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1. 发明专利

CA2612672C TREATMENT FOR SEXUAL DYSFUNCTION 未知
公开(公告)号：CA2612672C
公开(公告)日：2014-10-14
申请号：CA2612672
申请日：2006-06-13
申请人： JANSSEN PHARMACEUTICA NV
发明人： PALUMBO JOSEPH , SPORN JOHATHAN , STECKLER THOMAS , CHOI YONG , LEE JAMES S
IPC分类号： A61K31/27 , A61P15/00 , A61P15/10
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

2. 发明专利

CA2612672A1 TREATMENT OF SEXUAL DYSFUNCTION 未知
公开(公告)号：CA2612672A1
公开(公告)日：2007-01-04
申请号：CA2612672
申请日：2006-06-13
申请人： JANSSEN PHARMACEUTICA NV
发明人： CHOI YONG , PALUMBO JOSEPH , LEE JAMES S , STECKLER THOMAS , SPORN JOHATHAN
IPC分类号： A61P15/10 , A61K31/165
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt o r ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, B r and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethy l, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, wi th the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from t he group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

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