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1. 发明申请

US20060167564A1 Limb and digit movement system 审中-公开
标题翻译：肢体和数位运动系统
公开(公告)号：US20060167564A1
公开(公告)日：2006-07-27
申请号：US11319703
申请日：2005-12-29
申请人： J. Flaherty , R. Flaherty , Mijail Serruya , Burke Barrett , Gerhard Friehs
发明人： J. Flaherty , R. Flaherty , Mijail Serruya , Burke Barrett , Gerhard Friehs
IPC分类号： A61F2/66
CPC分类号： A61B5/0476 , A61B5/04888 , A61B5/407 , A61B5/4528 , A61F2/50 , A61F2/68 , A61F2/72 , A61F2002/701 , A61F2002/704 , A61F2002/705 , A61F2002/741 , A61F2002/7615 , G06F3/011 , G06F3/014 , G06F3/015 , G06N3/061
摘要： Systems, methods and devices for restoring or enhancing one or more motor functions of a patient are disclosed. The system comprises a biological interface apparatus and a joint movement device such as an exoskeleton device or FES device. The biological interface apparatus includes a sensor that detects the multicellular signals and a processing unit for producing a control signal based on the multicellular signals. Data from the joint movement device is transmitted to the processing unit for determining a value of a configuration parameter of the system. Also disclosed is a joint movement device including a flexible structure for applying force to one or more patient joints, and controlled cables that produce the forces required.
摘要翻译：公开了用于恢复或增强患者的一个或多个运动功能的系统，方法和装置。该系统包括生物界面装置和诸如外骨骼装置或FES装置的关节运动装置。生物界面装置包括检测多细胞信号的传感器和用于基于多细胞信号产生控制信号的处理单元。来自关节移动装置的数据被发送到处理单元，用于确定系统的配置参数的值。还公开了一种关节运动装置，其包括用于向一个或多个患者关节施加力的柔性结构，以及产生所需力的受控电缆。

2. 发明申请

US20060189899A1 Joint movement apparatus 审中-公开
标题翻译：联动装置
公开(公告)号：US20060189899A1
公开(公告)日：2006-08-24
申请号：US11319620
申请日：2005-12-29
申请人： J. Christopher Flaherty , R. Flaherty , Gerhard Friehs , Mijail Serruya , Burke Barrett , John Donoghue
发明人： J. Christopher Flaherty , R. Flaherty , Gerhard Friehs , Mijail Serruya , Burke Barrett , John Donoghue
IPC分类号： A61B5/103
CPC分类号： A61B5/0476 , A61B5/04888 , A61B5/407 , A61B5/4528 , A61F2/50 , A61F2/68 , A61F2/72 , A61F2002/701 , A61F2002/704 , A61F2002/705 , A61F2002/741 , A61F2002/7615 , G06F3/011 , G06F3/014 , G06F3/015 , G06N3/061
摘要： Systems, methods and devices for restoring or enhancing one or more motor functions of a patient are disclosed. The system comprises a biological interface apparatus and a joint movement device such as an exoskeleton device or FES device. The biological interface apparatus includes a sensor that detects the multicellular signals and a processing unit for producing a control signal based on the multicellular signals. Data from the joint movement device is transmitted to the processing unit for determining a value of a configuration parameter of the system. Also disclosed is a joint movement device including a flexible structure for applying force to one or more patient joints, and controlled cables that produce the forces required.
摘要翻译：公开了用于恢复或增强患者的一个或多个运动功能的系统，方法和装置。该系统包括生物界面装置和诸如外骨骼装置或FES装置的关节运动装置。生物界面装置包括检测多细胞信号的传感器和用于基于多细胞信号产生控制信号的处理单元。来自关节移动装置的数据被发送到处理单元，用于确定系统的配置参数的值。还公开了一种关节运动装置，其包括用于向一个或多个患者关节施加力的柔性结构，以及产生所需力的受控电缆。

3. 发明申请

US20060173259A1 Biological interface system 有权
公开(公告)号：US20060173259A1
公开(公告)日：2006-08-03
申请号：US11240652
申请日：2005-10-03
申请人： J. Flaherty , Burke Barrett , John Donoghue , Richard Van Wagenen , Christopher Smith , Andras Pungor , Christine Decaria , Almut Branner , Nephi Harvey , Anthony Misener , K. Guillory , Jon Joseph
发明人： J. Flaherty , Burke Barrett , John Donoghue , Richard Van Wagenen , Christopher Smith , Andras Pungor , Christine Decaria , Almut Branner , Nephi Harvey , Anthony Misener , K. Guillory , Jon Joseph
IPC分类号： A61B5/00
CPC分类号： A61B5/685 , A61B5/0031 , A61B5/04001 , A61B2562/0209 , A61B2562/046 , A61N1/0531 , A61N1/08 , A61N1/36003
摘要： A system and method for an improved biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system may include improved communication, self-diagnostics, and surgical insertion tools.

