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1. 发明授权

US5861501A Capped synthetic RNA, analogs, and aptamers 失效
公开(公告)号：US5861501A
公开(公告)日：1999-01-19
申请号：US807104
申请日：1997-02-04
申请人： Fritz Benseler , James L. Cole , David B. Olsen , Lawrence C. Kuo
发明人： Fritz Benseler , James L. Cole , David B. Olsen , Lawrence C. Kuo
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/16 , C07H21/00 , C07H21/02 , C12N15/113 , C12N15/115 , C12Q1/68
CPC分类号： C12N15/115 , C07H21/00 , C12N15/1131 , A61K38/00 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3513
摘要： A method is provided for making synthetic capped RNAs. These compounds serve as substrates for the virally encoded endonuclease associated with influenza virus. We are able to assay for this unique and specific viral activity of cleavage of a capped RNA in vitro. Therefore, screening of inhibitors of this activity is possible. In addition, short non-extendible (due to their length or because of the modification of the 3'-end of the oligo, i.e. 3'-dA) RNAs are potent inhibitors of the cleavage of capped RNAs by influenza endonuclease. Finally, these compounds may be used to investigate viral and cellular mechanisms of transcription/translation or mRNA maturation.

2. 发明授权

US6111095A Capped synthetic RNA, analogs, and aptamers 失效
公开(公告)号：US6111095A
公开(公告)日：2000-08-29
申请号：US480068
申请日：1995-06-07
申请人： Fritz Benseler , James L. Cole , David B. Olsen , Lawrence C. Kuo
发明人： Fritz Benseler , James L. Cole , David B. Olsen , Lawrence C. Kuo
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/16 , C07H21/00 , C07H21/02 , C12N15/113 , C12N15/115 , C12Q1/68 , C12N9/12
CPC分类号： C12N15/115 , C07H21/00 , C12N15/1131 , A61K38/00 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3513
摘要： A method is provided for making synthetic capped RNAs. These compounds serve as substrates for the virally encoded endonuclease associated with influenza virus. We are able to assay for this unique and specific viral activity of cleavage of a capped RNA in vitro. Therefore, screening of inhibitors of this activity is possible. In addition, short non-extendible (due to their length or because of the modification of the 3'-end of the oligo, i.e. 3'-dA) RNAs are potent inhibitors of the cleavage of capped RNAs by influenza endonuclease. Finally, these compounds may be used to investigate viral and cellular mechanisms of transcription/translation or mRNA maturation.

3. 发明授权

US06369208B1 Capped synthetic RNA, analogs, and aptamers 失效
标题翻译：封盖的合成RNA，类似物和适体
公开(公告)号：US06369208B1
公开(公告)日：2002-04-09
申请号：US08973137
申请日：1998-03-30
申请人： James L. Cole , Lawrence C. Kuo , David B. Olsen , Fritz Benseler
发明人： James L. Cole , Lawrence C. Kuo , David B. Olsen , Fritz Benseler
IPC分类号： C07H2102
CPC分类号： C12N15/115 , A61K38/00 , C07H21/00 , C12N15/1131 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3513 , C12N2310/3521
摘要： A method is provided for making synthetic capped RNAs. These compounds serve as substrates for the virally encoded endonuclease associated with influenza virus. We are able to assay for this unique and specific viral activity of cleavage of a capped RNA in vitro. Therefore, screening of inhibitors of this activity is possible. In addition, short non-extendible (due to their length or because of the modification of the 3′-end of the oligo, i.e. 3′-dA) RNAs are potent inhibitors of the cleavage of capped RNAs by influenza endonuclease. Finally, these compounds may be used to investigate viral and cellular mechanisms of transcription/translation or mRNA maturation.
摘要翻译：提供了制备合成上限RNA的方法。这些化合物用作与流感病毒相关的病毒编码的内切核酸酶的底物。我们能够测定这种在体外切割加盖RNA的独特且特异的病毒活性。因此，可以筛选该活性的抑制剂。此外，短的不可延伸的（由于其长度或由于寡核苷酸的3'末端的修饰，即3'-dA）RNA是流感内切核酸酶切割加帽RNA的有效抑制剂。最后，这些化合物可用于研究转录/翻译或mRNA成熟的病毒和细胞机制。

