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1. 发明授权

US07931643B2 Miniature pump for drug delivery 有权
标题翻译：用于药物递送的微型泵
公开(公告)号：US07931643B2
公开(公告)日：2011-04-26
申请号：US11490876
申请日：2006-07-21
申请人： James M. Olsen , Mark S. Lent , James G. Skakoon , Richard T. Stone , Laetitia Mayor , Dale F. Seeley , Michael T. Hegland
发明人： James M. Olsen , Mark S. Lent , James G. Skakoon , Richard T. Stone , Laetitia Mayor , Dale F. Seeley , Michael T. Hegland
IPC分类号： A61K9/22 , A61M37/00 , A61F5/00
CPC分类号： A61M5/14276 , A61M5/14593 , A61M5/16881 , A61M39/0208 , A61M2039/0205 , A61M2205/0266
摘要： A miniature drug delivery pump utilizes a shape memory Ni—Ti alloy. A flow restrictor is provided and the pump is refillable.
摘要翻译：微型药物输送泵采用形状记忆Ni-Ti合金。提供了一个流量限制器，并且该泵是可再填充的。

2. 发明申请

US20080262585A1 IMPLANTABLE MEDICAL ELECTRICAL LEAD AND CONNECTOR ASSEMBLY 审中-公开
标题翻译：可植入医用电线和连接器总成
公开(公告)号：US20080262585A1
公开(公告)日：2008-10-23
申请号：US11737915
申请日：2007-04-20
申请人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
发明人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
IPC分类号： A61N1/362
CPC分类号： A61N1/3752 , A61B2562/227 , A61N1/05 , H01R13/5224 , H01R13/64 , H01R2201/12
摘要： An implantable medical system that includes an implantable electrical lead having a lead body having a connector portion wherein at least the connector portion of the lead body has an axial cross section that is substantially non-circular; and a connector block that is configured to be operably coupled to the implantable electrical lead, wherein the connector block includes a lumen having an inner surface that is configured to be complementary to the outer surface of at least the connector portion of the lead body. Leads and connector blocks are also discussed.
摘要翻译：一种可植入医疗系统，其包括具有连接器部分的引线主体的可植入电引线，其中所述引线主体的至少所述连接器部分具有基本上非圆形的轴向横截面; 以及连接器块，其被配置为可操作地联接到所述可植入电引线，其中所述连接器块包括具有内表面的内腔，所述内表面被配置为与所述引线主体的至少所述连接器部分的外表面互补。还讨论了引线和连接器块。

3. 发明授权

US07668601B2 Implantable medical lead with multiple electrode configurations 有权
标题翻译：具有多种电极配置的植入式医用导线
公开(公告)号：US07668601B2
公开(公告)日：2010-02-23
申请号：US11740643
申请日：2007-04-26
申请人： Michael T. Hegland , James M. Olsen , Gabriela C. Miyazawa , Richard T. Stone
发明人： Michael T. Hegland , James M. Olsen , Gabriela C. Miyazawa , Richard T. Stone
IPC分类号： A61N1/04
CPC分类号： A61N1/0534 , A61N1/36082
摘要： Medical leads having at least one segmented row of electrodes, as well as at least one ring electrode that extends substantially completely around the periphery of the lead, are described. The electrodes in a segmented row extend around only a portion of the periphery of the lead, rather than substantially around the entire periphery. The electrodes in a segmented row may be distributed at respective locations around the periphery of the lead and separated by insulating material. The ring electrodes and segmented rows are located at respective axial positions. For example, in some embodiments, a plurality of segmented rows, such as two rows having three electrodes each, are located between two ring electrodes. Such a lead may, for example, provide a variety of stimulation modalities because of localized stimulation capabilities.
摘要翻译：描述了具有至少一个分段的电极列的医疗引线以及基本上完全围绕引线周边延伸的至少一个环形电极。分段行中的电极仅围绕引线周边的一部分延伸，而不是基本上围绕整个周边延伸。分段行中的电极可以分布在引线的周围的相应位置处并被绝缘材料隔开。环形电极和分段行位于相应的轴向位置。例如，在一些实施例中，多个分段行（例如具有三个电极的两行）分布在两个环形电极之间。例如，这样的引线可以由于局部刺激能力而提供各种刺激模式。

