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1. 发明授权

US06855833B2 Methods for producing amino substituted chromanes and intermediates thereof 有权
标题翻译：制备氨基取代的色烷的方法及其中间体
公开(公告)号：US06855833B2
公开(公告)日：2005-02-15
申请号：US10296873
申请日：2001-06-01
申请人： James Kanter , John J. G. Mullins , Robert Scarborough , Derek Walker , Thomas Hense
发明人： James Kanter , John J. G. Mullins , Robert Scarborough , Derek Walker , Thomas Hense
IPC分类号： A61P7/00 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/66
CPC分类号： C07D311/22 , C07D311/20 , C07D311/58
摘要： Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
摘要翻译：本发明公开了生产色氨酸化合物，优选苯并二氢吡喃-2-基乙酸化合物和6-氨基 - 苯并二氢吡喃-2-基乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。

2. 发明授权

US5660711A Process for the preparation of intermediates useful in the synthesis of cephalosporins 失效
标题翻译：制备可用于合成头孢菌素的中间体的方法
公开(公告)号：US5660711A
公开(公告)日：1997-08-26
申请号：US569631
申请日：1995-12-08
申请人： Derek Walker , Junning Lee , Charles R. Martin , Haiyan Zhang , Loris Sogli , Ermanno Bernasconi , Vinod Parakkal Menon
发明人： Derek Walker , Junning Lee , Charles R. Martin , Haiyan Zhang , Loris Sogli , Ermanno Bernasconi , Vinod Parakkal Menon
IPC分类号： C07D501/00 , C07D501/04 , C07D501/12 , C07D501/14 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/59 , C25B3/04 , C25B3/00
CPC分类号： C07D501/00 , Y02P20/55
摘要： A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R.sup.3 is CH.sub.3 C(O)--; ##STR2## is an optional sulfoxide group; n is 2 or 3; R.sup.1 is H and R is H or NHR.sup.2, where R.sup.2 is H or a protecting group selected from C.sub.6 H.sub.5 CH.sub.2 OC(O)--, C.sub.6 H.sub.5 C(O)-- or C.sub.1 -C.sub.6 alkoxy-C(O)--; or wherein R and R.sup.1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.
摘要翻译：描述了一种用于制备用于合成头孢菌素类抗生素如头孢他啶的3-异亚甲基头孢菌酸衍生物的方法。该方法包括电化学还原式（IV）化合物其中：R3是CH 3 C（O） - ; 是一个可选的亚砜基团; n为2或3; R1为H且R为H或NHR2，其中R2为H或选自C6H5CH2OC（O） - ，C6H5C（O） - 或C1-C6烷氧基-C（O） - 的保护基）。或其中R和R 1与它们所连接的碳原子一起包含-C（O） - 并且产生具有低水平的相应3-甲基互变异构体的所需3-异丙烯基化合物。

3. 发明授权

US4407755A 6-Amino penam derivatives 失效
标题翻译： 6-氨基penam衍生物
公开(公告)号：US4407755A
公开(公告)日：1983-10-04
申请号：US289621
申请日：1981-08-03
申请人： Robert L. Cundall , Derek Walker
发明人： Robert L. Cundall , Derek Walker
IPC分类号： C07D499/00 , C07D499/42 , C07D499/02
CPC分类号： C07D499/00
摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.
摘要翻译：将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

4. 发明授权

US4347354A Preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products obtained therefrom 失效
标题翻译：制备1-N- [ω-氨基-α-羟基烷酰基]氨基糖苷聚硅酸化抗生素及其产物
公开(公告)号：US4347354A
公开(公告)日：1982-08-31
申请号：US192656
申请日：1980-10-01
申请人： Martin J. Cron , John G. Keil , Jeng S. Lin , Mariano Ruggeri , Derek Walker
发明人： Martin J. Cron , John G. Keil , Jeng S. Lin , Mariano Ruggeri , Derek Walker
IPC分类号： C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/582
摘要： An improved process for the preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminoglycoside antibiotics comprises acylating a polysilylated aminoglycoside antibiotic in a substantially anhydrous organic solvent with an acylating derivative of an .omega.-amino-.alpha.-hydroxyalkanoic acid.
摘要翻译：用于制备1-N- [ω-氨基-α-羟基烷酰基]氨基糖苷类抗生素的改进方法包括用ω-氨基-α-羟基链烷酸的酰化衍生物在基本无水的有机溶剂中酰化聚硅酸化的氨基糖苷类抗生素。

