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1. 发明授权

US09592284B2 Immunization regimen with E4-deleted adenovirus prime and E1-deleted adenovirus boost 有权
标题翻译：用E4缺失的腺病毒引物和E1缺失的腺病毒加强免疫方案
公开(公告)号：US09592284B2
公开(公告)日：2017-03-14
申请号：US11587549
申请日：2005-04-27
申请人： James M. Wilson , Yan Zhi
发明人： James M. Wilson , Yan Zhi
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2750/14043 , C12N2760/14122 , C12N2760/14134 , Y02A50/484
摘要： An immunization regimen is provided which involves priming with an E1, E4-deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.
摘要翻译：提供免疫方案，其包括用E1，E4缺失的腺病毒引发并用E1缺失的腺病毒加强。第二次施用的腺病毒具有不与先前施用的腺病毒交叉反应的血清型的衣壳。此外，提供了含有进行免疫方案所必需的腺病毒的产品。

2. 发明授权

US09198984B2 Scalable production method for AAV 有权
标题翻译： AAV可扩展生产方法
公开(公告)号：US09198984B2
公开(公告)日：2015-12-01
申请号：US12226588
申请日：2007-04-27
申请人： Martin Lock , Luc H Vandenberghe , James M. Wilson
发明人： Martin Lock , Luc H Vandenberghe , James M. Wilson
IPC分类号： A61K38/00 , C12N7/00 , A61K48/00 , C07K14/005
CPC分类号： C12N7/00 , A61K48/0091 , C07K14/005 , C12N2750/14151
摘要： A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step.
摘要翻译：描述了不需要细胞裂解的生产AAV的方法。该方法包括从上清液中收获AAV。对于具有肝素结合位点的衣壳的AAV，该方法包括修饰AAV衣壳和/或培养条件以消除AAV肝素结合位点与细胞之间的结合，从而允许AAV进入上清液，即培养基。因此，与使用细胞裂解步骤的方法产生的AAV相比，本发明的方法提供了含有高产率的AAV的上清液，其具有比细胞膜和细胞内物质更高的纯度。

3. 发明授权

US08906675B2 Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby 有权
标题翻译：腺相关病毒（AAV）序列并分离鉴定的新序列
公开(公告)号：US08906675B2
公开(公告)日：2014-12-09
申请号：US11985096
申请日：2007-11-14
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N15/00 , C12N15/86 , C07K14/005 , C12N7/00 , C12Q1/70
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided.
摘要翻译：提供了腺相关病毒7序列，含有其的载体和使用方法。

4. 发明授权

US08470310B2 Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof 有权
标题翻译：猿猴腺病毒SAdV-36，-42.1，-42.2和-44及其用途
公开(公告)号：US08470310B2
公开(公告)日：2013-06-25
申请号：US12920648
申请日：2009-03-03
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K35/76 , C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K39/145 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10371 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒36，猿猴腺病毒42.1，猿腺病毒42.2和/或猿腺病毒44序列和在调节序列控制下的异源基因。还描述了表达一种或多种猿猴腺病毒-36，-42.1，-42.2或-44基因的细胞系。提供了使用载体和细胞系的方法。

5. 发明授权

US08231880B2 Simian subfamily C adenoviruses SAdV-40, -31, and -34 and uses thereof 有权
标题翻译：猿猴亚科C腺病毒SAdV-40,31和-34及其用途
公开(公告)号：US08231880B2
公开(公告)日：2012-07-31
申请号：US12744405
申请日：2008-11-24
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K39/235 , C12N15/00
CPC分类号： C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343
摘要： A recombinant vector comprises simian adenovirus SAdV-31 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-31 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒SAdV-31序列和在调控序列控制下的异源基因。还公开了表达猿猴腺病毒SAdV-31基因的细胞系。提供了使用载体和细胞系的方法。