4. 发明申请

US20080269854A1 IMPLANTABLE MEDICAL LEAD WITH MULTIPLE ELECTRODE CONFIGURATIONS 有权
标题翻译：具有多个电极配置的可植入医疗引线
公开(公告)号：US20080269854A1
公开(公告)日：2008-10-30
申请号：US11740643
申请日：2007-04-26
申请人： Michael T. Hegland , James M. Olsen , Gabriela C. Miyazawa , Richard T. Stone
发明人： Michael T. Hegland , James M. Olsen , Gabriela C. Miyazawa , Richard T. Stone
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/36082
摘要： Medical leads having at least one segmented row of electrodes, as well as at least one ring electrode that extends substantially completely around the periphery of the lead, are described. The electrodes in a segmented row extend around only a portion of the periphery of the lead, rather than substantially around the entire periphery. The electrodes in a segmented row may be distributed at respective locations around the periphery of the lead and separated by insulating material. The ring electrodes and segmented rows are located at respective axial positions. For example, in some embodiments, a plurality of segmented rows, such as two rows having three electrodes each, are located between two ring electrodes. Such a lead may, for example, provide a variety of stimulation modalities because of localized stimulation capabilities.
摘要翻译：描述了具有至少一个分段的电极列的医疗引线以及基本上完全围绕引线的周边延伸的至少一个环形电极。分段行中的电极仅围绕引线周边的一部分延伸，而不是基本上围绕整个周边延伸。分段行中的电极可以分布在引线的周围的相应位置处并被绝缘材料隔开。环形电极和分段行位于相应的轴向位置。例如，在一些实施例中，多个分段行（例如具有三个电极的两行）分布在两个环形电极之间。例如，这样的引线可以由于局部刺激能力而提供各种刺激模式。

5. 发明授权

US08433422B2 Implantable medical electrical lead and connector assembly 有权
标题翻译：可植入医用电线和连接器组件
公开(公告)号：US08433422B2
公开(公告)日：2013-04-30
申请号：US11737927
申请日：2007-04-20
申请人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
发明人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3752 , A61N2001/083
摘要： An implantable system that includes a lead and an implantable signal generator wherein the plurality of electrical contacts and the plurality of insulating regions on the lead, and the plurality of electrical connectors and the plurality of electrical insulators in the connector block are configured so that each of the plurality of electrical contacts form operable connections to the electronic circuitry through each of the plurality of electrical connector, and the insulating regions and the electrical insulators electrically isolate adjacent operable connections. Leads, and methods are also disclosed.
摘要翻译：一种包括引线和可植入信号发生器的可植入系统，其中所述多个电触点和所述引线上的所述多个绝缘区域以及所述连接器块中的所述多个电连接器和所述多个绝缘体被配置为使得每个多个电触头通过多个电连接器中的每一个形成与电子电路的可操作连接，并且绝缘区域和电绝缘体电隔离相邻的可操作连接。引线和方法也被公开。

6. 发明申请

US20080262582A1 IMPLANTABLE MEDICAL ELECTRICAL LEAD AND CONNECTOR ASSEMBLY 有权
标题翻译：可植入医用电线和连接器总成
公开(公告)号：US20080262582A1
公开(公告)日：2008-10-23
申请号：US11737927
申请日：2007-04-20
申请人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
发明人： James A. Alexander , James M. Olsen , Chad Q. Cai , Richard T. Stone , James G. Skakoon , Kristin J. Schneider
IPC分类号： A61N1/05 , H02H3/00
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3752 , A61N2001/083
摘要： An implantable system that includes a lead and an implantable signal generator wherein the plurality of electrical contacts and the plurality of insulating regions on the lead, and the plurality of electrical connectors and the plurality of electrical insulators in the connector block are configured so that each of the plurality of electrical contacts form operable connections to the electronic circuitry through each of the plurality of electrical connector, and the insulating regions and the electrical insulators electrically isolate adjacent operable connections. Leads, and methods are also disclosed.
摘要翻译：一种包括引线和可植入信号发生器的可植入系统，其中所述多个电触点和所述引线上的所述多个绝缘区域以及所述连接器块中的所述多个电连接器和所述多个绝缘体被配置为使得每个多个电触头通过多个电连接器中的每一个形成与电子电路的可操作连接，并且绝缘区域和电绝缘体电隔离相邻的可操作连接。引线和方法也被公开。

7. 发明申请

US20120035696A1 TERMINATION OF A SHIELD WITHIN AN IMPLANTABLE MEDICAL LEAD 审中-公开
标题翻译：在可植入医疗领域终止护理
公开(公告)号：US20120035696A1
公开(公告)日：2012-02-09
申请号：US13264179
申请日：2010-04-27
申请人： Michael J. Kern , James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Brian T. Stolz
发明人： Michael J. Kern , James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Brian T. Stolz
IPC分类号： A61N1/05 , H01B19/00
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： A shield located within an implantable medical lead may be terminated in various ways. The shield may be terminated by butt, scarf, lap, or other joints between insulation layers surrounding the lead and an insulation extension. For lap joints, a portion of an outer insulation layer may be removed and a replacement outer insulation layer is positioned in place of the removed outer insulation layer, where the replacement layer extends beyond an inner insulation layer and the shield. The replacement layer may also lap onto a portion of the insulation extension. Barbs may be located between the replacement layer and the inner insulation layer or the insulation extension. The shield wires have ends at the termination point that may be folded over individually or may be capped with a ring located within one of the insulation layers of the jacket.
摘要翻译：位于可植入医疗引线内的护罩可以以各种方式终止。护罩可以通过对接，围巾，搭接或围绕导线的绝缘层与绝缘延伸部分之间的其他接头来终止。对于搭接接头，可以去除外部绝缘层的一部分，并且替换外部绝缘层被定位成代替去除的外部绝缘层，其中替换层延伸超出内部绝缘层和屏蔽。替换层也可以搭接在绝缘延伸部分的一部分上。倒钩可以位于替换层和内绝缘层之间或绝缘延伸部分之间。屏蔽线在终止点处具有可以单独折叠的端部，或者可以用位于护套的绝缘层之一内的环来封盖。

