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1. 发明授权

US08636011B2 Tobacco compositions 有权
标题翻译：烟草成分
公开(公告)号：US08636011B2
公开(公告)日：2014-01-28
申请号：US12345012
申请日：2008-12-29
申请人： James A Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： James A Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B15/00
CPC分类号： A24B13/00 , A23L27/79 , A24B15/16 , A61K36/81 , A61K2300/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
摘要翻译：本发明的特征在于烟草组合物及其使用和制造方法。本发明的组合物可以基于各种技术。技术包括薄膜，薄片，成形部件，凝胶，消耗单元，不溶性基质和中空形状。除了烟草之外，组合物还可以含有如本文所述的香料，颜色和其它添加剂。组合物也可以口服分解。本文描述了其制造的示例性组合物和方法。

2. 发明申请

US20090133704A1 Tobacco Compositions 审中-公开
标题翻译：烟草成分
公开(公告)号：US20090133704A1
公开(公告)日：2009-05-28
申请号：US12345063
申请日：2008-12-29
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B1/10 , A24B13/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
摘要翻译：本发明的特征在于烟草组合物及其使用和制造方法。本发明的组合物可以基于各种技术。技术包括薄膜，薄片，成形部件，凝胶，消耗单元，不溶性基质和中空形状。除了烟草之外，组合物还可以含有如本文所述的香料，颜色和其它添加剂。组合物也可以口服分解。本文描述了其制造的示例性组合物和方法。

3. 发明授权

US10765140B2 Tobacco compositions 有权
公开(公告)号：US10765140B2
公开(公告)日：2020-09-08
申请号：US12345063
申请日：2008-12-29
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B13/00 , A24B15/16 , A61K36/81 , A23L27/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.

4. 发明申请

US20090133703A1 TOBACCO COMPOSITIONS 有权
标题翻译：烟草成分
公开(公告)号：US20090133703A1
公开(公告)日：2009-05-28
申请号：US12345012
申请日：2008-12-29
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B1/10 , A24B13/00
CPC分类号： A24B13/00 , A23L27/79 , A24B15/16 , A61K36/81 , A61K2300/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
摘要翻译：本发明的特征在于烟草组合物及其使用和制造方法。本发明的组合物可以基于各种技术。技术包括薄膜，薄片，成形部件，凝胶，消耗单元，不溶性基质和中空形状。除了烟草之外，组合物还可以含有如本文所述的香料，颜色和其它添加剂。组合物也可以口服分解。本文描述了其制造的示例性组合物和方法。

5. 发明申请

US20120199149A1 TOBACCO COMPOSITIONS 审中-公开
标题翻译：烟草成分
公开(公告)号：US20120199149A1
公开(公告)日：2012-08-09
申请号：US13370586
申请日：2012-02-10
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B13/00
CPC分类号： A24B13/00 , A23L27/79 , A24B15/16 , A61K36/81 , A61K2300/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
摘要翻译：本发明的特征在于烟草组合物及其使用和制造方法。本发明的组合物可以基于各种技术。技术包括薄膜，薄片，成形部件，凝胶，消耗单元，不溶性基质和中空形状。除了烟草之外，组合物还可以含有如本文所述的香料，颜色和其它添加剂。组合物也可以口服分解。本文描述了其制造的示例性组合物和方法。

6. 发明授权

US08627828B2 Tobacco compositions 有权
公开(公告)号：US08627828B2
公开(公告)日：2014-01-14
申请号：US11344848
申请日：2006-01-31
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson
IPC分类号： A24B15/00
CPC分类号： A24B13/00 , A23L27/79 , A24B3/14 , A24B13/02 , A24B15/10 , A24B15/16 , A24B15/18 , A24B15/186 , A61C15/02
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.

7. 发明授权

US10098376B2 Tobacco compositions 有权
公开(公告)号：US10098376B2
公开(公告)日：2018-10-16
申请号：US13370586
申请日：2012-02-10
申请人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson
发明人： James A. Strickland , Frank S. Atchley , James M. Rossman , Armand J. Desmarais , Scott A. Williams , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B13/00 , A24B15/16 , A61K36/81 , A23L27/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.

