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1. 发明申请

US20110046894A1 METHOD FOR DISCRIMINATING BETWEEN MALIGNANT AND BENIGN TISSUE LESIONS 审中-公开
标题翻译：鉴别恶性组织和组织组织淋巴结的方法
公开(公告)号：US20110046894A1
公开(公告)日：2011-02-24
申请号：US12864388
申请日：2009-01-26
申请人： Jakob Stamnes , Knut Stamnes , Gennady Ryzhikov , Marina Biryulina , Boerge Hamre , Endre R. Sommersten , Lu Zhao
发明人： Jakob Stamnes , Knut Stamnes , Gennady Ryzhikov , Marina Biryulina , Boerge Hamre , Endre R. Sommersten , Lu Zhao
IPC分类号： G06F19/00 , G01N33/48
摘要： An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and pure morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of pure morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each pure morphology parameter and a weight to a logarithm of each pure morphoiogy parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant.
摘要翻译：本发明的一个实施例包括用于区分良性和恶性组织损伤的方法。该方法包括使用由反射测量产生的生理学和形态参数的多个图以及由反射测量产生的纯形态参数的步骤。该方法还包括计算多个地图的熵和交叉熵，以及计算多个纯形态参数。此外，该方法包括将每个熵的权重和权重分配给每个熵的对数，每个交叉熵的权重和每个交叉熵的对数的权重，以及对每个纯形态参数的权重和权重每个纯形态参数的对数。该方法还包括计算诊断索引，定义成本函数，为诊断索引定义适当的阈值并解决优化问题，以从所分配的权重确定一组权重，以最大限度地提高100％灵敏度的特异性。此外，该方法使用计算，成本函数和诊断指标来确定组织损伤是良性还是恶性。

2. 发明申请

US20110054298A1 OPTICAL METHOD FOR DETERMINING MORPHOLOGICAL PARAMETERS AND PHYSIOLOGICAL PROPERTIES OF TISSUE 有权
标题翻译：用于确定组织形态参数和组织生理特性的光学方法
公开(公告)号：US20110054298A1
公开(公告)日：2011-03-03
申请号：US12933037
申请日：2009-03-18
申请人： Jakob J. Stamnes , Knut Stamnes , Lu Zhao , Boerge Hamre , Gennady Ryzhikov , Marina Biryulina , Endre R. Sommersten , Kristian Pagh Nielsen , Johan E. Moan
发明人： Jakob J. Stamnes , Knut Stamnes , Lu Zhao , Boerge Hamre , Gennady Ryzhikov , Marina Biryulina , Endre R. Sommersten , Kristian Pagh Nielsen , Johan E. Moan
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： G01N21/4738 , A61B5/0059 , A61B5/1455 , A61B5/444 , G06K9/00134 , G06T7/62 , G06T7/66 , G06T2207/30024
摘要： In an embodiment of the present disclosure, an optical method for determining morphological parameters and physiological properties of tissue is presented. The method includes using reflectance measurements from a tissue area for a plurality of wavelengths, using a bio-optical model, using radiative transfer modeling and using a non-linear inversion procedure. The method further includes systematically varying values of the morphological parameters and physiological properties of the tissue and simultaneously varying the inherent optical properties, which are linked to the morphological parameters and the physiological properties of the tissue, until the non-linear inversion procedure returns values for the morphological parameters and the physiological properties of the tissue such that an agreement between the reflectance measurements and reflectances computed by the radiative transfer model, based on the returned morphological parameters and the physiological properties of the tissue values and corresponding inherent optical properties values, reach a predetermined level of accuracy.
摘要翻译：在本公开的实施例中，提出了用于确定组织的形态参数和生理特性的光学方法。该方法包括使用生物光学模型，使用辐射传递建模和使用非线性反演程序，从组织区域对多个波长使用反射率测量。该方法还包括系统地改变组织的形态学参数和生理特性的值，并且同时改变固有的光学性质，其与组织的形态参数和生理特性相关，直到非线性反演程序返回值为基于返回的形态参数和组织值的生理特性和相应的固有光学性质值，通过辐射传递模型计算的反射率测量值和反射率之间的一致性达到了预先确定的准确度。

3. 发明授权

US09823189B2 Optical method for determining morphological parameters and physiological properties of tissue 有权
公开(公告)号：US09823189B2
公开(公告)日：2017-11-21
申请号：US12933037
申请日：2009-03-18
申请人： Jakob J. Stamnes , Knut Stamnes , Lu Zhao , Boerge Hamre , Gennady Ryzhikov , Marina Biryulina , Endre R. Sommersten , Kristian Pagh Nielsen , Johan E. Moan
发明人： Jakob J. Stamnes , Knut Stamnes , Lu Zhao , Boerge Hamre , Gennady Ryzhikov , Marina Biryulina , Endre R. Sommersten , Kristian Pagh Nielsen , Johan E. Moan
IPC分类号： A61B6/00 , G01N21/47 , A61B5/00 , A61B5/1455 , G06K9/00 , G06T7/62 , G06T7/66
CPC分类号： G01N21/4738 , A61B5/0059 , A61B5/1455 , A61B5/444 , G06K9/00134 , G06T7/62 , G06T7/66 , G06T2207/30024
摘要： In an embodiment of the present disclosure, an optical method for determining morphological parameters and physiological properties of tissue is presented. The method includes using reflectance measurements from a tissue area for a plurality of wavelengths, using a bio-optical model, using radiative transfer modeling and using a non-linear inversion procedure. The method further includes systematically varying values of the morphological parameters and physiological properties of the tissue and simultaneously varying the inherent optical properties, which are linked to the morphological parameters and the physiological properties of the tissue, until the non-linear inversion procedure returns values for the morphological parameters and the physiological properties of the tissue such that an agreement between the reflectance measurements and reflectances computed by the radiative transfer model, based on the returned morphological parameters and the physiological properties of the tissue values and corresponding inherent optical properties values, reach a predetermined level of accuracy.

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