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1. 发明公开

EP2207575A1 METHODS FOR FORMING STABILIZED METAL SALT PARTICLES 有权
标题翻译：用于生产稳定的金属的盐
公开(公告)号：EP2207575A1
公开(公告)日：2010-07-21
申请号：EP08836885.7
申请日：2008-10-07
申请人： Johnson & Johnson Vision Care, Inc. , Khanolkar, Amit , Kindt-Larsen, Ture , Sorensen, Jens-Erik , Yewey, Gerald L.
发明人： KHANOLKAR, Amit , KINDT-LARSEN, Ture , SORENSEN, Jens-Erik , YEWEY, Gerald L. , LI, Yongcheng
IPC分类号： A61L12/08 , A61L27/54 , G02B1/04
CPC分类号： A01N59/16 , A61L12/088 , C01G9/006 , C01P2004/64 , C01P2006/80 , C01P2006/82 , G02B1/043
摘要： Process for forming stabilized metal salt particles. The process comprises forming a salt precursor solution comprising at least one salt precursor; forming a metal agent solution comprising a complex formed from at least one dispersing agent having a weight average molecular weight of at least about 1000 and at least one metal agent; adding one solution to the other at a rate sufficient to maintain a clear solution throughout addition and to form a product solution comprising stabilized metal salt nanoparticles having a mean particle size of less than about 50 nm.
摘要翻译：本发明涉及用于形成稳定金属盐粒子的方法。

2. 发明申请

WO2009048556A1 METHODS FOR FORMING STABILIZED METAL SALT PARTICLES 审中-公开
标题翻译：形成稳定的金属盐颗粒的方法
公开(公告)号：WO2009048556A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011554
申请日：2008-10-07
申请人： JOHNSON & JOHNSON VISION CARE, INC. , KHANOLKAR, Amit , KINDT-LARSEN, Ture , SORENSEN, Jens-Erik , YEWEY, Gerald L.
发明人： KHANOLKAR, Amit , KINDT-LARSEN, Ture , SORENSEN, Jens-Erik , YEWEY, Gerald L.
IPC分类号： A61L12/08 , A61L27/54 , G02B1/04
CPC分类号： A01N59/16 , A61L12/088 , C01G9/006 , C01P2004/64 , C01P2006/80 , C01P2006/82 , G02B1/043
摘要： A process comprising: a) forming a first solution comprising at least one salt precursor; b) forming a second solution comprising a complex formed from at least one metal agent and at least one dispersing agent in a particle size stabilizing effective amount; c) adding said second solution to said first solution at a rate sufficient to maintain a clear solution throughout addition and to form a product solution comprising stabilized metal salt particle having a mean particler size of less than about 200 nm; d) drying said product solution to form an antimicrobial metal salt powder comprising 0.01 to about 10 weight % metal in the antimicrobial metal salt powder.
摘要翻译：一种方法，包括：a）形成包含至少一种盐前体的第一溶液; b）形成包含由至少一种金属试剂和至少一种分散剂形成的络合物的第二溶液，所述分散剂具有稳定粒度的有效量; c）以足以在整个添加过程中保持澄清溶液的速率将所述第二溶液加入到所述第一溶液中，并形成包含平均粒度小于约200nm的稳定的金属盐颗粒的产物溶液; d）干燥所述产品溶液以形成抗微生物金属盐粉末，其在抗微生物金属盐粉末中含有0.01至约10重量％的金属。

3. 发明申请

WO2008127299A3 ANTIMICROBIAL POLYMERIC ARTICLES, PROCESSES TO PREPARE THEM AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2008127299A3
公开(公告)日：2008-10-23
申请号：PCT/US2007/022491
申请日：2007-10-22
申请人： JOHNSON & JOHNSON VISION CARE, INC. , MAHADEVAN, Shivkumar , KHANOLKAR, Amit , RATHORE, Osman , LI, Yongcheng , WALKER, Craig, W. , ROONEY, Thomas, R.
发明人： MAHADEVAN, Shivkumar , KHANOLKAR, Amit , RATHORE, Osman , LI, Yongcheng , WALKER, Craig, W. , ROONEY, Thomas, R.
IPC分类号： A01N59/16 , A61L12/08 , A61L27/14 , A61L27/54 , G02B1/04
摘要： This invention relates to antimicrobial polymeric articles containing metal salt particles having a particle size of less than about 200 nm dispersed throughout the polymer and methods for their production.

