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1. 发明授权

US06828475B1 Nucleic acid sequences encoding a plant cytoplasmic protein involved in fatty acyl-CoA metabolism 失效
标题翻译：编码参与脂肪酰辅酶A代谢的植物细胞质蛋白的核酸序列
公开(公告)号：US06828475B1
公开(公告)日：2004-12-07
申请号：US08657749
申请日：1996-05-30
申请人： James George Metz , Kathryn Dennis Lardizabal , Michael W. Lassner
发明人： James George Metz , Kathryn Dennis Lardizabal , Michael W. Lassner
IPC分类号： A01H510
CPC分类号： C12N15/8247 , C12N9/1029
摘要： By this invention, a plant &bgr;-ketoacyl-CoA synthase condensing enzyme is provided free from intact cells of said plant and capable of catalyzing the production of very long chain fatty acid molecules. Also contemplated are constructs comprising the nucleic acid sequence and a heterologous DNA sequence not naturally associated with the condensing enzyme encoding sequences, and which provide for at least transcription of a plant condensing enzyme encoding sequence in a host cell. In this fashion very long chain fatty acid molecules may be produced in a plant cell. Included are methods of modifying the composition of very long chain fatty acid molecules in a plant cell.
摘要翻译：通过本发明，提供植物β-酮酰基-CoA合酶缩合酶，其不含所述植物的完整细胞，并能够催化非常长链脂肪酸分子的产生。还考虑了包含核酸序列和不与冷凝酶编码序列天然相关的异源DNA序列的构建体，其提供宿主细胞中植物冷凝酶编码序列的至少转录。在这种方式中，非常长链的脂肪酸分子可以在植物细胞中产生。包括改变植物细胞中非常长链脂肪酸分子的组成的方法。

2. 发明授权

US06596538B1 Fatty acyl-CoA: fatty alcohol acyltransferases 失效
标题翻译：脂肪酰基辅酶A：脂肪醇酰基转移酶
公开(公告)号：US06596538B1
公开(公告)日：2003-07-22
申请号：US09092562
申请日：1998-06-05
申请人： Kathryn Dennis Lardizabal , James George Metz , Michael W. Lassner
发明人： Kathryn Dennis Lardizabal , James George Metz , Michael W. Lassner
IPC分类号： C12N1532
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6463
摘要： By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein said wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.
摘要翻译：通过本发明，提供了编码脂肪酰基-CoA：脂肪醇酰基转移酶（蜡合酶）的核酸序列，其中所述蜡合酶在脂肪醇和脂肪酰辅酶A底物形成蜡酯中是有活性的。特别感兴趣的是可从表观分子量为约33kD的霍霍巴胚蜡合酶获得的核酸序列。还考虑了可从蜡合酶蛋白获得的氨基酸和核酸序列，以及使用这些序列提供能够生产蜡酯的转基因宿主细胞。

3. 发明授权

US06492509B1 Fatty acyl-CoA: fatty alcohol acyltransferases 有权
标题翻译：脂肪酰基辅酶A：脂肪醇酰基转移酶
公开(公告)号：US06492509B1
公开(公告)日：2002-12-10
申请号：US09205815
申请日：1998-12-04
申请人： Kathryn Dennis Lardizabal , James George Metz , Michael W. Lassner
发明人： Kathryn Dennis Lardizabal , James George Metz , Michael W. Lassner
IPC分类号： C07H2104
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6463
摘要： By this invention, nucleic acid sequences encoding for fatty acyl-CoA: fatty alcohol acyltransferase (wax synthase) are provided, wherein wax synthase is active in the formation of a wax ester from fatty alcohol and fatty acyl-CoA substrates. Of special interest is are nucleic acid sequences obtainable from a jojoba embryo wax synthase having an apparent molecular mass of approximately 33 kD. Also considered are amino acid and nucleic acid sequences obtainable from wax synthase proteins and the use of such sequences to provide transgenic host cells capable of producing wax esters.
摘要翻译：通过本发明，提供了编码脂肪酰-CoA：脂肪醇酰基转移酶（蜡合酶）的核酸序列，其中蜡合酶在脂肪醇和脂肪酰辅酶A底物形成蜡酯中是有活性的。特别感兴趣的是可从表观分子量为约33kD的霍霍巴胚蜡合酶获得的核酸序列。还考虑了可从蜡合酶蛋白获得的氨基酸和核酸序列，以及使用这些序列提供能够生产蜡酯的转基因宿主细胞。

