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1. 发明授权

US08198225B2 Sulfurized metal alkyl phenate compositions having a low alkyl phenol content 有权
标题翻译：具有低烷基苯酚含量的硫化金属烷基酚盐组合物
公开(公告)号：US08198225B2
公开(公告)日：2012-06-12
申请号：US11946878
申请日：2007-11-29
申请人： James J. Harrison , John McDonald
发明人： James J. Harrison , John McDonald
IPC分类号： C10M105/72 , C10M135/30 , C10M159/22
CPC分类号： C08G8/28 , C08L61/14 , C10M135/30 , C10M2219/087 , C10M2219/089 , C10N2230/04
摘要： Provided herein are sulfurized metal alkyl phenate compositions having a low alkyl phenol content. The sulfurized metal alkyl phenate compositions can be prepared by reacting a phenol compound of Formula (I) disclosed herein with an aldehyde to form a phenolic resin of Formula (II) disclosed herein and then by reacting the phenolic resin simultaneously with a metal base and a first sulfurizing agent. The sulfurized metal alkyl phenate compositions and the overbased sulfurized metal alkyl phenate compositions disclosed herein may be used as detergents for formulating lubricating oil compositions. The lubricating oil compositions disclosed herein have a reduced amount of the free phenol compound and a salt thereof.
摘要翻译：本文提供了具有低烷基苯酚含量的硫化金属烷基酚盐组合物。硫化金属烷基酚盐组合物可以通过使本文公开的式（I）的酚化合物与醛反应以形成本文公开的式（II）的酚醛树脂，然后通过使酚醛树脂与金属碱和第一次硫化剂。本文公开的硫化金属烷基酚盐组合物和高碱性硫化金属烷基酚盐组合物可用作配制润滑油组合物的洗涤剂。本文公开的润滑油组合物具有减少量的游离酚化合物及其盐。

2. 发明申请

US20090143264A1 SULFURIZED METAL ALKYL PHENATE COMPOSITIONS HAVING A LOW ALKYL PHENOL CONTENT 有权
标题翻译：具有低碱性酚醛含量的硫化金属碱金属组合物
公开(公告)号：US20090143264A1
公开(公告)日：2009-06-04
申请号：US11946878
申请日：2007-11-29
申请人： James J. Harrison , John McDonald
发明人： James J. Harrison , John McDonald
IPC分类号： C10M135/30
CPC分类号： C08G8/28 , C08L61/14 , C10M135/30 , C10M2219/087 , C10M2219/089 , C10N2230/04
摘要： Provided herein are sulfurized metal alkyl phenate compositions having a low alkyl phenol content. The sulfurized metal alkyl phenate compositions can be prepared by reacting a phenol compound of Formula (I) disclosed herein with an aldehyde to form a phenolic resin of Formula (II) disclosed herein and then by reacting the phenolic resin simultaneously with a metal base and a first sulfurizing agent. The sulfurized metal alkyl phenate compositions and the overbased sulfurized metal alkyl phenate compositions disclosed herein may be used as detergents for formulating lubricating oil compositions. The lubricating oil compositions disclosed herein have a reduced amount of the free phenol compound and a salt thereof.
摘要翻译：本文提供了具有低烷基苯酚含量的硫化金属烷基酚盐组合物。硫化金属烷基酚盐组合物可以通过使本文公开的式（I）的酚化合物与醛反应以形成本文公开的式（II）的酚醛树脂，然后通过使酚醛树脂与金属碱和第一次硫化剂。本文公开的硫化金属烷基酚盐组合物和高碱性硫化金属烷基酚盐组合物可用作配制润滑油组合物的洗涤剂。本文公开的润滑油组合物具有减少量的游离酚化合物及其盐。

3. 发明申请

US20180002095A1 HEAT SEALED PACKAGING ASSEMBLIES AND METHODS OF PRODUCING AND USING THE SAME 审中-公开
公开(公告)号：US20180002095A1
公开(公告)日：2018-01-04
申请号：US15706594
申请日：2017-09-15
申请人： John McDonald , Frank Comerford , Myles Comerford
发明人： John McDonald , Frank Comerford , Myles Comerford
IPC分类号： B65D81/07 , B65D5/50
CPC分类号： B65D81/075 , B65D5/5028
摘要： A packaging device can include a resilient member formed of one or more layers of different materials and a frame member. The resilient member can be heat sealed to the frame member or to a coating on the surface of the frame member. The layers can he made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics.

