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1. 发明申请

US20120245447A1 Devices, Systems, and Methods Associated with Analyte Monitoring Devices and Devices Incorporating the Same 有权
标题翻译：与分析物监测装置和装置相关的装置，系统和方法
公开(公告)号：US20120245447A1
公开(公告)日：2012-09-27
申请号：US13407617
申请日：2012-02-28
申请人： Jai Karan , Annie Tan , Marc B. Taub , Timothy C. Dunn , Joel Goldsmith , Christine M. Neuhaus , Stephen A. Rossi
发明人： Jai Karan , Annie Tan , Marc B. Taub , Timothy C. Dunn , Joel Goldsmith , Christine M. Neuhaus , Stephen A. Rossi
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0004 , A61B5/1468 , A61B5/6833 , A61B5/6847 , A61B5/7435 , A61B2560/0209 , A61B2560/0252 , G01N33/48792 , G06F19/00 , G16H40/63
摘要： Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.
摘要翻译：提供了与分析物监测装置相关的分析物监测系统，装置和方法以及包括其的装置。提供了各种图形用户界面（GUI）和导航流，用于执行与分析物监测装置或系统相关联的各种特征，活动，功能等。提供直观的导航以增强分析物测量的解释。

2. 发明授权

US09532737B2 Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same 有权
标题翻译：与分析物监测装置和结合其的装置相关联的装置，系统和方法
公开(公告)号：US09532737B2
公开(公告)日：2017-01-03
申请号：US13407617
申请日：2012-02-28
申请人： Jai Karan , Annie Tan , Marc B. Taub , Timothy C. Dunn , Joel Goldsmith , Christine M. Neuhaus , Stephen A. Rossi
发明人： Jai Karan , Annie Tan , Marc B. Taub , Timothy C. Dunn , Joel Goldsmith , Christine M. Neuhaus , Stephen A. Rossi
IPC分类号： A61B5/1468 , A61B5/145 , G06F19/00 , G01N33/487 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/0004 , A61B5/1468 , A61B5/6833 , A61B5/6847 , A61B5/7435 , A61B2560/0209 , A61B2560/0252 , G01N33/48792 , G06F19/00 , G16H40/63
摘要： Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.
摘要翻译：提供了与分析物监测装置相关的分析物监测系统，装置和方法以及包括其的装置。提供了各种图形用户界面（GUI）和导航流，用于执行与分析物监测装置或系统相关联的各种特征，活动，功能等。提供直观的导航以增强分析物测量的解释。

3. 发明申请

US20120232520A1 Multi-Function Analyte Monitor Device and Methods of Use 有权
标题翻译：多功能分析物监测装置及使用方法
公开(公告)号：US20120232520A1
公开(公告)日：2012-09-13
申请号：US13416934
申请日：2012-03-09
申请人： Mark K. Sloan , Frederic Arbogast , Jean-Pierre Cole , Namvar Kiaie , Jonathan Fern , Lynne K. Lyons , William Matievich, JR. , Lynn Dixon , Mark P. Jesser , Matthew T. Vogel , Jai Karan , Nathan C. Crouther , Marc B. Taub
发明人： Mark K. Sloan , Frederic Arbogast , Jean-Pierre Cole , Namvar Kiaie , Jonathan Fern , Lynne K. Lyons , William Matievich, JR. , Lynn Dixon , Mark P. Jesser , Matthew T. Vogel , Jai Karan , Nathan C. Crouther , Marc B. Taub
IPC分类号： A61M5/31
CPC分类号： A61B5/14532 , A61M5/14244 , A61M5/31533 , A61M2005/14208 , A61M2205/3553 , A61M2205/3584 , A61M2205/6054 , G01N33/48792 , G06F19/00 , G16H40/63
摘要： Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations are provided. For example, adjustments to dosage levels of long-acting insulin may be provided to assist in the management of diabetes and related conditions.
摘要翻译：用于检测分析物样品的方法，系统和装置，确定与检测到的分析物样品相关联的分析物浓度，存储所确定的分析物浓度和与所确定的分析物浓度相关联的时间，检索两个或多个储存的分析物浓度，以及确定调整剂量至少部分地基于当前剂量水平，并提供与两个或更多个检索到的分析物浓度相关联的数据。例如，可以提供对长效胰岛素的剂量水平的调整以帮助糖尿病和相关病症的管理。

