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    • 8. 发明申请
    • Medicament composition and method of administration
    • 药物组合物和给药方法
    • US20060063698A1
    • 2006-03-23
    • US10947484
    • 2004-09-22
    • James Patterson
    • James Patterson
    • A61K38/22A61K38/28
    • A61K9/0043A61K9/146A61K38/28A61K47/585Y10S514/951
    • A medicament powder, system and method for nasal administration of a pharmacologically active peptide across the nasal mucous membrane. A free-flowing powder having a low moisture content includes a cross-linked cation exchange resin in anionic form and a pharmacologically active peptide in cationic form ionically bound together. The particles of the powder function as carriers of the peptide during nasal administration. The cation exchange resin is taken from the group consisting of divinyl benzene cross-linked polystyrene-sulfonates and Na, NH4 and K salts thereof. An N-saline solution is sprayed into the nasal cavity after administration of the powder to effect ion exchange of Na in the N-saline with the peptide from the resin for efficient delivery of the peptide.
    • 一种药物粉末,系统和方法,其用于鼻内施用药理学活性肽穿过鼻粘膜。 具有低水分含量的自由流动粉末包括阴离子形式的交联阳离子交换树脂和离子键合在一起的阳离子形式的药理活性肽。 在鼻内给药期间,粉末的颗粒用作肽的载体。 阳离子交换树脂取自二乙烯基苯交联聚苯乙烯磺酸盐及其Na,NH 4和K盐。 在施用粉末之后,将N盐水溶液喷雾到鼻腔中,以利用来自树脂的肽进行N-盐水中的Na的离子交换,以有效递送肽。