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2. 发明专利

HRP20000620B1 HIV INHIBITING PYRIMIDINE DERIVATIVES 未知
公开(公告)号：HRP20000620B1
公开(公告)日：2009-07-31
申请号：HRP20000620
申请日：2000-09-19
申请人： JANSSEN PHARMACEUTICA NV
发明人： ANDRIES KOENRAAD JOZEF LODEWIJK , CORTE BART DE , JONGE MARC RENE DE , HEERES JAN , HO CHIH YUNG , JANSSEN MARCEL AUGUST CONSTANT , JANSSEN PAUL ADRIAAN JAN , KOYMANS LUCIEN MARIA HENRICUS , KUKLA MICHAEL JOSEPH , LUDOVICI DONALD WILLIAM , AKEN KOEN JEANNE ALFONS VAN
IPC分类号： C07D239/50 , A61K31/00 , A61K31/505 , A61K31/506 , A61P31/12 , A61P31/18 , A61P37/00 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/12 , C07D409/12
摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR or N; n is 0 to 4; Q is hydrogen or -NR R ; R and R are selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)-amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each C1-12alkyl may optionally be substituted; or R and R taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl, C1-6alkyloxy-carbonyl,; and R is hydroxy, halo, optionally substituted C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R is hydrogen or C1-4alkyl; L is optionally substituted C1-10alkyl, C3-10alkenyl, C3-10alkynyl, C3-7cycloalkyl; or L is -X -R or -X -Alk-R wherein R and R are optionally substituted phenyl; X and X are -NR -, -NH-NH-, -N=N-, -O-, -S-, -S(=O)- or -S(=O)2-; Alk is C1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

3. 发明专利

AU2002329238C1 HIV inhibiting pyrimidines derivatives 未知
公开(公告)号：AU2002329238C1
公开(公告)日：2008-08-28
申请号：AU2002329238
申请日：2002-08-09
申请人： JANSSEN PHARMACEUTICA NV
发明人： GUILLEMONT JEROME EMILE GEORGE , LEWI PAULUS JOANNES , JONGE MARC RENE DE , HEERES JAN , PALANDJIAN PATRICE , KOYMANS LUCIEN MARIA HENRICUS , DAEYAERT FREDERIK FRANS DESIRE , VINKERS HENDRIK MAARTEN , JANSSEN PAUL ADRIAAN JAN , AKEN KOEN JEANNE ALFONS VAN
IPC分类号： C07D403/12 , A61K20060101 , A61K31/505 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/551 , A61K45/00 , A61P31/18 , C07C20060101 , C07C211/00 , C07C255/42 , C07C257/12 , C07D20060101 , C07D233/96 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a 1 =a 2 -a 3 =a 4 - and -b 1 =b 2 -b 3 =b 4 - represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl;n is 0 to 5; m is 1 to 4; R 1 is hydrogen; aryl; formyl; C 1-6 alkylcarbonyl; C 1-6 alkyl; C 1-6 alkyloxycarbonyl; substituted C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyloxy; substituted C l - 6 alkyloxyC l - 6 alkylcarbonyl; R 2 is hydroxy, halo, optionally substituted C 1-6 alkyl, C 3-7 cycloalkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C 1-6 alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O) p R 6 , -NH-S(=O) p R 6 , -C(=O)R 6 , -NHC(=O)H, -C(=O)NHNH 2 , -NHC(=O)R 6 , -C(=NH)R 6 or a 5-membered heterocycle; X 1 is -NR 5 -, -NH-NH-, -N=N-, -O-, -C(=O)-, C 1-4 alkanediyl, -CHOH-, -S-, -S(=O) p -, -X 2 -C 1-4 alkanediyl- or -C 1-4 alkanediyl-X 2 -; R 3 is NHR 13 ; NR 13 R 14 ; -C(=O)-NER 13 ; -C(=O)-NR 13 R 14 ; -C(=O)-R 15 ; -CH=N-NH-C(=O)-R 16 ; substituted C 1-6 alkyl; optionally substituted C 1-6 alkyloxyC 1-6 alkyl; substituted C 2-6 alkenyl; substituted C 2-6 alkynyl; C 1-6 alkyl substituted with hydroxy and a second substituent; -C(=N-O-R 8 )-C 1-4 alkyl; R 7 ; or -X 3 -R 7 ; R 4 is halo, hydroxy, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, cyano, nitro, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkyloxy, aminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyl, formyl, amino, mono- or di(C 1-4 alkyl)amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

