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1. 发明专利

DK1485354T3 未知
公开(公告)号：DK1485354T3
公开(公告)日：2008-09-01
申请号：DK03743874
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： VAN EMELEN KRISTOF , BACKX LEO JACOBUS JOZEF , VAN BRANDT SVEN FRANCISCUS ANN , VERDONCK MARC GUSTAAF CELINE J , DE WINTER HANS LOUIS JOS , ANGIBAUD PATRICK RENE , PILATTE ISABELLE NOELLE C , VAN HEUSDEN JIMMY ARNORLD VIVI
IPC分类号： C07D211/58 , C07D239/42 , A61K31/40 , A61K31/4025 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D241/04 , C07D249/12 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

2. 发明专利

AT521592T 未知
公开(公告)号：AT521592T
公开(公告)日：2011-09-15
申请号：AT03711980
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： ANGIBAUD PATRICK RENE , PILATTE ISABELLE NOELLE C , VAN BRANDT SVEN FRANCISCUS ANNA , ROUX BRUNO , TEN HOLTE PETER , VERDONCK MARC , MEERPOEL LIEVEN , DYATKIN ALEXEY B
IPC分类号： C07D211/58 , C07D249/12 , A61K31/40 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D239/42 , C07D241/04 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/34 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

3. 发明专利

ES2371632T3 NUEVOS INHIBIDORES DE DESACETILASA DE HISTONA. 未知
公开(公告)号：ES2371632T3
公开(公告)日：2012-01-05
申请号：ES03711980
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： ANGIBAUD PATRICK RENE , PILATTE ISABELLE NOELLE C , VAN BRANDT SVEN FRANCISCUS ANNA , ROUX BRUNO , TEN HOLTE PETER , VERDONCK MARC , MEERPOEL LIEVEN , DYATKIN ALEXEY B
IPC分类号： C07D211/58 , C07D249/12 , A61K31/40 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D239/42 , C07D241/04 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/34 , C12Q1/48
摘要： Un compuesto de fórmula (I), las formas de N-óxido, las sales de adición farmacéuticamente aceptables 5 y las formas estereoquímicamente isoméricas del mismo, en el que : n es 0, 1, 2 ó 3, y cuando n es 0, entonces se busca un enlace directo; t es 0, 1, 2, 3 ó 4, y cuando t es 0, entonces se busca un enlace directo; R1 es -C(O)NH(OH); R2 es hidrógeno, halo, hidroxi, amino, nitro, C1-6 alquil, C1-6 alquiloxi, trifluorometil, di(C1-6 alquil) amino, hidroxiamino o naftalenilsulfonilpirazinil; -L- es un enlace directo; cada R3 representa independientemente un átomo de hidrógeno, y un átomo de hidrógeno puede ser sustituido por un sustituyente elegido a partir de aril; R4 es hidrógeno, hidroxi, amino, hidroxi C1-6 alquil, C1-6 alquil, C1-6 alquiloxi, aril C1-6 alquil, aminocarbonil, hidroxicarbonil, amino C1-6 alquil, aminocarbonil C1-6 alquil, hidroxicarbonil C1-6 alquil, hidroxiaminocarbonil, C1-6 alquiloxicarbonil, C1-6 alquilamino C1-6 alquil o di(C1-6 alquil) amino C1-6 alquil; en la que cada s es independientemente 0, 1, 2, 3, 4 ó 5; cada R5 y R6 se eligen independientemente a partir de hidrógeno; halo; hidroxi; amino; nitro; trihalo C1-6 alquil; trihalo C1-6 alcoxi; C1-6 alquil; C1-6 alquil sustituido con aril y C3-10 cicloalquil; C1-6 alquiloxi; C1-6 alquiloxi C1-6 alquiloxi; 5 C1-6 alquilcarbonil; C1-6 alquiloxicarbonil; C1-6 alquilsulfonil; ciano C1-6 alquil; hidroxi C1-6 alquil; hidroxi C1-6 alquiloxi; hidroxi C1-6 alquilamino; amino