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    • 6. 发明授权
    • Methods for proliferation of antigen-specific T cells
    • 抗原特异性T细胞增殖的方法
    • US09080152B2
    • 2015-07-14
    • US13254039
    • 2009-04-30
    • Bin GaoJie Ding
    • Bin GaoJie Ding
    • A61K39/12A61K39/02A61K45/06C12N5/0783A61K35/12
    • C12N5/0636A61K2035/124C12N2501/515C12N2510/00
    • Methods for expansion of antigen-specific T cells are provided. Said methods include following steps: generating antigen-specific T cells by stimulation of T cells with antigen A; introducing genes encoding immune recognition molecule specific to major histocompatibility complex (MHC) molecule bound with a peptide derived from antigen B into the antigen A specific T cell to produce bi-specific T cells recognizing both target cells expressing antigen A peptide associated MHC and target cells expressing antigen B peptide associated MHC; stimulating the bi-specific T cells by antigen A for expansion of the bi-specific T cells in vitro or in vivo. Methods of the present invention can be applied to expand various of T cells with specific to cancer cells with tumor antigen peptide loaded MHC molecules for adoptive therapy against unmet medical need such as tumors etc.
    • 提供了用于扩增抗原特异性T细胞的方法。 所述方法包括以下步骤:通过用抗原A刺激T细胞产生抗原特异性T细胞; 引入编码针对与源自抗原B的肽结合的主要组织相容性复合物(MHC)分子特异性的免疫识别分子的基因进入抗原A特异性T细胞,以产生识别表达抗原A肽相关MHC和靶细胞的两种靶细胞的双特异性T细胞 表达抗原B肽相关MHC; 通过抗原A刺激双特异性T细胞以在体外或体内扩增双特异性T细胞。 本发明的方法可应用于扩增具有癌细胞特异性的各种具有肿瘤抗原肽的MHC分子的T细胞用于针对未满足的医疗需要如肿瘤等的过继疗法。
    • 8. 发明授权
    • DRAM control method and the DRAM controller utilizing the same
    • DRAM控制方法和利用其的DRAM控制器
    • US08452918B2
    • 2013-05-28
    • US12855566
    • 2010-08-12
    • Jie Ding
    • Jie Ding
    • G06F13/14
    • G06F12/1027G06F13/1673
    • A Dynamic Random Access Memory (DRAM) controller for controlling read and write operations of a DRAM includes a storage unit and a control unit. The storage unit stores a first predetermined size of data including data written into the DRAM in response to a previous partial write request, and stores the corresponding store addresses of the first predetermined size of data in the DRAM. The control unit, in response to a read request, determines whether there exists any address in the store addresses equal to a read address of the read request, and read data corresponding to the read address from the storage unit when there exists same address in the store addresses equal to the read address.
    • 用于控制DRAM的读和写操作的动态随机存取存储器(DRAM)控制器包括存储单元和控制单元。 存储单元响应于先前的部分写入请求存储包括写入DRAM中的数据的第一预定大小的数据,并将第一预定大小的数据的对应存储地址存储在DRAM中。 响应于读取请求,控制单元确定存储地址中是否存在等于读取请求的读取地址的任何地址,并且当在存储单元中存在相同地址时从存储单元读取与读取地址对应的数据 存储地址等于读取地址。
    • 9. 发明申请
    • DRAM Control Method and the DRAM Controller Utilizing the Same
    • DRAM控制方法和使用它的DRAM控制器
    • US20110125961A1
    • 2011-05-26
    • US12855566
    • 2010-08-12
    • Jie Ding
    • Jie Ding
    • G06F12/00G06F12/10
    • G06F12/1027G06F13/1673
    • A Dynamic Random Access Memory (DRAM) controller for controlling read and write operations of a DRAM includes a storage unit and a control unit. The storage unit stores a first predetermined size of data including data written into the DRAM in response to a previous partial write request, and stores the corresponding store addresses of the first predetermined size of data in the DRAM. The control unit, in response to a read request, determines whether there exists any address in the store addresses equal to a read address of the read request, and read data corresponding to the read address from the storage unit when there exists same address in the store addresses equal to the read address.
    • 用于控制DRAM的读和写操作的动态随机存取存储器(DRAM)控制器包括存储单元和控制单元。 存储单元响应于先前的部分写入请求存储包括写入DRAM中的数据的第一预定大小的数据,并将第一预定大小的数据的对应存储地址存储在DRAM中。 响应于读取请求,控制单元确定存储地址中是否存在等于读取请求的读取地址的任何地址,并且当在存储单元中存在相同地址时从存储单元读取与读取地址对应的数据 存储地址等于读取地址。