved method for administering a bioactive agent having a net ionic charge. The [articles are] method is especially useful [as] for thromboresistant and/or antimicrobial medical devices.
摘要翻译：具有结合到聚合物基底表面上的净离子电荷的接枝聚合物的制品提供了用于施用具有净离子电荷的生物活性剂的改进方法。 [制品]方法对于抗血栓和/或抗微生物的医疗装置是特别有用的。

3. 发明授权

US5476509A Articles having graft polymer bioactive surfaces 失效
标题翻译：具有接枝聚合物生物活性表面的制品
公开(公告)号：US5476509A
公开(公告)日：1995-12-19
申请号：US255632
申请日：1994-06-09
申请人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
发明人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
IPC分类号： A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/00 , A61L33/00 , A61F2/06
CPC分类号： A61L29/16 , A61L27/54 , A61L33/0029 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/442 , A61L2300/602 , Y10S623/901 , Y10S623/921
摘要： Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm), and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.
摘要翻译：由接枝聚合物（例如由例如N-（3-氨基丙基）甲基丙烯酰胺盐酸盐（APMA），2-丙烯酰氨基-2-甲基丙烷磺酸（AMPS），丙烯酰胺等）的单体制成的生物活性剂（AAm）和丙烯酸（AA）），其又结合到聚合物基材表面。该制品可用作抗血栓和/或抗微生物的医疗装置。

4. 发明授权

US5344455A Graft polymer articles having bioactive surfaces 失效
标题翻译：具有生物活性表面的接枝聚合物制品
公开(公告)号：US5344455A
公开(公告)日：1994-09-06
申请号：US969692
申请日：1992-10-30
申请人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
发明人： James R. Keogh , Christopher M. Hobot , John W. Eaton , Allan H. Jevne , Matthew A. Bergan
IPC分类号： A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/00 , A61L33/00 , A61F2/02
CPC分类号： A61L29/16 , A61L27/54 , A61L33/0029 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/442 , A61L2300/602 , Y10S623/901 , Y10S623/921
摘要： Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm)m and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.
摘要翻译：由接枝聚合物（例如由例如N-（3-氨基丙基）甲基丙烯酰胺盐酸盐（APMA），2-丙烯酰氨基-2-甲基丙烷磺酸（AMPS），丙烯酰胺等）的单体制成的生物活性剂（AAm）m和丙烯酸（AA）），其又结合到聚合物基材表面。该制品可用作抗血栓和/或抗微生物的医疗装置。

5. 发明授权

US06464645B1 Ultrasonic transducer assembly controller 有权
标题翻译：超声波换能器组装控制器
公开(公告)号：US06464645B1
公开(公告)日：2002-10-15
申请号：US09434594
申请日：1999-11-05
申请人： William J. Park , Douglas B. Dull , John W. Eaton , Robert A Howard , Stephen L. Ijams
发明人： William J. Park , Douglas B. Dull , John W. Eaton , Robert A Howard , Stephen L. Ijams
IPC分类号： A61B812
CPC分类号： A61M25/0147 , A61B1/0052 , A61B8/12 , A61B8/4466 , A61B8/4488 , A61B2018/00916 , A61M25/0136
摘要： A controller for an ultrasonic transducer assembly includes a housing having a longitudinal axis that extends generally parallel to the proximal end of a conduit, such as a catheter. A steering actuator is mounted to the housing for rotation about the longitudinal axis, and a steering hub is mounted for rotation in the housing and coupled to the steering actuator such that rotation of the steering ring with respect to the housing causes rotation of the steering hub. A steering line is secured adjacent the steering hub and extends to the distal end of the conduit such that rotation of the steering hub alters the effective length of the steering line to steer the distal end. The steering line is wrapped at least partially around a stator to avoid threading the steering line through multiple holes and slots prior to termination to the steering hub. The steering line is preferably formed of a liquid crystal polymer, and the housing of the steering mechanism preferably contains an extension portion to ensure that the portion of the housing that the user grips to manipulate the steering mechanism is sufficiently far away from the cable to ensure that the cable will remain sterile and thus reusable. In an additional preferred embodiment, the controller is contoured to a human hand to provide a comfortable, efficient, and enjoyable one-handed operation.
摘要翻译：用于超声换能器组件的控制器包括壳体，该壳体具有大致平行于诸如导管的导管的近端延伸的纵向轴线。转向致动器安装到壳体上以围绕纵向轴线旋转，并且转向轮毂安装成用于在壳体中旋转并联接到转向致动器，使得转向环相对于壳体的旋转引起转向轮毂的旋转。转向线固定在转向轮毂附近并且延伸到导管的远端，使得转向轮毂的旋转改变转向线的有效长度以转向远端。转向线至少部分地围绕定子包裹，以避免在终止到转向轮毂之前将转向线穿过多个孔和槽。转向线优选地由液晶聚合物形成，并且转向机构的壳体优选地包含延伸部分，以确保用户抓住操纵转向机构的壳体部分足够远离电缆以确保电缆将保持无菌并因此可重复使用。在另外的优选实施例中，控制器被轮廓化为人的手，以提供舒适，有效和愉快的单手操作。

