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1. 发明授权

US08476450B2 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions 有权
标题翻译：发光和荧光化合物以及检测分子或条件的方法
公开(公告)号：US08476450B2
公开(公告)日：2013-07-02
申请号：US12217494
申请日：2008-07-03
申请人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
发明人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
IPC分类号： A61K31/428 , C07D417/04 , C07D417/14
CPC分类号： C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要： A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
摘要翻译：提供了检测采用荧光素衍生物或荧光团衍生物的样品中至少一种分子的存在或量的方法。还提供了用于实施本发明方法的化合物和组合物。

2. 发明授权

US07951550B2 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions 有权
标题翻译：发光和荧光化合物以及检测分子或条件的方法
公开(公告)号：US07951550B2
公开(公告)日：2011-05-31
申请号：US11444145
申请日：2006-05-31
申请人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
发明人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
IPC分类号： C12Q1/66 , C12Q1/26 , G01N33/573
CPC分类号： C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要： A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
摘要翻译：提供了检测采用荧光素衍生物或荧光团衍生物的样品中至少一种分子的存在或量的方法。

3. 发明申请

US20080299593A1 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions 有权
标题翻译：发光和荧光化合物以及检测分子或条件的方法
公开(公告)号：US20080299593A1
公开(公告)日：2008-12-04
申请号：US12217494
申请日：2008-07-03
申请人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
发明人： James J. Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John W. Shultz , James Unch , Michael P. Valley , Keith V. Wood , Wenhui Zhou
IPC分类号： C07D417/04 , C12Q1/66
CPC分类号： C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要： A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
摘要翻译：提供了检测采用荧光素衍生物或荧光团衍生物的样品中至少一种分子的存在或量的方法。还提供了用于实施本发明方法的化合物和组合物。

4. 发明申请

US20070015790A1 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions 有权
标题翻译：发光和荧光化合物以及检测分子或条件的方法
公开(公告)号：US20070015790A1
公开(公告)日：2007-01-18
申请号：US11444145
申请日：2006-05-31
申请人： James Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John Shultz , James Unch , Michael Valley , Keith Wood , Wenhui Zhou
发明人： James Cali , William Daily , Erika Hawkins , Dieter Klaubert , Jianquan Liu , Poncho Meisenheimer , Michael Scurria , John Shultz , James Unch , Michael Valley , Keith Wood , Wenhui Zhou
IPC分类号： C07D417/04 , A61K31/4709 , A61K31/428 , A61K31/427
CPC分类号： C07D277/66 , C07D277/68 , C07D311/16 , C07D417/04 , C07D417/14 , C07D493/10 , C07F9/65583 , C09B11/24 , C09B19/00 , C09B57/00 , C09B57/02 , C12Q1/66 , G01N2500/00
摘要： A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
摘要翻译：提供了检测采用荧光素衍生物或荧光团衍生物的样品中至少一种分子的存在或量的方法。

5. 发明申请

US20120046176A1 NUCLEIC ACID SEQUENCING 有权
标题翻译：核酸序列
公开(公告)号：US20120046176A1
公开(公告)日：2012-02-23
申请号：US12860462
申请日：2010-08-20
申请人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
发明人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
IPC分类号： C40B20/00
CPC分类号： C12Q1/6874 , C12Q2531/125 , C12Q2535/122 , C12Q2565/301 , C12Q2565/607
摘要： Nucleic acid sequencing using concatemers of DNA is provided. Optionally, amplified reaction products from the repeated incorporation and excision of a nucleoside complementary to a nucleoside of the DNA to be sequenced onto primer molecules hybridized to the concatemers of DNA are detected. Nucleic acid sequencing using concatemers of DNA and non-natural oligonucleotides is also provided. Nucleic acid sequencing reactions are detected electronically and or optically using arrays of detectors.
摘要翻译：提供使用DNA连接子的核酸测序。任选地，检测来自重复掺入和切除与待测序的DNA的核苷互补的核苷酸的扩增反应产物与DNA连接体杂交的引物分子上。还提供了使用DNA和非天然寡核苷酸的并联体的核酸测序。使用检测器阵列电子和/或光学检测核酸测序反应。

6. 发明申请

US20100330553A1 Chemically induced optical signals and DNA sequencing 有权
标题翻译：化学诱导光信号和DNA测序
公开(公告)号：US20100330553A1
公开(公告)日：2010-12-30
申请号：US12459309
申请日：2009-06-30
申请人： Xing Su , Liming Wang , Jianquan Liu , Kai Wu
发明人： Xing Su , Liming Wang , Jianquan Liu , Kai Wu
IPC分类号： C12Q1/68 , C12M1/00 , G02B6/10
CPC分类号： G02B6/1221 , C12Q1/6874 , C12Q2565/607 , C12Q2563/107 , C12Q2527/125
摘要： Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.
摘要翻译：介绍了核酸测序方法。通过化学扩增DNA合成产物和化学扩增产物的检测来完成测序。在本发明的实施方案中，提供了具有多个待测序的DNA分子的底物和能够螯合连接的焦磷酸根离子的多个分子，引入待测序的DNA分子，并且掺入下一个互补核苷酸，切除多次导致待测序的DNA分子局部周围的焦磷酸盐离子的积聚。焦磷酸根离子被底物附着的螯合剂捕获并光学检测以确定待测序的DNA分子中下一个互补核酸的同一性。

