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1. 发明授权

US10117972B2 Drug delivery medical device 有权
公开(公告)号：US10117972B2
公开(公告)日：2018-11-06
申请号：US14131878
申请日：2012-07-12
申请人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
发明人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC分类号： A61F2/07 , A61L31/08 , A61L29/08 , A61L29/16 , A61B17/12 , A61L31/16 , A61M25/10 , B05D7/24
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

2. 发明申请

US20130172853A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：US20130172853A1
公开(公告)日：2013-07-04
申请号：US13809324
申请日：2011-07-15
申请人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
发明人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/1011
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

3. 发明申请

US20140350522A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：US20140350522A1
公开(公告)日：2014-11-27
申请号：US14131878
申请日：2012-07-12
申请人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
发明人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC分类号： A61L31/08 , A61L31/16 , B05D7/24 , A61B17/12 , A61M25/10
CPC分类号： A61L31/08 , A61B17/12136 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/602 , A61L2420/06 , A61M25/10 , A61M2025/1081 , A61M2210/12 , B05D7/24
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

4. 发明授权

US09510856B2 Drug delivery medical device 有权
标题翻译：药物输送医疗器械
公开(公告)号：US09510856B2
公开(公告)日：2016-12-06
申请号：US13384216
申请日：2010-07-16
申请人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
发明人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
IPC分类号： A61M31/00 , A61M37/00 , A61B17/20 , A61B17/3207 , A61L29/08 , A61L29/16 , A61B17/00 , A61B17/22 , A61M25/10
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/00893 , A61B2017/22051 , A61B2017/22061 , A61B2017/22065 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/606 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

5. 发明申请

US20120172787A1 DRUG DELIVERY MEDICAL DEVICE 有权
标题翻译：药物递送医疗设备
公开(公告)号：US20120172787A1
公开(公告)日：2012-07-05
申请号：US13384216
申请日：2010-07-16
申请人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
发明人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
IPC分类号： A61M37/00 , A61L29/16 , A61M25/10
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/00893 , A61B2017/22051 , A61B2017/22061 , A61B2017/22065 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/606 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

6. 发明申请

US20160271303A1 STENTS HAVING CONTROLLED ELUTION 审中-公开
标题翻译：具有控制力的手柄
公开(公告)号：US20160271303A1
公开(公告)日：2016-09-22
申请号：US15169214
申请日：2016-05-31
申请人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
发明人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
IPC分类号： A61L31/16 , A61L31/10 , A61L31/14 , A61L31/02
CPC分类号： A61L31/16 , A61L31/022 , A61L31/024 , A61L31/028 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2300/63 , C08L67/04
摘要： Provided herein is a device comprising a stent and a coating on the stent; wherein the coating comprises at least one polymer and at least one active agent; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种包括支架和支架上的涂层的装置; 其中所述涂层包含至少一种聚合物和至少一种活性剂; 其中至少部分活性剂为结晶形式。

7. 发明授权

US09636309B2 Macrolide dosage forms 有权
公开(公告)号：US09636309B2
公开(公告)日：2017-05-02
申请号：US13229473
申请日：2011-09-09
申请人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
发明人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
IPC分类号： A61K47/34 , A61K9/70 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0021 , A61K9/7007 , A61K31/436
摘要： Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

8. 发明申请

US20120064124A1 MACROLIDE DOSAGE FORMS 有权
标题翻译： MACROLIDE剂型
公开(公告)号：US20120064124A1
公开(公告)日：2012-03-15
申请号：US13229473
申请日：2011-09-09
申请人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
发明人： James B. McClain , Charles Douglas Taylor , Wenda C. Carlyle
IPC分类号： A61K9/00 , A61P27/16 , A61P19/02 , A61P15/00 , A61P13/00 , A61M5/32 , A61P37/08 , A61P27/02 , A61P31/00 , A61P37/06 , A61M5/00 , A61M5/30 , A61K39/00 , A61P35/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0021 , A61K9/7007 , A61K31/436
摘要： Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.
摘要翻译：提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上，并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。

9. 发明申请

US20100239635A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：US20100239635A1
公开(公告)日：2010-09-23
申请号：US12729580
申请日：2010-03-23
申请人： James B. McClain , Douglas Taylor , John Neet
发明人： James B. McClain , Douglas Taylor , John Neet
IPC分类号： A61K9/00 , A61K38/22 , A61P43/00
CPC分类号： A61L31/16 , A61L27/16 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M25/0045
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

10. 发明授权

US09486431B2 Drug delivery medical device 有权
标题翻译：药物输送医疗器械
公开(公告)号：US09486431B2
公开(公告)日：2016-11-08
申请号：US12504597
申请日：2009-07-16
申请人： James B. McClain , Douglas Taylor , John Neet
发明人： James B. McClain , Douglas Taylor , John Neet
IPC分类号： A61K31/20 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61F2/30 , A61K9/00 , A61K38/00 , A61M25/10
CPC分类号： A61L29/16 , A61F2002/30535 , A61F2250/0058 , A61K9/0024 , A61K9/0034 , A61K31/20 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61K38/00 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/14 , A61L29/148 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

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