4. 发明申请

WO2009149022A2 SILICONE HYDROGEL CONTACT LENSES DISPLAYING REDUCED PROTEIN UPTAKE 审中-公开
标题翻译： SILICONE HYDROGEL联系眼镜显示减少的蛋白质摄取
公开(公告)号：WO2009149022A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/045869
申请日：2009-06-01
申请人： JOHNSON & JOHNSON VISION CARE, INC. , PINSLEY, Jeremy, B. , ADAMS, Jonathan, P. , KHANOLKAR, Amit , ZANINI, Diana , FADLI, Zohra , CLARK, Michael, R. , TURNER, David, C. , FORD, James, D. , MAGGIO, Thomas, L.
发明人： PINSLEY, Jeremy, B. , ADAMS, Jonathan, P. , KHANOLKAR, Amit , ZANINI, Diana , FADLI, Zohra , CLARK, Michael, R. , TURNER, David, C. , FORD, James, D. , MAGGIO, Thomas, L.
IPC分类号： G02B1/04 , B29D11/00
CPC分类号： G02B1/043 , C08L83/04 , C08L101/14
摘要： The present invention relates to silicone hydrogel contact lenses formed from a reactive mixture comprising at least one silicone containing compound and a protein uptake reducing amount of at least protein uptake reducing compound.
摘要翻译：本发明涉及由包含至少一种含硅氧烷的化合物和蛋白摄取减少量至少蛋白摄取降低化合物的反应性混合物形成的硅氧水凝胶隐形眼镜。

5. 发明授权

EP2207575B1 METHODS FOR FORMING STABILIZED METAL SALT PARTICLES 有权
标题翻译：稳定金属盐颗粒的形成方法
公开(公告)号：EP2207575B1
公开(公告)日：2017-08-23
申请号：EP08836885.7
申请日：2008-10-07
申请人： Johnson & Johnson Vision Care, Inc.
发明人： KHANOLKAR, Amit , KINDT-LARSEN, Ture , SORENSEN, Jens-Erik , YEWEY, Gerald L. , LI, Yongcheng
IPC分类号： A61L12/08 , A61L27/54 , G02B1/04
CPC分类号： A01N59/16 , A61L12/088 , C01G9/006 , C01P2004/64 , C01P2006/80 , C01P2006/82 , G02B1/043
摘要： Process for forming stabilized metal salt particles. The process comprises forming a salt precursor solution comprising at least one salt precursor; forming a metal agent solution comprising a complex formed from at least one dispersing agent having a weight average molecular weight of at least about 1000 and at least one metal agent; adding one solution to the other at a rate sufficient to maintain a clear solution throughout addition and to form a product solution comprising stabilized metal salt nanoparticles having a mean particle size of less than about 50 nm.
摘要翻译：本发明涉及形成稳定的金属盐颗粒的方法。

6. 发明公开

EP2283387A2 SILICONE HYDROGEL CONTACT LENSES DISPLAYING REDUCED PROTEIN UPTAKE 审中-公开
标题翻译：硅水凝胶隐形眼镜于显示还原蛋白RECORDINGS
公开(公告)号：EP2283387A2
公开(公告)日：2011-02-16
申请号：EP09759183.8
申请日：2009-06-01
申请人： Johnson & Johnson Vision Care, Inc.
发明人： PINSLEY, Jeremy, B. , ADAMS, Jonathan, P. , KHANOLKAR, Amit , ZANINI, Diana , FADLI, Zohra , CLARK, Michael, R. , TURNER, David, C. , FORD, James, D. , MAGGIO, Thomas, L.
IPC分类号： G02B1/04 , B29D11/00
CPC分类号： G02B1/043 , C08L83/04 , C08L101/14
摘要： The present invention relates to silicone hydrogel contact lenses formed from a reactive mixture comprising at least one silicone containing compound and a protein uptake reducing amount of at least protein uptake reducing compound.

