专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0174902A3 ADENINE BINDING G PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译：腺嘌呤结合G蛋白偶联受体
公开(公告)号：WO0174902A3
公开(公告)日：2002-03-21
申请号：PCT/EP0103688
申请日：2001-04-02
申请人： JANSSEN PHARMACEUTICA NV , BENDER ECKHARD , BUIST ARJAN , ERCKEN MARTINE , BAGGERMAN GEERT LUC ELISABETH , JURZAK MIREK , SCHOOFS LILIANE AMELIE HENRICA , LUYTEN WALTER HERMAN MARIA LOU
发明人： BENDER ECKHARD , BUIST ARJAN , ERCKEN MARTINE , BAGGERMAN GEERT LUC ELISABETH , JURZAK MIREK , SCHOOFS LILIANE AMELIE HENRICA , LUYTEN WALTER HERMAN MARIA LOU
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P1/06 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/20 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , A61K31/52 , A61K31/711 , C12N15/12 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.
摘要翻译：本发明提供了编码具有腺嘌呤特异性，分离的腺嘌呤结合GPCR，测定法和利用其的治疗方法的G蛋白偶联受体（腺嘌呤结合GPCR）的核酸。

2. 发明申请

WO03005036A3 EPF RECEPTOR ASSAYS, COMPOUNDS AND THERAPEUTIC COMPOSITIONS 审中-公开
标题翻译： EPF受体测定，化合物和治疗组合物
公开(公告)号：WO03005036A3
公开(公告)日：2003-10-16
申请号：PCT/EP0207263
申请日：2002-06-26
申请人： JANSSEN PHARMACEUTICA NV , BUIST ARJAN , BENDER ECKHARD , MEEUSEN TOM JULIA LEON , CLYNEN ELKE JENNY HENRIETTE , SCHOOFS LILIANE AMELIE HENRICA
发明人： BUIST ARJAN , BENDER ECKHARD , MEEUSEN TOM JULIA LEON , CLYNEN ELKE JENNY HENRIETTE , SCHOOFS LILIANE AMELIE HENRICA
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/68
CPC分类号： G01N33/689 , C07K14/4715 , C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2800/368
摘要： The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.
摘要翻译：本发明提供了研究EPF与其EPF相关肽与hDRR受体的相互作用的测定。在EPF或相关肽可以与受体结合的条件下，测定法可用于鉴定测试化合物是否可以结合hDRR受体。测定也可用于确定测试化合物是否是hDRR的激动剂或拮抗剂。上述测定可以以各种形式进行，包括竞争性，非竞争性和比较测定法，其中EPF或EPF相关肽与hDRR的相互作用被评估为阳性或阴性对照或与用测试获得的结果进行比较复合。

3. 发明专利

CA2450502C EPF RECEPTOR ASSAYS, COMPOUNDS AND THERAPEUTIC COMPOSITIONS 未知
公开(公告)号：CA2450502C
公开(公告)日：2017-10-31
申请号：CA2450502
申请日：2002-06-26
申请人： JANSSEN PHARMACEUTICA NV
发明人： BUIST ARJAN , BENDER ECKHARD , MEEUSEN TOM JULIA LEON , CLYNEN ELKE JENNY HENRIETTE , SCHOOFS LILIANE AMELIE HENRICA
IPC分类号： C12N15/12 , G01N33/50 , A61K38/00 , A61K38/17 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K7/08 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/18 , C07K16/28 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/543 , G01N33/566 , G01N33/68
摘要： The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.

4. 发明专利

NO331506B1 未知
公开(公告)号：NO331506B1
公开(公告)日：2012-01-16
申请号：NO20024779
申请日：2002-10-03
申请人： JANSSEN PHARMACEUTICA NV
发明人： LUYTEN WALTER HERMAN MARIA LOUIS , BENDER ECKHARD , JURZAK MIREK , BUIST ARJAN , ERCKEN MARTINE , BAGGERMAN GEERT LUC ELISABETH , SCHOOFS LILIANE AMELIE HENRICA
IPC分类号： C07K14/705 , C12N15/09 , A61K38/00 , A61K48/00 , A61P1/06 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/11 , C12N15/12 , C12Q1/68
摘要： The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.

5. 发明专利

DE60226867D1 未知
公开(公告)号：DE60226867D1
公开(公告)日：2008-07-10
申请号：DE60226867
申请日：2002-06-26
申请人： JANSSEN PHARMACEUTICA NV
发明人： BUIST ARJAN , BENDER ECKHARD , MEEUSEN TOM JULIA , CLYNEN ELKE JENNY , SCHOOFS LILIANE AMELIE
IPC分类号： G01N33/50 , G01N33/68 , A61K38/00 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/566
摘要： The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.

6. 发明专利

DE60133455T2 未知
公开(公告)号：DE60133455T2
公开(公告)日：2009-04-30
申请号：DE60133455
申请日：2001-04-02
申请人： JANSSEN PHARMACEUTICA NV
发明人： BENDER ECKHARD , BUIST ARJAN , ERCKEN MARTINE , BAGGERMAN GEERT LUC ELISABETH , JURZAK MIREK , SCHOOFS LILIANE AMELIE , LUYTEN WALTER HERMAN
IPC分类号： C07K14/705 , C12N15/09 , A61K38/00 , A61K48/00 , A61P1/06 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68
摘要： The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.