4. 发明专利

AU2002329238B2 HIV inhibiting pyrimidines derivatives 未知
公开(公告)号：AU2002329238B2
公开(公告)日：2008-01-24
申请号：AU2002329238
申请日：2002-08-09
申请人： JANSSEN PHARMACEUTICA NV
发明人： GUILLEMONT JEROME EMILE GEORGE , LEWI PAULUS JOANNES , JONGE MARC RENE DE , HEERES JAN , PALANDJIAN PATRICE , KOYMANS LUCIEN MARIA HENRICUS , DAEYAERT FREDERIK FRANS DESIRE , VINKERS HENDRIK MAARTEN , JANSSEN PAUL ADRIAAN JAN , AKEN LOEN JEANNE ALFONS VAN
IPC分类号： C07D403/12 , A61K20060101 , A61K31/505 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/551 , A61K45/00 , A61P31/18 , C07C20060101 , C07C211/00 , C07C255/42 , C07C257/12 , C07D20060101 , C07D233/96 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a 1 =a 2 -a 3 =a 4 - and -b 1 =b 2 -b 3 =b 4 - represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl;n is 0 to 5; m is 1 to 4; R 1 is hydrogen; aryl; formyl; C 1-6 alkylcarbonyl; C 1-6 alkyl; C 1-6 alkyloxycarbonyl; substituted C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyloxy; substituted C l - 6 alkyloxyC l - 6 alkylcarbonyl; R 2 is hydroxy, halo, optionally substituted C 1-6 alkyl, C 3-7 cycloalkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C 1-6 alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O) p R 6 , -NH-S(=O) p R 6 , -C(=O)R 6 , -NHC(=O)H, -C(=O)NHNH 2 , -NHC(=O)R 6 , -C(=NH)R 6 or a 5-membered heterocycle; X 1 is -NR 5 -, -NH-NH-, -N=N-, -O-, -C(=O)-, C 1-4 alkanediyl, -CHOH-, -S-, -S(=O) p -, -X 2 -C 1-4 alkanediyl- or -C 1-4 alkanediyl-X 2 -; R 3 is NHR 13 ; NR 13 R 14 ; -C(=O)-NER 13 ; -C(=O)-NR 13 R 14 ; -C(=O)-R 15 ; -CH=N-NH-C(=O)-R 16 ; substituted C 1-6 alkyl; optionally substituted C 1-6 alkyloxyC 1-6 alkyl; substituted C 2-6 alkenyl; substituted C 2-6 alkynyl; C 1-6 alkyl substituted with hydroxy and a second substituent; -C(=N-O-R 8 )-C 1-4 alkyl; R 7 ; or -X 3 -R 7 ; R 4 is halo, hydroxy, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, cyano, nitro, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkyloxy, aminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkylcarbonyl, formyl, amino, mono- or di(C 1-4 alkyl)amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

5. 发明专利

NO20072237A 未知
公开(公告)号：NO20072237A
公开(公告)日：2007-06-25
申请号：NO20072237
申请日：2007-04-30
申请人： JANSSEN PHARMACEUTICA NV
发明人： ANDRIES KOENRAAD JOZEF LODEWIJ , GOHLMANN HINRICH WILHELM HELMU , NEEFS JEAN-MARC EDMOND FERNAND , VERHASSELT PETER KAREL MARIA , WINKLER JOHANN , JONGE MARC RENE DE , KOYMANS LUCIEN MARIA HENRICUS
IPC分类号： C07K14/35 , A61K31/00 , C12N15/31 , C12N15/52 , G01N33/50
CPC分类号： C07K14/35 , A61K38/00 , C12N9/14

6. 发明专利

HRP20050688A2 PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION 未知
公开(公告)号：HRP20050688A2
公开(公告)日：2006-08-31
申请号：HRP20050688
申请日：2005-08-01
申请人： JANSSEN PHARMACEUTICA NV
发明人： HEERES JAN , LEWI PAULUS JOANNES , JONGE MARC RENE DE , KOYMANS LUCIEN MARIA HENRICUS , DAEYAERT FREDERIK FRANS DESIRE , VINKERS HENDRIK MAARTEN , ARTS FRANK XAVIER HERWIG , GUILLEMONT JEROME EMILE GEORGE , PASQUIER ELISABETH THERESE JEA
IPC分类号： A61K31/505 , C07D239/47 , A61P31/18 , C07D239/46
摘要： This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy; substituted C1-6alkyloxyC1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocycle; X1 is —NR5—, —NH—NH—, —N═N—, —O—, —C(═O)—, C1-4alkanediyl, —CHOH—, —S—, —S(═O)p—, —X2—C1-4alkanediyl- or —C1-4alkanediyl-X2—; R3 is NHR13; NR13R14; —C(═O)—NHR13; —C(═O)—NR13R14; —C(═O)—R15; —CH═N—NH—C(═O)—R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; —C(═N—O—R8)—C1-4alkyl; R7; or —X3—R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino; and pharmaceutical compositions comprising them.