4. 发明授权

US5660989A DNA polymerase extension assay for influenza virus endonuclease 失效
标题翻译：流感病毒内切核酸酶的DNA聚合酶延伸测定
公开(公告)号：US5660989A
公开(公告)日：1997-08-26
申请号：US487759
申请日：1995-06-07
申请人： James L. Cole , Lawrence C. Kuo , David B. Olsen
发明人： James L. Cole , Lawrence C. Kuo , David B. Olsen
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/701 , C12Q1/6846
摘要： An assay for the influenza virus endonuclease has been developed which involves DNA polymerase-catalyzed extension of the viral endonuclease cleavage product using labeled nucleotides and a DNA template containing a 3' region complementary to the product joined to a 5' region consisting of repeated residues. The DNA polymerase coupled assay does not involve gel electrophoretic separation and is amenable to high volume screening of potential inhibitors. Another key feature of the assay is that it is sensitive enough to detect 200 attomoles of product.
摘要翻译：已经开发了用于流感病毒核酸内切酶的测定法，其涉及使用标记的核苷酸对病毒核酸内切酶切割产物进行DNA聚合酶催化的延伸，并且包含与连接到由重复残基组成的5'区域的产物互补的3'区域的DNA模板。 DNA聚合酶偶联测定不涉及凝胶电泳分离，并且适于对潜在的抑制剂进行高体积筛选。该测定的另一个关键特征是足够敏感以检测200个产品的阿托莫尔。

5. 发明授权

US6100028A DNA polymerase extension assay 失效
标题翻译： DNA聚合酶延伸测定
公开(公告)号：US6100028A
公开(公告)日：2000-08-08
申请号：US973139
申请日：1998-07-31
申请人： James L. Cole , Lawrence C. Kuo , David B. Olsen
发明人： James L. Cole , Lawrence C. Kuo , David B. Olsen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806
摘要： The present invention provides rapid accurate sensitive assays specific for the detection of at least one a single stranded oligonucleotide produced by the action of an enzyme on a substrate. The assays are useful to detect the presence in a sample of an enzyme which acts on an oligonucleotide substrate to generate a single stranded oligonucleotide product and to detect inhibitors of such an enzyme.
摘要翻译： PCT No.PCT / US96 / 08330 Sec。 371日期：1998年7月31日 102（e）1998年7月31日PCT PCT 1996年6月3日PCT公布。出版物WO96 / 40994 日期1996年12月19日本发明提供了对通过酶在基质上的作用产生的至少一种单链寡核苷酸的检测特异性的快速精确的敏感性测定。测定法可用于检测在寡核苷酸底物上作用于酶的样品中的存在以产生单链寡核苷酸产物并检测这种酶的抑制剂。

6. 发明授权

US5886626A System and method for performing jamming testing on communication networks 失效
标题翻译：在通信网络上执行干扰测试的系统和方法
公开(公告)号：US5886626A
公开(公告)日：1999-03-23
申请号：US942120
申请日：1997-10-01
申请人： Mark W. Hynes , James L. Cole , Barry C. Miller , Scott A. Morris , Robert E. Reiner
发明人： Mark W. Hynes , James L. Cole , Barry C. Miller , Scott A. Morris , Robert E. Reiner
IPC分类号： G01S1/00 , G01S7/38
CPC分类号： H04K3/94 , H04K3/43
摘要： A system is tested for jamming resistance by supplying a simulated jammingignal. The simulated jamming signal is produced by calculating a propagation path loss in the terrain between the system under test and a location where the jammer would be, predicting a jamming level in accordance with the propagation path loss, and generating a simulated jamming signal. The simulated jamming signal is supplied to the antenna port of the system under test. The testing does not require the use of either a real jammer or a pilot signal generator at the location where the jammer would be.
摘要翻译：通过提供模拟干扰信号来测试系统的抗干扰性。模拟干扰信号是通过计算被测系统之间的地形和干扰器的位置之间的传播路径损耗来产生的，根据传播路径损耗预测干扰水平，并产生模拟干扰信号。模拟干扰信号被提供给被测系统的天线端口。测试不需要在干扰器的位置使用真正的干扰信号或导频信号发生器。

