专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050191613A1 Device for monitoring cells 有权
公开(公告)号：US20050191613A1
公开(公告)日：2005-09-01
申请号：US10957802
申请日：2004-10-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard Guarino , Magdalena Wodnicka , David Stitt , Gregory Burrell , Timothy Foley , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard Guarino , Magdalena Wodnicka , David Stitt , Gregory Burrell , Timothy Foley , Patrick Shawn Beaty
IPC分类号： C12Q1/04 , C12Q1/18 , C12Q1/00
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.

2. 发明授权

US07338778B2 Luminescent method for determining cell oxygen consumption 有权
标题翻译：用于确定细胞氧消耗的发光方法
公开(公告)号：US07338778B2
公开(公告)日：2008-03-04
申请号：US10957802
申请日：2004-10-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
IPC分类号： C12Q1/04
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.
摘要翻译：本发明涉及基于其消耗溶解氧的能力来检测和评价真核细胞和/或原核细胞的代谢活性的方法。该方法利用了发光检测系统，其利用某些化合物的发光发射对氧的存在的敏感性，其以浓度依赖性方式猝灭（减少）化合物的发光发射。呼吸真核细胞和/或原核细胞将影响浸入其中的液体培养基的氧浓度。因此，本发明提供了一种方便的系统，用于通过确定它们对存在的介质的氧浓度的影响来收集关于真核细胞和/或原核细胞的存在，鉴定，定量和细胞毒活性的信息。

3. 发明授权

US06900030B2 Device for monitoring cells 有权
标题翻译：用于监控单元的设备
公开(公告)号：US06900030B2
公开(公告)日：2005-05-31
申请号：US10116777
申请日：2002-04-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
IPC分类号： C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.
摘要翻译：本发明涉及基于其消耗溶解氧的能力来检测和评价真核细胞和/或原核细胞的代谢活性的方法。该方法利用了发光检测系统，其利用某些化合物的发光发射对氧的存在的敏感性，其以浓度依赖性方式猝灭（减少）化合物的发光发射。呼吸真核细胞和/或原核细胞将影响浸入其中的液体培养基的氧浓度。因此，本发明提供了一种方便的系统，用于通过确定它们对存在的介质的氧浓度的影响来收集关于真核细胞和/或原核细胞的存在，鉴定，定量和细胞毒活性的信息。

4. 发明授权

US06395506B1 Device for monitoring cells 有权
标题翻译：用于监控单元的设备
公开(公告)号：US06395506B1
公开(公告)日：2002-05-28
申请号：US09342720
申请日：1999-06-29
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
IPC分类号： C12Q118
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.
摘要翻译：本发明涉及基于其消耗溶解氧的能力来检测和评价真核细胞和/或原核细胞的代谢活性的方法。该方法利用了发光检测系统，其利用某些化合物的发光发射对氧的存在的敏感性，其以浓度依赖性方式猝灭（减少）化合物的发光发射。呼吸真核细胞和/或原核细胞将影响浸入其中的液体培养基的氧浓度。因此，本发明提供了一种方便的系统，用于通过确定它们对存在的介质的氧浓度的影响来收集关于真核细胞和/或原核细胞的存在，鉴定，定量和细胞毒活性的信息。

5. 发明授权

US10337046B2 High confidence in positive status determination 有权
公开(公告)号：US10337046B2
公开(公告)日：2019-07-02
申请号：US12918019
申请日：2008-02-19
申请人： Patrick Shawn Beaty
发明人： Patrick Shawn Beaty
IPC分类号： C12Q1/04
摘要： Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.

6. 发明申请

US20110208432A1 SYSTEMS AND METHODS FOR PRESUMPTIVE IDENTIFICATION OF MICROORGANISM TYPE IN A CULTURE 审中-公开
标题翻译：用于文化中微生物类型的预测鉴定的系统和方法
公开(公告)号：US20110208432A1
公开(公告)日：2011-08-25
申请号：US12918011
申请日：2008-02-19
申请人： Patrick Shawn Beaty
发明人： Patrick Shawn Beaty
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： C12Q1/04 , C12M41/46
摘要： Systems, methods and apparatus for identifying a microorganism type in a culture are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a first derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each respective set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the rate transformation values in the set is computed, thereby forming a plurality of average relative transformation values. A maximum metabolic rate and an extent of growth, determined from the normalization relative values and the average relative transformation values, are compared against a lookup table that matches these values to a microorganism type.
摘要翻译：提供了用于鉴定培养物中的微生物类型的系统，方法和装置。对于（i）各测量和（ii）初始生物状态之间的培养生物状态的每个相应测量，计算归一化相对值。对于每个固定的时间间隔，计算时间间隔中的归一化相对值的一阶导数，从而形成多个速率变换值。对于多个速率变换值中的每一组速率变换值，计算该组中速率变换值的集中趋势的度量，由此形成多个平均相对变换值。将从归一化相对值和平均相对转化值确定的最大代谢率和生长程度与将这些值与微生物类型相匹配的查找表进行比较。

