专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07250279B2 Human pyruvate dehydrogenese phosphatase 失效
标题翻译：人丙酮酸脱氢磷酸酶
公开(公告)号：US07250279B2
公开(公告)日：2007-07-31
申请号：US10240774
申请日：2001-04-06
申请人： Izaak Den Daas , Michael Gassen , Joachim Leibrock , Laurie Von Melchner
发明人： Izaak Den Daas , Michael Gassen , Joachim Leibrock , Laurie Von Melchner
IPC分类号： C12N9/00 , C12N9/04 , C12N9/12 , C12N9/14 , C12N9/16 , C07K1/00
CPC分类号： C12N9/16
摘要： hPDP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hPDP polypeptides and polynucleotides in diagnostic assays.
摘要翻译：公开了通过重组技术产生这种多肽的hPDP多肽和多核苷酸和方法。还公开了在诊断测定中利用hPDP多肽和多核苷酸的方法。

2. 发明授权

US07312328B2 Benzoylpyridazines 有权
标题翻译：苯甲酰哒嗪
公开(公告)号：US07312328B2
公开(公告)日：2007-12-25
申请号：US10451393
申请日：2001-12-19
申请人： Hans-Michael Eggenweiler , Michael Wolf , Norbert Beier , Joachim Leibrock , Michael Gassen , Thomas Ehring
发明人： Hans-Michael Eggenweiler , Michael Wolf , Norbert Beier , Joachim Leibrock , Michael Gassen , Thomas Ehring
IPC分类号： A61K31/50 , A61K31/495
CPC分类号： C07D403/12 , C07D237/04
摘要： This invention relates to compounds of the formula (I) in which R1, R2, R3, X and Q are as defined above and their use as PDE IV inhibitors.
摘要翻译：本发明涉及其中R 1，R 2，R 3，X和Q如上定义的式（I）化合物并将其用作PDE IV抑制剂。

3. 发明授权

US07485639B2 4-(benzylidene-amino)-3-(methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a PDE-IV inhibiting and TNF-antagonistic effect for the treatment of cardiac diseases and allergies 失效
标题翻译：具有PDE-IV抑制和TNF拮抗作用的4-（亚苄基 - 氨基）-3-（甲基硫烷基）-4h-（1,2,4）三嗪-5-酮衍生物，用于治疗心脏病和过敏
公开(公告)号：US07485639B2
公开(公告)日：2009-02-03
申请号：US10484172
申请日：2002-06-19
申请人： Hans-Michael Eggenweiler , Michael Wolf , Norbert Beier , Joachim Leibrock , Pierre Schelling , Michael Gassen , Thomas Ehring
发明人： Hans-Michael Eggenweiler , Michael Wolf , Norbert Beier , Joachim Leibrock , Pierre Schelling , Michael Gassen , Thomas Ehring
IPC分类号： A01N43/64 , A61K31/53 , C07D253/00
CPC分类号： C07D253/075 , C07D401/12
摘要： Triazine derivatives of the formula (I) and physiologically acceptable salts and solvates thereof, in which R1, R2, A and R5 are as defined in Claim 1, exhibit phosphodiesterase IV inhibition and can be employed for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune diseases, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disorders, atherosclerosis and AIDS, furthermore for inhibiting the formation of TNFα.
摘要翻译：式（I）的三嗪衍生物及其生理上可接受的盐和溶剂化物，其中R1，R2，A和R5如权利要求1所定义，表现出磷酸二酯酶IV抑制作用，可用于治疗过敏性疾病，哮喘，慢性支气管炎，特应性皮炎，牛皮癣和其他皮肤疾病，炎性疾病，自身免疫疾病，例如类风湿性关节炎，多发性硬化，克罗恩病，糖尿病或溃疡性结肠炎，骨质疏松症，移植排斥反应，恶病质，肿瘤生长或肿瘤转移，败血症，记忆障碍，动脉粥样硬化和AIDS，此外用于抑制TNFα的形成。