7. 发明授权

US06748351B1 Modular covert remote electronic warfare simulator 失效
标题翻译：模块化隐蔽遥控电子战模拟器
公开(公告)号：US06748351B1
公开(公告)日：2004-06-08
申请号：US09718153
申请日：2000-11-22
申请人： Mark W. Hynes , Robert L. Weeks , James L. Cole , Robert E. Reiner , Timothy T. Taylor
发明人： Mark W. Hynes , Robert L. Weeks , James L. Cole , Robert E. Reiner , Timothy T. Taylor
IPC分类号： G06G762
CPC分类号： H04K3/94 , H04B17/23 , H04K3/20 , H04K3/42 , H04K3/44
摘要： An apparatus for electronic warfare signal simulation which is used in an external test system to simultaneously test a plurality of “victim” communication systems for vulnerability to jamming. The test system includes a remote radiator of a signal free of jamming effects, and a remote radiator of one or more radio frequency control signals which represent one or more predetermined jamming threats in the low and mid bands. The simulation apparatus has a pair of couplers, each adapted to be coupled between a respective one of a plurality of “victim” antennas and its associated “victim” receiver, for coupling off the control signals to a receiving circuit, a plurality of modules for generating simulated jamming signals, and a band select circuit for translating the frequency of each simulated jamming signal, setting its level to that determined for its control signal, and replicating the “victim” antenna gains, and feeding the modified simulated jamming signals together with the desired signal to the plurality of “victim” receivers.
摘要翻译：一种用于电子战信号模拟的装置，其用于外部测试系统以同时测试多个“受害者”通信系统以使其易受到干扰。测试系统包括无干扰效应的信号的远程辐射器，以及表示低频和中频带中的一个或多个预定的干扰威胁的一个或多个射频控制信号的远程辐射器。模拟装置具有一对耦合器，每个耦合器适于耦合在多个“受害者”天线中的相应一个天线及其相关联的“受害者”接收器之间，用于将控制信号耦合到接收电路，多个模块用于产生模拟干扰信号，以及用于转换每个模拟干扰信号的频率的频带选择电路，将其电平设置为对其控制信号确定的电平，并复制“受害者”天线增益，并将修改的模拟干扰信号与对多个“受害者”接收者的期望信号。

8. 发明授权

US5583509A Communications electronic warfare trainer 失效
标题翻译：通讯电子战教练
公开(公告)号：US5583509A
公开(公告)日：1996-12-10
申请号：US504304
申请日：1995-07-20
申请人： Mark W. Hynes , James L. Cole , Garrett W. Conover , Michael J. O'Connor
发明人： Mark W. Hynes , James L. Cole , Garrett W. Conover , Michael J. O'Connor
IPC分类号： H04K3/00 , G01S7/38
CPC分类号： H04K3/45 , H04K3/41 , H04K3/42
摘要： A communications electronic warfare trainer that includes apparatus and a thod by which a training umpire can control the localized jamming of a victim communications system. A control signal containing an address and duration of jamming is generated and transmitted using the same frequency as the victim communications system. The control signal is processed by a Receiver Unit collocated with the victim communications system to determine if the control signal address matches the address of the victim communications system. If an address match is found, a jamming signal is produced for the specified duration causing disruption of the normal operation of the victim communications system.
摘要翻译：一种通信电子战训练机，其包括训练公断员可以控制受害者通信系统的局部干扰的装置和方法。使用与受害者通信系统相同的频率来产生并发送包含地址和干扰持续时间的控制信号。控制信号由与受害者通信系统并置的接收器单元进行处理，以确定控制信号地址是否与受害者通信系统的地址相匹配。如果发现地址匹配，则在指定的时间内产生干扰信号，导致受害者通信系统的正常操作中断。

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