7. 发明申请

US20110029249A1 DETERMINATION OF BLOOD VOLUME IN A CULTURE BOTTLE 审中-公开
标题翻译：文化瓶中血液体积的测定
公开(公告)号：US20110029249A1
公开(公告)日：2011-02-03
申请号：US12867980
申请日：2008-02-19
申请人： Patrick Shawn Beaty
发明人： Patrick Shawn Beaty
IPC分类号： G06F19/00 , G01J1/58
CPC分类号： G01N21/27 , G01N21/6428 , G01N2021/3144 , G16H40/63 , Y02A90/26
摘要： Systems, methods and apparatus for determining an amount of blood in a blood culture are provided where an initial biological state and then periodic measurements of the biological state of the culture are taken. For each respective measurement, a normalization relative value between the respective measurement and the initial measurement is made thereby forming normalization relative values. For each interval of time points represented by the normalization relative values, a first derivative of the normalization relative values in the interval is made thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, an average relative transformation value is computed, thereby forming average relative transformation values. A lookup table that matches a measure of central tendency of the average relative transformation values to a blood amount is used to determine the amount of blood in the culture.
摘要翻译：提供用于确定血液培养物中的血液量的系统，方法和装置，其中采用初始生物状态，然后对培养物的生物状态进行周期性测量。对于各个测量，进行各测量与初始测量之间的归一化相对值，由此形成归一化相对值。对于由归一化相对值表示的每个时间间隔的间隔，由此形成间隔中的归一化相对值的一阶导数，从而形成多个速率变换值。对于多个速率变换值中的每组速率变换值，计算平均相对变换值，从而形成平均相对变换值。使用将平均相对转化值与血液量的中心倾向度量相匹配的查找表来确定培养物中的血液量。

8. 发明授权

US10481083B2 Determination of blood volume in a culture bottle 有权
公开(公告)号：US10481083B2
公开(公告)日：2019-11-19
申请号：US12867980
申请日：2008-02-19
申请人： Patrick Shawn Beaty
发明人： Patrick Shawn Beaty
IPC分类号： G01N21/27 , G01N21/64 , G16H40/63 , G06F19/00 , G01N21/31
摘要： Systems, methods and apparatus for determining an amount of blood in a blood culture are provided where an initial biological state and then periodic measurements of the biological state of the culture are taken. For each respective measurement, a normalization relative value between the respective measurement and the initial measurement is made thereby forming normalization relative values. For each interval of time points represented by the normalization relative values, a first derivative of the normalization relative values in the interval is made thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, an average relative transformation value is computed, thereby forming average relative transformation values. A lookup table that matches a measure of central tendency of the average relative transformation values to a blood amount is used to determine the amount of blood in the culture.

9. 发明申请

US20110029252A1 HIGH CONFIDENCE IN POSITIVE STATUS DETERMINATION 审中-公开
标题翻译：高度信心的积极状态决定
公开(公告)号：US20110029252A1
公开(公告)日：2011-02-03
申请号：US12918019
申请日：2008-02-19
申请人： Patrick Shawn Beaty
发明人： Patrick Shawn Beaty
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： C12Q1/04
摘要： Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.
摘要翻译：提供了用于确定容器中的培养物是否含有多种微生物的系统，方法和装置。对于（i）各测量和（ii）初始生物状态之间的培养生物状态的每个相应测量，计算归一化相对值。对于每个固定的时间间隔，计算时间间隔中的归一化相对值的导数，从而形成多个速率变换值。对于多个速率变换值中的每组速率变换值，计算集合中的值的集中趋势的度量，从而形成多个平均相对变换值。基于任何计算的平均相对转化值是否超过第一阈值或培养物显示的生长程度是否超过第二阈值来确定培养物是否含有微生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式