4. 发明授权

US09198623B2 Devices, systems, and methods related to analyte monitoring and management 有权
标题翻译：与分析物监测和管理相关的设备，系统和方法
公开(公告)号：US09198623B2
公开(公告)日：2015-12-01
申请号：US13091557
申请日：2011-04-21
申请人： Jonathan Fern , Mark P. Jesser , Lynn Dixon , Jai Karan , Charles Wei , Matthew T. Vogel , Tim S. Gasperak , Kim Cullen , Kim Ladin , Marc B. Taub , Gary A. Hayter
发明人： Jonathan Fern , Mark P. Jesser , Lynn Dixon , Jai Karan , Charles Wei , Matthew T. Vogel , Tim S. Gasperak , Kim Cullen , Kim Ladin , Marc B. Taub , Gary A. Hayter
IPC分类号： C12M1/34 , A61B5/00 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0022 , A61B5/14546 , A61B5/150358 , A61B5/72 , A61B5/742 , A61B5/743 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B2560/0295 , A61B2560/045 , G06F19/00 , G16H40/67
摘要： Analyte monitoring devices, systems, and methods are provided that relate to: enabling different application features on a data processing device for analyte monitoring devices with different analyte monitoring features; programming analyte monitoring devices in advance; personalizing an analyte monitoring device; graphically representing a remaining insulin level in a user body; and graphically representing analyte measurement related data for on-demand readings; protecting access to feature of an analyte monitoring device.
摘要翻译：提供了分析物监测装置，系统和方法，其涉及：在具有不同分析物监测特征的分析物监测装置的数据处理装置上实现不同的应用特征; 提前编程分析物监测装置; 个性化分析物监测装置; 以图形方式表示用户身体中的剩余胰岛素水平; 并以图形方式表示用于按需读数的分析物测量相关数据; 保护对分析物监测装置的特征的访问。

5. 发明申请

US20110287528A1 Devices, Systems, and Methods Related to Analyte Monitoring and Management 有权
标题翻译：与分析物监测和管理相关的设备，系统和方法
公开(公告)号：US20110287528A1
公开(公告)日：2011-11-24
申请号：US13091557
申请日：2011-04-21
申请人： Jonathan Fern , Mark P. Jesser , Lynn Dixon , Jai Karan , Charles Wei , Matthew T. Vogel , Tim S. Gasperak , Kim Cullen , Kim Ladin , Marc B. Taub , Gary A. Hayter
发明人： Jonathan Fern , Mark P. Jesser , Lynn Dixon , Jai Karan , Charles Wei , Matthew T. Vogel , Tim S. Gasperak , Kim Cullen , Kim Ladin , Marc B. Taub , Gary A. Hayter
IPC分类号： C12M1/34
CPC分类号： A61B5/14532 , A61B5/0022 , A61B5/14546 , A61B5/150358 , A61B5/72 , A61B5/742 , A61B5/743 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B2560/0295 , A61B2560/045 , G06F19/00 , G16H40/67
摘要： Analyte monitoring devices, systems, and methods are provided that relate to: enabling different application features on a data processing device for analyte monitoring devices with different analyte monitoring features; programming analyte monitoring devices in advance; personalizing an analyte monitoring device; graphically representing a remaining insulin level in a user body; and graphically representing analyte measurement related data for on-demand readings; protecting access to feature of an analyte monitoring device.
摘要翻译：提供了分析物监测装置，系统和方法，其涉及：在具有不同分析物监测特征的分析物监测装置的数据处理装置上实现不同的应用特征; 提前编程分析物监测装置; 个性化分析物监测装置; 以图形方式表示用户身体中的剩余胰岛素水平; 并以图形方式表示用于按需读数的分析物测量相关数据; 保护对分析物监测装置的特征的访问。

