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1. 发明申请

WO2010036947A3 LIPID BASED PHARMACEUTICAL PREPARATIONS FOR ORAL AND TOPICAL APPLICATION; THEIR COMPOSITIONS, METHODS, AND USES THEREOF 审中-公开
公开(公告)号：WO2010036947A3
公开(公告)日：2010-04-01
申请号：PCT/US2009/058463
申请日：2009-09-25
申请人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran , JINA PHARMACEUTICALS, INC.
发明人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K47/44 , A61P17/14 , A61K31/58 , A61K31/506
摘要： The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases. The present invention provides a method of preparation of a composition comprising at least one active compound and at least one lipid and administering the composition to a subject by oral or topical delivery. In certain embodiments the subject is a mammal. In certain preferred embodiment, the subject is human.

2. 发明公开

EP3681484A2 METHODS OF PREPARING COMPOSITIONS CONTAINING THYMOQUINONE 审中-实审
公开(公告)号：EP3681484A2
公开(公告)日：2020-07-22
申请号：EP18855389.5
申请日：2018-09-12
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath M. , SHEIKH, Saifuddin , AHMAD, Ateeq , AHMAD, Moghis U. , CHEN, Paul , AHMAD, Imran
IPC分类号： A61K9/20

3. 发明申请

WO2019055550A2 METHODS OF PREPARING COMPOSITIONS CONTAINING THYMOQUINONE 审中-公开
公开(公告)号：WO2019055550A2
公开(公告)日：2019-03-21
申请号：PCT/US2018/050728
申请日：2018-09-12
申请人： JINA PHARMACEUTICALS, INC.
发明人： ALI, Shoukath M. , SHEIKH, Saifuddin , AHMAD, Ateeq , AHMAD, Moghis U. , CHEN, Paul , AHMAD, Imran
IPC分类号： A61K9/20
摘要： The invention relates to stable preparations of thymoquinone and methods of making and administering stable preparations of thymoquinone. Embodiments of the methods provide compositions comprising thymoquinone with phosphatidylcholine and/or guggulsterol and/or guggulsterol derivatives and/or sodium cholesteryl sulfate, in tablet, capsule, gel, or ointment forms, and method of administering the preparations.

4. 发明申请

WO2012122493A1 LIPID BASED CLOPIDOGREL COMPOSITIONS, METHODS, AND USES 审中-公开
标题翻译：基于脂质的胶体组合物，方法和用途
公开(公告)号：WO2012122493A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028530
申请日：2012-03-09
申请人： JINA PHARMACEUTICALS, INC. , ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Moghis U. , AHMAD, Imran
发明人： ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Moghis U. , AHMAD, Imran
IPC分类号： A61K9/20 , A01N43/42 , A61K31/44
CPC分类号： A61K9/10 , A61K9/1075 , A61K31/44 , A61K47/24
摘要： The present invention relates to a methods of preparing clopidogrel complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising clopidogrel and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.
摘要翻译：本发明涉及使用不含有机溶剂的水性体系制备与脂质复合的氯吡格雷的方法，以及使用复合物例如治疗受试者疾病的方法。在一些实施方案中，本发明提供了包括制备包含含有氯吡格雷和至少一种脂质的脂质复合物并将组合物给予受试者的组合物的方法。在某些实施方案中，受试者是哺乳动物。在某些优选实施方案中，受试者是人。

5. 发明授权

EP2101731B1 ENDOXIFEN FOR USE IN THE TREATMENT OF CANCER 有权
标题翻译： ENDOXIFEN用于治疗癌症
公开(公告)号：EP2101731B1
公开(公告)日：2018-01-31
申请号：EP07871563.8
申请日：2007-11-21
申请人： Jina Pharmaceuticals Inc.
发明人： AHMAD, Ateeq , ALI, Shoukath M. , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/00 , A61K9/127 , A61K9/19 , A61K31/138 , A61K31/35 , C07D309/10 , A61P35/00
CPC分类号： A61K31/138 , A61K9/0014 , A61K9/127 , A61K9/19 , A61K31/35 , C07D309/10
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

6. 发明授权

EP2088865B1 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 有权
标题翻译： GUGGULPHOSPHOLIPID的方法和组合物
公开(公告)号：EP2088865B1
公开(公告)日：2015-10-21
申请号：EP07864003.4
申请日：2007-11-06
申请人： Jina Pharmaceuticals Inc.
发明人： AHMAD, Moghis U. , ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A01N65/00 , A61K36/328 , C07J7/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J51/00
CPC分类号： C07J13/007 , A61K31/337 , A61K47/554 , A61K47/6907 , A61K47/6911 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0088 , C07J51/00 , C12N15/85

