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1. 发明申请

WO2009126806A8 THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开
标题翻译：作为水杨酸A4水解酶的调节剂的噻唑吡啶-2-氧基苯基和噻唑啉-2-甲氧基苯胺
公开(公告)号：WO2009126806A8
公开(公告)日：2010-11-18
申请号：PCT/US2009040070
申请日：2009-04-09
申请人： JANSSEN PHARMACEUTICA NV , BACANI GENESIS M , BROGGINI DIEGO , CHEUNG EUGENE Y , CHROVIAN CHRISTA C , DENG XIAOHU , FOURIE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , LIANG JIMMY T , LOCHNER SUSANNE , MANI NEELAKANDHA S , SANTILLAN ALEJANDRO JR , SAPPEY KATHLEEN C , SEPASSI KIA , TANIS VIRGINIA M , WICKBOLDT ALVAH T , WIENER JOHN J M , ZINSER HARTMUT
发明人： BACANI GENESIS M , BROGGINI DIEGO , CHEUNG EUGENE Y , CHROVIAN CHRISTA C , DENG XIAOHU , FOURIE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , LIANG JIMMY T , LOCHNER SUSANNE , MANI NEELAKANDHA S , SANTILLAN ALEJANDRO JR , SAPPEY KATHLEEN C , SEPASSI KIA , TANIS VIRGINIA M , WICKBOLDT ALVAH T , WIENER JOHN J M , ZINSER HARTMUT
IPC分类号： C07D498/04 , A61K31/4985
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译：描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

2. 发明申请

WO2009126806A2 THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开
标题翻译：作为水杨酸A4水解酶的调节剂的噻唑吡啶-2-氧基苯基和噻唑啉-2-甲氧基苯胺
公开(公告)号：WO2009126806A2
公开(公告)日：2009-10-15
申请号：PCT/US2009040070
申请日：2009-04-09
申请人： JANSSEN PHARMACEUTICA NV , BACANI GENESIS M , BROGGINI DIEGO , CHEUNG EUGENE Y , CHROVIAN CHRISTA C , DENG XIAOHU , FOURINE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , LIANG JIMMY T , LOCHNER SUSANNE , MANI NEELAKANDHA S , SANTILLAN ALEJANDRO , SAPPEY KATHLEEN C , SEPASSI KIA , TANIS VIRGINIA M , WICKBOLDT ALVAH T , WIENER JOHN J M , ZINSER HARTMUT
发明人： BACANI GENESIS M , BROGGINI DIEGO , CHEUNG EUGENE Y , CHROVIAN CHRISTA C , DENG XIAOHU , FOURINE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , LIANG JIMMY T , LOCHNER SUSANNE , MANI NEELAKANDHA S , SANTILLAN ALEJANDRO , SAPPEY KATHLEEN C , SEPASSI KIA , TANIS VIRGINIA M , WICKBOLDT ALVAH T , WIENER JOHN J M , ZINSER HARTMUT
IPC分类号： A61K31/437 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61P29/00 , C07D453/02 , C07D513/04 , C12N9/50
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译：描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

3. 发明申请

WO2008008359A2 BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 审中-公开
标题翻译：组胺H4受体的苯并呋喃和苯并噻吩并嘧啶调节剂
公开(公告)号：WO2008008359A2
公开(公告)日：2008-01-17
申请号：PCT/US2007015763
申请日：2007-07-10
申请人： JANSSEN PHARMACEUTICA NV , CHAVEZ FRANK , CURTIS MICHAEL P , EDWARDS JAMES P , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , SAVALL BRAD M , FITZGERALD ANNE E , LIU JING , MANI NEELAKANDHA S
发明人： CHAVEZ FRANK , CURTIS MICHAEL P , EDWARDS JAMES P , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , SAVALL BRAD M , FITZGERALD ANNE E , LIU JING , MANI NEELAKANDHA S
IPC分类号： A61K31/4985 , A61K31/519 , A61P1/00 , A61P5/00 , A61P9/00 , A61P17/00 , A61P27/00 , A61P37/00 , C07D239/70 , C07D403/14
CPC分类号： C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00
摘要： Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译：描述了苯并呋喃和苯并噻吩并嘧啶化合物，其可用作H 4受体调节剂。这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。