C1-6 alquiloxi; di(C1-6 alquil) aminocarbonil; di(hidroxi C1-6 alquil) amino; (aril) (C1-6 alquil) amino; di(C1-6 alquil) amino C1-6 alquiloxi; di(C1-6 alquil) amino C1-6 alquilamino; di(C1-6 alquil) amino C1-6 alquilamino C1-6 alquil; arilsulfonil; arilsulfonilamino; ariloxi; ariloxi C1-6 alquil; aril C2-6 alquenodiil; di(C1-6 alquil) amino; di(C1-6 alquil) amino C1-6 alquil; di(C1-6 alquil) amino (C1-6 alquil) amino; di(C1-6 alquil) amino (C1-6 alquil) amino C1-6 alquil; di(C1-6 alquil) amino C1-6 5 alquil (C1-6 alquil) amino; di(C1-6 alquil) amino C1-6 alquil (C1-6 alquil) amino C1-6 alquil; aminosulfonilamino (C1-6 alquil) amino; aminosulfonilamino (C1-6 alquil) amino C1-6 alquil; di(C1-6 alquil) aminosulfonilamino (C1-6 alquil) amino; di(C1-6 alquil) aminosulfonilamino (C1-6 alquil) amino C1-6 alquil; ciano; tiofenil; tiofenil sustituido con di(C1-6 alquil) amino C1-6) alquil (C1-6 alquil) amino C1-6 alquil, di(C1-6 alquil) amino C1-6 alquil, C1-6 alquilpiperazinil C1-6 alquil, hidroxi C1-6 alquilpiperazinil C1-6 alquil, hidroxi C1-6 alquilpiperazinil C1-6 alquil, di(C1-6 alquil) aminosulfonilpiperazinil C1-6 alquil, C1-6 alquiloxipiperidinil, C1-6 alquiloxipiperidinil C1-6 alquil, morfolinil C1-6 alquil, hidroxi C1-6 alquil (C1-6 alquil) amino C1-6 alquil; o di(hidroxi C1-6 alquil) amino C1-6 alquil; furanil; furanil sustituido con hidroxi C1-6 alquil; benzofuranil; imidazolil; oxazolil; oxazolil sustituido con aril y C1-6 alquil; C1-6 alquiltriazolil; tetrazolil; pirrolidinil; pirrolil; piperidinil C1-6 alquiloxi; morfolinil; C1-6 alquilmorfilinil; morfolinil C1,6 alquiloxi; morfolinil C1,6 alquil; morfolinil C1-6 alquilamino; morfolinil C1,6 alquilamino C1-6 alquil; piperazinil; C1-6 alquilpiperazinil; C1-6 alquilpiperazinil C1-6 alquiloxi; piperazinil C1-6 alquil; naftalenilsulfonilpiperazinil; naftalenilsulfonilpiperidinil; naftalenilsulfonil; C1-6 alquilpiperazinil C1-6 alquil; C1-6 alquilpiperazinil C1-6 alquilamino; C1-6 alquilpiperazinil C1-6 alquilamino C1-6 alquil; C1-6 alquilpiperazinilsulfonil; aminosulfonilpiperazinil C1-6 alquiloxi; aminosulfonilpiperazinil; aminosulfonilpiperazinil C1-6 alquil; di(C1-6 alquil) aminosulfonilpiperazinil; di(C1-6 alquil) aminosulfonilpiperazinil C1-6 alquil; hidroxi C1-6 alquilpiperazinil; hidroxi C1-6 alquilpiperazinil C1-6 alquil; C1-6 alquiloxipiperidinil; C1-6 alquiloxipiperidinil C1-6 alquil; piperidinilamino C1-6 alquilamino; piperidinilamino C1-6 alquilamino C1-6 alquil; (C1-6 alquilpiperidinil) (hidroxi C1-6 alquil) amino C1-6 alquilamino; (C1-6 alquilpiperidinil) (hidroxi C1-6 alquil) amino C1-6 alquilamino C1-6 alquil; hidroxi C1-6 alquiloxi C1-6 alquilpiperazinil; hidroxi C1-6 alquiloxi C1-6 alquilpiperazinil C1-6 alquil; (hidroxi C1-6 alquil) (C1-6 alquil) amino; (hidroxi C1-6 alquil) (C1-6 alquil) amino C1-6 alquil; hidroxi C1-6 alquilamino C1-6 alquil; di(hidroxi C1-6 alquil) amino C1-6 alquil; pirrolidinil C1-6 alquil; pirrolidinil C1-6 alquiloxi; pirazolil; tiopirazolil; pirazolil sustituido con dos sustituyentes elegidos a partir de C1-6 alquil o trihalo C1-6 alquil; piridinil; piridinil