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1. 发明授权

US4690749A Polymer-coated surfaces to control surface zeta potential 失效
标题翻译：聚合物涂层表面以控制表面ζ电位
公开(公告)号：US4690749A
公开(公告)日：1987-09-01
申请号：US808981
申请日：1985-12-16
申请人： James M. Van Alstine , J. Milton Harris , Steve Shafer , Robert S. Snyder , Blair Herren
发明人： James M. Van Alstine , J. Milton Harris , Steve Shafer , Robert S. Snyder , Blair Herren
IPC分类号： B01D57/02 , C03C17/32 , C08J7/04 , G01N27/447 , B01D13/02 , C25D13/00
CPC分类号： B01D57/02 , C03C17/32 , C08J7/047 , G01N27/44752 , Y10T428/2991 , Y10T428/2995 , Y10T428/2998
摘要： A method for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising conducting electrophoresis employing electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers is described. An electrophoretic chamber for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers, is also disclosed as well as particles exhibiting controlled electrophoretic mobility. The method and electrophoretic chamber not only eliminate electroosmosis, but allow for specific control of electroosmosis. The coated electrophoretic surface is stable relative to prior art coatings and over a broad range of pH. The point of optical focus for accurate mobility measurements is increased from a narrow stationary level to the entire chamber, facilitating accurate measurements by mechanical means. The method also reduces or eliminates assymetric fluid flows due to electroosmosis in electrophoresis chambers of square or rectangular cross-section.
摘要翻译：描述了消除或控制电泳中的电渗和其他ζ电位相关现象的方法，包括使用涂覆有共价结合的亲水性中性聚合物的电泳表面进行电泳。还公开了一种用于消除或控制电泳中电渗和其它ζ电位相关现象的电泳室，其包括用共价结合的亲水性中性聚合物涂覆的电泳表面，以及显示受控电泳迁移率的颗粒。该方法和电泳室不仅消除了电渗，而且允许特定的电渗控制。涂覆的电泳表面相对于现有技术的涂层和宽泛的pH值是稳定的。精确移动性测量的光学焦点从狭窄的静止水平增加到整个腔室，有助于通过机械手段进行精确的测量。该方法还减少或消除由于正方形或矩形横截面的电泳室中的电渗而导致的不对称流体流动。

2. 发明授权

US08604159B2 Method for preparing functionalized polymers from polymer alcohols 有权
标题翻译：从聚合物醇制备官能化聚合物的方法
公开(公告)号：US08604159B2
公开(公告)日：2013-12-10
申请号：US10897386
申请日：2004-07-22
申请人： Samuel P. McManus , Antoni Kozlowski , J. Milton Harris
发明人： Samuel P. McManus , Antoni Kozlowski , J. Milton Harris
IPC分类号： C08G65/34 , A61K31/74 , A61K47/48 , C08G63/48 , C08G63/91 , C08L89/00
CPC分类号： C08G65/33337 , A61K47/60 , B01D15/361 , C08G65/00 , C08G65/30 , C08G65/322 , C08G65/323 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33365 , C08G65/48 , C08G2650/38 , C08L2203/02
摘要： The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.
摘要翻译：本发明尤其提供了从聚合物醇如聚（乙二醇）的聚合物制备官能化和其它聚合物的方法。此外，还提供了聚合物组合物，共轭物，聚合物试剂。

3. 发明授权

US08119756B2 Hydrolytically degradable polymers and hydrogels made therefrom 有权
标题翻译：水解可降解的聚合物和水凝胶
公开(公告)号：US08119756B2
公开(公告)日：2012-02-21
申请号：US13027218
申请日：2011-02-14
申请人： J. Milton Harris , Michael D. Bentley , Xuan Zhao , Xiaoming Shen
发明人： J. Milton Harris , Michael D. Bentley , Xuan Zhao , Xiaoming Shen
IPC分类号： C07K1/107 , A01N37/00
CPC分类号： C08G64/0208 , C08G64/0216 , C08G64/183
摘要： Methods for delivering a biologically active agent into the body of a mammal are provided, the method comprising administering a carbamate-containing conjugate to the mammal.
摘要翻译：提供了将生物活性剂递送到哺乳动物的体内的方法，所述方法包括向哺乳动物施用含氨基甲酸酯的缀合物。

