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1. 发明授权

US08481292B2 Increasing confidence of allele calls with molecular counting 有权
标题翻译：通过分子计数增加等位基因呼叫的置信度
公开(公告)号：US08481292B2
公开(公告)日：2013-07-09
申请号：US13237124
申请日：2011-09-20
申请人： James Casbon , Sydney Brenner , Robert Osborne , Conrad Lichtenstein , Andreas Claas
发明人： James Casbon , Sydney Brenner , Robert Osborne , Conrad Lichtenstein , Andreas Claas
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6855 , C12N15/1065 , C12Q1/6869 , C12Q1/6886 , C12Q1/70 , G06F19/18 , C12Q2525/179 , C12Q2525/191 , C12Q2545/101
摘要： Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.
摘要翻译：本发明的方面包括用于确定源自在特定序列分析配置或过程中测序的相同原始样品的相同基因组区域的单个多核苷酸分子数目的方法和组合物。在本发明的这些方面，将简并碱基区（DBR）连接到随后进行测序的起始多核苷酸分子（例如，在进行某些工艺步骤之后，例如扩增和/或富集）。存在于测序运行中的不同DBR序列的数目可用于确定/估计已测序的不同起始多核苷酸的数目。 DBR可用于增强许多不同的核酸序列分析应用，包括在基因分型应用中允许更高置信等位基因调用确定。

2. 发明申请

US20120071331A1 INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING 有权
标题翻译：增加对分子计数的可信度的信心
公开(公告)号：US20120071331A1
公开(公告)日：2012-03-22
申请号：US13237124
申请日：2011-09-20
申请人： James Casbon , Sydney Brenner , Robert Osborne , Conrad Lichtenstein
发明人： James Casbon , Sydney Brenner , Robert Osborne , Conrad Lichtenstein
IPC分类号： C40B20/04
CPC分类号： C12Q1/6855 , C12N15/1065 , C12Q1/6869 , C12Q1/6886 , C12Q1/70 , G06F19/18 , C12Q2525/179 , C12Q2525/191 , C12Q2545/101
摘要： Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.
摘要翻译：本发明的方面包括用于确定源自在特定序列分析配置或过程中测序的相同原始样品的相同基因组区域的单个多核苷酸分子数目的方法和组合物。在本发明的这些方面，将简并碱基区（DBR）连接到随后进行测序的起始多核苷酸分子（例如，在进行某些工艺步骤之后，例如扩增和/或富集）。存在于测序运行中的不同DBR序列的数目可用于确定/估计已测序的不同起始多核苷酸的数目。 DBR可用于增强许多不同的核酸序列分析应用，包括在基因分型应用中允许更高置信等位基因调用确定。

3. 发明授权

US08298767B2 Compositions and methods for intramolecular nucleic acid rearrangement 有权
标题翻译：分子内核酸重排的组合物和方法
公开(公告)号：US08298767B2
公开(公告)日：2012-10-30
申请号：US13387343
申请日：2010-08-13
申请人： Sydney Brenner , Gi Mikawa , Robert Osborne , Andrew Slatter
发明人： Sydney Brenner , Gi Mikawa , Robert Osborne , Andrew Slatter
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q2563/179 , C12Q2537/143 , C12Q2535/122 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143
摘要： Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided.
摘要翻译：本发明的方面涉及将多核苷酸中的感兴趣区域从第一位置移动到第二位置的方法，该多核苷酸相对于多核苷酸内的结构域也称为反射方法。在某些实施方案中，反射方法导致将感兴趣区域移动到存在于多核苷酸（例如，引物位点和/或MID）中的特定结构域元件的功能接近。还提供了用于实施本文所述的反射过程的组合物，试剂盒和系统。

4. 发明申请

US20120135407A1 Compositions and Methods for Intramolecular Nucleic Acid Rearrangement 有权
标题翻译：分子内核酸重排的组成和方法
公开(公告)号：US20120135407A1
公开(公告)日：2012-05-31
申请号：US13387343
申请日：2010-08-13
申请人： Sydney Brenner , Gi Mikawa , Robert Osborne , Andrew Slatter
发明人： Sydney Brenner , Gi Mikawa , Robert Osborne , Andrew Slatter
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q2563/179 , C12Q2537/143 , C12Q2535/122 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143
摘要： Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided.
摘要翻译：本发明的方面涉及将多核苷酸中的感兴趣区域从关于多核苷酸内的结构域的第一位置移动至第二位置的方法，也被称为“反射方法”。在某些实施方案中，反射方法导致将感兴趣区域移动到存在于多核苷酸（例如，引物位点和/或MID）中的特定结构域元件的功能接近。还提供了用于实施本文所述的反射过程的组合物，试剂盒和系统。