4. 发明公开

EP2217237A4 ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开
标题翻译：芳基取代的或稠桥接二胺作为白三烯A4水解酶的调节剂
公开(公告)号：EP2217237A4
公开(公告)日：2011-08-17
申请号：EP08845395
申请日：2008-10-31
申请人： JANSSEN PHARMACEUTICA NV
发明人： BACANI GENESIS M , BEMBENEK SCOTT D , ECCLES WENDY , EDWARDS JAMES P , EPPERSON MATTHEW T , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , MCCLURE KELLY J , MIRZADEGAN TARANEH , SANTILLAN ALEJANDRO JR
IPC分类号： A61K31/495 , A61K31/445 , A61K31/496 , A61K31/551
CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04

5. 发明公开

EP2040549A4 BENZOFURO-AND BENZOTHIENOPYRYIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 无效
标题翻译：苯并呋喃和BENZOTHIENOPYRYIMIDIN调制器组胺H4受体的
公开(公告)号：EP2040549A4
公开(公告)日：2010-09-08
申请号：EP07796782
申请日：2007-07-10
申请人： JANSSEN PHARMACEUTICA NV
发明人： CHAVEZ FRANK , CURTIS MICHAEL P , EDWARDS JAMES P , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , SAVALL BRAD M , FITZGERALD ANNE E , LIU JING , MANI NEELAKANDHA S
IPC分类号： A01N43/54 , A61K31/519 , A61P29/00 , C07D239/42 , C07D471/04
CPC分类号： C07D491/048 , C07D491/147 , C07D495/04 , C07D519/00

6. 发明专利

CA2704320C ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 未知
公开(公告)号：CA2704320C
公开(公告)日：2017-01-03
申请号：CA2704320
申请日：2008-10-31
申请人： JANSSEN PHARMACEUTICA NV
发明人： BACANI GENESIS M , BEMBENEK SCOTT D , ECCLES WENDY , EDWARDS JAMES P , EPPERSON MATTHEW T , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE M , LEE-DUTRA ALICE , MCCLURE KELLY J , MIRZADEGAN TARANEH , SANTILLAN ALEJANDRO JR
IPC分类号： C07D487/08 , A61K31/439 , A61K31/4995 , C07D451/02
摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

8. 发明专利

EA015344B1 БЕНЗОФУРО- И БЕНЗОТИЕНОПИРИМИДИНОВЫЕ МОДУЛЯТОРЫ ГИСТАМИНОВОГО РЕЦЕПТОРА Н 未知
公开(公告)号：EA015344B1
公开(公告)日：2011-06-30
申请号：EA200970113
申请日：2007-07-10
申请人： JANSSEN PHARMACEUTICA NV
发明人： CHAVEZ FRANK , CURTIS MICHAEL P , EDWARDS JAMES P , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , SAVALL BRAD M , FITZGERALD ANNE E , LIU JING , MANI NEELAKANDHA S
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
摘要： Визобретенииописаныбензофуро- ибензотиенопиримидиновыесоединенияформулы (I), которыеприменимыв качествемодулятороврецептора Hгде Rи RнезависимопредставляютсобойН, Cl, F, Br, метил, этил, метокси, NOили CF; RпредставляетсобойН, метокси, Cl, F, Br или CF; фрагментА представляетсобой N или CR, где RпредставляетсобойН или Cl; приусловии, чтопоменьшеймередвазаместителяизчисла R, R, Rи RпредставляютсобойН; X представляетсобойО или S; -N(R)Rявляетсяоднимизследующихфрагментов:где q представляетсобой 0 или 1; R, Rи RнезависимопредставляютсобойН или C-алкили Rпредставляетсобойметилилидвазаместителя Rсовместнообразуютметиленовыйилиэтиленовыймостик; RпредставляетсобойН илиметил; RпредставляетсобойН; C-алкил, незамещенныйилизамещенныйгруппами -ОН, -SCHили -NH; аллилилициклопропил; атакжефармацевтическиихприемлемыесоли. Описанныесоединениямогутприменятьсяв фармацевтическихкомпозицияхи способахлечениязаболеваний, расстройстви болезненныхсостояний, опосредованныхактивностьюрецептораН, напримераллергии, астмы, аутоиммунныхзаболеванийи зуда.

