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1. 发明申请

US20090250136A1 CORROSION RESISTANT SHEET METAL JACKETING 审中-公开
标题翻译：耐腐蚀板金属外壳
公开(公告)号：US20090250136A1
公开(公告)日：2009-10-08
申请号：US12405708
申请日：2009-03-17
申请人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin , Michael B. Scoby , Algis P. Suopys
发明人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin , Michael B. Scoby , Algis P. Suopys
IPC分类号： F16L9/14 , F16L58/00
CPC分类号： F16L58/1054 , B32B1/08 , B32B7/12 , B32B15/08 , B32B15/18 , B32B15/20 , B32B27/16 , B32B27/304 , B32B27/308 , B32B27/32 , B32B27/322 , B32B27/36 , B32B2255/06 , B32B2255/26 , B32B2307/304 , B32B2307/308 , B32B2307/554 , B32B2307/712 , B32B2307/714 , B32B2307/7242 , B32B2307/7265 , B32B2597/00 , F16L59/10
摘要： A corrosion resistant jacket for insulated pipes and components includes an outer polymeric layer film, an inner polymeric layer and a core layer of a lesser stainless steel material disposed between the outer polymeric layer film and the inner polymeric layer.
摘要翻译：用于绝缘管和部件的耐腐蚀护套包括外部聚合物层膜，内部聚合物层和设置在外部聚合物层膜和内部聚合物层之间的较小不锈钢材料的芯层。

2. 发明授权

US10208885B2 Corrosion resistant sheet metal jacketing 有权
公开(公告)号：US10208885B2
公开(公告)日：2019-02-19
申请号：US12405708
申请日：2009-03-17
申请人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin , Michael B. Scoby , Algis P. Suopys
发明人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin , Michael B. Scoby , Algis P. Suopys
IPC分类号： F16L9/14 , F16L58/00 , F16L58/10 , B32B1/08 , B32B15/08 , B32B15/18 , B32B27/32 , F16L59/10 , B32B7/12 , B32B15/20 , B32B27/16 , B32B27/30 , B32B27/36
摘要： A corrosion resistant jacket for insulated pipes and components includes an outer polymeric layer film, an inner polymeric layer and a core layer of a lesser stainless steel material disposed between the outer polymeric layer film and the inner polymeric layer.

3. 发明申请

US20090114305A1 CORROSION RESISTANT SHEET METAL JACKETING 审中-公开
标题翻译：耐腐蚀板金属外壳
公开(公告)号：US20090114305A1
公开(公告)日：2009-05-07
申请号：US11934224
申请日：2007-11-02
申请人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin
发明人： James M. Roberts , Michael Starozhitsky , Andrea C. McMartin
IPC分类号： F16L9/00 , B21D51/00
CPC分类号： B32B1/08 , B32B3/04 , B32B7/12 , B32B15/08 , B32B15/18 , B32B27/304 , B32B2250/40 , B32B2250/42 , B32B2255/06 , B32B2307/50 , B32B2307/554 , B32B2307/712 , B32B2307/714 , B32B2597/00 , F16L9/147 , F16L58/16 , F16L59/143 , Y10T29/49826
摘要： A corrosion resistant jacket for insulated pipes comprising an outer polymeric layer, an inner polymeric layer, and a sheet metal layer disposed between the outer and the inner polymeric layers. Also disclosed is a method of making a corrosion resistant sheet metal jacket.
摘要翻译：一种用于绝缘管的耐腐蚀护套，其包括外部聚合物层，内部聚合物层和设置在外部聚合物层和内部聚合物层之间的钣金层。还公开了一种制造耐腐蚀金属夹套的方法。

4. 发明授权

US5783661A Human cyclin E polypeptides 失效
标题翻译：人细胞周期蛋白E多肽
公开(公告)号：US5783661A
公开(公告)日：1998-07-21
申请号：US522166
申请日：1995-06-07
申请人： James M. Roberts , Motoaki Ohtsubo , Andrew C. Koff , Frederick Cross
发明人： James M. Roberts , Motoaki Ohtsubo , Andrew C. Koff , Frederick Cross
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/12 , C12N15/70 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/91 , G01N33/53 , C07K5/00 , C07K14/00
CPC分类号： C12N9/12 , C07K14/4738 , C07K16/18 , A61K38/00 , Y10S436/813
摘要： Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2. Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.
摘要翻译：能够在严格条件下与位于图1所示的人细胞周期蛋白E cDNA序列的位置1和1185之间的核苷酸序列杂交的核酸分子。由这些核酸分子编码的多肽，以及针对这种多肽的免疫结合伙伴。