6. 发明申请

US20110236353A1 ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR 审中-公开
标题翻译： ADENO相关病毒（AAV）分类，序列，包含它们的载体及其用途
公开(公告)号：US20110236353A1
公开(公告)日：2011-09-29
申请号：US13023918
申请日：2011-02-09
申请人： James M. Wilson , Guangping Gao , Mauricio R. Alvira , Luc H. Vandenberghe
发明人： James M. Wilson , Guangping Gao , Mauricio R. Alvira , Luc H. Vandenberghe
IPC分类号： A61K48/00 , C12N7/00 , C12N15/63 , C12N1/00 , C12N5/10 , C12N7/01 , A61K38/16 , A61P7/00 , A61P11/00
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译：提供新的腺相关病毒衣壳和含有这些序列的载体和宿主细胞的序列。还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。还提供使用本发明的载体的AAV介导的治疗和免疫原性基因的递送。

7. 发明授权

US07906111B2 Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor 有权
标题翻译：腺相关病毒（AAV）进化枝，序列，含有其的载体及其用途
公开(公告)号：US07906111B2
公开(公告)日：2011-03-15
申请号：US10573600
申请日：2004-09-30
申请人： James M. Wilson , Guangping Gao , Mauricio R. Alvira , Luc H. Vandenberghe
发明人： James M. Wilson , Guangping Gao , Mauricio R. Alvira , Luc H. Vandenberghe
IPC分类号： C12N15/86 , C12N5/10 , C12N15/37 , C12N15/11 , C12N7/01
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
摘要： Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
摘要翻译：提供新的腺相关病毒衣壳和含有这些序列的载体和宿主细胞的序列。还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。还提供使用本发明的载体的AAV介导的治疗和免疫原性基因的递送。

8. 发明申请

US20100247490A1 SIMIAN E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 有权
标题翻译： SIMIAN E ADENOVIRUSES SAdV-39，-25.2，-26，-30，-37和-38
公开(公告)号：US20100247490A1
公开(公告)日：2010-09-30
申请号：US12744441
申请日：2008-11-24
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K35/76 , C12N7/00 , C12N7/01 , C07H21/04 , C12N15/861 , C07K14/075 , A61K38/16 , A61P31/12 , C12N5/02
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361 , C12N2760/16122
摘要： A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-38序列，以及在调控序列控制下的异源基因。还公开了表达猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-383基因的细胞系。提供了使用载体和细胞系的方法。

9. 发明申请

US20090197338A1 Method of Increasing the Function of an AAV Vector 有权
标题翻译：增加AAV矢量功能的方法
公开(公告)号：US20090197338A1
公开(公告)日：2009-08-06
申请号：US11887679
申请日：2006-04-07
申请人： Luk Vandenberghe , Guangping Gao , James M. Wilson
发明人： Luk Vandenberghe , Guangping Gao , James M. Wilson
IPC分类号： C12N15/74 , C12N15/63 , C07H21/04
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译：提供了一种校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能性AAV衣壳序列的相应位置中的氨基酸一致。

10. 发明授权

US07358787B2 Dual operational mode CML latch 失效
标题翻译：双操作模式CML锁存器
公开(公告)号：US07358787B2
公开(公告)日：2008-04-15
申请号：US11307923
申请日：2006-02-28
申请人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
发明人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
IPC分类号： H03K3/289
CPC分类号： H03K3/356043
摘要： A dual purpose current mode logic (“CML”) latch circuit is provided which includes a CML latch operable to receive at least a pair of differential input data signals and at least one clock signal. The CML latch is operable to generate at least one output signal in accordance with the states of the pair of input differential data signals. A mode control device is operable to receive a mode control signal to operate the CML latch as a buffer or as a latch. In such way, when the mode control signal is inactive, the CML latch generates and latches the output signal at a timing determined by the at least one clock signal, and when the mode control signal is active the CML latch generates the output signal such that the output signal changes whenever the states of the pair of differential input data signals change.
摘要翻译：提供了一种双用途电流模式逻辑（“CML”）锁存电路，其包括可操作以接收至少一对差分输入数据信号和至少一个时钟信号的CML锁存器。 CML锁存器可操作以根据输入差分数据信号对的状态产生至少一个输出信号。模式控制装置可操作以接收模式控制信号以将CML锁存器作为缓冲器或锁存器操作。以这种方式，当模式控制信号无效时，CML锁存器产生并以由至少一个时钟信号确定的定时锁存输出信号，并且当模式控制信号有效时，CML锁存器产生输出信号，使得每当差分输入数据信号对的状态改变时，输出信号就会改变。

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