9. 发明专利

CO6260069A2 TIAZOLOPIRIDIN-2-ILOXI-FENIL Y TIAZOLOPIRAZIN-2-ILOXI-FENIL AMINAS COMO MODULADORES DE LA LEUCOTRIENO A4 HIDROLASA 未知
公开(公告)号：CO6260069A2
公开(公告)日：2011-03-22
申请号：CO10131314
申请日：2010-10-22
申请人： JANSSEN PHARMACEUTICA NV
发明人： BACANI GENESIS , BROGGINI DIEGO , CHEUNG EUGENE , CHROVIAN CHRISTA , DENG XIAOHU , FOURIE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE , LEE-DUTRA ALICE , LIANG JIMMY T , LOCHNER SUSANNE , MANI NEELAKANDHA , SANTILLAN ALEJANDRO , SAPPEY KATHLEEN , SEPASSI KIA , TANIS VIRGINIA , WICKBOLDT ALVAH , WIENER JOHN , ZINSER HARTMUT
IPC分类号： A61K31/437
摘要： Se describen compuestos de tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil amina útiles como moduladores de la LTA4 hidrolasa (LTA4H). Esos compuestos se pueden usar en composiciones farmacéuticas y métodos para la modulación de LTA4H y para el tratamiento de estados de enfermedad, trastornos, y afecciones mediados por la actividad de la LTA4 hidrolasa. 1.- Una entidad química seleccionada de los compuestos de la Fórmula (I), sales farmacéuticamente aceptables de los compuestos de la Fórmula (I), profármacos farmacéuticamente aceptables de los compuestos de la Fórmula (I), y solvatos de los compuestos de la Fórmula (I)en donde X4, X5, X6 y X7 se definen como uno de los siguientes a) y b): a) un X4, X5, X6 y X7 es N y los otros son CRa; en donde cada Ra es independientemente H, metilo, cloro, fluoro, o trifluorometilo; b) cada X4 y X7 es N y cada X5 y X6 es CH; cada R1 y R2 es independientemente H, -(CH2)2-3OCH3, -CH2C(O)NH2, -(CH2)3NH2, -(CH2)1-2CO2H, -CH2CO2CH2CH3, bencilo, 3-(2-oxo-pirrolidin-1-il)-propilo, 1-acetil-azetidina-3ilmetilo, cicloalquilo monocíclico, 1-metilo-4-piperidinilo, o alquilo de -C1-4 no sustituido o sustituido con fenilo, cicloalquilo monocíclico, OH, o NRbRc; en donde Rb y Rc son, independientemente, H, -C(O)CH3, o alquilo de C1-4, o y Rb y Rc tomados junto con el nitrógeno al cual están unidos a partir de un anillo heterocicloalquilo monocíclico saturado; o R1 o y R2 tomados junto con el nitrógeno al cual están unidos forman i) un anillo heterocicloalquilo monocíclico saturado, opcionalmente, fusionado a un anillo fenilo y no sustituido o sustituido con uno o dos sustituyentes Rd; en donde cada sustituyente Rd es independientemente un alquilo de C1-4 no sustituido o sustituido con -OH; -OH; ...

10. 发明专利

CA2761881A1 COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 未知
公开(公告)号：CA2761881A1
公开(公告)日：2010-11-18
申请号：CA2761881
申请日：2010-05-12
申请人： JANSSEN PHARMACEUTICA NV
发明人： BACANI GENESIS M , CHROVIAN CHRISTA C , ECCLES WENDY , FOURIE ANNE M , GOMEZ LAURENT , GRICE CHERYL A , KEARNEY AARON M , LANDRY-BAYLE ADRIENNE , LEE-DUTRA ALICE , SANTILLAN ALEJANDRO , TANIS VIRGINIA M , WIENER JOHN J M
IPC分类号： C07D413/12 , A61K31/423 , A61K31/424 , A61K31/428 , A61K31/429 , A61P29/00 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties of formula I and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.

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