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1. 发明申请

US20050272718A1 Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes 失效
标题翻译：用作黑色素浓缩激素拮抗剂治疗肥胖和糖尿病的多环化合物
公开(公告)号：US20050272718A1
公开(公告)日：2005-12-08
申请号：US10512986
申请日：2003-05-06
申请人： Jochen Ammenn , James Gillig , Lawrence Heinz , Philip Hipskind , Michael Kinnick , Yen-Shi Lai , John Morin , James Nixon , Carsten Ott , Kenneth Savin , Theo Schotten , Lawrence Slieker , Nancy Snyder , Michael Robertson
发明人： Jochen Ammenn , James Gillig , Lawrence Heinz , Philip Hipskind , Michael Kinnick , Yen-Shi Lai , John Morin , James Nixon , Carsten Ott , Kenneth Savin , Theo Schotten , Lawrence Slieker , Nancy Snyder , Michael Robertson
IPC分类号： A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P11/14 , A61P13/02 , A61P13/08 , A61P15/12 , A61P19/02 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P43/00 , C07D207/333 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/12 , C07D307/42 , C07D333/18 , C07D413/02 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D333/18 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译：本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）; 或其药学上可接受的盐，溶剂化物，对映异构体或前药，用于治疗，预防或改善与肥胖症和相关疾病相关的症状。

2. 发明申请

US20060052449A1 Novel mch receptor antagonists 失效
标题翻译：新型mch受体拮抗剂
公开(公告)号：US20060052449A1
公开(公告)日：2006-03-09
申请号：US10536053
申请日：2003-12-03
申请人： James Gillig , Lawrence Heinz , Michael Kinnick , Yen-Shi Lai , John Morin , Nancy Snyder
发明人： James Gillig , Lawrence Heinz , Michael Kinnick , Yen-Shi Lai , John Morin , Nancy Snyder
IPC分类号： A61K31/205 , C07C323/39
CPC分类号： C07C323/60
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereomers thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and Related Diseases.
摘要翻译：本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）其中Ar 1，Ar 2，Ar 3，L 限定的1个或2个Q区域，或其可用于治疗，预防或改善与肥胖有关的症状的非对映异构体的药学上可接受的盐，溶剂合物，对映异构体或混合物和相关疾病

3. 发明申请

US20050197299A1 Peptidomimetic protease inhibitors 有权
标题翻译：拟肽蛋白酶抑制剂
公开(公告)号：US20050197299A1
公开(公告)日：2005-09-08
申请号：US10344112
申请日：2001-08-31
申请人： Robert Babine , Shu-Hul Chen , Jason Lamar , Nancy Snyder , Xicheng Sun , Mark Tebbe , Frantz Victor , Q. Wang , Yvonne Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Parker , Ling Jing , Deqi Guo , John Glass
发明人： Robert Babine , Shu-Hul Chen , Jason Lamar , Nancy Snyder , Xicheng Sun , Mark Tebbe , Frantz Victor , Q. Wang , Yvonne Yip , Ivan Collado , Cristina Garcia-Paredes , Raymond Parker , Ling Jing , Deqi Guo , John Glass
IPC分类号： C12N9/99 , A61K20060101 , A61K31/13 , A61K31/437 , A61K31/7052 , A61K31/713 , A61K38/00 , A61K38/04 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P20060101 , A61P1/16 , A61P31/14 , A61P43/00 , C07D209/02 , C07D209/52 , C07K20060101 , C07K5/02 , C07K5/023 , C07K5/027 , C07K5/03 , C07K5/04 , C07K5/06 , C07K7/02 , C07K7/06 , C07K14/18 , C12N7/06
CPC分类号： C07K7/02 , A61K38/07 , A61K38/08 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07D209/02 , C07D209/52 , C07K5/0202 , C07K5/0205 , C07K5/06052 , C07K5/0808 , C07K5/101 , C07K5/1016 , C07K7/06 , C07K14/005 , C12N2770/24222 , Y02P20/55 , A61K2300/00
摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法使用该组合物的患者中的HCV感染。本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

4. 发明授权

US06513301B1 Method of and instrument or arrangement for installing thermal insulation sheets in confined areas 失效
标题翻译：密封区域安装保温板的方法和仪器或布置
公开(公告)号：US06513301B1
公开(公告)日：2003-02-04
申请号：US09687305
申请日：2000-10-13
申请人： Robert Snyder , Nancy Snyder
发明人： Robert Snyder , Nancy Snyder
IPC分类号： E04B100
CPC分类号： E04F21/00 , E04F21/1861 , Y10S52/01
摘要： A thermal insulation sheet is maneuvered into position, especially in closely confined corners in an attic, by a tool having a prong which is inserted into the sheet, and a pusher surface which contacts the sheet to limit the depth of insertion of the prong, and which guides the sheet while an installer pushes the pusher surface against the sheet while maintaining the prong in the sheet.
摘要翻译：通过具有插入片材的插脚的工具以及与片材接触以限制插脚的插入深度的推动器表面，将热绝缘片材操作到位置，特别是在阁楼的紧密限制的角落中，以及其在安装者将保持插脚保持在片材中的同时将推动器表面压靠在片材上时引导片材。

5. 发明授权

US5207651A Traction tube holder and method 失效
标题翻译：牵引管支架和方法
公开(公告)号：US5207651A
公开(公告)日：1993-05-04
申请号：US797042
申请日：1991-11-25
申请人： Nancy Snyder
发明人： Nancy Snyder
IPC分类号： A61M25/02
CPC分类号： A61M25/02 , A61M2025/0226 , A61M2025/028 , A61M2210/0618
摘要： There is provided an improvement to a device for slidably mounting a tube against an orifice of a medical patient, the device including a polygonal section of sponge foam, a bore through this foam and a slot for enabling the polygonal section of foam to be slid over and onto a tube. The improvement comprises a rigid backing plate that fixedly attaches to the sponge foam in an area apart from, and preferably opposite, the surface of the sponge foam section in contact with the patient's orifice. This backing plate has a bore and slot corresponding to those in the sponge foam section. With this improvement, such mounting devices may be placed in more permanent traction against the patient's nose, mouth or other orifice. A further improvement includes a gauge for varying the amount of substantially permanent traction placed on a medical tube with this device. There is also disclosed a method for supplying variable amounts of substantially permanent traction to a medical tube with the holder of this invention.
摘要翻译：提供了一种用于将管可滑动地安装到医疗患者的孔口上的装置的改进，该装置包括海绵泡沫的多边形部分，穿过该泡沫的孔，以及用于使多边形部分的泡沫能够滑过的狭槽并放在管子上。该改进包括刚性背板，其在与患者孔口接触的海绵泡沫部分的表面之外的区域（优选相对的）上固定地附接到海绵状泡沫体。该背板具有对应于海绵泡沫部分中的孔和槽。通过这种改进，这种安装装置可以被放置在更持久的牵引力下，抵靠患者的鼻子，嘴部或其他孔口。进一步的改进包括用该装置改变放置在医疗管上的基本上永久牵引的量的量规。还公开了一种用于向具有本发明的保持器的医用管提供可变量的基本永久牵引的方法。

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