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1. 发明申请

US20090186069A1 Coatings Containing Multiple Drugs 有权
标题翻译：含多种药物的涂料
公开(公告)号：US20090186069A1
公开(公告)日：2009-07-23
申请号：US12298459
申请日：2007-04-26
申请人： James DeYoung , Doug Taylor , Jim McClain , Clint Smoke , Mike Cole
发明人： James DeYoung , Doug Taylor , Jim McClain , Clint Smoke , Mike Cole
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61L31/16 , A61F2/90 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/20 , A61L2300/216 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/61 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
摘要翻译：一种用于在基底上沉积包含聚合物和至少两种药剂的涂层的方法，包括以下步骤：提供支架框架; 在所述支架框架上沉积包含第一药剂的第一层; 沉积包含第二药剂的第二层; 其中所述第一和第二药剂选自两种不同类型的药剂。

2. 发明申请

US20130006351A1 POLYMER COATINGS CONTAINING DRUG POWDER OF CONTROLLED MORPHOLOGY 有权
公开(公告)号：US20130006351A1
公开(公告)日：2013-01-03
申请号：US13605904
申请日：2012-09-06
申请人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
发明人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
IPC分类号： A61F2/06 , A61P3/10 , A61P29/00 , A61P9/12 , A61P1/04 , A61K38/02 , A61K38/43 , A61P25/16 , A61K31/551 , A61K31/436 , B32B5/00 , B32B27/30 , B32B27/32 , B32B27/40 , B32B27/36 , B32B27/00 , A61K9/00
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/426 , A61L2300/606 , A61L2300/63 , A61L2420/08 , Y10T428/264 , Y10T428/265 , Y10T428/31507 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31786 , Y10T428/31935 , Y10T428/31938
摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

3. 发明授权

US08298565B2 Polymer coatings containing drug powder of controlled morphology 有权
标题翻译：含有受控形态药物粉末的聚合物涂层
公开(公告)号：US08298565B2
公开(公告)日：2012-10-30
申请号：US11995687
申请日：2006-07-14
申请人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
发明人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
IPC分类号： A61F2/00 , A61K31/436 , B05D7/02
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/426 , A61L2300/606 , A61L2300/63 , A61L2420/08 , Y10T428/264 , Y10T428/265 , Y10T428/31507 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31786 , Y10T428/31935 , Y10T428/31938
摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto the substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming the coating; and sintering the coating under conditions that do not substantially modify the morphology of the pharmaceutical agent.
摘要翻译：一种用于在基底上沉积包含聚合物和药剂的涂层的方法，包括以下步骤：通过第一孔排出至少一种治疗上需要的干粉形式的药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将聚合物和/或药物颗粒沉积到基底上，其中在基底和药物和/或聚合物颗粒之间保持电位，从而形成涂层; 并在不显着改变药剂形态的条件下烧结涂层。

4. 发明申请

US20090123515A1 POLYMER COATINGS CONTAINING DRUG POWDER OF CONTROLLED MORPHOLOGY 有权
标题翻译：含有控制形态的药物粉末的聚合物涂料
公开(公告)号：US20090123515A1
公开(公告)日：2009-05-14
申请号：US11995687
申请日：2006-07-14
申请人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
发明人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
IPC分类号： A61F2/00 , A61K31/436 , B05D7/02
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/426 , A61L2300/606 , A61L2300/63 , A61L2420/08 , Y10T428/264 , Y10T428/265 , Y10T428/31507 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31786 , Y10T428/31935 , Y10T428/31938
摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
摘要翻译：一种用于在基底上沉积包含聚合物和药剂的涂层的方法，包括以下步骤：通过第一孔排出至少一种治疗上需要的干粉形式的药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将所述聚合物和/或药物颗粒沉积到所述基底上，其中在所述基底和所述药物和/或聚合物颗粒之间保持电位，从而形成所述涂层; 并且在基本上不改变所述药剂的形态的条件下烧结所述涂层。

5. 发明授权

US08852625B2 Coatings containing multiple drugs 有权
标题翻译：含多种药物的涂料
公开(公告)号：US08852625B2
公开(公告)日：2014-10-07
申请号：US12298459
申请日：2007-04-26
申请人： James DeYoung , Doug Taylor , Jim McClain , Clint Smoke , Mike Cole
发明人： James DeYoung , Doug Taylor , Jim McClain , Clint Smoke , Mike Cole
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61F2/90 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/20 , A61L2300/216 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/61 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
摘要翻译：一种用于在基底上沉积包含聚合物和至少两种药剂的涂层的方法，包括以下步骤：提供支架框架; 在所述支架框架上沉积包含第一药剂的第一层; 沉积包含第二药剂的第二层; 其中所述第一和第二药剂选自两种不同类型的药剂。