6. 发明授权

US10010273B2 Multi-function analyte monitor device and methods of use 有权
公开(公告)号：US10010273B2
公开(公告)日：2018-07-03
申请号：US13416934
申请日：2012-03-09
申请人： Mark K. Sloan , Frederic Arbogast , Jean-Pierre Cole , Namvar Kiaie , Jonathan Fern , Lynne K. Lyons , William Matievich, Jr. , Lynn Dixon , Mark P. Jesser , Matthew T. Vogel , Jai Karan , Nathan C. Crouther , Marc B. Taub
发明人： Mark K. Sloan , Frederic Arbogast , Jean-Pierre Cole , Namvar Kiaie , Jonathan Fern , Lynne K. Lyons , William Matievich, Jr. , Lynn Dixon , Mark P. Jesser , Matthew T. Vogel , Jai Karan , Nathan C. Crouther , Marc B. Taub
IPC分类号： A61M31/00 , A61B5/145 , G01N33/487 , A61M5/315 , A61M5/142 , G06F19/00
CPC分类号： A61B5/14532 , A61M5/14244 , A61M5/31533 , A61M2005/14208 , A61M2205/3553 , A61M2205/3584 , A61M2205/6054 , G01N33/48792 , G06F19/00 , G16H40/63
摘要： Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations are provided. For example, adjustments to dosage levels of long-acting insulin may be provided to assist in the management of diabetes and related conditions.

7. 发明申请

US20120010600A1 METHOD OF OVERNIGHT CLOSED-LOOP INSULIN DELIVERY WITH MODEL PREDICTIVE CONTROL AND GLUCOSE MEASUREMENT ERROR MODEL 有权
标题翻译：用模型预测控制和葡萄糖测量误差模型的闭合闭合胰岛素分娩方法
公开(公告)号：US20120010600A1
公开(公告)日：2012-01-12
申请号：US13240855
申请日：2011-09-22
申请人： Malgorzata E. Wilinska , Erwin S. Budiman , Gary A. Hayter , Marc B. Taub , Roman Hovorka
发明人： Malgorzata E. Wilinska , Erwin S. Budiman , Gary A. Hayter , Marc B. Taub , Roman Hovorka
IPC分类号： A61M5/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/1495 , A61M5/142 , A61M2005/14208 , A61M2005/14292 , A61M2005/14296 , A61M2205/50 , A61M2205/52 , A61M2205/70 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： A closed-loop method for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.
摘要翻译：胰岛素输注过夜的闭环方法使用模型预测控制算法（“MPC”）。与MPC一起使用的是葡萄糖测量误差模型，该误差模型来自实际的葡萄糖传感器误差数据。该传感器误差数据包括传感器伪像分量，包括丢失，以及包括校准误差在内的持续误差分量，所有这些均由实验受试者实验获得。 MPC算法建议胰岛素输注每十五分钟。通过将模型计算的无噪声间质葡萄糖与与FreeStyleNavigator®连续葡萄糖监测系统（“FSN”）相关的实验衍生的瞬时和持续传感器伪像组合，可以获得传感器葡萄糖输入到MPC。在使用葡萄糖测量误差模型的MPC算法模拟过夜闭环控制期间，严重和显着低血糖的发生率分别降低了2300和200倍，表明连续葡萄糖监测技术有助于安全闭环胰岛素输送。

8. 发明授权

US08062249B2 Overnight closed-loop insulin delivery with model predictive control and glucose measurement error model 有权
标题翻译：过夜闭环胰岛素输送与模型预测控制和葡萄糖测量误差模型
公开(公告)号：US08062249B2
公开(公告)日：2011-11-22
申请号：US12751668
申请日：2010-03-31
申请人： Malgorzata E. Wilinska , Erwin S. Budiman , Gary A. Hayter , Marc B. Taub , Roman Hovorka
发明人： Malgorzata E. Wilinska , Erwin S. Budiman , Gary A. Hayter , Marc B. Taub , Roman Hovorka
IPC分类号： A61M5/14
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/1495 , A61M5/142 , A61M2005/14208 , A61M2005/14292 , A61M2005/14296 , A61M2205/50 , A61M2205/52 , A61M2205/70 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.
摘要翻译：用于胰岛素输注的闭环系统使用模型预测控制算法（“MPC”）。与MPC一起使用的是葡萄糖测量误差模型，该误差模型来自实际的葡萄糖传感器误差数据。该传感器误差数据包括传感器伪像分量，包括丢失，以及包括校准误差在内的持续误差分量，所有这些均由实验受试者实验获得。 MPC算法建议胰岛素输注每十五分钟。通过将模型计算的无噪声间质葡萄糖与与FreeStyleNavigator®连续葡萄糖监测系统（“FSN”）相关的实验衍生的瞬时和持续传感器伪像组合，可以获得传感器葡萄糖输入到MPC。在使用葡萄糖测量误差模型的MPC算法模拟过夜闭环控制期间，严重和显着低血糖的发生率分别降低了2300和200倍，表明连续葡萄糖监测技术有助于安全闭环胰岛素输送。

