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1. 发明授权

US06855251B2 Microfabricated electrospray device 有权
标题翻译：微型电喷雾装置
公开(公告)号：US06855251B2
公开(公告)日：2005-02-15
申请号：US10771553
申请日：2004-02-04
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： G01N27/62 , B01D15/08 , G01N30/60 , G01N30/72 , G01N37/00 , H01J49/04 , H01J49/10
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device is disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray.
摘要翻译：公开了一种电喷雾装置。电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。

2. 发明授权

US06579452B1 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
公开(公告)号：US06579452B1
公开(公告)日：2003-06-17
申请号：US09707653
申请日：2000-11-07
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： B01D1508
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

3. 发明授权

US06569324B1 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
公开(公告)号：US06569324B1
公开(公告)日：2003-05-27
申请号：US09703005
申请日：2000-10-31
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： H01J4910
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

4. 发明授权

US06563111B1 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
公开(公告)号：US06563111B1
公开(公告)日：2003-05-13
申请号：US09703246
申请日：2000-10-31
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： H01J4904
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

5. 发明授权

US06858842B2 Electrospray nozzle and monolithic substrate 有权
标题翻译：电喷雾喷嘴和整体式基板
公开(公告)号：US06858842B2
公开(公告)日：2005-02-22
申请号：US10814207
申请日：2004-03-31
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： G01N27/62 , B01D15/08 , G01N30/60 , G01N30/72 , G01N37/00 , H01J49/04 , B01D59/44 , H01J49/10
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray nozzle system is disclosed. The electrospray portion of the device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The nozzle system may be utilized alone or as part of a liquid chromatography system.
摘要翻译：公开了一种电喷雾喷嘴系统。该装置的电喷雾部分包括限定喷射表面上的入口孔和喷射表面上的出口之间的通道的基底，由从出射孔周围的喷射表面凹陷的部分限定的喷嘴和用于应用的电极对基板进行电势优化并产生电喷雾; 和可选的附加电极以进一步改变电喷雾。喷嘴系统可以单独使用或作为液相色谱系统的一部分使用。

6. 发明授权

US06800202B2 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
标题翻译：集成的单片微电解电喷雾和液相色谱系统及方法
公开(公告)号：US06800202B2
公开(公告)日：2004-10-05
申请号：US09745629
申请日：2000-12-21
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： B01D1508
CPC分类号： G01N30/7266 , G01N30/6095 , H01J49/0018 , H01J49/167 , Y10T29/49002 , Y10T436/25375 , Y10T436/255
摘要： An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.
摘要翻译：公开了电喷雾装置，液相色谱装置和电喷雾液相色谱系统。电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。多个系统的阵列可以制造在单个单片芯片中，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。

7. 发明授权

US06790354B1 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
标题翻译：集成的单片微电解电喷雾和液相色谱系统及方法
公开(公告)号：US06790354B1
公开(公告)日：2004-09-14
申请号：US09698329
申请日：2000-10-27
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： B01D1508
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.
摘要翻译：公开了电喷雾装置，液相色谱装置和电喷雾 - 液相色谱系统。电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。多个系统的阵列可以制造在单个单片芯片中，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。

8. 发明授权

US06780313B1 Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
公开(公告)号：US06780313B1
公开(公告)日：2004-08-24
申请号：US09702955
申请日：2000-10-31
申请人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
发明人： James E. Moon , Timothy J. Davis , Gregory J. Galvin , Gary A. Schultz , Thomas N. Corso , Stephen Lowes
IPC分类号： B01D1508
CPC分类号： G01N30/6095 , G01N30/7266 , G01N2030/6013 , H01J49/0018 , H01J49/167 , Y10T436/24 , Y10T436/2575
摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

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