5. 发明授权

US4310459A Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters 失效
标题翻译：用于从青霉素亚砜酯生产氨基甲酰取代的阴茎和氨基甲酰取代的Cepham的方法
公开(公告)号：US4310459A
公开(公告)日：1982-01-12
申请号：US092248
申请日：1979-11-07
申请人： Robert L. Cundall , Derek Walker
发明人： Robert L. Cundall , Derek Walker
IPC分类号： C07D499/00 , C07D499/04 , C07D501/04 , C07D501/02
CPC分类号： C07D499/00
摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.
摘要翻译：将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。可以从（取代-2-氨基甲酰氧基草丁腈或（取代的）-3-氨基甲酰氧基头孢中除去取代基，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

6. 发明授权

US06955193B2 Fire resistant textile material 有权
标题翻译：耐火纺织材料
公开(公告)号：US06955193B2
公开(公告)日：2005-10-18
申请号：US10363753
申请日：2001-09-05
申请人： Thomas Hainsworth , Derek Walker
发明人： Thomas Hainsworth , Derek Walker
IPC分类号： D03D11/00 , D03D15/12 , B27N9/00
CPC分类号： D03D15/12 , D03D11/00 , D10B2331/021 , Y10S428/921 , Y10T442/3276 , Y10T442/3285
摘要： A fire resistant material comprising a woven faced fabric composed or fibers from meta-aramid, polyamideimide and mixtures thereof, the woven back fabric of low thermal shrinkage fibers selected from para-aramid, polyparaphenylene terephthalamide copolymer and mixtures thereof.
摘要翻译：一种耐火材料，包括由间位芳族聚酰胺，聚酰胺酰亚胺及其混合物组成的织物织物或选自对芳族聚酰胺，聚对苯二甲酰对苯二甲酰胺共聚物及其混合物的低热收缩纤维的编织后织物。

7. 发明授权

US4340344A Apparatus for manufacture of thermoplastics pipe 失效
标题翻译：热塑性塑料管制造装置
公开(公告)号：US4340344A
公开(公告)日：1982-07-20
申请号：US185926
申请日：1980-09-10
申请人： William C. Aston , Derek Walker
发明人： William C. Aston , Derek Walker
IPC分类号： B29C49/00 , B29C33/02 , B29C33/76 , B29C35/04 , B29C49/46 , B29C49/48 , B29C49/58 , B29C49/62 , B29C49/64 , B29C49/66 , B29C57/02 , B29C65/00 , B29L31/24 , B29C17/07
CPC分类号： B29C49/48 , B29C49/46 , B29C49/6418 , B29C2049/0089 , B29C2049/465 , B29C2049/4652 , B29C2049/4655 , B29C35/041 , B29K2105/258 , B29L2023/22
摘要： A mould for use in the manufacture of thermoplastics eg PVC pipe by radial expansion of a pipe blank, the mould comprising a cylindrical central portion 10 and two removable mould end portions 11, 12. The pipe blank 14 is located centrally within the mould by mandrels 13 within each mould end portion 11, 12. Water inlet/outlet ports 15, 16 are provided in each mould end portion 11, 12 to admit water to and remove it from the region between the blank 14 and the mould walls, and the mandrels 13 are hollow to permit inlet/outlet of water through the interior of the blank 14.
摘要翻译：用于制造热塑性塑料的模具，例如通过管坯的径向膨胀的PVC管，该模具包括圆柱形中心部分10和两个可拆卸的模具端部11,12。管坯14通过心轴位于模具的中心在每个模具端部11,12中设置有水入口/出口15,16，每个模具端部11,12中都允许水从坯件14和模具壁之间的区域中移出并移除，并且心轴 13是中空的，以允许水的入口/出口通过坯料14的内部。