5. 发明授权

US07970844B2 Replicating message queues between clustered email gateway systems 有权
标题翻译：在群集电子邮件网关系统之间复制消息队列
公开(公告)号：US07970844B2
公开(公告)日：2011-06-28
申请号：US12548286
申请日：2009-08-26
申请人： Robert Osborne , Bill Simpson , Rod Gilchrist
发明人： Robert Osborne , Bill Simpson , Rod Gilchrist
IPC分类号： G06F15/16
CPC分类号： H04L51/30
摘要： A method of “stateful failover” is provided that allows email gateway systems in a cluster to deliver email messages that have been accepted for delivery by a member of the cluster, but has failed with out delivering the messages. The method involves creating a backup copy of the messages that have been accepted for delivery by one email gateway system in the stateful failover cluster on one or more other email gateway systems in the stateful failover cluster. Upon detecting the failure of the email gateway system that accepted the message, another member of the stateful failover cluster that has access to the backup copy of the message queue takes responsibility for the delivery of the messages on the mirrored queue.
摘要翻译：提供了一种“状态故障切换”的方法，允许集群中的电子邮件网关系统传送已被群集成员接受传送的电子邮件，但在传送邮件时失败。该方法涉及创建已被接受以在状态故障转移群集中的一个或多个其他电子邮件网关系统上的状态故障转移群集中的一个电子邮件网关系统传送的邮件的备份副本。在检测到接受该消息的电子邮件网关系统的故障时，有权访问消息队列的备份副本的状态故障转移群集的另一成员负责在镜像队列上传递消息。

6. 发明申请

US20080304635A1 USER INTERFACE ARCHITECTURE AND PROTOCOL FOR RICH CLIENT CONTROLLED VOICEMAIL 有权
标题翻译：用户界面架构和客户端控制的VOICEMAIL协议
公开(公告)号：US20080304635A1
公开(公告)日：2008-12-11
申请号：US11759734
申请日：2007-06-07
申请人： Rajesh Ramanathan , Eran Shtiegman , Paul Tidwell , Robert Osborne , Justin Maguire
发明人： Rajesh Ramanathan , Eran Shtiegman , Paul Tidwell , Robert Osborne , Justin Maguire
IPC分类号： H04M1/64
CPC分类号： H04M3/533
摘要： Systems and methods that control a voice mail experience from a client side of a voice mail server system and enhance features thereof. A dynamic voice mail user interface can change based on what predetermined activity the user engages in. Moreover, a field component further enables a caller to identify characteristics of the voice mail. An XML based protocol empowers a client application to control state of the voice mail system, wherein a session Initiation Protocol (SIP) INFO request or response can carry out voicemail control command, result and event.
摘要翻译：从语音邮件服务器系统的客户端控制语音邮件体验并增强其功能的系统和方法。动态语音邮件用户界面可以基于用户所参与的预定活动而改变。此外，场分量进一步使呼叫者能够识别语音邮件的特征。基于XML的协议授权客户端应用程序控制语音邮件系统的状态，其中会话发起协议（SIP）INFO请求或响应可以执行语音邮件控制命令，结果和事件。

7. 发明申请

US20060248193A1 State management in a distributed computing system 有权
公开(公告)号：US20060248193A1
公开(公告)日：2006-11-02
申请号：US11118154
申请日：2005-04-29
申请人： Ferhan Elvanoglu , Mark Markaryan , Nirav Kamdar , Robert Osborne , Sanjib Dutta
发明人： Ferhan Elvanoglu , Mark Markaryan , Nirav Kamdar , Robert Osborne , Sanjib Dutta
IPC分类号： G06F15/173
CPC分类号： H04L65/1006 , H04L29/06027 , H04L67/10
摘要： Techniques to allow applications to propagate information to the other instances of the applications running on downstream servers are provided. An indicator, such as a token, tag, etc., is placed within or added to a message that is flowing through the distributed environment to signify that a process has been performed on the message. For example, when an instance of an application running on a server receives a message, the application instance can examine the indicator contained in the message and take appropriate action. If the application instance decides to process the message, the application instance can include an indicator in the message to signify that the application instance processed the message. The presence of the indicator signifies that the message has been processed by an upstream instance of the same application.