4. 发明授权

US5679881A Nucleic acid sequences encoding a plant cytoplasmic protein involved in fatty acyl-CoA metabolism 失效
标题翻译：编码参与脂肪酰辅酶A代谢的植物细胞质蛋白的核酸序列
公开(公告)号：US5679881A
公开(公告)日：1997-10-21
申请号：US265047
申请日：1994-06-23
申请人： James George Metz , Kathryn Dennis Lardizabal , Michael Lassner
发明人： James George Metz , Kathryn Dennis Lardizabal , Michael Lassner
IPC分类号： C12N15/09 , C12N9/00 , C12N9/10 , C12N15/54 , C12N15/82 , C12P7/64 , C12R1/91 , C12N15/29 , A01H4/00 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/1029
摘要： By this invention, a plant cytoplasmic synthase protein is provided which is selected from the group consisting of a .beta.-ketoacyl-CoA synthase and a wax synthase, and is also free from intact cells of said plant and capable of catalyzing the production of very long chain fatty acid molecules. Also contemplated are constructs comprising the nucleic acid sequence and a heterologous DNA sequence not naturally associated with the plant cytoplasmic protein encoding sequences, and which provide for at least transcription of a plant cytoplasmic protein encoding sequence in a host cell. In this fashion very long chain fatty acid molecules may be produced in a host cell. Included are methods of modifying the composition of very long chain fatty acid molecules in a plant cell.
摘要翻译：通过本发明，提供了选自β-酮酰基-CoA合成酶和蜡合酶的植物细胞质合酶蛋白质，并且也不含所述植物的完整细胞并且能够催化非常长的生产链脂肪酸分子。还考虑了包含核酸序列和不与植物细胞质蛋白编码序列天然相关的异源DNA序列的构建体，其至少提供宿主细胞中植物细胞质蛋白编码序列的至少转录。以这种方式，可能在宿主细胞中产生非常长链的脂肪酸分子。包括改变植物细胞中非常长链脂肪酸分子的组成的方法。

5. 发明授权

US5723747A Wax esters in transformed plants 失效
标题翻译：转化植物中的蜡酯
公开(公告)号：US5723747A
公开(公告)日：1998-03-03
申请号：US251464
申请日：1994-06-01
申请人： Michael Lassner , James George Metz
发明人： Michael Lassner , James George Metz
IPC分类号： A01H1/00 , C11B1/00 , C11B11/00 , C11C1/00 , C12N5/10 , C12N9/02 , C12N9/04 , C12N15/09 , C12N15/53 , C12N15/82 , C12P7/64 , A01H5/00 , A01H5/10
CPC分类号： C12N9/0008 , C11B11/00 , C12N15/8247 , C12Y102/01042
摘要： The invention provides a method of producing a wax ester in a plant cell whereby a plant cell having a fatty acyl reductase expressed from a sequence heterologous to said plant is grown in the absence of a wax synthase expressed from a sequence which is heterologous to the plant. The invention also provides plant cells containing wax ester.
摘要翻译：本发明提供了一种在植物细胞中生产蜡酯的方法，其中具有由与所述植物异源的序列表达的脂肪酰基还原酶的植物细胞在不存在由植物异源的序列表达的蜡合酶的情况下生长。本发明还提供含有蜡酯的植物细胞。

6. 发明授权

US06566583B1 Schizochytrium PKS genes 有权
标题翻译：裂殖酵母PKS基因
公开(公告)号：US06566583B1
公开(公告)日：2003-05-20
申请号：US09231899
申请日：1999-01-14
申请人： Daniel Facciotti , James George Metz , Michael Lassner
发明人： Daniel Facciotti , James George Metz , Michael Lassner
IPC分类号： C12N1582
CPC分类号： C12N15/8247 , C07K14/21 , C07K14/28 , C07K14/405 , C12N15/52 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。用于编码多不饱和长链脂肪酸生产所需的PKS样基因的核酸序列和构建体，包括负责枯草芽孢杆菌的二十碳五烯酸生产的基因以及与弧菌弧菌中二十二碳六烯酸的生产相关的新基因。转基因植物，植物部分和细胞，其含有和表达一种或多种编码一种或多种与这种长链多不饱和脂肪酸生产相关的PKS样基因的转基因。在植物系统中PKS样基因的表达允许大规模生产多不饱和长链脂肪酸如二十碳五烯酸和二十二碳六烯酸，用于修饰植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

7. 发明授权

US07214853B2 Schizochytrium PKS genes 有权
标题翻译：裂殖酵母PKS基因
公开(公告)号：US07214853B2
公开(公告)日：2007-05-08
申请号：US10331061
申请日：2002-12-27
申请人： Daniel Facciotti , James George Metz , Michael Lassner
发明人： Daniel Facciotti , James George Metz , Michael Lassner
IPC分类号： C12N15/82 , C12N5/04 , C12N1/20 , C07H21/04
CPC分类号： C12N15/8247 , C07K14/21 , C07K14/28 , C07K14/405 , C12N15/52 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。用于编码多不饱和长链脂肪酸生产所需的PKS样基因的核酸序列和构建体，包括负责枯草芽孢杆菌的二十碳五烯酸生产的基因以及与弧菌弧菌中二十二碳六烯酸的生产相关的新基因。转基因植物，植物部分和细胞，其含有和表达一种或多种编码一种或多种与这种长链多不饱和脂肪酸生产相关的PKS样基因的转基因。在植物系统中PKS样基因的表达允许大规模生产多不饱和长链脂肪酸如二十碳五烯酸和二十二碳六烯酸，用于修饰植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