5. 发明授权

US5645999A Assays for compounds that modulate or alter cyclin E activity 失效
标题翻译：测定调节或改变细胞周期蛋白E活性的化合物
公开(公告)号：US5645999A
公开(公告)日：1997-07-08
申请号：US485859
申请日：1995-06-07
申请人： James M. Roberts , Motoaki Ohtsubo , Andrew C. Koff , Frederick Cross
发明人： James M. Roberts , Motoaki Ohtsubo , Andrew C. Koff , Frederick Cross
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/12 , C12N15/70 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/91 , G01N33/53 , C12Q1/02 , C12Q1/48 , G01N33/50
CPC分类号： C12N9/12 , C07K14/4738 , C07K16/18 , A61K38/00 , Y10S436/813
摘要： Whole cell or cell-free test systems for screening and identifying compounds that modulate or alter Cyclin E activity. Whole cell assays measure the G1 phase of cells in the presence or absence of the test compound. Additional whole cell or cell-free assays measure binding of cyclin E to a cell division kinase, measure cyclin E activity directly, or measure the cell division kinase activity directly in the presence or absence of the test compound.
摘要翻译：用于筛选和鉴定调节或改变细胞周期蛋白E活性的化合物的全细胞或无细胞测试系统。全细胞测定在存在或不存在测试化合物的情况下测量细胞的G1期。额外的全细胞或无细胞测定法测量细胞周期蛋白E与细胞分裂激酶的结合，直接测量细胞周期蛋白E活性，或在存在或不存在测试化合物时直接测量细胞分裂激酶活性。

6. 发明申请

US20120096590A1 METHODS FOR INCREASING PLANT CELL PROLIFERATION BY FUNCTIONALLY INHIBITING A PLANT CYCLIN INHIBITOR GENE 审中-公开
标题翻译：通过功能性抑制植物细胞抑制基因增加植物细胞增殖的方法
公开(公告)号：US20120096590A1
公开(公告)日：2012-04-19
申请号：US13301421
申请日：2011-11-21
申请人： James M. Roberts , Beth L. Kelly
发明人： James M. Roberts , Beth L. Kelly
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprise the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided.
摘要翻译：本发明提供调节植物生长和/或产量的方法。特别地，所述方法包括使用功能性抑制植物D样细胞周期蛋白抑制剂表达的试剂，包括与编码能够结合植物D样细胞周期蛋白的蛋白质的DNA或RNA相互作用的分离的多核苷酸序列。此外，本发明提供重组多核苷酸序列，载体和宿主细胞，其编码能够结合和失活植物D样细胞周期蛋白/细胞周期蛋白依赖性激酶复合物的活性的蛋白质，从而阻止植物细胞离开细胞周期。还提供了用于测定和能够调节植物细胞周期进程的BRO细胞周期蛋白依赖性激酶抑制剂蛋白质抑制剂的试剂的方法。还提供了与野生型植物相比生产具有增加的生长速率和产量的转基因植物细胞和植物的方法。

7. 发明授权

US07230089B1 Methods for increasing plant cell proliferation by functionally inhibiting a plant cyclin inhibitor gene 失效
标题翻译：通过功能性抑制植物细胞周期蛋白抑制基因增加植物细胞增殖的方法
公开(公告)号：US07230089B1
公开(公告)日：2007-06-12
申请号：US09980758
申请日：2000-05-15
申请人： James M. Roberts , Beth L. Kelly
发明人： James M. Roberts , Beth L. Kelly
IPC分类号： C12N15/29 , C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprise the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided.
摘要翻译：本发明提供调节植物生长和/或产量的方法。特别地，所述方法包括使用功能性抑制植物D样细胞周期蛋白抑制剂表达的试剂，包括与编码能够结合植物D样细胞周期蛋白的蛋白质的DNA或RNA相互作用的分离的多核苷酸序列。此外，本发明提供重组多核苷酸序列，载体和宿主细胞，其编码能够结合和失活植物D样细胞周期蛋白/细胞周期蛋白依赖性激酶复合物的活性的蛋白质，从而阻止植物细胞离开细胞周期。还提供了用于测定和能够调节植物细胞周期进程的BRO细胞周期蛋白依赖性激酶抑制剂蛋白质抑制剂的试剂的方法。还提供了与野生型植物相比生产具有增加的生长速率和产量的转基因植物细胞和植物的方法。

