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1. 发明申请

US20070197537A1 Heterobicyclic thiophene compounds and methods of use 有权
标题翻译：异双环噻吩化合物及其使用方法
公开(公告)号：US20070197537A1
公开(公告)日：2007-08-23
申请号：US11699830
申请日：2007-01-30
申请人： James Blake , Steven Boyd , Jason De Meese , John Gaudino , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian
发明人： James Blake , Steven Boyd , Jason De Meese , John Gaudino , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian
IPC分类号： A61K31/503 , A61K31/519 , A61K31/4743 , C07D498/02
CPC分类号： C07D495/04 , C07D519/00
摘要： Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物及其药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。公开了使用式I化合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

2. 发明申请

US20070238726A1 Heterobicyclic pyrazole compounds and methods of use 有权
标题翻译：异双环吡唑化合物及其使用方法
公开(公告)号：US20070238726A1
公开(公告)日：2007-10-11
申请号：US11714342
申请日：2007-03-06
申请人： James Blake , Steven Boyd , Jason De Meese , Kin Fong , John Gaudino , Tomas Kaplan , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian , Frederick Cohen , Wendy Young
发明人： James Blake , Steven Boyd , Jason De Meese , Kin Fong , John Gaudino , Tomas Kaplan , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian , Frederick Cohen , Wendy Young
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式Ia和Ib的化合物及其立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。使用式Ia和Ib化合物及其立体异构体，几何异构体，互变异构体，溶剂化物及其药学上可接受的盐的方法用于体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这种病症或相关病理学条件被公开。

3. 发明授权

US08003662B2 Heterobicyclic thiophene compounds and methods of use 有权
标题翻译：异双环噻吩化合物及其使用方法
公开(公告)号：US08003662B2
公开(公告)日：2011-08-23
申请号：US11699830
申请日：2007-01-30
申请人： James F. Blake , Steven Boyd , Jason De Meese , John J. Gaudino , Allison L. Marlow , Jeongbeob Seo , Allen A. Thomas , Hongqi Tian
发明人： James F. Blake , Steven Boyd , Jason De Meese , John J. Gaudino , Allison L. Marlow , Jeongbeob Seo , Allen A. Thomas , Hongqi Tian
IPC分类号： A61K31/4365
CPC分类号： C07D495/04 , C07D519/00
摘要： Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物及其药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。公开了使用式I化合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

4. 发明申请

US20070293501A1 Thioalkeneamides as Transketolase Inhibitors 失效
标题翻译：硫代烯酰胺作为转酮醇酶抑制剂
公开(公告)号：US20070293501A1
公开(公告)日：2007-12-20
申请号：US10593911
申请日：2005-03-23
申请人： Steven Boyd , Kevin Condroski , Allen Thomas , Stephen Gonzales , Indrani Gunawardana , Yvan Huerou , Todd Romoff , Francis Sullivan
发明人： Steven Boyd , Kevin Condroski , Allen Thomas , Stephen Gonzales , Indrani Gunawardana , Yvan Huerou , Todd Romoff , Francis Sullivan
IPC分类号： A61K31/44 , A61K31/444 , A61K31/4965 , A61K31/497 , A61P35/00 , C07D213/70 , C07D401/12 , C07D403/12
CPC分类号： C07D213/73 , C07D405/12 , C07D411/12
摘要： The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
摘要翻译：本发明提供了可用作转酮酶抑制剂的式（I）的硫代链烯酰胺：其中R 1，R 2，R 3，R 3， R 4，R 5，R 6，R 9，R 11，环A如本文所定义。本发明还提供包含式（I）化合物的药物组合物。本发明提供了抑制转酮醇酶活性，减少细胞核糖-5-磷酸水平，抑制核酸合成，抑制体外和体内细胞增殖和肿瘤细胞生长，刺激肿瘤细胞凋亡和通过给予式（I）化合物或其药物组合物。