4. 发明申请

US20050070529A1 Use of type 4 phosphodiesterase inhibitors in myocardial diseases 审中-公开
标题翻译：在心肌疾病中使用4型磷酸二酯酶抑制剂
公开(公告)号：US20050070529A1
公开(公告)日：2005-03-31
申请号：US10467793
申请日：2002-01-15
申请人： Arne Sutter , Thomas Ehring , Thomas Welge , Klause Minck , Claudia Wilm , Michael Gassen , Hans-Michael Eggenweiler , Michael Wolf , Pierre Schelling , Norbert Beier , Joachim Leibrock
发明人： Arne Sutter , Thomas Ehring , Thomas Welge , Klause Minck , Claudia Wilm , Michael Gassen , Hans-Michael Eggenweiler , Michael Wolf , Pierre Schelling , Norbert Beier , Joachim Leibrock
IPC分类号： A61K31/50 , A61K31/501 , A61K31/535 , A61K31/5395 , A61K31/54 , A61K31/549 , A61P9/00 , A61P29/00 , A61P37/02
CPC分类号： A61K31/50 , A61K31/5395 , A61K31/549
摘要： The invention relates to the use of type 4 phosphodiesterase inhibitors to treat myocardial diseases.
摘要翻译：本发明涉及使用4型磷酸二酯酶抑制剂来治疗心肌疾病。

5. 发明申请

US20050176686A1 Novel compounds as histone deacetylase inhibitors 审中-公开
标题翻译：新型化合物作为组蛋白脱乙酰酶抑制剂
公开(公告)号：US20050176686A1
公开(公告)日：2005-08-11
申请号：US10624571
申请日：2003-07-23
申请人： Alexander Maurer , Sascha Hoevelmann , Elke Martin , Bernd Hentsch , Michael Gassen , Juergen Kraus , Rolf Krauss , Adam-Spencer Vincek
发明人： Alexander Maurer , Sascha Hoevelmann , Elke Martin , Bernd Hentsch , Michael Gassen , Juergen Kraus , Rolf Krauss , Adam-Spencer Vincek
IPC分类号： A61K31/19 , A61K31/66 , C07C259/04
CPC分类号： C07C259/04 , C07C2601/08 , C07C2601/14
摘要： The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH2; Y is selected from C, CH, CH2, S, NR, CH2-CH2, H2C—CH, HC—CH2, C—CH2, H2C—C, or C—C; one or more of the hydrogen atoms can optionally be substituted by one or more substituents R′; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R′ is independently H, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.
摘要翻译：本发明涉及通式（I）的化合物或其药学上可接受的盐或生理功能衍生物，其中：n是含有2至7个碳原子的非芳族环系统，其中所述环体系可以包含一个二价双债券 X是C，CH或CH 2; Y选自C，CH，CH 2，S，NR，CH 2 -CH 2，H 2， C-CH，HC-CH 2，C-CH 2，H 2 CC或CC; 一个或多个氢原子可以任选被一个或多个取代基R'取代; 每个虚线意味着单，双或三键，排除三元组与三键的组合和具有三键的双键; R'独立地是H，-CN，烷基，环烷基，氨基烷基，烷基氨基，烷氧基，-OH，-SH，烷硫基，羟基烷基，羟烷基氨基，卤素基，卤代烷基，卤代烷氧基。 R是H，烷基或环烷基; Z是CH，C或P; p为0或1。