8. 发明授权

US06635450B1 Isolated P27 protein, nucleic acid molecules encoding same, methods of identifying agents acting on same, and uses of said agents 失效
标题翻译：分离的P27蛋白，编码相同的核酸分子，鉴定作用于其上的试剂的方法以及所述试剂的用途
公开(公告)号：US06635450B1
公开(公告)日：2003-10-21
申请号：US08765702
申请日：1997-04-28
申请人： Joan Massague , James M. Roberts , Andrew Koff , Kornelia Polyak
发明人： Joan Massague , James M. Roberts , Andrew Koff , Kornelia Polyak
IPC分类号： C12N121
CPC分类号： C07K14/4738 , A61K38/00
摘要： An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. in vitro assays for discovering agents which effect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative and hyperproliferative disorders are provided.
摘要翻译：公开了一种称为p27的分离的蛋白质。 p27蛋白具有约27kD的表观分子量，并且能够结合并抑制细胞周期蛋白E-Cdk2复合物的活化。公开了编码p27蛋白的核酸序列，以及培养细胞中p27的产生方法。还提供了影响p27活性的发现剂的体外测定。提供诊断和治疗低增殖和过度增殖性疾病的方法。

9. 发明授权

US5808583A System for using sunshine and shadows to locate unobstructed satellite reception sites and for orientation of signal gathering devices 失效
标题翻译：使用阳光和阴影定位无障碍卫星接收站点和信号采集设备方向的系统
公开(公告)号：US5808583A
公开(公告)日：1998-09-15
申请号：US405267
申请日：1995-03-13
申请人： James M. Roberts
发明人： James M. Roberts
IPC分类号： H01Q1/12 , H01Q3/02 , H01Q3/00
CPC分类号： H01Q1/1264 , H01Q1/125 , H01Q3/02
摘要： A new and improved system which facilitates the use of sunlight and sun shadows to optimize site surveys and the placement of satellite dish antennas and the like in order to provide unobstructive reception from a satellite transmitter and, further, facilitate alignment of the dish relative to a satellite.
摘要翻译：一种新的和改进的系统，其有助于使用阳光和太阳阴影来优化场地调查和放置卫星天线等，以便提供来自卫星发射机的无阻碍的接收，并且进一步促进盘相对于卫星。

10. 发明授权

US5149636A Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products 失效
标题翻译：将克隆的可扩增基因导入真核细胞并产生蛋白质产物的方法
公开(公告)号：US5149636A
公开(公告)日：1992-09-22
申请号：US249454
申请日：1988-09-26
申请人： Richard Axel , James M. Roberts
发明人： Richard Axel , James M. Roberts
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , Y10S435/811 , Y10S435/948
摘要： Multiple copies of a foreign DNA I coding for the production of a protein may be introduced into eucaryotic cells by cotransforming suitable cells with foreign DNA I and with foreign DNA II which includes a functionally deficient, amplifiable gene coding for a selectable or identifiable trait, preferably carried on the same DNA molecule as a foreign DNA III, which includes a functional, amplifiable gene coding for another selectable or identifiable trait. The cotransformation is carried out under suitable conditions permitting selection or identification of cells expressing the gene on DNA I or that on DNA III, but not that on DNA II. The cotransformed cells so identified or selected are recovered and cloned under conditions where the functionally deficient gene on DNA II is expressed. Cells expressing the gene on DNA II are recovered. They contain multiple copies of DNA I. This method can be used to produce mRNA transcripts or protein products such as human and animal growth hormone, insulin and the like.
摘要翻译：编码用于产生蛋白质的外源DNA I的多个拷贝可以通过与外源DNA I共转化合适的细胞和外源DNA II引入真核细胞，外源DNA II包括编码可选择或可鉴定性状的功能缺陷的可扩增基因，优选地携带与外来DNA III相同的DNA分子，其包括编码另一可选择或可鉴定性状的功能性可扩增基因。共转化在合适的条件下进行，允许选择或鉴定在DNA I上表达基因的细胞或DNA III上的基因，而不是DNA II上的细胞。如此鉴定或选择的共转化细胞在表达DNA II的功能缺陷基因的条件下被回收和克隆。回收表达DNA II上的基因的细胞。它们含有多个拷贝的DNA I.该方法可用于产生mRNA转录物或蛋白质产物如人和动物生长激素，胰岛素等。

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