sustituido con C1-6 alquiloxi, ariloxi o aril; pirimidinil; tetrahidropirimidinilpiperazinil; tetrahidropirimidinilpiperazinil C1-6 alquil; quinolinil; indol; fenil; fenil sustituido con uno, dos o tres sustituyentes elegidos independientemente a partir de halo, amino, nitro, C1-6 alquil, C1-6 alquiloxi, hidroxi C1-4 alquil, trifluorometil, trifluorometiloxi, hidroxi C1-4 alquiloxi, C1-4 alquilsulfonil, C1-4 alquiloxi, C1-4 alquiloxicarbonil, amino C1-4 alquiloxi, di(C1-4 alquil) amino C1-4 alquiloxi, di(C1-4 alquil) amino, di(C1-4 alquil) aminocarbonil, di(C1-4 alquil) amino C1-4 alquil, di(C1-4 alquil) amino C1-4 alquilamino C1-4 alquil, di(C1-4 alquil) amino (C1-4 alquil) amino C1-4 alquil, di(C1-4 alquil) amino C1-4 alquil amino C1-4 alquil, di(C1-4 alquil) amino (C1-4 alquil) amino, di(C1-4 alquil) amino (C1-4 alquil) amino C1-4 alquil, di(C1-4 alquil) amino C1-4 alquil (C1-4 alquil) amino, di(C1-4 alquil) amino C1-4 alquil (C1-4 alquil) amino C1-4 alquil, aminosulfonilamino (C1-4 alquil) amino, aminosulfonilamino (C1-4 alquil) amino C1-4 alquil, di(C1-4 alquil) aminosulfonilamino (C1-4 alquil) amino, di(C1-4 alquil) aminosulfonilamino (C1-4 alquil) amino C1-6 alquil, ciano, piperidinil C1-4 alquiloxi, pirrolidinil C1-4 alquiloxi, aminosulfonilpiperazinil, aminosulfonilpiperazinil C1-4 alquil, di(C1-4 alquil) aminosulfonilpiperazinil, di(C1-4 alquil) sulfonilpiperazinil C1-4 alquil, hidroxi C1-4 alquilpiperazinil, hidroxi C1-4 alquilpiperazinil C1-4 alquiloxipiperidinil, C1-4 alquiloxipiperidinil C1-4 alquil, hidroxi C1-4 alquiloxi C1-4 alquilpiperazinil, hidroxi C1-4 alquiloxi C1-4 alquilpiperazinil C1-4 alquil, (hidroxi C1-4 alquil) (C1-4 alquil) amino, (hidroxi C1-4 alquil) (C1-4 alquil) amino C1-4 alquil, di(hidroxi C1-4 alquil) amino, di(hidroxi C1-4 alquil) amino C1-4 alquil, furanil, furanil sustituido con -CH=CH-CH=CH-, pirrolidinil C1-4 alquil, pirrolidinil C1-4 alquiloxi, morfolinil, morfolinil C1-4 alquiloxi, morfolinil C1-4 alquil, morfolinil C1-4 alquilamino, morfolinil C1-4 alquilamino C1-4 alquil, piperazinil, C1-4 alquilpiperazinil, C1-4 alquilpiperazinil C1-4 alquiloxi, piperazinil C1-4 alquil, C1-4 alquilpiperazinil C1-4 alquil, C1-4 alquilpiperazinil C1-4 alquilamino, C1-4 alquilpiperazinil C1-4 alquilamino C1-6 alquil, tetrahidropirimidinilpiperazinil, tetrahidropirimidinilpiperazinil C1-4 alquil, piperidinilamino C1-4 alquilamino, piperidinilamino C1-4 alquilamino C1-4 alquil, (C1-4 alquilpiperidinil) (Hidroxi C1-4 alquil) amino C1-4 alquilamino, (C1-4 alquilpiperidinil) (hidroxi C1-4 alquil) amino C1-4 alquilamino C1-4 alquil, piridinil C1-4 alquiloxi, hidroxi C1-4 alquilamino, hidroxi C1-4 alquilamino C1-4 alquil, di(C1-4 alquil) amino C1-4 alquilamino, aminotiadiazolil, aminosulfonilpiperazinil C1-4 alquiloxi, o tiofenil C1-4 alquilamino; pudiendo ser cada R5 y R6 colocado sobre el nitrógeno en sustitución del hidrógeno; aril es, en lo que antecede, fenil o fenil sustituido con uno o más sustituyentes elegidos independientemente cada uno de ellos a partir de halo, C1-6 alquil, C1-6 alquiloxi, trifluorometil, ciano o hidroxicarbonil.