6. 发明授权

US06737436B1 Pyrrole derivatives as phosphodiesterase VII inhibitors 失效
标题翻译：吡咯衍生物作为磷酸二酯酶VII抑制剂
公开(公告)号：US06737436B1
公开(公告)日：2004-05-18
申请号：US10129261
申请日：2002-05-03
申请人： Hans-Michael Eggenweiler , Rochus Jonas , Michael Wolf , Michael Gassen , Thomas Welge
发明人： Hans-Michael Eggenweiler , Rochus Jonas , Michael Wolf , Michael Gassen , Thomas Welge
IPC分类号： A61K31402
CPC分类号： C07D207/34
摘要： Compounds of the formula I in which R1 and R2, independently of one another, each denote H, A, OA, SA or HaI, R3 denotes H or A, R4 denotes A or NH2, R5 denotes H, NH2, NHA or NA2, A denotes alkyl having 1 to 10 carbon atoms, alkenyl, cycloalkyl or alkylenecycloalkyl, Hal denotes F, Cl, Br or I, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors.
摘要翻译： R 1和R 2彼此独立的式Iin的化合物各自表示H，A，OA，SA或HaI，R 3表示H或A，R 4表示A或NH 2， R 5表示H，NH 2，NHA或NA 2，A表示具有1至10个碳原子的烷基，烯基，环烷基或亚烷基环烷基，Hal表示F，Cl，Br或I及其生理学上可接受的盐和/或溶剂化物，磷酸二酯酶VII抑制剂。

7. 发明授权

US06737426B1 Sulfonyloxazoleamines 失效
标题翻译：磺酰基恶唑胺
公开(公告)号：US06737426B1
公开(公告)日：2004-05-18
申请号：US10148078
申请日：2002-05-28
申请人： Rolf Gericke , Henning Böttcher , Michael Gassen , Hartmut Greiner
发明人： Rolf Gericke , Henning Böttcher , Michael Gassen , Hartmut Greiner
IPC分类号： A61K31496
CPC分类号： C07D213/81 , C07D213/82 , C07D307/68 , C07D333/38 , C07D413/04
摘要： The invention relates to compounds of the general formula (I) where R1 and R2 independently of one another are H, —R6, C3-C8-cycloalkyl, —(CH2)n—R7, —(CH2)n—O—R6, —(CH2)n—NH2, —(CH2)n—NHR6, —(CH2)—N(R6)2, C2-C6-alkenyl or, where appropriate, together form a mononuclear saturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms, R3 and R4 independently of one another are H, —R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, R5 is a 5- or 6-membered, saturated or unsaturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms which may be mono- or disubstituted by R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, and R6 is C1-C6-alkyl, R7 is R3- and/or R4-substituted phenyl, n is 0 to 2, and physiologically acceptable salts or solvates thereof. The invention also relates to the use of the compounds of the general formula I as medicaments.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1和R 2彼此独立地为H，-R 6，C 3 -C 8 - 环烷基， - （CH 2）n -R 7， - （CH 2）n O-R 6， - （CH 2 ）n-NH 2， - （CH 2）n -NHR 6， - （CH 2）-N（R 6）2，C 2 -C 6 - 烯基或在适当的情况下一起形成具有一个或两个氮，氧和/ 硫原子，R3和R4彼此独立地是H，-R6，-CF3，-NO2，-Hal，-OH，-O-R6，-NH2，-NH-R6或-N（R6）2，R5是具有一个或两个可被R 6，-CF 3，-NO 2，-Hal，-OH，-O-R 6单价或二取代的氮，氧和/或硫原子的5-或6-元饱和或不饱和杂环，-NH 2，-NH-R 6或-N（R 6）2，R 6为C 1 -C 6烷基，R 7为R 3 - 和/或R 4取代的苯基，n为0至2，以及其生理上可接受的盐或溶剂化物。本发明还涉及通式I的化合物作为药物的用途。

