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1. 发明授权

US08673856B2 Omega conotoxins 有权
标题翻译：欧米茄芋螺毒素
公开(公告)号：US08673856B2
公开(公告)日：2014-03-18
申请号：US12513182
申请日：2007-11-02
申请人： Jae II Kim , Hye Whon Rhim , Hyun Jeong Kim , Hong Won Suh , Soung Hun Roh , Jung A Yun , Seung Kyu Lee , Young Jae Eu , Heung Sik Na
发明人： Jae II Kim , Hye Whon Rhim , Hyun Jeong Kim , Hong Won Suh , Soung Hun Roh , Jung A Yun , Seung Kyu Lee , Young Jae Eu , Heung Sik Na
IPC分类号： A61K38/16 , A61K38/00 , C07K14/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention relates to a method for increasing the binding reversibility of a ω-conotoxin to a N-type calcium channel, which comprises preparing a ω-conotoxin having a Ile and/or Ala residue at a position of amino acid (11 and/or 12), respectively in the second loop between cysteine residues (2 and 3) of the ω-conotoxin represented by the formula I, such that the prepared ω-conotoxin has the increased binding reversibility to N-type calcium channel. In addition, the present invention relates to a novel ω-conotoxin and a pharmaceutical composition having plausible properties in view of blocking activity to and specificity to N-type calcium channel, and dramatically improved binding reversibility to N-type calcium channel.
摘要翻译：本发明涉及一种增加ω-芋螺毒素与N型钙通道的结合可逆性的方法，其包括在氨基酸（11和/或其氨基酸）的位置制备具有Ile和/或Ala残基的ω-芋螺毒素，或12）分别在由式I表示的ω-芋螺毒素的半胱氨酸残基（2和3）之间的第二环中，使得所制备的ω-芋螺毒素具有增加的对N-型钙通道的结合可逆性。此外，本发明涉及一种新型的ω-芋螺毒素和具有似乎合理的性质的药物组合物，其特征在于阻断N-型钙通道的活性和特异性，并显着提高了对N-型钙通道的结合可逆性。

2. 发明申请

US20100056456A1 Omega Conotoxins 有权
标题翻译：欧米茄芋螺毒素
公开(公告)号：US20100056456A1
公开(公告)日：2010-03-04
申请号：US12513182
申请日：2007-11-02
申请人： Jae Il Kim , Hye Whon Rhim , Hyun Jeong Kim , Hong Won Suh , Soung Hun Roh , Jung A. Yun , Seung Kyu Lee , Young Jae Eu , Heung Sik Na
发明人： Jae Il Kim , Hye Whon Rhim , Hyun Jeong Kim , Hong Won Suh , Soung Hun Roh , Jung A. Yun , Seung Kyu Lee , Young Jae Eu , Heung Sik Na
IPC分类号： A61K38/10 , C07K7/08 , C07H21/00 , A61P25/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention relates to a method for increasing the binding reversibility of a ω-conotoxin to a N-type calcium channel, which comprises preparing a ω-conotoxin having a Ile and/or Ala residue at a position of amino acid (11 and/or 12), respectively in the second loop between cysteine residues (2 and 3) of the ω-conotoxin represented by the formula I, such that the prepared ω-conotoxin has the increased binding reversibility to N-type calcium channel. In addition, the present invention relates to a novel ω-conotoxin and a pharmaceutical composition having plausible properties in view of blocking activity to and specificity to N-type calcium channel, and dramatically improved binding reversibility to N-type calcium channel.
摘要翻译：本发明涉及一种增加ω-芋螺毒素与N-型钙通道的结合可逆性的方法，其包括在氨基酸（11和/或其氨基酸）的位置制备具有Ile和/或Ala残基的ω-芋螺毒素，或12）分别在由式I表示的ω-芋螺毒素的半胱氨酸残基（2和3）之间的第二环中，使得制备的ω-芋螺毒素对N-型钙通道具有增加的结合可逆性。此外，本发明涉及一种新型的ω-芋螺毒素和具有似乎合理的性质的药物组合物，其特征在于阻断N-型钙通道的活性和特异性，并显着提高了与N-型钙通道的结合可逆性。

3. 发明授权

US06915233B2 Apparatus and method for measuring a weight load exerted by a leg of a lab animal or a human being 失效
标题翻译：用于测量由实验室动物或人的腿施加的重量负荷的装置和方法
公开(公告)号：US06915233B2
公开(公告)日：2005-07-05
申请号：US10645770
申请日：2003-08-21
申请人： Hee Chul Han , Seung Kil Hong , Heung Sik Na , Young Wook Yoon , Yang In Kim , Sun Seek Min , Jeong Seok Han
发明人： Hee Chul Han , Seung Kil Hong , Heung Sik Na , Young Wook Yoon , Yang In Kim , Sun Seek Min , Jeong Seok Han
IPC分类号： G01G17/08 , G01C19/00
CPC分类号： G01G17/08
摘要： An apparatus and method capable of measuring a weight load of an inflamed leg of a lab animal or a human being objectively and precisely while the lab animal or the human being is walking freely in a non-binding state. A pathway sized depending on a size and a stride of the lab animal or the human being is provided in a weight load measuring apparatus, and a weight sensor is attached to a bottom of the pathway. Thus, artificial operations to be applied to the lab animal or human being walking the pathway can be minimized such that the weight load exerted in the inflamed leg can be measured objectively and precisely with time periods.
摘要翻译：一种能够在实验动物或人在非结合状态下自由行走的情况下，客观且准确地测量实验动物或人的发炎腿的重量负荷的装置和方法。根据实验动物或人的大小和步幅尺寸的通路设置在重量载重测量装置中，并且重量传感器附接到路径的底部。因此，可以将要应用于实验动物或人走路的人工操作最小化，使得可以在时间上精确地测量施加在发炎腿部的重量负荷。