6. 发明授权

US6149599A Method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer 有权
标题翻译：用于制造围绕导管安装的相控阵超声换能器的端部的方法
公开(公告)号：US6149599A
公开(公告)日：2000-11-21
申请号：US206680
申请日：1998-12-07
申请人： Randall L. Schlesinger , Michael G. Curley , John W. Eaton
发明人： Randall L. Schlesinger , Michael G. Curley , John W. Eaton
IPC分类号： A61B1/005 , A61B8/12 , A61M25/01 , A61B8/00
CPC分类号： A61B8/12 , A61B1/0052 , A61B8/4488 , A61M25/0133 , A61M25/0136 , A61B2018/00916 , A61B8/445
摘要： The preferred embodiments include a method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer. The material used for the end portion can be altered to give the end portion focusing, defocusing, or non-focusing characteristics. In one preferred embodiment, a thermoplastic material is injection molded or insert molded around a phased-array ultrasound transducer carried at a distal end of a catheter. In another preferred embodiment, a thermoset material is used to form the end portion using a casting or transfer molding technique. In yet another preferred embodiment, the phased-array ultrasound transducer is placed into a pre-formed end portion. The pre-formed end portion can be adhesively-attached to the phased-array transducer and catheter. If the pre-formed end portion is made from a thermoplastic material, the end portion can be thermally melted to attach the end portion to the phased-array transducer and catheter.
摘要翻译：优选实施例包括用于制造围绕导管安装的相控阵超声换能器的端部的方法。用于端部的材料可以改变以给出端部聚焦，散焦或非聚焦特性。在一个优选实施例中，将热塑性材料注射模制或插入模制在围绕导管远端承载的相控阵超声换能器周围。在另一个优选实施例中，使用热固性材料来使用铸造或传递模塑技术形成端部。在另一优选实施例中，将相控阵超声波换能器放置在预先形成的端部。预成形的端部可以粘附到相控阵换能器和导管上。如果预先形成的端部由热塑性材料制成，则端部可以被热熔化以将端部附接到相控阵换能器和导管。

7. 发明授权

US5479929A Drive system with a multiturn rotary stop 失效
标题翻译：带多圈旋转停止的驱动系统
公开(公告)号：US5479929A
公开(公告)日：1996-01-02
申请号：US267594
申请日：1994-06-27
申请人： Thomas G. Cooper , David V. Adams , John W. Eaton
发明人： Thomas G. Cooper , David V. Adams , John W. Eaton
IPC分类号： A61B8/12 , A61B8/00
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： A drive system with a rotary stop for driving a rotatable load is provided having a motor, a rotary stop and a spring stop assembly for coupling the motor to the rotary stop. The spring stop assembly has a motor-driven gear coupled to a hub by a torsional spring. A position encoder may be attached to the motor. In addition, a drive shaft may be coupled to the motor and the multiturn rotary stop through the spring stop assembly.
摘要翻译：提供具有用于驱动可旋转负载的旋转止动件的驱动系统，其具有电动机，旋转止动器和用于将电动机联接到旋转止动件的弹簧止动组件。弹簧止动组件具有通过扭转弹簧联接到轮毂的电机驱动齿轮。位置编码器可以附接到电动机。此外，驱动轴可以通过弹簧止动组件联接到马达和多圈旋转止动件。