5. 发明申请

US20110005813A1 RIBBON CONNECTING ELECTRICAL COMPONENTS 有权
标题翻译： RIBBON连接电气元件
公开(公告)号：US20110005813A1
公开(公告)日：2011-01-13
申请号：US12499319
申请日：2009-07-08
申请人： Steven Boyd
发明人： Steven Boyd
IPC分类号： H05K1/09 , H05K1/16 , H05K3/30
CPC分类号： A61N1/375 , A61N1/025 , A61N1/3758 , B23K26/0006 , B23K35/325 , H01L24/05 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/85 , H01L2224/04042 , H01L2224/05554 , H01L2224/05556 , H01L2224/05644 , H01L2224/45014 , H01L2224/45015 , H01L2224/45124 , H01L2224/45144 , H01L2224/45166 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48472 , H01L2224/48644 , H01L2224/48655 , H01L2224/48699 , H01L2224/48755 , H01L2224/49175 , H01L2224/85205 , H01L2224/85214 , H01L2224/85444 , H01L2224/85455 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01018 , H01L2924/01022 , H01L2924/01028 , H01L2924/01029 , H01L2924/01033 , H01L2924/01041 , H01L2924/0106 , H01L2924/01079 , H01L2924/01082 , H01L2924/01087 , H01L2924/01327 , H01L2924/014 , H01L2924/14 , H01L2924/19041 , H01L2924/20752 , H01L2924/20753 , H01L2924/20754 , H01L2924/20755 , H01L2924/20756 , H01L2924/20757 , Y10T29/49144 , Y10T29/49147 , H01L2224/78 , H01L2924/00 , H01L2224/48744 , H01L2924/00015
摘要： Articles and methods of manufacture are provided for using laser energy in an automated bonding machine to effect laser welding of ribbons to electronic components, particularly conductive ribbons comprising titanium for microelectronic circuits. Bonding and connection of microelectronic circuits with discrete heating avoids heat damage to peripheral microelectronic components. Bonding of flexible materials and low-resistance materials are possible, and are less dependant on substrate and terminal stability in comparison to other bonding methods. The ribbon-connections can forgo the use of blocks, bond pads, and bond pad arrays for attaching ribbon to a printed wiring board. Profile height of the ribbon-connection is decreased and the density of ribbons and bonding sites can be increased compared to ribbon-connections employing bonding pads.
摘要翻译：提供制造的制品和方法，用于在自动焊接机中使用激光能量，以实现带状物到电子部件的激光焊接，特别是包括用于微电子电路的钛的导电带。具有分立加热的微电子电路的接合和连接避免了外围微电子元件的热损伤。柔性材料和低电阻材料的结合是可能的，并且与其它粘合方法相比较，其基材和端子的稳定性较少。带状连接可以放弃使用块，接合垫和接合焊盘阵列，以将带附着到印刷线路板上。与使用接合垫的带状连接相比，带状连接件的型材高度降低，并且可以增加带状物和结合部位的密度。

6. 发明申请

US20050284850A1 Method and apparatus for automated assembly and laser welding of medical devices 审中-公开
标题翻译：医疗器械的自动装配和激光焊接的方法和装置
公开(公告)号：US20050284850A1
公开(公告)日：2005-12-29
申请号：US10876303
申请日：2004-06-24
申请人： Steven Boyd
发明人： Steven Boyd
IPC分类号： A61N1/00 , A61N1/375 , B23K26/00 , B23K26/12 , B23K26/24 , B23K31/02
CPC分类号： B23K26/032 , A61N1/3754 , B23K26/123 , B23K26/24
摘要： A method and system for assembling a component within a medical device that includes a test station to determine whether the component is in a predetermined working state, and an orientation sensor to sense an orientation vector of the component. A first sensor senses a position of the component within an aperture of the device and plots a weld path associated with the component. An installation head obtains the component, advances the component between the test station, the orientation sensor and the first sensor, and through the aperture, and a weld head generates a weld along a generated weld path.
摘要翻译：一种用于组装医疗装置内的部件的方法和系统，其包括测试台以确定部件是否处于预定工作状态，以及用于感测部件的取向矢量的定向传感器。第一传感器感测组件在设备的孔内的位置并且绘制与组件相关联的焊接路径。安装头获得部件，使测试台，定位传感器和第一传感器之间的部件前进，并通过孔，焊头沿着所产生的焊接路径产生焊缝。