4. 发明专利

DE60321324D1 未知
公开(公告)号：DE60321324D1
公开(公告)日：2008-07-10
申请号：DE60321324
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： VAN EMELEN KRISTOF JANSSEN PHA , BACKX LEO JACOBUS JOZEF JANSSE , VAN BRANDT SVEN FRANCISCUS ANN , ANGIBAUD PATRICK RENE , PILATTE ISABELLE NOELLE C , VERDONCK MARC GUSTAAF , DE WINTER HANS LOUIS , VAN HEUSDEN JIMMY ARNORLD VIVI
IPC分类号： C07D211/58 , C07D239/42 , A61K31/40 , A61K31/4025 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D241/04 , C07D249/12 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

6. 发明专利

ES2306880T3 DERIVADOS DE SULFONILAMINO COMO INHIBIDORES NOVEDOSOS DE LA HISTONA DESACETILASA. 未知
公开(公告)号：ES2306880T3
公开(公告)日：2008-11-16
申请号：ES03743874
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： VAN EMELEN KRISTOF , BACKX LEO JACOBUS JOZEF , VAN BRANDT SVEN FRANCISCUS ANNA , ANGIBAUD PATRICK RENE , PILATTE ISABELLE NOELLE C , VERDONCK MARC GUSTAAF CELINE J
IPC分类号： C07D211/58 , C07D239/42 , A61K31/40 , A61K31/4025 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D241/04 , C07D249/12 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/48
摘要： Un compuesto de fórmula (I), (Ver fórmula) las formas de N-óxido, las sales de adición farmacéuticamente aceptables y las formas estereoquímicamente isoméricas del mismo, en donde: n es 0, 1, 2 ó 3 y cuando n es 0 entonces se prevé un enlace directo; t es 0, 1, 2, 3 ó 4 y cuando t es 0 entonces se prevé un enlace directo; cada Q es nitrógeno o (Ver fórmula) cada X es nitrógeno o (Ver fórmula) cada Y es nitrógeno o (Ver fórmula) cada Z es nitrógeno o (Ver fórmula) R 1 es -C(O)NR 8 R 9 , -N(H)C(O)R 10 , -C(O)-alcanodiilo C1 - 6-SR 10 , -NR 11 C(O)N(OH)R 10 , -NR 11 C(O)-alcanodiilo C1 - 6-SR 10 o -NR 11 C(O)C=N(OH)R 10 en los que R 8 y R 9 se seleccionan cada uno independientemente de hidrógeno, hidroxilo, alquilo C1 - 6, hidroxialquilo C1 - 6, amino-alquilo C1 - 6 o aminoarilo; R 10 se selecciona independientemente de hidrógeno, alquilo C1 - 6, alquilcarbonilo C1 - 6, arilalquilo C1 - 6, alquilpirazinilo C1 - 6, piridinona, pirrolidinona o metilimidazolilo; R 11 se selecciona independientemente de hidrógeno o alquilo C1 - 6; R 2 es...

7. 发明专利

AT396971T 未知
公开(公告)号：AT396971T
公开(公告)日：2008-06-15
申请号：AT03743874
申请日：2003-03-11
申请人： JANSSEN PHARMACEUTICA NV
发明人： VAN EMELEN KRISTOF , BACKX LEO JACOBUS JOZEF , VAN BRANDT SVEN FRANCISCUS ANN , ANGIBAUD PATRICK , PILATTE ISABELLE NOELLE C , VERDONCK MARC , DE WINTER HANS , VAN HEUSDEN JIMMY ARNORLD VIVI
IPC分类号： C07D211/58 , C07D239/42 , A61K31/40 , A61K31/4025 , A61K31/438 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/09 , C07D207/14 , C07D211/26 , C07D213/74 , C07D213/78 , C07D217/02 , C07D217/04 , C07D241/04 , C07D249/12 , C07D295/14 , C07D295/155 , C07D295/20 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D471/10 , C12Q1/48
摘要： This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

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