7. 发明申请

US20070148634A1 CELLS HAVING A SPECTRAL SIGNATURE AND METHODS OF PREPARATIONS AND USE THEREOF 审中-公开
标题翻译：具有光谱签名的细胞及其制备方法及其用途
公开(公告)号：US20070148634A1
公开(公告)日：2007-06-28
申请号：US11682063
申请日：2007-03-05
申请人： Marcel Bruchez , R. Daniels , Jennifer Dias , Larry Mattheakis , Jianquan Liu
发明人： Marcel Bruchez , R. Daniels , Jennifer Dias , Larry Mattheakis , Jianquan Liu
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5041 , G01N33/5076 , G01N33/5097 , G01N33/566 , G01N2333/726 , G01N2500/10
摘要： Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed.
摘要翻译：提供了用于编码具有半导体纳米晶体和/或其它荧光体的电池的方法，组合物和制品。编码的细胞可以在混合群体中进行功能测定，并且可以通过其代码确定测定结果并与单个细胞相关联。该方法在多重设置中特别有用，其中要测定多个编码的细胞。

8. 发明授权

US08715932B2 Nucleic acid sequencing 有权
标题翻译：核酸测序
公开(公告)号：US08715932B2
公开(公告)日：2014-05-06
申请号：US12860462
申请日：2010-08-20
申请人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
发明人： Xing Su , Kai Wu , Liming Wang , Jianquan Liu , Grace M. Credo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2531/125 , C12Q2535/122 , C12Q2565/301 , C12Q2565/607
摘要： Nucleic acid sequencing using concatemers of DNA is provided. Optionally, amplified reaction products from the repeated incorporation and excision of a nucleoside complementary to a nucleoside of the DNA to be sequenced onto primer molecules hybridized to the concatemers of DNA are detected. Nucleic acid sequencing using concatemers of DNA and non-natural oligonucleotides is also provided. Nucleic acid sequencing reactions are detected electronically and or optically using arrays of detectors.
摘要翻译：提供使用DNA连接子的核酸测序。任选地，检测来自重复掺入和切除与待测序的DNA的核苷互补的核苷酸的扩增反应产物与DNA连接体杂交的引物分子上。还提供了使用DNA和非天然寡核苷酸的并联体的核酸测序。使用检测器阵列电子和/或光学检测核酸测序反应。

9. 发明授权

US08674086B2 Nucleotides and oligonucleotides for nucleic acid sequencing 有权
标题翻译：用于核酸测序的核苷酸和寡核苷酸
公开(公告)号：US08674086B2
公开(公告)日：2014-03-18
申请号：US12823995
申请日：2010-06-25
申请人： Jianquan Liu , Xing Su , Kai Wu
发明人： Jianquan Liu , Xing Su , Kai Wu
IPC分类号： C07H19/20 , C07H19/00 , C07H19/04
CPC分类号： C07H19/10 , C12Q1/6874 , C12Q2521/101 , C12Q2521/319 , C12Q2521/525 , C12Q2525/186 , C12Q2537/157 , C12Q2565/537 , C12Q2565/607
摘要： Embodiments of the invention provide non-natural bifunctional nucleotides having both nuclease resistance and nucleic acid synthesis blocking properties and methods of sequencing nucleic acids that employ non-natural bifunctional nucleic acids. Additional embodiments provide non-natural oligonucleotides and methods for sequencing nucleic acids using the non-natural oligonucleotides. Methods according to embodiments of the invention employ electronic detection and fluorescent detection of nucleic acid sequencing reactions.
摘要翻译：本发明的实施方案提供具有核酸酶抗性和核酸合成阻断性质的非天然双功能核苷酸，以及使用非天然双功能核酸测序核酸的方法。另外的实施方案提供非天然寡核苷酸和使用非天然寡核苷酸测序核酸的方法。根据本发明的实施方案的方法使用核酸测序反应的电子检测和荧光检测。

10. 发明授权

US09671558B2 Chemically induced optical signals and DNA sequencing 有权
公开(公告)号：US09671558B2
公开(公告)日：2017-06-06
申请号：US12459309
申请日：2009-06-30
申请人： Xing Su , Liming Wang , Jianquan Liu , Kai Wu
发明人： Xing Su , Liming Wang , Jianquan Liu , Kai Wu
IPC分类号： C12Q1/68 , G02B6/122
CPC分类号： G02B6/1221 , C12Q1/6874 , C12Q2565/607 , C12Q2563/107 , C12Q2527/125
摘要： Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and optically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced.

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