7. 发明公开

EP3248621A1 METHODS FOR FORMING STABILIZED METAL SALT PARTICLES 无效
标题翻译：稳定金属盐颗粒的形成方法
公开(公告)号：EP3248621A1
公开(公告)日：2017-11-29
申请号：EP17181166.4
申请日：2008-10-07
申请人： Johnson & Johnson Vision Care, Inc.
发明人： KHANOLKAR, Amit , KINDT-LARSEN, Ture , SORENSEN, Jens-Erik , YEWEY, Gerald L. , LI, Yongcheng
IPC分类号： A61L12/08 , A61L27/54 , G02B1/04 , C01G9/00 , A01N59/16
CPC分类号： A01N59/16 , A61L12/088 , C01G9/006 , C01P2004/64 , C01P2006/80 , C01P2006/82 , G02B1/043
摘要： Process for forming stabilized metal salt particles. The process comprises forming a salt precursor solution comprising at least one salt precursor; forming a metal agent solution comprising a complex formed from at least one dispersing agent having a weight average molecular weight of at least about 1000 and at least one metal agent; adding one solution to the other at a rate sufficient to maintain a clear solution throughout addition and to form a product solution comprising stabilized metal salt nanoparticles having a mean particle size of less than about 50 nm.
摘要翻译：形成稳定的金属盐颗粒的方法。该方法包括形成包含至少一种盐前体的盐前体溶液; 形成包含由至少一种重均分子量为至少约1000的分散剂和至少一种金属试剂形成的配合物的金属试剂溶液; 以足以在整个添加过程中保持澄清溶液的速率向另一个添加一种溶液，并形成包含平均粒度小于约50nm的稳定的金属盐纳米粒子的产品溶液。

8. 发明公开

EP2083631A2 ANTIMICROBIAL POLYMERIC ARTICLES, PROCESSES TO PREPARE THEM AND METHODS OF THEIR USE 审中-公开
标题翻译：防腐胶POLYMERARTIKEL，HERSTELLUNGSVERFAHRENDAFÜRUND IHRE VERWENDUNG
公开(公告)号：EP2083631A2
公开(公告)日：2009-08-05
申请号：EP07873457.1
申请日：2007-10-22
申请人： Johnson & Johnson Vision Care Inc.
发明人： MAHADEVAN, Shivkumar , KHANOLKAR, Amit , RATHORE, Osman , LI, Yongcheng , WALKER, Craig, W. , ROONEY, Thomas, R.
IPC分类号： A01N59/16 , A61L12/08 , A61L27/14 , A61L27/54 , G02B1/04
CPC分类号： A01N25/00 , A01N25/12 , A01N59/16 , A61L12/088 , A61L27/14 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/624 , C08G77/04 , C08G77/18 , C08G77/20 , C08G77/442 , C08L83/04 , C08L83/06 , G02B1/043 , A01N25/10 , A01N2300/00
摘要： This invention relates to antimicrobial polymeric articles containing metal salt particles having a particle size of less than about 200 nm dispersed throughout the polymer and methods for their production.
摘要翻译：本发明涉及分散在整个聚合物中的粒径小于约200nm的金属盐颗粒的抗微生物聚合物及其生产方法。

9. 发明申请

WO2012109187A1 METHODS AND DEVICES FOR PREVENTING CATHETER RELATED URINARY TRACT INFECTIONS 审中-公开
标题翻译：用于预防导管相关尿路感染的方法和装置
公开(公告)号：WO2012109187A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024069
申请日：2012-02-07
申请人： ETHICON, INC. , WEADOCK, Kevin , KHANOLKAR, Amit
发明人： WEADOCK, Kevin , KHANOLKAR, Amit
IPC分类号： A61M25/00
CPC分类号： A61M25/0017 , A61L29/145 , A61L29/16 , A61L2300/404 , A61M2025/0019 , A61M2025/0056
摘要： Methods and devices for preventing urinary tract infections in catheterized patients are disclosed. The device may be a cylindrically shaped antimicrobial hydrogel having a central opening and a slit along its length so that it can be applied directly over a previously inserted urinary catheter. An optional locking mechanism disposed about the slit can be used to secure the antimicrobial device to a catheter shaft. The antimicrobial device has features that conform to tissues near both male and female urethral openings. The inner surface of the device is adapted to provide for releasable engagement with the shaft of the urinary catheter. In one embodiment, the device may be placed on a urinary catheter prior to inserting the catheter in a patient. Locking fittings to secure the antimicrobial device against the urethral opening may also be used. Antimicrobial agents can be incorporated within the hydrogel or coated onto its surface.
摘要翻译：公开了用于预防导尿患者尿路感染的方法和装置。该装置可以是圆柱形的抗微生物水凝胶，其具有沿其长度的中心开口和狭缝，使得其可以直接施加在先前插入的导尿管上。可以使用围绕狭缝设置的可选的锁定机构来将抗微生物装置固定到导管轴上。抗微生物装置具有符合男性和女性尿道口附近的组织的特征。该装置的内表面适于提供与导尿管的轴可释放接合。在一个实施例中，在将导管插入患者体内之前，可将该装置放置在导尿管上。还可以使用锁定配件以将抗微生物装置固定在尿道开口处。抗微生物剂可以掺入水凝胶中或涂覆在其表面上。

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