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1. 发明授权

US4066763A Thiazinoindoles useful as antidepressants 失效
标题翻译：噻嗪类可用作抗抑郁药
公开(公告)号：US4066763A
公开(公告)日：1978-01-03
申请号：US750293
申请日：1976-12-13
申请人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
发明人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
IPC分类号： C07D209/08 , C07D513/04 , A61K31/38
CPC分类号： C07D209/08
摘要： Thiazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-thiazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The thiazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.
摘要翻译：公开了以1H-1,4-噻嗪并[4,3-a]吲哚核的1位连接的氨基（低级）烷基为特征的噻唑啉衍生物。氨基（低级）烷基的氨基部分可以进一步被一个或两个低级烷基取代或并入杂环胺基中。衍生物在位置1和10进一步被取代，并且可以任选地在3,4,6,7,8和9位被取代。本发明的噻嗪吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。还公开了使用这些衍生物和含有它们的组合物的方法。

2. 发明授权

US4066779A Pyranoindole derivatives, compositions and method of use 失效
标题翻译：吡咯啉衍生物，组合物和使用方法
公开(公告)号：US4066779A
公开(公告)日：1978-01-03
申请号：US736613
申请日：1976-10-28
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D209/08 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535
CPC分类号： C07D209/08 , Y10S514/925
摘要： Pyranolindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino-(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano- and thiopyranindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：吡喃并吲哚和噻喃并吲哚衍生物，其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基，或具有所述基团公开了吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位。氨基（低级）烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物，其仅在位置9具有氨基（低级）烷基，在位置1具有两个取代基，并且可以任选在3,4,5,6,7和8位上被取代 ; 具有位置1和9位置上的氨基 - （低级）烷基的衍生物在位置1进一步被取代，并且可以在3,4,5,6,7和8位任意取代。这种吡喃和噻喃衍生物本发明是有用的抗抑郁药和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

3. 发明授权

US4041169A Pharmaceutical method for using pyrano-and thiopyranoindole derivatives 失效
标题翻译：吡喃并噻唑衍生物的制备方法
公开(公告)号：US4041169A
公开(公告)日：1977-08-09
申请号：US736624
申请日：1976-10-28
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D209/08 , A61K31/40
CPC分类号： C07D209/08 , Y10S514/925
摘要： Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：吡喃并吲哚和噻喃并吲哚衍生物，其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基，或具有所述基团公开了连接于吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位的化合物。氨基（低级）烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物，其仅在位置9具有氨基（低级）烷基，在位置1具有两个取代基，并且可以任选在3,4,5,6,7和8位上被取代 ; 具有位置1和9的氨基（低级）烷基的衍生物在1位进一步被取代，并且可以在3,4,5,6,7和8位任意被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁药和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

4. 发明授权

US4056538A Process for preparing pyrano- and thiopyranoindole derivatives 失效
标题翻译：吡喃并噻唑衍生物的制备方法
公开(公告)号：US4056538A
公开(公告)日：1977-11-01
申请号：US733834
申请日：1976-10-18
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D491/04 , C07D491/052 , C07D495/04
CPC分类号： C07D491/04 , C07D495/04
摘要： Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[ 3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino position of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 posses two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：公开了以吡喃并吲哚和噻喃并吲哚为衍生物，其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基。氨基（低级）烷基的氨基位置可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基（低级）仅在位置9的烷基在位置1具有两个取代基，并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9处具有氨基（低级）烷基的衍生物进一步在位置1被取代，并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

5. 发明授权

US4012511A Oxazinoindole derivatives useful as antidepressants 失效
标题翻译：恶唑诺吲哚衍生物可用作抗抑郁药
公开(公告)号：US4012511A
公开(公告)日：1977-03-15
申请号：US593582
申请日：1975-07-07
申请人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
发明人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
IPC分类号： C07D209/08 , A01N9/00 , A01N9/22 , C07D265/00 , C07D273/00
CPC分类号： C07D209/08
摘要： Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.
摘要翻译：公开了具有与1 H-1,4-恶嗪并[4,3-a]吲哚核的1位连接的氨基（低级）烷基的恶嗪基吲哚衍生物。氨基（低级）烷基的氨基部分可以进一步被一个或两个低级烷基取代或并入杂环胺基中。衍生物在位置1和10进一步被取代，并且可以任选地在3,4,6,7,8和9位被取代。本发明的恶嗪基吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。还公开了使用这些衍生物和含有它们的组合物的方法。

6. 发明授权

US3962236A Oxazinoindole- and thiazinoindole derivatives 失效
标题翻译： OXAZINOINDOLE-和THIAZINOINDOLE DERIVATIVES
公开(公告)号：US3962236A
公开(公告)日：1976-06-08
申请号：US473646
申请日：1974-05-28
申请人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
发明人： Christopher A. Demerson , Leslie G. Humber , George Santroch , Thomas A. Dobson , Ivo Jirkovsky
IPC分类号： C07D209/08 , C07D265/16 , C07D273/00 , C07D295/00
CPC分类号： C07D209/08
摘要： Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.

