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    • 4. 发明申请
    • Ferrocenyl ligands, production and use thereof
    • 二茂铁基配体,其生产和使用
    • US20090082581A1
    • 2009-03-26
    • US11919762
    • 2006-05-02
    • Benoit PuginXiangdong Feng
    • Benoit PuginXiangdong Feng
    • C07F17/02
    • C07F17/02
    • The invention relates to the compounds of formula (I) in the form of enantiomer-pure diastereomers or a mixture of diastereomers, wherein R′1 represents C1-C4 alkyl, C6-C10 aryl, C7-C10 alkyl or C7-C12 alkaralkyl and n is 0 or an integer of from 1 to 5; R1 represents a hydrogen atom, halogen, a hydrocarbon group with 1 to 20 C atoms that is either unsubstituted or substituted with —SC1-C4 alkyl, —OC1-C4 alkyl, —OC6-C10 aryl or —Si(C1C4 alkyl)3, or a silyl group with 3 C1-C12 hydrocarbon groups; Y represents vinyl, methyl, ethyl, —CH2—OR, —CH2—N(C1-C4 alkyl)2, a C-bound chiral group that directs metals of metallation reagents to the ortho position X1, or Y is a group —CHR2—OR′2; R2 represents C1-C8 alkyl, C5-C8 cycloalkyl, C6-C10 aryl, C7-C12 aralkyl or C7-C12 alkaralkyl; R′2 represents hydrogen or C1-C18 acyl; X1 and X2 independently represent a P-bound P(III) substituent, —SH or an S-bound group of mercaptan; and R represents hydrogen, a silyl group or an aliphatic, cycloaliphatic, aromatic or aromatic-aliphatic hydrocarbon group with 1 to 18 C atoms which is unsubstituted or substituted with C1-C4 alkyl, C1-C4 alkoxy, F or CF3. The inventive compounds are ligands for metal complexes of transition metals such as Ru, Rh or Ir which are catalysts for especially the enantioselective hydration of prochiral unsaturated compounds. Use of these compounds allows to achieve high catalyst activities and an excellent stereoselectivity.
    • 本发明涉及对映异构体纯的非对映异构体形式的式(I)化合物或非对映异构体的混合物,其中R'1代表C1-C4烷基,C6-C10芳基,C7-C10烷基或C7-C12烷基烷基, n为0或1〜5的整数, R 1表示氢原子,卤素,未取代或被-SC 1 -C 4烷基,-OC 1 -C 4烷基,-OC 6 -C 10芳基或-Si(C 1 -C 4烷基)3取代的具有1至20个碳原子的烃基, 或具有3个C 1 -C 12烃基的甲硅烷基; Y表示乙烯基,甲基,乙基,-CH 2 -OR,-CH 2 -N(C 1 -C 4烷基)2,将金属化试剂的金属引导至邻位X1的C-键手性基团,或Y为基团-CHR2 -OR'2; R2代表C1-C8烷基,C5-C8环烷基,C6-C10芳基,C7-C12芳烷基或C7-C12烷基烷基; R'2表示氢或C 1 -C 18酰基; X 1和X 2独立地表示P键的P(III)取代基-SH或S结合的硫醇基团; 并且R表示氢,具有未取代的或被C 1 -C 4烷基,C 1 -C 4烷氧基,F或CF 3取代的具有1至18个C原子的脂族,脂环族,芳族或芳族 - 脂族烃基的甲硅烷基或脂族,脂环族,芳族或芳族 - 脂族烃基。 本发明化合物是过渡金属如Ru,Rh或Ir的金属络合物的配体,其是用于特别是前手性不饱和化合物的对映选择性水合的催化剂。 使用这些化合物可以实现高催化剂活性和优异的立体选择性。