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    • 3. 发明授权
    • Method for separation and recovery of biological materials
    • 生物材料的分离和回收方法
    • US5552325A
    • 1996-09-03
    • US916801
    • 1992-07-17
    • Samuel NochumsonBruce S. Goldberg
    • Samuel NochumsonBruce S. Goldberg
    • G01N1/10B01L3/14G01N33/49G01N33/543G01N1/18
    • B01L3/5021G01N33/491G01N33/54366Y10T436/25375Y10T436/255
    • Disclosed is a centrifuge tube containing a porous selection means for selectively separating and recovering biological substances from gels, broths, or solutions containing the same, and thus concentrating them, the tube comprising separate upper and lower containers and means for joining the two containers to form a unitary device, the bottom of the upper container comprising a porous selection means, preferably a membrane containing a particulate substance which will selectively bind the biological substances while allowing unbound substances to pass through from the upper to lower container while being centrifuged. A method for recovering the biological substances in high concentration using the centrifuge tube is also provided, comprising introducing said gels, broths, or solutions containing the desired biological substances, centrifuging the same until the desired substance is bound to the selection means, and eluting the bound material from the selection means to recover the substance in concentrated form.
    • 公开了一种离心管,其包含多孔选择装置,用于从凝胶,肉汤或含有它们的溶液中选择性分离和回收生物物质,并因此浓缩它们,所述管包括分开的上部和下部容器以及用于连接两个容器以形成 上部容器的底部包括多孔选择装置,优选是含有颗粒物质的膜,该颗粒物质将选择性地结合生物物质同时允许未结合的物质在离心时从上到下容器通过。 还提供了使用离心管回收高浓度生物物质的方法,包括引入所述凝胶,肉汤或含有所需生物物质的溶液,将其离心,直到所需物质与选择装置结合, 来自选择的结合材料意味着以浓缩形式回收物质。
    • 10. 发明授权
    • Spiral designed reactor
    • 螺旋设计反应堆
    • US4689302A
    • 1987-08-25
    • US595954
    • 1984-04-02
    • Bruce S. GoldbergRichard Chen
    • Bruce S. GoldbergRichard Chen
    • A23C21/00B01J8/00B01J8/02B01J16/00C12C13/00C12M1/40C12N11/00
    • B01J16/00C12M21/18C12M23/02C12M23/26
    • A flow reactor for reacting a feedstock with a proteinaceous preparation immobilized on and within the pores of a support medium while traversing a spiral path between adjacent turns of said spiral. A support medium has a spacing means placed on one surface thereof. The support medium and spacing means are then wound upon a porous core to form a jelly roll-like spiral configuration. The marginal edges of the reactors are sealed but provision is made to introduce or remove materials from said core and the free end of the spiral is left open to also introduce or remove materials. In a first form the feedstock is introduced into the core and the reacted feedstock is removed from the spiral free end. In a second form the introduction and removal of the feedstock and reacted feedstock is reversed. The spacing means may be a series of ribs on the support medium or may be a net-like sheet.
    • 一种流动反应器,用于使原料与固定在载体介质的孔内和内部的蛋白质制剂反应,同时穿过所述螺旋的相邻匝之间的螺旋路径。 支撑介质具有放置在其一个表面上的间隔装置。 然后将支撑介质和间隔装置卷绕在多孔芯上以形成果冻卷状螺旋构型。 反应器的边缘被密封,但是提供从所述芯引入或移除材料,并且螺旋的自由端保持打开以也引入或去除材料。 在第一种形式中,将原料引入核心,并将反应的原料从螺旋自由端除去。 在第二种形式中,引入和除去原料和反应的原料是相反的。 间隔装置可以是支撑介质上的一系列肋,或者可以是网状片。