7. 发明专利

NO319788B1 未知
公开(公告)号：NO319788B1
公开(公告)日：2005-09-12
申请号：NO20011934
申请日：2001-04-19
申请人： JANSSEN PHARMACEUTICA NV
发明人： HEERES JAN , KUKLA MICHAEL JOSEPH , CORTE BART DE , JONGE MARC RENE DE , KAVASH ROBERT W , KOYMANS LUCIEN MARIA HENRICUS , LUDOVICI DONALD WILLIAM , AKEN KOEN JEANNE ALFONS VAN , JANSSEN PAUL ADRIANN JAN
IPC分类号： A61K9/14 , C07D251/46 , A61K31/53 , A61P31/18 , C07D251/16 , C07D251/18 , C07D251/48 , C07D251/00
摘要： This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a 1 =a 2 -a 3 =a 4 - forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R 1 is hydrogen, aryl, formyl, C 1-6 alkylcarbonyl, C 1-6 alkyl, C 1-6 alkyloxycarbonyl or substituted C 1-6 alkyl; each R 2 independently is hydroxy, halo, optionally substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C 1-6 alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(-O) p R 4 , -NH-S(-O) p R 4 , -C(-O)R 4 , -NHC(-O)H, -C(-O)NHNH 2 , -NHC(-O)R 4 , -C(-NH)R 4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl or C 3-7 cycloalkyl; or L is -X-R 3 wherein R 3 is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is -NR 1 -, -NH-NH-, -N-N-, -O-, -C(=O)-, -CHOH-, -S-, -S(-O)- or -S(-O) 2 -; aryl is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

8. 发明专利

NO20054143L 未知
公开(公告)号：NO20054143L
公开(公告)日：2005-09-06
申请号：NO20054143
申请日：2005-09-06
申请人： JANSSEN PHARMACEUTICA NV
发明人： HEERES JAN , GUILLEMONT JEROME EMILE GEORGE , JONGE MARC RENE DE , KOYMANS LUCIEN MARIA HENRICUS , VINKERS HENDRIKK MAARTEN , DAEYAERT FREDERIK FRANS DESIRE , LEWI PAULUS JOANNES , JANSSEN PAUL ADRIAAN JAN , PASQUIER ELISABETH THERESE JEA
IPC分类号： A61P31/18 , C07D239/46 , C07D239/47 , A61K31/505
摘要： This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy; substituted C1-6alkyloxyC1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR6, —NH—S(═O)pR6, —C(═O)R6, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R6, —C(═NH)R6 or a 5-membered heterocycle; X1 is —NR5—, —NH—NH—, —N═N—, —O—, —C(═O)—, C1-4alkanediyl, —CHOH—, —S—, —S(═O)p—, —X2—C1-4alkanediyl- or —C1-4alkanediyl-X2—; R3 is NHR13; NR13R14; —C(═O)—NHR13; —C(═O)—NR13R14; —C(═O)—R15; —CH═N—NH—C(═O)—R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; —C(═N—O—R8)—C1-4alkyl; R7; or —X3—R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino; and pharmaceutical compositions comprising them.

9. 发明专利

NO318801B1 未知
公开(公告)号：NO318801B1
公开(公告)日：2005-05-09
申请号：NO20011696
申请日：2001-04-04
申请人： JANSSEN PHARMACEUTICA NV
发明人： HEERES JAN , KUKLA MICHAEL JOSEPH , JANSSEN PAUL ADRIAAN JAN , CORTE BART DE , JONGE MARC RENE DE , HO CHIH YUNG , KAVASH ROBERT W , KOYMANS LUCIEN MARIA HENRICUS , LUDOVICI DONALD WILLIAM , AKEN KOEN JEANNE ALFONS VAN
IPC分类号： C07D239/47 , A61K20060101 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/551 , A61K31/5513 , A61K31/675 , A61K31/715 , A61P31/18 , C07D20060101 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/80 , C07D401/12 , C07D403/12
摘要： This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a =a -a =a - forms a pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, substituted C1-6alkyl, or substituted C1-6alkyloxyC1-6alkylcarbonyl; each R independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O)pR , -NH-S(=O)pR , -C(=O)R , -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R ,-C(=NH)R or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkenyl, C2-10alkynyl or C3-7cycloalkyl; or L is -X-R wherein R is optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is -NR -, -NH-NH-, -N=N-, -O-, -C(=O)-, -CHOH-, -S-, -S(=O)- or -S(=O)2-; Q is hydrogen, C1-6alkyl, halo, polyhalo-C1-6alkyl or an optionally substituted amino group; Y represents hydroxy, halo, C3-7cycloalkyl, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O)pR , -NH-S(=O)pR , -C(=O)R , -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R ,-C(=NH)R or aryl; aryl is optionally substituted phenyl; Het is an optionally substituted heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection.

10. 发明专利

AU2004213173A1 HIV inhibiting 1,2,4-triazines 未知
公开(公告)号：AU2004213173A1
公开(公告)日：2004-09-02
申请号：AU2004213173
申请日：2004-02-05
申请人： JANSSEN PHARMACEUTICA NV
发明人： JANSSEN PAUL ADRIAAN JAN , LEWI PAULUS JOANNES , JONGE MARC RENE DE , KOYMANS LUCIEN MARIA HENRICUS , VINKERS HENDRIK MAARTEN , DAEYAERT FREDERIK FRANS DESIRE , HEERES JAN , LEENDERS RUBEN GERARDUS GEORGE , HOORNAERT GEORGES JOSEPH CORNE , KILONDA AMURI , LUDOVICI DONALD WILLIAM
IPC分类号： A61K31/53 , C07D253/06 , C07D253/07 , C07D253/075
摘要： The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

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