4. 发明申请

US20110123453A1 Polyoxazolines with Inert Terminating Groups, Polyoxazolines Prepared from Protected Initiating Groups and Related Compounds 有权
标题翻译：具有惰性终止基团的聚恶唑啉，由保护起始基团和相关化合物制备的聚恶唑啉
公开(公告)号：US20110123453A1
公开(公告)日：2011-05-26
申请号：US13003306
申请日：2009-07-10
申请人： Michael David Bentley , J. Milton Harris , Michael Reif , Rainer Jordon , Kunsang Yoon
发明人： Michael David Bentley , J. Milton Harris , Michael Reif , Rainer Jordon , Kunsang Yoon
IPC分类号： A61K49/00 , C08G73/06 , A61K9/127 , A61K31/787
CPC分类号： C08G73/0233 , A61K9/1272 , C08L79/02
摘要： The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other poly-oxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.
摘要翻译：本公开提供通过用惰性化学基团终止聚恶唑啉聚合制备的新型功能性聚恶唑啉衍生物。此外，本公开内容显示了具有能够引发恶唑啉聚合并能够在聚合条件下存活的受保护官能团的新型亲电子引发剂的合成。这些引发剂用于合成上述惰性末端聚恶唑啉衍生物以及具有活性末端基团的其它多 - 恶唑啉。此外，本公开提供使用这种聚恶唑啉 - 脂质缀合物制备的聚恶唑啉 - 脂质缀合物和脂质体组合物。还公开了使用前述物质与靶分子制备缀合物的方法。

5. 发明申请

US20100184937A1 Polymer Derivatives with Proximal Reactive Groups 有权
标题翻译：具有近端反应性基团的聚合物衍生物
公开(公告)号：US20100184937A1
公开(公告)日：2010-07-22
申请号：US12749399
申请日：2010-03-29
申请人： J. Milton Harris , Antoni Kozlowski
发明人： J. Milton Harris , Antoni Kozlowski
IPC分类号： C08G73/06
CPC分类号： C08G65/33396 , A61K47/60 , C08G65/329 , C08G65/33313 , C08G65/33337 , Y10S530/816
摘要： An activated, substantially water-soluble polyoxazoline is provided having a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated polyoxazoline and the biologically active agent.
摘要翻译：提供活化的基本上水溶性的聚恶唑啉，其具有直链或支链的聚（乙二醇）主链和至少一个通过水解稳定键连接至主链的末端，其中末端是支链的且具有近端反应性基团。游离反应性基团能够与生物活性剂如蛋白质或肽中的活性部分反应，从而在活化的聚恶唑啉和生物活性剂之间形成共轭物。

6. 发明申请

US20100069579A1 Activated Polyoxazolines and Compositions Comprising the Same 有权
标题翻译：活性聚唑啉及其组合物
公开(公告)号：US20100069579A1
公开(公告)日：2010-03-18
申请号：US12529001
申请日：2008-02-28
申请人： J. Milton Harris , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Francesco Maria Veronese
发明人： J. Milton Harris , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Francesco Maria Veronese
IPC分类号： C08G73/00
CPC分类号： A61K31/787 , A61K47/60 , C07D207/452 , C07D207/46 , C07D401/12 , C08G73/0233 , C08L79/02
摘要： The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.
摘要翻译：本公开提供具有一定范围的官能活性基团的末端活化单官能POZ衍生物，其允许在宽范围的反应条件下将单官能POZ衍生物缀合到多种靶分子以产生水解稳定的靶分子-POZ缀合物。此外，本公开提供了所公开的末端活化单官能POZ衍生物和使用所公开的末端活化单官能POZ衍生物产生的水解稳定的靶分子-POZ共轭物的合成新方法。