6. 发明授权

US08758429B2 Polymer coatings containing drug powder of controlled morphology 有权
标题翻译：含有受控形态药物粉末的聚合物涂层
公开(公告)号：US08758429B2
公开(公告)日：2014-06-24
申请号：US13605904
申请日：2012-09-06
申请人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
发明人： Doug Taylor , Jim McClain , Clint Smoke , Mike Cole , James DeYoung
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/426 , A61L2300/606 , A61L2300/63 , A61L2420/08 , Y10T428/264 , Y10T428/265 , Y10T428/31507 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31786 , Y10T428/31935 , Y10T428/31938
摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
摘要翻译：一种用于在基底上沉积包含聚合物和药剂的涂层的方法，包括以下步骤：通过第一孔排出至少一种治疗上需要的干粉形式的药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将所述聚合物和/或药物颗粒沉积到所述基底上，其中在所述基底和所述药物和/或聚合物颗粒之间保持电位，从而形成所述涂层; 并且在不显着改变所述药剂的形态的条件下烧结所述涂层。

7. 发明授权

US07275590B2 Submersible pump 失效
标题翻译：潜水泵
公开(公告)号：US07275590B2
公开(公告)日：2007-10-02
申请号：US10854862
申请日：2004-05-27
申请人： Jim McClain
发明人： Jim McClain
IPC分类号： E21B43/00
CPC分类号： F04B47/04 , F04B47/08
摘要： A submersible pump for attachment to the lower end of a well pipe discharge tube for insertion in liquid includes a stationary collecting tube for collecting the liquid and an upward and downward reciprocating pumping tube within the collecting tube for pushing and lifting the liquid into the discharge tube; source of pressurized gas, a casing assembly including a casing tube and a gas valve, and a piston assembly with the casing tube including a piston tube having a lower end connected to the pumping tube for reciprocating the pumping tube and an upper portion having pistons for moving in chambers with the inside of the casing tube. Preferably the same amount of liquid is pumped during the upward movement of the pumping tube as during the downward movement.
摘要翻译：用于连接到用于插入液体的井管放电管的下端的潜水泵包括用于收集液体的固定收集管和在收集管内的向上和向下往复泵送管，用于将液体推入和提升到排放管中 ; 加压气体源，包括套管和气阀的壳体组件以及具有套管的活塞组件，所述活塞组件包括活塞管，所述活塞管具有连接到泵管的下端，用于往复运动泵管和具有活塞的上部，在室内与套管的内部移动。优选地，在向下运动期间，在泵管的向上运动期间泵送相同量的液体。

8. 发明授权

US08636767B2 Surgical sutures having increased strength 有权
标题翻译：手术缝线具有增强的力量
公开(公告)号：US08636767B2
公开(公告)日：2014-01-28
申请号：US12443959
申请日：2007-10-02
申请人： Jim McClain
发明人： Jim McClain
IPC分类号： A61B17/04
CPC分类号： A61L17/145 , A61L17/005 , A61L17/12 , A61L2300/00
摘要： The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in ‘barbed’ form.
摘要翻译：本发明涉及提高生物吸收性外科缝合线的强度。本发明允许缝合材料的延迟生物吸收以允许维持例如“倒刺”形式的缝合线的机械强度。

9. 发明申请

US20100030261A1 Surgical Sutures Having Increased Strength 有权
标题翻译：手术缝线增强
公开(公告)号：US20100030261A1
公开(公告)日：2010-02-04
申请号：US12443959
申请日：2007-10-02
申请人： Jim McClain
发明人： Jim McClain
IPC分类号： A61L17/00 , B29C47/06
CPC分类号： A61L17/145 , A61L17/005 , A61L17/12 , A61L2300/00
摘要： The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in ‘barbed’ form.
摘要翻译：本发明涉及提高生物吸收性外科缝合线的强度。本发明允许缝合材料的延迟生物吸收以允许维持例如“倒刺”形式的缝合线的机械强度。

10. 发明申请

US20050265874A1 Submersible pump 失效
标题翻译：潜水泵
公开(公告)号：US20050265874A1
公开(公告)日：2005-12-01
申请号：US10854862
申请日：2004-05-27
申请人： Jim McClain
发明人： Jim McClain
IPC分类号： F04B37/00 , F04B47/04 , F04B47/08 , F04B53/00
CPC分类号： F04B47/04 , F04B47/08
摘要： A submersible pump for attachment to the lower end of a well pipe discharge tube for insertion in liquid includes a stationary collecting tube for collecting the liquid and an upward and downward reciprocating pumping tube within the collecting tube for pushing and lifting the liquid into the discharge tube; source of pressurized gas, a casing assembly including a casing tube and a gas valve, and a piston assembly with the casing tube including a piston tube having a lower end connected to the pumping tube for reciprocating the pumping tube and an upper portion having pistons for moving in chambers with the inside of the casing tube. Preferably the same amount of liquid is pumped during the upward movement of the pumping tube as during the downward movement.
摘要翻译：用于连接到用于插入液体的井管放电管的下端的潜水泵包括用于收集液体的固定收集管和在收集管内的向上和向下往复泵送管，用于将液体推入和提升到排放管中 ; 加压气体源，包括套管和气阀的壳体组件以及具有套管的活塞组件，所述活塞组件包括活塞管，所述活塞管具有连接到泵管的下端，用于往复运动泵管和具有活塞的上部，在室内与套管的内部一起移动。优选地，在向下运动期间，在泵管的向上运动期间泵送相同量的液体。

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