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1. 发明授权

US07183317B2 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality 失效
标题翻译：提高血浆HDL胆固醇水平和提高HDL功能的化合物和方法
公开(公告)号：US07183317B2
公开(公告)日：2007-02-27
申请号：US10886927
申请日：2004-07-08
申请人： James A. Sikorski , Jayraz Luchoomun , Charles Q. Meng , Uday Saxena
发明人： James A. Sikorski , Jayraz Luchoomun , Charles Q. Meng , Uday Saxena
IPC分类号： A61K31/255 , C07C323/00 , C07C229/00
CPC分类号： G01N33/92 , C07C323/20 , G01N2500/00 , G01N2500/10 , G01N2800/044
摘要： It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
摘要翻译：已经发现，普罗布考的某些选择的醚及其药学上可接受的盐或前药可用于增加循环HDL胆固醇。这些化合物还可以通过（a）增加胆固醇酯的清除率，（b）增加对肝细胞表面受体的HDL-粒子亲和力或（c）增加apoAI-HDL的半衰期来改善HDL功能。

2. 发明授权

US06881860B2 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality 失效
标题翻译：提高血浆HDL胆固醇水平和提高HDL功能的化合物和方法
公开(公告)号：US06881860B2
公开(公告)日：2005-04-19
申请号：US09833407
申请日：2001-04-11
申请人： Jayraz Luchoomun , Charles Q. Meng , Uday Saxena , James A. Sikorski
发明人： Jayraz Luchoomun , Charles Q. Meng , Uday Saxena , James A. Sikorski
IPC分类号： A61K31/7034 , A61K31/10 , A61K31/192 , A61K31/198 , A61K31/255 , A61P3/06 , C07C323/20 , G01N33/92 , C07C321/00
CPC分类号： G01N33/92 , C07C323/20 , G01N2500/00 , G01N2500/10 , G01N2800/044
摘要： It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
摘要翻译：已经发现，普罗布考的某些选择的醚及其药学上可接受的盐或前药可用于增加循环HDL胆固醇。这些化合物还可以通过（a）增加胆固醇酯的清除率，（b）增加对肝细胞表面受体的HDL-粒子亲和力或（c）增加apoAI-HDL的半衰期来改善HDL功能。

3. 发明授权

US07247714B2 Protection against oxidative stress and inflammation by a cytoprotective response element 失效
标题翻译：通过细胞保护反应元件保护免受氧化应激和炎症
公开(公告)号：US07247714B2
公开(公告)日：2007-07-24
申请号：US10271429
申请日：2002-10-16
申请人： Charles Kunsch , Signe E. Varner , Xilin Chen , Jayraz Luchoomun
发明人： Charles Kunsch , Signe E. Varner , Xilin Chen , Jayraz Luchoomun
IPC分类号： C07H21/04 , C07K1/00 , C12Q1/00 , C12Q1/68 , C12N1/20 , C12N15/00
CPC分类号： C07K14/4702
摘要： This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.
摘要翻译：本发明在调节DNA序列及其使用方法领域。具体来说，描述了在细胞保护基因的调节区中发现的称为细胞保护反应元件的DNA序列。还提供了包括可操作地连接到异源蛋白质编码序列的细胞保护反应元件的DNA构建体，以及包括任选可操作地连接到异源蛋白质编码序列的细胞保护反应元件的细胞和非人生物，以及筛选增加由细胞保护反应元件调节的mRNA或蛋白质的化合物。已经发现，细胞保护反应元件介导某些保护细胞免受氧化应激影响的基因的配位活化，例如在血液动力学剪切应力的条件下。

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