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1. 发明申请

WO1998001493A1 HIGH IMPACT STRENGTH BIODEGRADABLE MATERIAL 审中-公开
标题翻译：高冲击强度可生物降解材料
公开(公告)号：WO1998001493A1
公开(公告)日：1998-01-15
申请号：PCT/FI1997000416
申请日：1997-06-27
申请人： JVS-POLYMERS OY , HILJANEN-VAINIO, Mari, Pauliina , KYLMÄ, Janne, Matias , SEPPÄLÄ, Jukka, Veli
发明人： JVS-POLYMERS OY
IPC分类号： C08G63/06
CPC分类号： C08G18/4283 , C08G18/4277 , C08G63/06 , C08G63/08 , C08G2170/20 , C08G2230/00
摘要： Polyesters of organic hydroxy acids and their derivatives are, because of their ester linkages prone to hydrolysis, an important group of potentially biodegradable polymers. The mechanical properties of thermoplastic materials based on them have, however, been inferior for many applications, especially when melt processability is required. By the present method which comprises a two-step reaction and the use of a linking monomer it is possible to produce copolyester based polyurethanes from lactic acid and another organic hydroxy acid having a long flexible hydrocarbon chain in its molecules or corresponding lactone, as epsilon -caprolactone. By the proper choice of reaction parameters one can thus get materials which are unexpectedly strong, tough and/or elastic. By melt blending inherently brittle biodegradable polymers with a copolyester based polyurethane according to the invention it has been possible to prepare materials with significantly improved impact strength.
摘要翻译：有机羟基酸及其衍生物的聚酯，因为它们的酯键易于水解，是一组重要的潜在可生物降解的聚合物。然而，基于它们的热塑性材料的机械性能对于许多应用来说是劣质的，特别是当需要熔融加工性时。通过包括两步反应和使用连接单体的本发明方法，可以从乳酸和其分子中具有长柔性烃链的另一有机羟基酸或相应的内酯生产共聚酯基聚氨酯，己内酯。通过适当选择反应参数，可以得到出乎意料的坚固，坚韧和/或弹性的材料。通过将本发明的易生物降解聚合物与基于共聚酯的聚氨酯熔融共混，可以制备具有显着改善的冲击强度的材料。

2. 发明申请

WO1998026814A1 PLASTICIZABLE IMPLANT MATERIAL 审中-公开
标题翻译：可塑性植物材料
公开(公告)号：WO1998026814A1
公开(公告)日：1998-06-25
申请号：PCT/FI1997000786
申请日：1997-12-16
申请人： JVS-POLYMERS OY , SEPPÄLÄ, Jukka , ORAVA, Petri
发明人： JVS-POLYMERS OY
IPC分类号： A61L31/00
CPC分类号： A61K9/0024 , A61K6/033 , A61K6/087 , A61K9/204 , A61L26/0019 , A61L27/18 , A61L31/06 , C08L67/04
摘要： The invention is related to an implanting or filling method in connection with clinical treatments, and to biocompatible and at a controlled rate biodegradable synthetic polymer materials used in connection with the same. The materials are copolymers of derivatives of organic hydroxy acids, such as lactides and lactones, having a melting temperature adjusted to be most preferably 6 - 12 DEG C above the body temperature through selection of monomer composition and preparation parameters. Thus said material in a molten state or as plasticized can be, through injection or using a suitable heated press, transferred to its target area and there shaped before it solidifies to a solid plastic, a wax or a rubbery material. The method can be utilized in medical applications aiming at controlled release of drugs or other active agents when the material acts as a matrix, as well as in surgery and dentistry for different kinds of treatments of tissue damages.
摘要翻译：本发明涉及与临床治疗相关的植入或填充方法，以及与生物相容性和受控速率的可生物降解的合成聚合物材料相关的材料。该材料是通过选择单体组成和制备参数，将有机羟基酸衍生物如丙交酯和内酯的共聚物的熔点温度调节到比体温最高6-12℃。因此，处于熔融状态或塑化的材料可以通过注射或使用合适的加热压力机转移到其目标区域，并且在其固化成固体塑料，蜡或橡胶材料之前成形。该方法可用于旨在控制释放药物或其他活性剂的医学应用，当材料作为基质时，以及用于不同种类的组织损伤治疗的手术和牙科学。

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