4. 发明授权

US07299091B2 Treatment of obesity by bilateral vagus nerve stimulation 有权
标题翻译：双侧迷走神经刺激治疗肥胖
公开(公告)号：US07299091B2
公开(公告)日：2007-11-20
申请号：US10612683
申请日：2003-07-01
申请人： Burke Barrett , Ramish K. Reddy , Mitchell S. Roslin
发明人： Burke Barrett , Ramish K. Reddy , Mitchell S. Roslin
IPC分类号： A61N1/36
CPC分类号： A61N1/05 , A61N1/32
摘要： A method of treating patients for compulsive overeating includes stimulating left and right branches of the patient's vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied. The electrical pulses are preferably applied to the vagus nerve at a supradiaphragmatic location.
摘要翻译：一种治疗患者强迫性暴饮暴食的方法包括：以连续施加脉冲的第一周期的预定顺序与电脉冲同时刺激患者迷走神经的左右分支，与不施加脉冲的第二周期交替。电脉冲优选在超膈位置施加到迷走神经。

5. 发明申请

US20070027504A1 Cranial nerve stimulation to treat a hearing disorder 审中-公开
标题翻译：颅神经刺激治疗听力障碍
公开(公告)号：US20070027504A1
公开(公告)日：2007-02-01
申请号：US11190796
申请日：2005-07-27
申请人： Burke Barrett , Steven Parnis , Steven Maschino , Albert Guzman
发明人： Burke Barrett , Steven Parnis , Steven Maschino , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/0456 , A61N1/0551 , A61N1/36014 , A61N1/36036 , A61N2/006
摘要： We disclose a method of treating a patient having a hearing disorder, including coupling at least one electrode to at least one vagus nerve of the patient and applying an electrical signal to the vagus nerve using the electrode to treat the hearing disorder. We also disclose a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a hearing disorder treatment system that may be used in performance of the method.
摘要翻译：我们公开了一种治疗患有听力障碍的患者的方法，包括将至少一个电极耦合到患者的至少一个迷走神经，并使用电极将电信号施加到迷走神经以治疗听力障碍。我们还公开了一种用计算机执行的指令编码的计算机可读程序存储设备，以及可用于执行该方法的医疗设备和听觉障碍治疗系统。

6. 发明申请

US20050251220A1 Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation 审中-公开
标题翻译：通过近膈神经刺激治疗神经精神障碍
公开(公告)号：US20050251220A1
公开(公告)日：2005-11-10
申请号：US10661641
申请日：2003-09-15
申请人： Burke Barrett , Reese Terry
发明人： Burke Barrett , Reese Terry
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36082 , A61N1/36114 , A61N1/37217
摘要： A method and apparatus for treating patients with neuropsychiatric disorder includes unilaterally or bilaterally stimulating one or both of the left and right branches of a patient's vagus nerve directly or indirectly with an electrical pulse signal generated by an implantable neurostimulator with at least one operatively coupled nerve electrode to apply the pulse signal to the selected nerve branch at a location in the vicinity of the patient's diaphragm, either slightly above or slightly below the diaphragm. The implantable neurostimulator is programmable to enable physician programming of electrical and timing parameters of the pulse signal, to generate the desired therapy regimen for alleviating the disorder. Patient activation of the device is permitted in the case of treating a neuropsychiatric disorder such as depression, where the patient is able to sense a symptom of a disorder.
摘要翻译：用于治疗神经精神障碍患者的方法和装置包括直接或间接地用患有至少一个可操作耦合的神经电极的可植入神经刺激器产生的电脉冲信号单向或双向刺激患者迷走神经中的一个或两个，将脉冲信号施加到患者隔膜附近位置处的所选择的神经分支，稍微高于或稍低于隔膜。可植入式神经刺激器是可编程的，以使得医师能够对脉冲信号的电和定时参数进行编程，以产生用于减轻病症的期望的治疗方案。在治疗诸如抑郁症的神经精神障碍的情况下，允许患者激活该装置，其中患者能够感测到病症的症状。