8. 发明授权

US08469036B2 Tobacco compositions 有权
标题翻译：烟草成分
公开(公告)号：US08469036B2
公开(公告)日：2013-06-25
申请号：US10982248
申请日：2004-11-05
申请人： Scott A. Williams , James Arthur Strickland , Frank Scott Atchley , Armand J. Desmarais , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
发明人： Scott A. Williams , James Arthur Strickland , Frank Scott Atchley , Armand J. Desmarais , Tod J. Miller , Cherne W. Johnson , Vernie A. Due
IPC分类号： A24B15/00
CPC分类号： A24B13/00 , A23L27/79 , A24B15/16 , A61K36/81 , A61K2300/00
摘要： The invention features tobacco compositions and methods of their use and manufacture. Compositions of the invention may be based on a variety of technologies. Technologies include films, tabs, shaped parts, gels, consumable units, insoluble matrices, and hollow shapes. In addition to tobacco, compositions may also contain flavors, colors, and other additives as described herein. Compositions may also be orally disintegrable. Exemplary compositions and methods of their manufacture are described herein.
摘要翻译：本发明的特征在于烟草组合物及其使用和制造方法。本发明的组合物可以基于各种技术。技术包括薄膜，薄片，成形部件，凝胶，消耗单元，不溶性基质和中空形状。除了烟草之外，组合物还可以含有如本文所述的香料，颜色和其它添加剂。组合物也可以口服分解。本文描述了其制造的示例性组合物和方法。

9. 发明授权

US07345022B2 Anti-fibril peptides 有权
标题翻译：抗原纤维肽
公开(公告)号：US07345022B2
公开(公告)日：2008-03-18
申请号：US10666095
申请日：2003-09-18
申请人： Robert P. Hammer , Yanwen Fu , Tod J. Miller , Mark L. McLaughlin
发明人： Robert P. Hammer , Yanwen Fu , Tod J. Miller , Mark L. McLaughlin
IPC分类号： A61K38/03 , A61K38/08 , A61K38/10 , C07K4/00 , C07K7/06 , C07K7/08
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0806 , C07K5/1008 , C07K5/1019 , C07K7/08 , C07K14/4711
摘要： Novel peptides are disclosed that may be used as inhibitors of amyloidogenesis, as suppressors of amyloid toxicity, and as therapeutic agents for amyloid-associated diseases such as Alzheimer's disease, Parkinson's Disease, Creutzfeldt-Jakob Disease, Huntington's Disease, and Type II Diabetes. These new β-strand mimics (β-sheet “blockers”), containing Cα,α-disubstituted amino acids, specifically interact with and block the development of the β-sheet structure of the developing fibrils of amyloid diseases, such as Alzheimer's disease amyloid β-peptide (Aβ). We have discovered that oligomerization of β-sheet structures, including those implicated in amyloid-associated diseases, may be inhibited or even reversed by the presence of extended peptide structures that have only one edge available for hydrogen bonding. Without a second edge that is also available for hydrogen bonding, the extension of a developing β-sheet is blocked by binding to the novel peptides.
摘要翻译：公开了可用作淀粉样蛋白发生抑制剂的新型肽，作为淀粉样蛋白毒性的抑制剂，以及作为淀粉样蛋白相关疾病如阿尔茨海默氏病，帕金森氏病，克雅氏病，亨廷顿氏病和II型糖尿病的治疗剂。这些新的β链模拟物（β-片段“阻断剂”），含有Cα，α - 二取代的氨基酸，特异性地相互作用并阻断了发展中的原纤维的β-折叠结构淀粉样蛋白疾病，如阿尔茨海默病淀粉样蛋白β-肽（Abeta）。我们已经发现，β-片结构的低聚，包括涉及淀粉样蛋白相关疾病的那些，可能被抑制或甚至被仅具有一个可用于氢键的边缘的延伸肽结构的存在所逆转。没有可用于氢键的第二边缘，通过与新肽的结合阻断了显影的β-折叠片的延伸。

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