8. 发明授权

US08897426B2 User interface architecture and protocol for rich client controlled voicemail 有权
标题翻译：用户界面架构和协议，丰富的客户端控制语音信箱
公开(公告)号：US08897426B2
公开(公告)日：2014-11-25
申请号：US11759734
申请日：2007-06-07
申请人： Rajesh Ramanathan , Eran Shtiegman , Paul Tidwell , Robert Osborne , Justin Michael Maguire, III
发明人： Rajesh Ramanathan , Eran Shtiegman , Paul Tidwell , Robert Osborne , Justin Michael Maguire, III
IPC分类号： H04M1/64 , H04M3/533 , H04M11/10
CPC分类号： H04M3/533
摘要： Systems and methods that control a voice mail experience from a client side of a voice mail server system and enhance features thereof. A dynamic voice mail user interface can change based on what predetermined activity the user engages in. Moreover, a field component further enables a caller to identify characteristics of the voice mail. An XML based protocol empowers a client application to control state of the voice mail system, wherein a session Initiation Protocol (SIP) INFO request or response can carry out voicemail control command, result and event.
摘要翻译：从语音邮件服务器系统的客户端控制语音邮件体验并增强其功能的系统和方法。动态语音邮件用户界面可以基于用户所参与的预定活动而改变。此外，场分量进一步使呼叫者能够识别语音邮件的特征。基于XML的协议授权客户端应用程序控制语音邮件系统的状态，其中会话发起协议（SIP）INFO请求或响应可以执行语音邮件控制命令，结果和事件。

9. 发明授权

US08223751B2 Method and apparatus for controlling unsolicited messaging 有权
标题翻译：用于控制未经请求的消息的方法和装置
公开(公告)号：US08223751B2
公开(公告)日：2012-07-17
申请号：US12610978
申请日：2009-11-02
申请人： Rod Gilchrist , Richard Fogel , Robert Osborne , John Alsop
发明人： Rod Gilchrist , Richard Fogel , Robert Osborne , John Alsop
IPC分类号： H04L12/66 , H04M15/06
CPC分类号： H04L63/0218 , H04L29/06027 , H04L51/04 , H04L51/12 , H04L63/1458 , H04L65/1079 , H04L65/403 , H04M3/436 , H04M7/006
摘要： Sensor nodes (or addresses therefore), acting as real-time message decoys, are distributed across a real-time communications network to attract unsolicited real-time messages. Filtering rules are derived from the message characteristics (such as the source address) and messaging content of the traffic encountered at the sensor nodes. The filtering rules are distributed to filtering agents positioned in the communications network in such a way that they can filter traffic for legitimate users. The filtering agents may identify and control the disposition of real-time messaging traffic that is part of a mass communication campaign on behalf of legitimate users of the real-time messaging communication system. Disposition may include suppressing, diverting, or labeling.
摘要翻译：作为实时消息诱饵的传感器节点（或地址）分布在实时通信网络中，以吸引未经请求的实时消息。过滤规则是从传感器节点遇到的流量的消息特征（如源地址）和消息传递内容得出的。将过滤规则分配给位于通信网络中的过滤代理，使得它们可以过滤合法用户的流量。过滤代理可以代表实时消息通信系统的合法用户来识别和控制作为大众传播活动的一部分的实时消息流量的处置。处置可能包括抑制，转移或标记。

10. 发明授权

US6005698A Non-blocking multi-cast WDM coupling arrangement 失效
标题翻译：无阻塞多层WDM耦合布置
公开(公告)号：US6005698A
公开(公告)日：1999-12-21
申请号：US952015
申请日：1997-11-13
申请人： Manfred Huber , Robert Osborne
发明人： Manfred Huber , Robert Osborne
IPC分类号： H04Q11/00 , H04J14/00
CPC分类号： H04Q11/0005 , H04Q2011/0011 , H04Q2011/0013 , H04Q2011/0015 , H04Q2011/0039 , H04Q2011/0047 , H04Q2011/0052
摘要： In a coupling arrangement for freely selectively switching through optical WDM (Wavelength Division Multiplex) signals, the input stage is formed with 1-x-m switching matrices, an optical signal with exactly one wavelength being fed to each 1-x-m switching matrix. In addition, the 1-x-m switching matrices and/or the space division multiplex switches of a central stage connected to the input stage are formed with semiconductor amplifiers (Semiconductor Optical Amplifiers). The coupling arrangement has the capability of switching through individual input signals in a non-blocking fashion to a plurality of output signals (multi-cast capability).
摘要翻译： PCT No.PCT / DE96 / 00990 Sec。 371日期：1997年11月13日 102（e）1997年11月13日PCT PCT 1996年6月5日PCT公布。出版物WO96 / 42180 PCT 日期1996年12月27日在用于通过光WDM（波分复用）信号自由选择切换的耦合布置中，输入级由1-xm开关矩阵形成，具有正好一个波长的光信号被馈送到每个1-xm开关矩阵。此外，连接到输入级的中心级的1-x-m开关矩阵和/或空分复用开关由半导体放大器（半导体光放大器）形成。耦合布置具有以非阻塞方式将各个输入信号切换到多个输出信号（多播能力）的能力。

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