8. 发明授权

US6140486A Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants 失效
标题翻译：通过在植物中表达聚酮化合物合成基因来生产多不饱和脂肪酸
公开(公告)号：US6140486A
公开(公告)日：2000-10-31
申请号：US90793
申请日：1998-06-04
申请人： Daniel Facciotti , James George Metz , Michael Lassner
发明人： Daniel Facciotti , James George Metz , Michael Lassner
IPC分类号： A01H5/00 , C07K14/21 , C07K14/28 , C12N1/12 , C12N1/13 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/52 , C12N15/82 , C12P7/64 , C12R1/01 , C12R1/225 , C07H21/04
CPC分类号： C12P7/6427 , C07K14/21 , C07K14/28 , C12N15/52 , C12N15/8247 , C12P7/6472
摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。用于编码多不饱和长链脂肪酸生产所需的PKS样基因的核酸序列和构建体，包括负责枯草芽孢杆菌的二十碳五烯酸生产的基因以及与弧菌弧菌中二十二碳六烯酸的生产相关的新基因。转基因植物，植物部分和细胞，其含有和表达一种或多种编码一种或多种与这种长链多不饱和脂肪酸生产相关的PKS样基因的转基因。在植物系统中PKS样基因的表达允许大规模生产多不饱和长链脂肪酸如二十碳五烯酸和二十二碳六烯酸，用于修饰植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

9. 发明授权

US08829274B2 Schizochytrium PKS genes 有权
标题翻译：裂殖酵母PKS基因
公开(公告)号：US08829274B2
公开(公告)日：2014-09-09
申请号：US11674574
申请日：2007-02-13
申请人： Daniel Facciotti , James George Metz , Michael Lassner
发明人： Daniel Facciotti , James George Metz , Michael Lassner
IPC分类号： C12N15/82 , A01H5/00 , C07H21/04
CPC分类号： C12N15/8247 , C07K14/21 , C07K14/28 , C07K14/405 , C12N15/52 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。用于编码多不饱和长链脂肪酸生产所需的PKS样基因的核酸序列和构建体，包括负责枯草芽孢杆菌的二十碳五烯酸生产的基因以及与弧菌弧菌中二十二碳六烯酸的生产相关的新基因。转基因植物，植物部分和细胞，其含有和表达一种或多种编码一种或多种与这种长链多不饱和脂肪酸生产相关的PKS样基因的转基因。在植物系统中PKS样基因的表达允许大规模生产多不饱和长链脂肪酸如二十碳五烯酸和二十二碳六烯酸，用于修饰植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

10. 发明申请

US20090098622A1 SCHIZOCHYTRIUM PKS GENES 有权
标题翻译： SCHIZOCHYTRIUM PKS基因
公开(公告)号：US20090098622A1
公开(公告)日：2009-04-16
申请号：US11674574
申请日：2007-02-13
申请人： Daniel Facciotti , James George Metz , Michael Lassner
发明人： Daniel Facciotti , James George Metz , Michael Lassner
IPC分类号： C12P7/64 , C12N15/11 , C12N1/19 , C12N1/21 , C12N1/13 , C12N5/04
CPC分类号： C12N15/8247 , C07K14/21 , C07K14/28 , C07K14/405 , C12N15/52 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible for eicosapentenoic acid production of Shewanella putrefaciens and novel genes associated with the production of docosahexenoic acid in Vibrio marinus are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more of the PKS-like genes associated with such long chain polyunsaturated fatty acid production. Expression of the PKS-like genes in the plant system permits the large scale production of poly-unsaturated long chain fatty acids such as eicosapentenoic acid and docosahexenoic acid for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.
摘要翻译：本发明涉及在植物，植物部分和植物细胞如叶，根，果实和种子中制备多不饱和长链脂肪酸的组合物和方法。用于编码多不饱和长链脂肪酸生产所需的PKS样基因的核酸序列和构建体，包括负责枯草芽孢杆菌的二十碳五烯酸生产的基因以及与弧菌弧菌中二十二碳六烯酸的生产相关的新基因。转基因植物，植物部分和细胞，其含有和表达编码与这种长链多不饱和脂肪酸生产相关的一种或多种PKS样基因的一种或多种转基因。在植物系统中PKS样基因的表达允许大规模生产多不饱和长链脂肪酸如二十碳五烯酸和二十二碳六烯酸，用于修饰植物，植物部分和组织的脂肪酸分布。脂肪酸分布的操作允许生产商业数量的新型植物油和产品。

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