8. 发明授权

US09205253B2 Shielding an implantable medical lead 有权
标题翻译：屏蔽植入式医疗用铅
公开(公告)号：US09205253B2
公开(公告)日：2015-12-08
申请号：US13264067
申请日：2010-04-27
申请人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号： A61N1/05 , A61N1/08 , A61N1/37 , A61N1/375 , A61M25/01 , A61B19/00
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： Implantable medical leads are shielded with a braided shield that surrounds an inner layer of insulation. An outer layer of insulation may also surround the shield. The shield is designed with parameters that limit the passage of radio frequency energy, particularly in the magnetic resonance imaging spectrum, to filars that are surrounded by the inner layer of insulation. The braided shield has a plurality of parameters and corresponding ranges. The parameters include one or more of braid angle, wire size, number of wires wound per direction, number of wires in a bundle, wire spacing in an axial dimension, ultimate tensile strength, cross-sectional wire shape, material, and distance from termination to a nearest electrode. Additional parameters of the lead related to the shielding also include one or more of inner insulation thickness, and outer insulation thickness.
摘要翻译：可植入的医用引线用围绕绝缘层内层的编织屏蔽屏蔽。绝缘外层也可围绕屏蔽。屏蔽设计有限制射频能量通过的参数，特别是在磁共振成像光谱中，由绝缘层内层包围的丝束。编织屏蔽具有多个参数和相应的范围。这些参数包括一个或多个编织角度，线径，每个方向缠绕的线数，束中的线数，轴向尺寸的线间距，极限拉伸强度，截面线形状，材料和距离终止到最近的电极。与屏蔽相关的引线的附加参数还包括内绝缘厚度和外绝缘厚度中的一个或多个。

9. 发明授权

US09186499B2 Grounding of a shield within an implantable medical lead 有权
标题翻译：在植入式医疗导线内接地护罩
公开(公告)号：US09186499B2
公开(公告)日：2015-11-17
申请号：US13264171
申请日：2010-04-27
申请人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号： A61N1/05 , A61N1/08 , A61N1/375 , A61N1/37 , A61M25/01 , A61B19/00
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： Grounding of a shield that is located in an implantable medical lead may be done in many ways. The ground pathway may couple to the shield at a point that is outside of a header of an implantable medical device to which the implantable medical lead is attached. The ground pathway may couple to the shield at a point that is within the header of the implantable medical device. The ground pathway may terminate at the metal can of the implantable medical device. As another option, the ground pathway may terminate at a ground plate that is mounted to the header. The ground pathway may be direct current coupled from the shield to the can or ground plate. Alternatively, the ground pathway may include one or more capacitive couplings that provide a pathway for induced radio frequency current.
摘要翻译：位于植入式医疗引线中的护罩的接地可以以许多方式进行。接地路径可以在可植入医疗引线附接到的可植入医疗装置的头部之外的点处联接到屏蔽件。接地路径可以在可植入医疗设备的头部内的点处耦合到屏蔽。接地路径可以终止于可植入医疗装置的金属罐。作为另一选择，接地路径可以终止于安装到集管的接地板上。接地路径可以是从屏蔽件连接到罐或接地板的直流电流。或者，接地路径可以包括提供用于感应射频电流的路径的一个或多个电容耦合。

10. 发明授权

US10035014B2 Steering an implantable medical lead via a rotational coupling to a stylet 有权
公开(公告)号：US10035014B2
公开(公告)日：2018-07-31
申请号：US13264013
申请日：2010-04-27
申请人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conway , Timothy R. Abraham
发明人： James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conway , Timothy R. Abraham
IPC分类号： A61N1/05 , A61N1/08 , A61N1/37 , A61N1/375 , A61B90/00
CPC分类号： A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要： An implantable medical lead has a torsional stiffness and is rotationally coupled to a stylet. Applying rotation directly to the lead in turn causes rotation of the stylet. Where the stylet has a bent tip for purposes of steering the lead, the rotation applied to the lead rotates the bent tip so that the lead can be steered by rotating the lead rather than rotating a hub of the stylet. The rotational coupling may be achieved through one or more features provided for the lead and/or the stylet, such as a feature within a lumen of the lead that mates to a feature along the stylet or a feature of the stylet hub that engages the proximal end of the lead. The torsional stiffness of the lead may be provided by adding a feature within the lead body, such as a braided metal wire or an overlapping foil.

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