7. 发明专利

AT397218T 未知
公开(公告)号：AT397218T
公开(公告)日：2008-06-15
申请号：AT02745422
申请日：2002-06-26
申请人： JANSSEN PHARMACEUTICA NV
发明人： BUIST ARJAN , BENDER ECKHARD , MEEUSEN TOM , CLYNEN ELKE , SCHOOFS LILIANE
IPC分类号： G01N33/50 , G01N33/68 , A61K38/00 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/566
摘要： The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.

8. 发明专利

AU2002317013B2 EPF receptor assays, compounds and therapeutic compositions 未知
公开(公告)号：AU2002317013B2
公开(公告)日：2007-11-01
申请号：AU2002317013
申请日：2002-06-26
申请人： JANSSEN PHARMACEUTICA NV
发明人： MEEUSEN TOM JULIA LEON , BENDER ECKHARD , CLYNEN ELKE JENNY HENRIETTE , BUIST ARJAN , SCHOOFS LILIANE AMELIE HENRICA
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/68
摘要： The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind to the hDRR receptor under conditions in which EPF or related peptide can bind to the receptor. The assays are also useful to determine whether the test compound is an agonist or antagonist of hDRRs. The above assays can be performed in a variety of formats including competitive, non-competitive and comparative assays in which the interaction of EPF or EPF-related peptides with hDRRs is assessed as a positive or negative control or compared to the results obtained with the test compound.

9. 发明专利

CA2569916A1 FUNCTIONAL SCREENING ASSAY 未知
公开(公告)号：CA2569916A1
公开(公告)日：2006-01-12
申请号：CA2569916
申请日：2005-06-22
申请人： JANSSEN PHARMACEUTICA NV
发明人： BUIST ARJAN
IPC分类号： C12N15/12 , C07K14/705 , C12N15/63 , C12N15/85 , G01N33/50 , G01N33/94
摘要： In a first aspect the present invention provides an inducible expression vector encoding a metabotropic glutamate receptor. In particular a tetracycline inducible expression vector such as for example the commercially available pcDNA4/TO mammalian expression vector (Invitrogen, Carlsbad, Calif. USA) comprising the nucleotide sequence encoding for a member of the Group I mGluRs, in particular for the human mGluR1a (SEQ ID No1) or mGluR5 receptor (SEQ ID No.3). In a more preferred embodiment the inducible expression vector is selected from the tetracycline inducible expression plasmids hmGlu1a-pcDNA4/TO (FIG. 4 ) and hmGlu5a-pcDNA4/TO (FIG. 5 ). In a second aspect, the present invention provides a cell line comprising any of the aforementioned inducible expression vectors. In particular the T-Rex-293 cells stably transfected with the tetracycline inducible expression plasmids hmGlu1a-pcDNA4/TO (FIG. 4 ) and hmGlu5a-pcDNA4/TO (FIG. 5 ) which where deposited at the Belgian Coordinated Collections of Microorganisms (BCCM) as T-Rex-293-hmGlu1a-pcDNA4/TO clone on Jun. 24, 2004. In a third aspect the present invention provides a method to identify compounds capability to modulate the activity of a metabotropic glutamate receptor said method comprising the steps of; contacting the aforementioned cell line with the compound to be tested, and determining the effect of said test compound on the metabotropic glutamate receptor activity. The effect on the metabotropic glutamate receptor activity is typically determined by assessing the change in intracellular calcium, in particular using a fluorescent dye such as for example fluo-3-AM. It is also an object of the present invention to provide a method to identify a compound capable to interact with a metabotrobic glutamate receptor, in particular with a Group I mGluR receptor, said method comprising the steps of contacting the cells according to the invention with the compounds to be tested under appropriate conditions and determining the binding of said test compounds to the cells.

10. 发明专利

NO341778B1 Assays for EPF-reseptorforbindelser samt terapeutiske sammensetninger 未知
公开(公告)号：NO341778B1
公开(公告)日：2018-01-15
申请号：NO20035771
申请日：2003-12-22
申请人： JANSSEN PHARMACEUTICA NV
发明人： BENDER ECKHARD , BUIST ARJAN , MEEUSEN TOM JULIA LEON , CLYNEN ELKE JENNY HENRIETTE , SHOOFS LILIANE AMELIE HENRICA
IPC分类号： C07K14/47 , G01N33/50 , A61K38/00 , A61K45/00 , A61P15/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/22 , C07K14/705 , C07K14/72 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/68
摘要： S a m m e n d r a g Det tilveiebringes assayer for å undersøke vekselvirkningen mellom EPF og EPF-beslektede peptider med en hDRR-receptor. Assayene er nyttige for å identifisere om en testforbindelse kan bindes til hDRR-receptor under betingelser hvor EPF eller beslektede peptider kan bindes til receptoren. Assayene er også nyttige for å bestemme om testforbindelsen er en agonist eller antagonist av hDRR'er. De ovennevnte assayer kan utføres i forskjellige formater, bl.a. kompetitive, ikke-kompetitive og sammenlignende assayer, hvor vekselvirkningen mellom EPF eller EPF-beslektede peptider og hDRR'er bedømmes som positiv- eller negativ-kontroll eller sammenlignes med resultatene som ble erholdt med testforbindelsen.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式