8. 发明授权

US4316017A Cephalosporin intermediates 失效
标题翻译：头孢菌素中间体
公开(公告)号：US4316017A
公开(公告)日：1982-02-16
申请号：US158546
申请日：1980-06-11
申请人： Derek Walker , Herbert H. Silvestri , Chester Sapino , David A. Johnson
发明人： Derek Walker , Herbert H. Silvestri , Chester Sapino , David A. Johnson
IPC分类号： C07D501/06 , C07D501/36 , C07F7/10
CPC分类号： C07D501/36 , C07D501/04 , C07D501/06 , C07F7/10
摘要： In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
摘要翻译：在本发明的优选实施方案中，7-三甲基甲硅烷氧基羰基氨基头孢烷酸三甲基甲硅烷基酯通过将干二氧化碳鼓泡至6-三甲基甲硅烷基氨基头孢烷酸三甲基甲硅烷基酯的无水溶液中而制备，发现它是通过其在无水介质中的酰化生产头孢羟氨苄和头孢氨苄的有用中间体合适的2-苯基甘氨酰氯盐酸盐。其它头孢菌素是通过在3-位上具有各种取代基的7-三甲基甲硅烷氧基羰基氨基头孢-3-烯-4-羧酸或酯而产生的。

9. 发明授权

US4083837A Oxidation of hydrazones to the corresponding diazo compound 失效
标题翻译：将腙氧化成相应的重氮化合物
公开(公告)号：US4083837A
公开(公告)日：1978-04-11
申请号：US721330
申请日：1976-09-07
申请人： Gerard Gallagher , Derek Walker
发明人： Gerard Gallagher , Derek Walker
IPC分类号： C07C245/14 , C07C113/00 , C07C113/02 , C07C113/04
CPC分类号： C07C245/14 , C07C2103/18
摘要： A process for the preparation of diazo compounds, particularly diazoalkanes, is described in which a hydrazone is oxidized with an oxidizing agent, said oxidizing agent comprising an organic peracid, chloramine-T or N-chlorosuccinimide to a corresponding diazo compound, preferably in the presence of a base. The reaction may be catalyzed by an oxidation catalyst such as iodine.
摘要翻译：描述了制备重氮化合物，特别是重氮烷烃的方法，其中腙用氧化剂氧化，所述氧化剂包含有机过酸，氯胺-T或N-氯代琥珀酰亚胺至相应的重氮化合物，优选在存在下的基地。反应可以通过氧化催化剂如碘催化。

10. 发明授权

US4059573A Extraction of N-blocked amino acids from aqueous media 失效
标题翻译：从含水介质中提取N-封闭的氨基酸
公开(公告)号：US4059573A
公开(公告)日：1977-11-22
申请号：US671935
申请日：1976-03-30
申请人： Colin Robinson , Derek Walker
发明人： Colin Robinson , Derek Walker
IPC分类号： C07D499/00 , C07D499/18 , C07D501/12 , C07C103/52
CPC分类号： C07D499/00
摘要： N-blocked amino acids, particularly derived from natural sources such as fermentation liquors, are extractively esterified from aqueous media by treatment of the aqueous solution with a diazoalkane, e.g. diphenyldiazomethane, in the presence of a water-immiscible organic solvent. Useful applications of the process include the extractive esterification of N-blocked derivatives of cephalosporin C and desacetyl cephalosporin C from fermentation broths.
摘要翻译：特别是衍生自天然来源例如发酵液的N-封闭的氨基酸通过用重氮烷（例如水溶液）处理水溶液从水性介质中萃取酯化。二苯基重氮甲烷，在与水不混溶的有机溶剂的存在下。该方法的有用应用包括从发酵液中提取酯化头孢菌素C和去乙酰基头孢菌素C的N-封闭衍生物。

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