9. 发明申请

US20110166875A1 SYSTEM AND METHOD FOR MANAGING MEDICAL DATA AND FACILITATING REIMBURSEMENT FOR HEALTH CARE 审中-公开
标题翻译：用于管理医疗数据和促进健康护理的系统和方法
公开(公告)号：US20110166875A1
公开(公告)日：2011-07-07
申请号：US12985233
申请日：2011-01-05
申请人： Gary A. Hayter , Charles Wei , Marc B. Taub
发明人： Gary A. Hayter , Charles Wei , Marc B. Taub
IPC分类号： G06Q50/00 , G06Q10/00
CPC分类号： G06Q50/22 , G06Q10/10
摘要： System and method receive medical data of a patient having a disease afflicted health condition for processing and analysis of that data. Software installed on a health care provider's computer for processing the medical data includes a GUI reimbursement window that informs the HCP of reimbursement possibilities for analysis of the data and counseling of the patient. The reimbursement window also includes hyperlinks and may also include codes for insurance claims. Lists of reimbursement entities, pre-authorization instructions, coding instructions, and contacts may all be included and may be personalized for a particular patient. In one case, a complete bill is created and submitted to an insurance entity. In another, a patient data base is created so that the reimbursement window can inform the HCP of patient analysis frequency, which may affect reimbursement.
摘要翻译：系统和方法接收具有疾病影响的健康状况的患者的医疗数据，用于处理和分析该数据。在医疗保健提供者的计算机上安装的用于处理医疗数据的软件包括GUI报销窗口，其向HCP通知用于分析患者的数据和咨询的可能性。报销窗口还包括超链接，还可能包括保险索赔代码。报销实体，预授权指令，编码说明和联系人的列表可以全部包括在内，并且可以针对特定患者进行个性化。在一种情况下，创建完整的帐单并提交给保险实体。另一方面，创建了一个病人数据库，以便报销窗口可以向HCP通知患者分析频率，这可能会影响报销。

10. 发明申请

US20100298765A1 SAFETY FEATURES FOR INTEGRATED INSULIN DELIVERY SYSTEM 有权
标题翻译：一体化胰岛素输送系统的安全性能
公开(公告)号：US20100298765A1
公开(公告)日：2010-11-25
申请号：US12785104
申请日：2010-05-21
申请人： Erwin S. Budiman , Gary A. Hayter , Nathan Crouther , Marc B. Taub , Wesley Scott Harper , Charles Wei
发明人： Erwin S. Budiman , Gary A. Hayter , Nathan Crouther , Marc B. Taub , Wesley Scott Harper , Charles Wei
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/1495 , A61B5/4839 , A61B2562/0295 , A61M2005/14208 , A61M2005/14296 , A61M2205/3569 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Safety features are applied to an integrated insulin delivery system to enhance safety while accounting for glucose sensor bias and calibration errors. One safety feature includes comparisons of calibrations of the sensor to nominal sensitivity and taking action, such as limiting insulin delivery or taking a further calibration of the sensor. In another feature, an automatic resumption of a basal delivery rate is programmed into the delivery device to avoid the possibility of complete loss of delivery of insulin in the event that communication with the delivery device is disrupted. Other features include steps taken to avoid hypoglycemia in the event that the sensor is negatively biased.
摘要翻译：安全功能应用于集成的胰岛素输送系统，以增强安全性，同时考虑到葡萄糖传感器偏差和校准误差。一个安全特征包括将传感器的校准与标称灵敏度进行比较，并采取行动，例如限制胰岛素输送或进一步校准传感器。在另一特征中，将自动恢复基本递送速率编程到递送设备中，以避免在与递送设备的通信被中断的情况下胰岛素完全丢失的可能性。其他功能包括在传感器受到负偏压的情况下避免低血糖的步骤。

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