7. 发明申请

US20070179165A1 Cyclic compounds 失效
标题翻译：环状化合物
公开(公告)号：US20070179165A1
公开(公告)日：2007-08-02
申请号：US10593891
申请日：2005-04-06
申请人： Albert Gyorkos , Christopher Corrette , Suk Cho , Timothy Turner , Kazuyoshi Aso , Masakuni Kori , Michiyo Mochizuki , Kevin Condroski , Christopher Siedem , Steven Boyd
发明人： Albert Gyorkos , Christopher Corrette , Suk Cho , Timothy Turner , Kazuyoshi Aso , Masakuni Kori , Michiyo Mochizuki , Kevin Condroski , Christopher Siedem , Steven Boyd
IPC分类号： A61K31/44 , A61K31/513 , C07D239/22
CPC分类号： C07D213/74 , C07C225/20 , C07C2602/08 , C07D215/233 , C07D215/56 , C07D231/56 , C07D237/28 , C07D239/46 , C07D239/47 , C07D239/56 , C07D239/94 , C07D239/95 , C07D239/96 , C07D265/36 , C07D455/02 , C07D471/04 , C07D487/04
摘要： There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W—Ar (I) wherein, A is a group represented by the formula (A1) or (A2): (wherein, ring Aa is a 5- or 6-membered ring which may be further substituted; ring Ab is a 5- or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, —O—, —S—, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, —O—, —S—, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.
摘要翻译：提供了包含式（I）化合物的CRF受体拮抗剂：<？in-line-formula description =“In-line Formulas”end =“lead”？> AW-Ar（I）式中，A为式（A1）或（A2）表示的基团：（其中，环Aa为5-或6-元环，其中，环Ab是可以被进一步取代的5-或6-元环;环Ac是可以被取代的5或6元环; R 1是任选取代的烷基，取代的氨基，取代的羟基等; X是羰基，-O-，-S-等; Y 1，Y 2和Q独立地是取代的碳或氮; 是单键或双键）; W是一个键，任意取代的亚甲基，任选取代的亚氨基，-O - ， - S-等; Ar是任选取代的芳基或任选取代的杂芳基; 或其盐或其前药。