7. 发明申请

US20100004392A1 Hydrolytically Degradable Polymers and Hydrogels Made Therefrom 有权
标题翻译：水解降解聚合物和水凝胶
公开(公告)号：US20100004392A1
公开(公告)日：2010-01-07
申请号：US12559162
申请日：2009-09-14
申请人： J. Milton Harris , Michael David Bentley , Xuan Zhao , Xiaoming Shen
发明人： J. Milton Harris , Michael David Bentley , Xuan Zhao , Xiaoming Shen
IPC分类号： C08G69/00 , C08F283/02
CPC分类号： C08G64/0208 , C08G64/0216 , C08G64/183
摘要： A water soluble polymer comprising multiple degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched.
摘要翻译：在主链中包含多个可降解碳酸酯键的水溶性聚合物，并且对于骨架中的每个碳酸酯键，由碳酸酯键连接的低聚物，其中低聚物是支链的。

8. 发明授权

US07608678B2 Hydrolytically degradable polymers and hydrogels made therefrom 有权
标题翻译：水解可降解的聚合物和水凝胶
公开(公告)号：US07608678B2
公开(公告)日：2009-10-27
申请号：US11890162
申请日：2007-08-03
申请人： J. Milton Harris , Michael D. Bentley , Xuan Zhao , Xiaoming Shen
发明人： J. Milton Harris , Michael D. Bentley , Xuan Zhao , Xiaoming Shen
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08G64/0208 , C08G64/0216 , C08G64/183
摘要： A water soluble polymer is described, the water soluble polymer comprising multiple hydrolytically degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched and, prior to being linked by the carbonate linkage, has the formula: R3[O—(—CHR1CH2—O—)n—]mH where R3 is a core branching moiety, R1 is H, (n) can range from 2 to 2000, and m is at least 3.
摘要翻译：描述了水溶性聚合物，水溶性聚合物在骨架中包含多个可水解降解的碳酸酯键，并且对于主链中的每个碳酸酯键，由碳酸酯键连接的低聚物，其中低聚物是分支的，并且在连接之前通过碳酸酯键合具有下式：R 3 [O - （ - CHR 1 CH 2 -O-）n - ] mH，其中R 3是核心支化部分，R 1是H，（n）可以在2至2000的范围内，m是至少3。

9. 发明申请

US20090186984A1 Poly(Ethylene Glycol) Derivatives with Proximal Reactive Groups 有权
标题翻译：具有近端反应性基团的聚（乙二醇）衍生物
公开(公告)号：US20090186984A1
公开(公告)日：2009-07-23
申请号：US12410438
申请日：2009-03-24
申请人： J. Milton Harris , Antoni Kozlowski
发明人： J. Milton Harris , Antoni Kozlowski
IPC分类号： C08G65/333
CPC分类号： C08G65/33396 , A61K47/60 , C08G65/329 , C08G65/33313 , C08G65/33337 , Y10S530/816
摘要： An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent.
摘要翻译：提供活化的，基本上水溶性的聚（乙二醇），其具有直链或支链的聚（乙二醇）主链和至少一个通过水解稳定键连接至主链的末端，其中末端是支链的并具有近端反应性团体游离反应性基团能够与生物活性剂如蛋白质或肽中的活性部分反应，从而在活化的（聚乙二醇）与生物活性剂之间形成共轭物。

10. 发明授权

US07528202B2 Poly (ethylene glycol) derivatives with proximal reactive groups 有权
标题翻译：具有近端反应性基团的聚（乙二醇）衍生物
公开(公告)号：US07528202B2
公开(公告)日：2009-05-05
申请号：US11799259
申请日：2007-04-30
申请人： J. Milton Harris , Antoni Kozlowski
发明人： J. Milton Harris , Antoni Kozlowski
IPC分类号： C08F12/30 , C08F28/02 , C08F118/00 , C08F120/00 , C08F122/00 , C08F218/00
CPC分类号： C08G65/33396 , A61K47/60 , C08G65/329 , C08G65/33313 , C08G65/33337 , Y10S530/816
摘要： An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent.
摘要翻译：提供活化的，基本上水溶性的聚（乙二醇），其具有直链或支链的聚（乙二醇）主链和至少一个通过水解稳定键连接至主链的末端，其中末端是支链的并具有近端反应性团体游离反应性基团能够与生物活性剂如蛋白质或肽中的活性部分反应，从而在活化的（聚乙二醇）与生物活性剂之间形成共轭物。

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