8. 发明授权

US06613778B1 Imidazopyridine derivatives as phosphodiesterase VII inhibitors 失效
标题翻译：咪唑并吡啶衍生物作为磷酸二酯酶VII抑制剂
公开(公告)号：US06613778B1
公开(公告)日：2003-09-02
申请号：US10129274
申请日：2002-05-03
申请人： Hanse-Michael Eggenweiler , Karl-August Ackermann , Rochust Jonas , Michael Wolf , Michael Gassen , Thomas Welge
发明人： Hanse-Michael Eggenweiler , Karl-August Ackermann , Rochust Jonas , Michael Wolf , Michael Gassen , Thomas Welge
IPC分类号： A01N4342
CPC分类号： C07D471/04
摘要： Compounds of the formula I in which R1 denotes CONR4R5, R2 denotes H or A, R4 and R5, independently of one another, each denote H or A1, R3 denotes Hal, Hal denotes F, Cl, Br or I, A denotes alkyl having 1-4 carbon atoms, A1 denotes alkyl having 1-10 carbon atoms, X denotes alkylene having 1-4 carbon atoms, in which an ethylene group may also be replaced by a double or triple bond, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors, and their use for the preparation of a medicament.
摘要翻译： R1表示CONR4R5的式Iin的化合物，R2表示H或A，R4和R5彼此独立地表示H或A1，R3表示Hal，Hal表示F，Cl，Br或I，A表示具有1- 4个碳原子，A1表示具有1-10个碳原子的烷基，X表示具有1-4个碳原子的亚烷基，其中亚乙基也可以被双键或三键替代，以及它们的生理上可接受的盐和/或溶剂合物，作为磷酸二酯酶VII抑制剂，及其用于制备药物的用途。

9. 发明申请

US20090088478A1 NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS 失效
标题翻译：新型化合物作为脱乙酰壳多糖酶抑制剂
公开(公告)号：US20090088478A1
公开(公告)日：2009-04-02
申请号：US11778297
申请日：2007-07-16
申请人： Alexander B. Maurer , Sascha Hoevelmann , Elke Martin , Bernd Hentsch , Michael Gassen , Juergen Kraus , Rolf Krauss , Adam-Spencer Vincek
发明人： Alexander B. Maurer , Sascha Hoevelmann , Elke Martin , Bernd Hentsch , Michael Gassen , Juergen Kraus , Rolf Krauss , Adam-Spencer Vincek
IPC分类号： A61K31/164 , C07C237/22 , A61P35/00
CPC分类号： C07C259/04 , C07C2601/08 , C07C2601/14
摘要： The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.
摘要翻译：本发明涉及作为具有组蛋白脱乙酰酶活性的酶的抑制剂的化合物，这些化合物的制备方法及其用于治疗与组蛋白和/或其他分子的低乙酰化相关的疾病的用途，或其中超乙酰化的诱导例如通过抑制转化细胞（例如癌症）的增殖和/或诱导分化和/或诱导细胞凋亡具有有益的作用。此外，该化合物可用于治疗其他增殖性疾病，用于治疗或预防与异常基因表达相关的病症。

10. 发明授权

US07491742B2 Imidazole derivatives as phosphodiesterase VII inhibitors 失效
标题翻译：咪唑衍生物作为磷酸二酯酶VII抑制剂
公开(公告)号：US07491742B2
公开(公告)日：2009-02-17
申请号：US10750878
申请日：2004-01-05
申请人： Hans-Michael Eggenweiler , Rochus Jonas , Michael Wolf , Michael Gassen , Oliver Pöschke
发明人： Hans-Michael Eggenweiler , Rochus Jonas , Michael Wolf , Michael Gassen , Oliver Pöschke
IPC分类号： A61K31/415
CPC分类号： C07D491/04 , C07D495/04
摘要： Imidazole derivatives of the formula I in which R1 is H, A, benzyl, indan-5-yl, 1,2,3,4-tetrahydronaphthalen-5-yl, dibenzothien-2-yl, or phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, A-CO—NH, benzyloxy, alkoxy, COOH or COOA, R2 is H or A, X is O or S, Hal is F, Cl, Br or I, A is alkyl with 1 to 6 C atoms, and the physiologically acceptable salts and/or solvates thereof as phosphodiesterase VII inhibitors and the use thereof for producing a pharmaceutical.
摘要翻译：式I的咪唑衍生物，其中R 1是H，A，苄基，茚满-5-基，1,2,3,4-四氢萘-5-基，二苯并噻吩-2-基或未取代或单 - ，Hal，A，A-CO-NH，苄氧基，烷氧基，COOH或COOA二取代或三取代，R 2为H或A，X为O或S，Hal为F，Cl，Br或I， 1至6个C原子，以及其作为磷酸二酯酶VII抑制剂的生理学上可接受的盐和/或溶剂合物及其用于制备药物的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式