8. 发明申请

US20070000825A1 PROCESS AND APPARATUS FOR MICROBIAL FILTRATION AND BACTERIAL INJECTION FOR ONE OR MORE ENVIRONMENTAL CONTAMINANTS 失效
标题翻译：一种或多种环境污染物的微生物过滤和细菌注射的方法和装置
公开(公告)号：US20070000825A1
公开(公告)日：2007-01-04
申请号：US10833409
申请日：2004-04-28
申请人： Steven Boyd
发明人： Steven Boyd
IPC分类号： B01D33/70
CPC分类号： A01K63/04 , C02F3/006 , C02F3/06 , C02F3/10 , C02F3/102 , C02F3/286 , C02F3/288 , C02F3/348 , C02F2103/20 , C02F2209/22 , Y02W10/15
摘要： Scaleable bacterial injection, aeration and filtration system to effectively control microbial community function of aquatic systems. The present invention is a substantially simplified system with respect to handling growth and dispersion of microorganisms in solution and is also adaptable to many different end-use applications, including treatment of ornamental fish and aquaculture, pond and streams and sewage treatment systems. Initial microorganism materials are provided in the form of aqueous suspensions, which are incorporated into a large volume of water in a vessel. Microorganisms are entrapped inside a carrier that serves as a physical enclosure for cell retention. It has a porous structure to facilitate the diffusion of substances, such as ammonia, nitrate, nutrients, fuels and organic carbon, into its internal void volume, where substrate reduction is accomplished by entrapped cells. Specific species of microbes are injected into a filtration matrix that is bathed in oxygenated effluent and a portion of which is dispensed into an aqueous environment. The apparatus can be electronic, air or fluid driven and injected with the desired microbial species, preferably multiple time per day. Multi-stage media can be placed into packed filter units of convenient sizes for wastewater regeneration as well as natural water pollution reduction. The reactor canisters containing entrapped cells are portable and can be assembled off-site and then delivered to the field for installation and immediate operation. Bio-solid reduction, odor reduction, unplugging of leaching fields, conversion and reduction of nitrogen species in natural waters such as lakes and ponds, etc. can be accomplished.
摘要翻译：可扩展的细菌注射，曝气和过滤系统，有效控制水生系统的微生物群落功能。本发明是关于处理微生物在溶液中的生长和分散的基本简化的系统，并且也适用于许多不同的最终用途应用，包括观赏鱼和水产养殖，池塘和溪流以及污水处理系统的处理。初始微生物材料以水性悬浮液的形式提供，其被并入容器中的大量水中。微生物被捕获在用作细胞保留的物理外壳的载体内。它具有多孔结构，以促进物质如氨，硝酸盐，营养物质，燃料和有机碳的扩散到其内部空隙体积中，其中底物还原通过包埋的细胞完成。将特定种类的微生物注入过滤基质中，沐浴在含氧流出物中，其一部分被分配到水性环境中。该设备可以是电子的，空气的或流体驱动的并且注入所需的微生物物种，优选每天多次。多级介质可以放置在方便尺寸的包装过滤器中，用于废水再生以及天然水污染减少。含有捕获的细胞的反应器罐是便携式的，可以非现场组装，然后输送到现场进行安装和立即操作。可以实现生物固体减少，气味降低，浸出场的拔出，天然水如湖泊和池塘等中的氮物质的转化和还原。

9. 发明申请

US20050250768A1 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds 审中-公开
标题翻译：细胞粘附抑制抗炎和免疫抑制化合物
公开(公告)号：US20050250768A1
公开(公告)日：2005-11-10
申请号：US10921965
申请日：2004-08-20
申请人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。

10. 发明申请

US20050145563A1 Process and apparatus for waste water treatment 审中-公开
标题翻译：废水处理工艺及设备
公开(公告)号：US20050145563A1
公开(公告)日：2005-07-07
申请号：US11061297
申请日：2005-02-18
申请人： Steven Boyd , Abdul Azad
发明人： Steven Boyd , Abdul Azad
IPC分类号： C02F1/00 , C02F3/00 , C02F3/02 , C02F3/12 , C02F3/28 , C02F3/30 , C02F3/34 , C12N1/20
CPC分类号： C02F3/306 , C02F3/006 , C02F3/02 , C02F3/286 , C02F3/302 , C02F3/348 , C02F2001/007 , C02F2103/005 , C02F2209/44 , C02F2305/06 , Y02E50/343 , Y02W10/15 , Y02W10/37 , Y10S210/903 , Y10S210/904 , Y10S210/908 , Y10S210/909
摘要： Systems for treating water containing unwanted contaminants. More particularly, the present invention relates to waste water treatment systems including biological media used to aerobically or anaerobically treat solid and liquid waste in water for large and small-scale waste water systems in a way that minimizes the size of the system required to output high-quality, environmentally suitable water that is depleted of ammonia, nitrites, nitrates and other contaminants.
摘要翻译：用于处理含有不需要的污染物的水的系统。更具体地说，本发明涉及废水处理系统，包括用于有氧或厌氧地处理大型和小型废水系统中的固体和液体废物在水中的生物介质，其方法是使输出高度所需的系统的尺寸最小化优质，环保的水，其中的氨，亚硝酸盐，硝酸盐和其他污染物都耗尽。

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