4. 发明授权

US09463915B2 Compressible packaging assembly 有权
公开(公告)号：US09463915B2
公开(公告)日：2016-10-11
申请号：US14065304
申请日：2013-10-28
申请人： John McDonald , Frank Comerford , Myles Comerford
发明人： John McDonald , Frank Comerford , Myles Comerford
IPC分类号： B65D81/107 , B65D5/02 , B65D5/20 , B65D5/50
CPC分类号： B65D81/1075 , B65D5/02 , B65D5/20 , B65D5/5028 , B65D5/509
摘要： A packaging container can be configured to include cushioning material and to be foldable between an expanded state in which the container can be used to ship an article and a compressed state in which the container occupies a smaller volumetric space without the article being contained therein. This can reduce shipping costs associated with transporting the empty container.

5. 发明授权

US08895509B2 MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells 有权
标题翻译： MIR-200家族在卵巢癌细胞中诱导间充质转化（MET）
公开(公告)号：US08895509B2
公开(公告)日：2014-11-25
申请号：US13989312
申请日：2011-11-23
申请人： John McDonald , Nathan John Bowen , LiJuan Wang
发明人： John McDonald , Nathan John Bowen , LiJuan Wang
IPC分类号： A61K48/00 , A61K9/51 , A61K45/06 , A61K31/713 , A61K31/7105 , C12N15/113 , A61K9/00
CPC分类号： C12N15/1135 , A61K9/00 , A61K9/51 , A61K9/5138 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , A61N2005/1098 , C12N15/113 , C12N2310/141 , C12N2320/31
摘要： The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
摘要翻译：本发明提供了一种治疗卵巢癌的方法，所述方法包括以有效治疗卵巢癌的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。还提供了预防卵巢癌转移的方法，所述方法包括以有效预防转移的量将一种或多种miR-200家族成员递送至有需要的哺乳动物受试者。还提供了使卵巢癌对细胞毒性疗法敏感的方法，该方法包括以有效使卵巢癌对细胞毒性疗法敏感的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。本发明还考虑了在卵巢癌或癌细胞中减少上皮 - 间质转化（EMT）的方法以及诱导间充质 - 上皮转换（MET）的方法。

6. 发明申请

US20140076769A1 MULTI-LAYERED SUSPENSION PACKAGE ASSEMBLY 有权
标题翻译：多层悬挂包装配
公开(公告)号：US20140076769A1
公开(公告)日：2014-03-20
申请号：US13620543
申请日：2012-09-14
申请人： John McDonald , Frank Comerford , Myles Comerford
发明人： John McDonald , Frank Comerford , Myles Comerford
IPC分类号： B65D81/02
CPC分类号： B65D81/075 , B32B3/04 , B32B3/266 , B32B3/30 , B32B7/02 , B32B7/045 , B32B7/12 , B32B7/14 , B32B27/08 , B32B27/10 , B32B27/32 , B32B27/40 , B32B29/08 , B32B2307/31 , B32B2307/41 , B32B2307/412 , B32B2307/414 , B32B2307/51 , B32B2307/558 , B32B2307/56 , B32B2439/40 , B32B2553/00 , B32B2553/02 , B65B55/20 , B65B61/02 , B65B61/065 , B65D5/5028 , B65D81/02 , B65D81/022 , B65D2313/00 , B65D2313/02 , B65D2313/04 , B65D2581/055
摘要： A packaging device can include a resilient member formed of two layers of different material, connected together such as by heat sealing. The layers can be made from different materials or the same materials having different thicknesses, modules of elasticity, melting index, or other different characteristics.
摘要翻译：包装装置可以包括由两层不同材料形成的弹性构件，例如通过热封连接在一起。这些层可以由不同的材料或具有不同厚度，弹性模块，熔融指数或其他不同特性的相同材料制成。

7. 发明申请

US20130243876A1 MIR-200 FAMILY INDUCES MESENCHYMAL-TO-EPITHELIAL TRANSITION (MET) IN OVARIAN CANCER CELLS 有权
标题翻译： MIR-200家族在OVARIAN癌细胞中诱导MESENCHYMAL-E上皮转移（MET）
公开(公告)号：US20130243876A1
公开(公告)日：2013-09-19
申请号：US13989312
申请日：2011-11-23
申请人： John McDonald , Nathan John Bowen , LiJuan Wang
发明人： John McDonald , Nathan John Bowen , LiJuan Wang
IPC分类号： A61K31/7105 , A61K9/51 , A61K45/06
CPC分类号： C12N15/1135 , A61K9/00 , A61K9/51 , A61K9/5138 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , A61N2005/1098 , C12N15/113 , C12N2310/141 , C12N2320/31
摘要： The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to treat the ovarian cancer. Also provided are methods of preventing metastasis of an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to prevent metastasis. Further provided are methods of sensitizing an ovarian cancer to a cytotoxic therapy, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount effective to sensitize the ovarian cancer to the cytotoxic therapy. The invention also contemplates methods of reducing epithelial-to-mesenchymal transition (EMT) in an ovarian cancer or cancer cell as well as methods of inducing mesenchymal-to-epithelial transition (MET).
摘要翻译：本发明提供了一种治疗卵巢癌的方法，所述方法包括以有效治疗卵巢癌的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。还提供了预防卵巢癌转移的方法，所述方法包括以有效预防转移的量将一种或多种miR-200家族成员递送至有需要的哺乳动物受试者。还提供了使卵巢癌对细胞毒性疗法敏感的方法，该方法包括以有效使卵巢癌对细胞毒性疗法敏感的量递送一种或多种miR-200家族成员到有需要的哺乳动物受试者。本发明还考虑了在卵巢癌或癌细胞中减少上皮 - 间质转化（EMT）的方法以及诱导间充质 - 上皮转换（MET）的方法。