7. 发明授权

US06587719B1 Treatment of obesity by bilateral vagus nerve stimulation 有权
标题翻译：双侧迷走神经刺激治疗肥胖
公开(公告)号：US06587719B1
公开(公告)日：2003-07-01
申请号：US09346396
申请日：1999-07-01
申请人： Burke Barrett , Ramish K. Reddy , Mitchell S. Roslin
发明人： Burke Barrett , Ramish K. Reddy , Mitchell S. Roslin
IPC分类号： A61N132
CPC分类号： A61N1/05 , A61N1/32
摘要： A method of treating patients for compulsive overeating includes stimulating left and right branches of the patient's vagus nerve simultaneously with electrical pulses in a predetermined sequence of a first period in which pulses are applied continuously, alternating with a second period in which no pulses are applied. The electrical pulses are preferably applied to the vagus nerve at a supradiaphragmatic location.
摘要翻译：一种治疗患者强迫性暴饮暴食的方法包括：以连续施加脉冲的第一周期的预定顺序与电脉冲同时刺激患者迷走神经的左右分支，与不施加脉冲的第二周期交替。电脉冲优选在超膈位置施加到迷走神经。

8. 发明授权

US06473644B1 Method to enhance cardiac capillary growth in heart failure patients 有权
标题翻译：增加心力衰竭患者心脏毛细血管生长的方法
公开(公告)号：US06473644B1
公开(公告)日：2002-10-29
申请号：US09417080
申请日：1999-10-13
申请人： Reese S. Terry, Jr. , Burke Barrett , Alan Adkins
发明人： Reese S. Terry, Jr. , Burke Barrett , Alan Adkins
IPC分类号： A61N136
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method is disclosed for treating patients suffering from heart failure to increase cardiac output. The patient's vagus nerve is electrically stimulated or modulated with a sequence of substantially equally spaced pulses by an implanted neurostimulator, and the frequency of the stimulating pulses is adjusted until the patient's heart rate reaches a target rate within a relatively stable target rate range below the low end of the patient's customary resting heart rate. The frequency of the stimulating pulses is maintained at the frequency which ultimately produced the relatively stable target rate range so as not to deviate markedly from the target rate, at least so long as the patient remains at rest. An activity sensor associated with the implanted neurostimulator detects physical activity of the patient and adjusts the frequency of the stimulating pulses accordingly, to elevate the heart rate during periods of physical activity by the patient. When the patient ceases the activity, the vagal stimulation reverts along a prescribed fall-back path to a frequency that will reproduce the target heart rate.
摘要翻译：公开了一种治疗患有心力衰竭的患者以增加心输出量的方法。患者的迷走神经通过植入的神经刺激器用基本相等间隔的脉冲序列进行电刺激或调节，并且刺激脉冲的频率被调整直到患者的心率达到低于低的相对稳定的目标速率范围内的目标速率患者习惯性静息心率结束。刺激脉冲的频率保持在最终产生相对稳定的目标速率范围的频率，以便不会显着地偏离目标速率，至少只要患者保持静止。与植入的神经刺激器相关联的活动传感器检测患者的身体活动并相应地调节刺激脉冲的频率，以在患者的身体活动期间升高心率。当患者停止活动时，迷走神经刺激沿规定的后退路径恢复到将再现目标心率的频率。

9. 发明申请

US20050251222A1 Treatment of movement disorders by near-diaphragmatic nerve stimulation 审中-公开
标题翻译：通过近膈神经刺激治疗运动障碍
公开(公告)号：US20050251222A1
公开(公告)日：2005-11-10
申请号：US10661640
申请日：2003-09-15
申请人： Burke Barrett , Reese Terry
发明人： Burke Barrett , Reese Terry
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36082 , A61N1/36114
摘要： A method for treating patients with movement disorders includes unilaterally or bilaterally stimulating one or both of the left and right branches of a patient's vagus nerve directly or indirectly with an electrical pulse signal generated by an implantable neurostimulator with at least one operatively coupled nerve electrode to apply the pulse signal to the selected nerve branch at a location in the vicinity of the patient's diaphragm, either slightly above or slightly below the diaphragm. A device for performing the method includes a government approved implantable neurostimulator which is programmable to enable physician programming of electrical and timing parameters of the pulse signal, to generate the desired therapy regimen for alleviating the disorder by application of the therapeutic electrical stimulation signal to a selected nerve. Automatic detection or patient sensing of a symptom of the disorder may be utilized for activating the device.
摘要翻译：用于治疗运动障碍的患者的方法包括直接或间接地用患有至少一个可操作耦合的神经电极的可植入神经刺激器产生的电脉冲信号单向或双向刺激患者迷走神经中的一个或两个，以应用在患者隔膜附近的位置处，选择的神经分支的脉冲信号，稍微高于或稍低于隔膜。用于执行该方法的装置包括政府批准的可植入神经刺激器，其可编程以使得能够对脉搏信号的电和定时参数进行医师编程，以产生用于通过将治疗性电刺激信号施加到所选择的治疗电刺激信号来减轻紊乱的期望的治疗方案神经。可以利用自动检测或病人感染该病症的症状来激活该装置。

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