8. 发明授权

US5626138A Ultrasonic transducer probe with axisymmetric lens 失效
标题翻译：超声波换能器探头带有轴对称镜头
公开(公告)号：US5626138A
公开(公告)日：1997-05-06
申请号：US482922
申请日：1995-06-07
申请人： John A. Hossack , John W. Eaton , Thomas G. Cooper
发明人： John A. Hossack , John W. Eaton , Thomas G. Cooper
IPC分类号： A61B8/12 , G10K11/00 , G10K11/02 , G10K11/30 , H04R1/34
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , G10K11/004 , G10K11/02 , G10K11/30
摘要： According to the present invention, an ultrasonic transducer probe is provided having an array of ultrasonic transducers rotatably mounted about an axis within the ultrasonic transducer probe, a lens mounted to the array, and a housing encasing the array and the lens. The lens is symmetric about the axis of rotation of the array. In addition, the housing has a continuous upper surface that is formed, in a region adjacent to the symmetric lens, to mate with the symmetric lens.
摘要翻译：根据本发明，提供一种超声波换能器探头，其具有围绕超声波换能器探针中的轴线可旋转地安装的超声波换能器阵列，安装到阵列的透镜以及包围阵列和透镜的壳体。透镜相对于阵列的旋转轴线是对称的。此外，壳体具有在与对称透镜相邻的区域中形成的连续上表面，以与对称透镜配合。

9. 发明授权

US5073171A Biocompatible materials comprising albumin-binding dyes 失效
标题翻译：包含ALBUMIN-BINDING DYES的生物成分材料
公开(公告)号：US5073171A
公开(公告)日：1991-12-17
申请号：US296496
申请日：1989-01-12
申请人： John W. Eaton
发明人： John W. Eaton
IPC分类号： A61L33/12
CPC分类号： A61L33/128 , Y10S623/92 , Y10S623/921
摘要： A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. A method of increasing the albumin-binding ability of a prosthetic device is also provided.
摘要翻译：提供了一种生物相容性假体装置，其包括固体聚合物体，当该装置与含有白蛋白的生理液体接触时，该固体聚合物体结合了一定量的能够在所述装置上形成内源白蛋白涂层的白蛋白结合染料。还提供了增加假体装置的白蛋白结合能力的方法。

10. 发明授权

US4652521A Method for the early diagnosis of bordetella diseases and kit therefor 失效
标题翻译：波尔多氏病早期诊断方法及其试剂盒
公开(公告)号：US4652521A
公开(公告)日：1987-03-24
申请号：US707806
申请日：1985-03-04
申请人： Dennis L. Confer , John W. Eaton
发明人： Dennis L. Confer , John W. Eaton
IPC分类号： G01N33/50 , C12M1/34 , C12Q1/00 , C12Q1/04 , C12Q1/16 , C12Q1/527 , G01N33/566 , C12M1/24 , C12M1/30 , C12M1/40 , C12Q1/06
CPC分类号： G01N33/566 , C12Q1/04 , C12Q1/527 , G01N2333/235 , Y10S435/803 , Y10S436/81
摘要： A method for the early diagnosis of Bordetella diseases based on the detection of Bordetella adenylate cyclase and the ability of this enzyme to catalyze the formation of cyclic adenosine monophosphate (cAMP). A sample secretion is taken from a suspected victim of a Bordetella disease (the most common of which in humans is whooping cough) and incubated under conditions to promote the formation of cAMP, which may then be measured as evidence of the presence of the disease. A sample of nasopharyngeal secretions is maintained in a nutrient medium pending assay. An adenylate cyclase assay is made by incubating the sample with adenosine triphosphate (ATP) and the calcium binding protein calmodulin to generate cAMP. The cAMP is measured by any of several known available methods. To facilitate diagnosis, a kit is provided containing the materials necessary for collection of secretion specimens, for storage of specimens pending assay, and transport of specimens to the assay laboratory, and for performing the assay and determining the result.
摘要翻译：一种基于伯氏杆菌腺苷酸环化酶的检测和该酶催化环磷酸腺苷（cAMP）形成的能力，早期诊断博德氏病的方法。样品分泌物是从疑似Bordetella病患者（其中最常见的是百日咳）中取出，并在促进cAMP形成的条件下培养，然后可以将其作为该疾病存在的证据进行测量。将待分析的鼻咽分泌物样品保持在营养培养基中。通过将样品与三磷酸腺苷（ATP）和钙结合蛋白钙调素一起孵育以产生cAMP来制备腺苷酸环化酶测定。 cAMP通过几种已知的可用方法中的任何一种来测量。为了便于诊断，提供了一个试剂盒，其中包含收集分泌标本所需的材料，用于储存待测试的样品，并将样品运送到测定实验室，以及进行测定和确定结果。

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