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    • 3. 发明授权
    • Laparoscopic suturing instrument with manual drive
    • 腹腔镜缝合仪器,手动驱动
    • US09277916B2
    • 2016-03-08
    • US13419514
    • 2012-03-14
    • David T. MartinWilliam J. WhiteRobert BrikMatthew Rohr DanielDaniel J. Prenger
    • David T. MartinWilliam J. WhiteRobert BrikMatthew Rohr DanielDaniel J. Prenger
    • A61B17/04A61B17/06A61B17/29
    • A61B17/0469A61B17/0482A61B2017/06052A61B2017/2936
    • A suture needle driving instrument comprises a shaft, an end effector, and a handle assembly. The end effector is located at the distal end of the shaft and includes a pair of grasping arms operable to grasp and release a needle. The handle assembly comprises a trigger-operated actuation assembly that is operable to rotate a second grasping arm relative to the shaft. The trigger-operated actuation assembly may include a trigger and a trigger gear assembly that is operable to rotate the second grasping arm. A clutch assembly may also be included to selectively couple a drive shaft associated with the second grasping arm to another shaft. The handle assembly may further include a toggle actuation assembly that is operable to grasp and release a needle with the grasping arms. A locking feature may be included to prevent use of the toggle actuation assembly until trigger-operated actuation assembly has been operated.
    • 缝合针驱动装置包括轴,端部执行器和手柄组件。 末端执行器位于轴的远端,并且包括一对可操作地抓住和释放针的把持臂。 手柄组件包括触发器操作的致动组件,其可操作以相对于轴旋转第二把持臂。 触发器操作的致动组件可以包括触发器和可操作以使第二抓握臂旋转的触发器齿轮组件。 还可以包括离合器组件以选择性地将与第二把持臂相关联的驱动轴联接到另一轴。 手柄组件还可以包括肘杆致动组件,其可操作以用所述把持臂来抓握和释放针头。 可以包括锁定特征以防止在触发器操作的致动组件已被操作之前使用肘节致动组件。
    • 4. 发明申请
    • LAPAROSCOPIC SUTURING INSTRUMENT WITH MANUAL DRIVE
    • LAPAROSCOPIC SUTURING仪器与手动驱动
    • US20130245647A1
    • 2013-09-19
    • US13419514
    • 2012-03-14
    • David T. MartinWilliam J. WhiteRobert BrikMatthew Rohr DanielDaniel J. Prenger
    • David T. MartinWilliam J. WhiteRobert BrikMatthew Rohr DanielDaniel J. Prenger
    • A61B17/04
    • A61B17/0469A61B17/0482A61B2017/06052A61B2017/2936
    • A suture needle driving instrument comprises a shaft, an end effector, and a handle assembly. The end effector is located at the distal end of the shaft and includes a pair of grasping arms operable to grasp and release a needle. The handle assembly comprises a trigger-operated actuation assembly that is operable to rotate a second grasping arm relative to the shaft. The trigger-operated actuation assembly may include a trigger and a trigger gear assembly that is operable to rotate the second grasping arm. A clutch assembly may also be included to selectively couple a drive shaft associated with the second grasping arm to another shaft. The handle assembly may further include a toggle actuation assembly that is operable to grasp and release a needle with the grasping arms. A locking feature may be included to prevent use of the toggle actuation assembly until trigger-operated actuation assembly has been operated.
    • 缝合针驱动装置包括轴,端部执行器和手柄组件。 末端执行器位于轴的远端,并且包括一对可操作以抓握和释放针的把持臂。 手柄组件包括触发器操作的致动组件,其可操作以相对于轴旋转第二把持臂。 触发器操作的致动组件可以包括触发器和可操作以使第二抓握臂旋转的触发器齿轮组件。 还可以包括离合器组件以选择性地将与第二把持臂相关联的驱动轴联接到另一轴。 手柄组件还可以包括肘杆致动组件,其可操作以用所述把持臂来抓握和释放针头。 可以包括锁定特征以防止在触发器操作的致动组件已被操作之前使用肘节致动组件。
    • 10. 发明授权
    • Therapeutic fibrinogen compositions
    • 治疗性纤维蛋白原组合物
    • US5605887A
    • 1997-02-25
    • US225853
    • 1994-04-08
    • Eli PinesWilliam J. White
    • Eli PinesWilliam J. White
    • A61K38/00A61L24/10C07K14/75
    • C07K14/75A61L24/106A61K38/00
    • A therapeutic composition effective on contact with thrombin at a site of treatment in a patient as a tissue adhesive, hemostat or sealant, said composition comprising non-autologous, non-single donor mammalian fibrinogen that is capable of polymerizing when provided in solution at said site at a concentration of about 30 mg/ml thereof or less, to a fibrin network having therapeutically effective strength, wherein said composition contains less than about 30% (w/w), based on total protein mass present therein, of proteins other than fibrinogen, and further comprises a sufficient amount of one or more low molecular weight physiologically-compatible solutes such that said composition, if formulated as a lyophilized material, can be reconstituted therefrom at room temperature in sterile water for injection in about 30 minutes or less, at about 25 mg/ml of said fibrinogen. Additionally, methods for producing and maintaining said composition, and methods for the use thereof.
    • 一种在作为组织粘合剂,止血剂或密封剂的患者的治疗部位与凝血酶接触有效的治疗组合物,所述组合物包含非自体非单供体哺乳动物纤维蛋白原,当在所述部位的溶液中提供时能够聚合 其浓度为约30mg / ml或更低,具有治疗有效强度的纤维蛋白网络,其中所述组合物基于其中存在的蛋白质总量含有小于约30%(w / w)的除纤维蛋白原以外的蛋白质 并且还包含足够量的一种或多种低分子量生理上相容的溶质,使得如果配制为冻干材料,则所述组合物可以在室温下在约30分钟或更少的注射用无菌水中在室温下重构, 约25mg / ml的所述纤维蛋白原。 另外,用于生产和维持所述组合物的方法及其使用方法。