8. 发明授权

US08499937B2 Suspension packaging system 有权
标题翻译：悬挂包装系统
公开(公告)号：US08499937B2
公开(公告)日：2013-08-06
申请号：US13472394
申请日：2012-05-15
申请人： John McDonald , Frank Comerford , Myles Comerford
发明人： John McDonald , Frank Comerford , Myles Comerford
IPC分类号： B65D81/02
CPC分类号： B65D81/07 , B65D5/5021 , B65D5/5028
摘要： A suspension packaging system can include a foldable member configured to form a cavity as well as a suspension device for suspending an article to be packaged within the cavity. The suspension portion can include foldable portions configured to cooperate with a retention member having pockets. The foldable portions can fit into the pockets and then be folded so as to generate tension in the retention member. The entire device, with the exception of the retention member, can be made from a single piece of material, such as corrugated cardboard, which thus reduces waste and simplifies bulk distribution of such a suspension packaging system.
摘要翻译：悬挂包装系统可以包括构造成形成空腔的可折叠构件以及用于悬挂待包装物品在空腔内的悬挂装置。悬挂部分可以包括被配置为与具有口袋的保持构件配合的可折叠部分。可折叠部分可以装配到袋中，然后被折叠以便在保持构件中产生张力。除了保持构件之外，整个装置可以由单件材料制成，例如瓦楞纸板，从而减少浪费并简化这种悬挂包装系统的散装。

9. 发明申请

US20130180938A1 ELEVATED TOOL HOLDER 审中-公开
标题翻译：高级工具夹
公开(公告)号：US20130180938A1
公开(公告)日：2013-07-18
申请号：US13741006
申请日：2013-01-14
申请人： John McDonald
发明人： John McDonald
IPC分类号： A47B81/00 , A47G21/14
CPC分类号： A47B81/00 , A47G21/14 , B25H1/12 , B25H3/00
摘要： An elevated tool holder system includes a storage block that is raised from the surface on which it is placed and has a storage area underneath the storage block to accommodate the storage of other items. The elevated tool holder can be placed inside a drawer to enable the drawer to be used for safe storage of tools as well as storage of other items.
摘要翻译：升高的工具架系统包括从其放置的表面上升起的存储块，并且在存储块下方具有容纳其它物品的存储的存储区域。升高的工具架可以放置在抽屉内，以使抽屉可用于安全存放工具以及储存其他物品。

10. 发明申请

US20130091807A1 SUSPENSION PACKAGING ASSEMBLY 审中-公开
标题翻译：悬挂包装总成
公开(公告)号：US20130091807A1
公开(公告)日：2013-04-18
申请号：US13568034
申请日：2012-08-06
申请人： John McDonald , Frank Comerford , Myles Comerford
发明人： John McDonald , Frank Comerford , Myles Comerford
IPC分类号： B65D81/02 , B65B5/04
CPC分类号： B65D81/022 , B65B5/04 , B65D5/5028 , B65D81/05 , B65D2585/6842
摘要： A suspension package assembly can include a package member and a stretchable retention member. The package member and a stretchable retention member cooperate to suspend at least one article. At least one article can be held securely between the retention member and a base member of the foldable member. The pocket of the retention member can be positioned over the foldable portions of the package member. The foldable portions can fit into the pockets and then can be folded so as to generate tension in the retention member. Coupling assemblies inhibit relative movement of the retention member and the packaging member.
摘要翻译：悬挂包装组件可以包括包装件和可拉伸保持件。包装构件和可拉伸的保持构件配合以悬挂至少一个物品。至少一个物品可以牢固地保持在保持构件和可折叠构件的基部构件之间。保持构件的凹部可以定位在包装构件的可折叠部分上方。可折叠部分可以装配到袋中，然后可以折叠以便在保持构件中产生张力。联接组件阻止保持构件和包装构件的相对移动。

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