4. 发明申请

US20120015886A1 METHOD FOR PREPARING RECOMBINANT PEPTIDE FROM SPIDER VENOM AND METHOD FOR RELIEVING PAIN 审中-公开
标题翻译：从天花板制备重组蛋白的方法及缓解疼痛的方法
公开(公告)号：US20120015886A1
公开(公告)日：2012-01-19
申请号：US12907475
申请日：2010-10-19
申请人： UhTaek OH , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
发明人： UhTaek OH , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
IPC分类号： A61K38/17 , A61P29/00
CPC分类号： C07K14/43518 , C12N15/815
摘要： The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence of the alpha factor and under the control of methanol-inducible alcohol oxidase (AOX) promoter to construct a recombinant yeast expression plasmid. Yeast cells are transformed with this plasmid to produce the GsMTx4 peptide and analgesic compositions containing said peptide. The recombinant yeast expression system of the present invention affords a more stable method for producing GsMTx4 than its natural route. Thus the GsMTx4 peptide and its derivatives produced by the method of this invention can be used in the cure of related diseases such as heart failure as the peptide specifically inhibits mechanosensitive ion channels.
摘要翻译：本发明涉及一种生产含有所述肽的重组蜘蛛毒素肽和镇痛组合物的方法。更具体地，本发明涉及将GsMTx4的基因亚克隆到载体中的方法，使其与α因子的分泌信号序列连接并在甲醇诱导型醇氧化酶（AOX）启动子的控制下构建重组酵母表达质粒。用该质粒转化酵母细胞以产生含有所述肽的GsMTx4肽和镇痛组合物。本发明的重组酵母表达系统提供比其自然途径更稳定的产生GsMTx4的方法。因此，通过本发明方法产生的GsMTx4肽及其衍生物可用于治疗诸如心力衰竭等相关疾病，因为该肽特异性抑制机械敏感离子通道。

5. 发明申请

US20090023183A1 Method For Preparing Recombinant Peptide From Spider Venom and Analgesic Composition Containing The Peptide 审中-公开
标题翻译：从蜘蛛毒液制备重组肽的方法和含有肽的止痛组合物
公开(公告)号：US20090023183A1
公开(公告)日：2009-01-22
申请号：US12090664
申请日：2006-10-18
申请人： UhTaek Oh , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
发明人： UhTaek Oh , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
IPC分类号： C12P21/02 , C07H21/04 , C07K14/435
CPC分类号： C07K14/43518 , C12N15/815
摘要： The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence of the alpha factor and under the control of methanol-inducible alcohol oxidase (AOX) promoter to construct a recombinant yeast expression plasmid. Yeast cells are transformed with this plasmid to produce the GsMTx4 peptide and analgesic compositions containing said peptide. The recombinant yeast expression system of the present invention affords a more stable method for producing GsMTx4 than its natural route. Thus the GsMTx4 peptide and its derivatives produced by the method of this invention can be used in the cure of related diseases such as heart failure as the peptide specifically inhibits mechanosensitive ion channels.
摘要翻译：本发明涉及一种生产含有所述肽的重组蜘蛛毒素肽和镇痛组合物的方法。更具体地，本发明涉及将GsMTx4的基因亚克隆到载体中的方法，使其与α因子的分泌信号序列连接并在甲醇诱导型醇氧化酶（AOX）启动子的控制下构建重组酵母表达质粒。用该质粒转化酵母细胞以产生含有所述肽的GsMTx4肽和镇痛组合物。本发明的重组酵母表达系统提供比其自然途径更稳定的产生GsMTx4的方法。因此，通过本发明方法产生的GsMTx4肽及其衍生物可用于治疗诸如心力衰竭等相关疾病，因为该肽特异性抑制机械敏感离子通道。

6. 发明授权

US06629056B2 Apparatus and method for measuring a weight load exerted by a leg of a lab animal 有权
公开(公告)号：US06629056B2
公开(公告)日：2003-09-30
申请号：US09820536
申请日：2001-03-29
申请人： Hee Chul Han , Seung Kil Hong , Heung Sik Na , Young Wook Yoon , Yang In Kim , Sun Seek Min , Jeong Seok Han
发明人： Hee Chul Han , Seung Kil Hong , Heung Sik Na , Young Wook Yoon , Yang In Kim , Sun Seek Min , Jeong Seok Han
IPC分类号： G01G1900
CPC分类号： G01G17/08
摘要： An apparatus and a method capable of measuring a weight load of an inflamed foot of a lab animal objectively and precisely while the lab animal is walking freely in a non-binding state is provided. A pathway sized depending on a size and a stride of the lab animal is provided in a weight load measuring apparatus, and a weight sensor is attached to a bottom of the pathway. Thus, artificial operations to be applied to the lab animal walking the pathway can be minimized such that the weight load exerted in the inflamed foot can be measured objectively and precisely with time periods.

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