7. 发明授权

US4118394A Pyrano- and thiopyranoindole derivatives 失效
标题翻译：吡喃和噻喃并吲哚衍生物
公开(公告)号：US4118394A
公开(公告)日：1978-10-03
申请号：US822456
申请日：1977-08-08
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D491/04 , C07D491/052 , C07D495/04 , C07D513/04
CPC分类号： C07D491/04 , C07D495/04 , Y10S514/925
摘要： Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indone nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：披露了具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基的吡喃并吲哚和噻喃并吲哚衍生物。氨基（低级）烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基（低级）仅在位置9的烷基基团在位置1具有两个取代基，并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9位置具有氨基（低级）烷基的衍生物进一步在位置1被取代，并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

8. 发明授权

US4056537A Process for making pyrano- and thiopyranoindole derivatives 失效
标题翻译：制备吡喃和噻喃并吲哚衍生物的方法
公开(公告)号：US4056537A
公开(公告)日：1977-11-01
申请号：US733829
申请日：1976-10-18
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D491/04 , C07D491/052 , C07D495/04
CPC分类号： C07D491/04 , C07D495/04
摘要： Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：公开了以吡喃并吲哚和噻喃并吲哚衍生物为特征的具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基。氨基（低级）烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基（低级）仅在位置9的烷基基团在位置1具有两个取代基，并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9位置具有氨基（低级）烷基的衍生物进一步在位置1被取代，并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

9. 发明授权

US3995052A Indenopyran- and indenothiopyranalkylamines III in the treatment of depression 失效
标题翻译：吲哚吡喃和茚硫吡喃烷基胺III治疗抑郁症
公开(公告)号：US3995052A
公开(公告)日：1976-11-30
申请号：US578688
申请日：1975-05-19
申请人： Ivo Jirkovsky , Leslie G. Humber , Christopher A. Demerson , Thomas A. Dobson
发明人： Ivo Jirkovsky , Leslie G. Humber , Christopher A. Demerson , Thomas A. Dobson
IPC分类号： C07D209/08 , A61K31/35 , A61K31/38 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535
CPC分类号： C07D209/08
摘要： Indenopyran- and indenothiopyranalkylamine derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of an indeno[2,1-c]pyran or indeno[2,1-c]thiopyran nucleus are disclosed. Also included are the corresponding derivatives having an indeno[1,2-c]pyran and an indeno[1,2-c]-thiopyran nucleus. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incoporated into a heterocyclic amine radical. The derivatives are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The indenopyran- and indenothiopyranalkylamine derivatives of this invention are useful antidepressant agents. Methods for their preparation and use are disclosed.
摘要翻译：公开了具有连接茚并[2,1-c]吡喃或茚并[2,1-c]噻喃核的1位上的氨基（低级）烷基的茚并吡喃和茚并吡喃烷基胺衍生物。还包括具有茚并[1,2-c]吡喃和茚并[1,2-c] - 噻喃核的相应衍生物。氨基（低级）烷基的氨基部分可以进一步被一个或两个低级烷基取代或引入到杂环胺基中。衍生物在1位进一步被取代，并且可以任选在3,4,5,6,7,8,9位上被取代。本发明的茚并吡喃和茚并吡喃烷基胺衍生物是有用的抗抑郁剂。公开了其制备和使用方法。

10. 发明授权

US4066780A Pyranoindole derivatives as antiulcer agents 失效
标题翻译：吡咯并吲哚衍生物作为抗溃疡剂
公开(公告)号：US4066780A
公开(公告)日：1978-01-03
申请号：US736606
申请日：1976-10-28
申请人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
发明人： Christopher A. Demerson , Leslie G. Humber , Andre A. Asselin , Ivo Jirkovsky , Thomas A. Dobson
IPC分类号： C07D209/08 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535
CPC分类号： C07D209/08 , Y10S514/925
摘要： Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substitutents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano-and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
摘要翻译：吡喃并吲哚和噻喃并吲哚衍生物，其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基（低级）烷基，或具有所述基团公开了连接于吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位的化合物。氨基（低级）烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。仅在位置1具有氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物，其仅在位置9具有氨基（低级）烷基，在位置1具有两个取代基，并且可以在3,4,5,6,7和8位上任选被取代 ; 具有位置1和9位置上的氨基（低级）烷基的衍生物在位置1处进一步被取代，并且可以在3,4,5,6,7和8位任意被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁药和抗溃疡剂。还公开了这些衍生物的制备和使用方法。

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