7. 发明申请

WO2019055550A3 METHODS OF PREPARING COMPOSITIONS CONTAINING THYMOQUINONE 审中-公开
公开(公告)号：WO2019055550A3
公开(公告)日：2019-03-21
申请号：PCT/US2018/050728
申请日：2018-09-12
申请人： JINA PHARMACEUTICALS, INC.
发明人： ALI, Shoukath M. , SHEIKH, Saifuddin , AHMAD, Ateeq , AHMAD, Moghis U. , CHEN, Paul , AHMAD, Imran
IPC分类号： A61K31/122 , A61K31/05 , A61K47/38 , C07C49/543
摘要： The invention relates to stable preparations of thymoquinone and methods of making and administering stable preparations of thymoquinone. Embodiments of the methods provide compositions comprising thymoquinone with phosphatidylcholine and/or guggulsterol and/or guggulsterol derivatives and/or sodium cholesteryl sulfate, in tablet, capsule, gel, or ointment forms, and method of administering the preparations.

8. 发明授权

EP2344198B1 LIPID BASED PHARMACEUTICAL PREPARATIONS FOR TOPICAL APPLICATION 有权转让
公开(公告)号：EP2344198B1
公开(公告)日：2020-11-04
申请号：EP09816940.2
申请日：2009-09-25
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K47/44 , A61P17/14 , A61K31/58 , A61K31/506 , A61K8/49 , A61K8/14 , A61K8/63 , A61Q7/00 , A61K9/08 , A61K9/10 , A61K45/06 , A61K47/24 , A61K9/00

9. 发明公开

EP2088865A2 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 有权
标题翻译： GUGGULPHOSPHOLIPID的方法和组合物
公开(公告)号：EP2088865A2
公开(公告)日：2009-08-19
申请号：EP07864003.4
申请日：2007-11-06
申请人： Jina Pharmaceuticals Inc.
发明人： AHMAD, Moghis U. , ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A01N65/00 , A61K36/328
CPC分类号： C07J13/007 , A61K31/337 , A61K47/554 , A61K47/6907 , A61K47/6911 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0088 , C07J51/00 , C12N15/85
摘要： The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactiv molecules. The present invention relates to E-guggulsterone and Z- guggulsterone or mixture of E- and Z-guggulsterones. The present invention also provides a novel method for the preparation of E-guggulsterol and Z- guggulsterol or mixture of E-and Z-guggulsterols from a mixture of E- and Z- guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include othe active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.

10. 发明公开

EP2344198A2 LIPID BASED PHARMACEUTICAL PREPARATIONS FOR ORAL AND TOPICAL APPLICATION; THEIR COMPOSITIONS, METHODS, AND USES THEREOF 有权转让
标题翻译：药物制剂脂质基础口服和外用给药，组合物THEREOF AND METHOD FOR USE
公开(公告)号：EP2344198A2
公开(公告)日：2011-07-20
申请号：EP09816940.2
申请日：2009-09-25
申请人： Jina Pharmaceuticals Inc.
发明人： ALI, Shoukath M. , AHAMD, Ateeq , AHMAD, Moghis U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K47/44 , A61P17/14 , A61K31/58 , A61K31/506
摘要： The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases. The present invention provides a method of preparation of a composition comprising at least one active compound and at least one lipid and administering the composition to a subject by oral or topical delivery. In certain embodiments the subject is a mammal. In certain preferred embodiment, the subject is human.
摘要翻译：本发明涉及包含一种或多种活性剂用于在受试者中治疗疾病或症状的组合物的局部和口服递送。在一些实施方案中，本发明包括一种组合物，其包含至少一种活性化合物，E. G.，非那雄胺或米诺地尔，和一种或多种脂质。在一些实施方案中，本发明涉及制备组合物和方法，用于治疗雄激素性脱发（AGA），预防脱发和女性多毛症的。在一些实施方案中，本发明包括非那雄胺和良性前列腺增生症的治疗中的至少一种脂质组分。在一些实施方案中，本发明包括他克莫司或两性霉素B和用于皮肤或眼睛有关的疾病的治疗中的至少一种脂质组分。本发明提供了制备包含至少一种活性化合物和至少一种脂质和通过口服或局部递送施用组合物至受试者的组合物的方法。在某些实施方案中，受试者是哺乳动物。在某些优选的实施方案中，受试者是人。

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