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1. 发明授权

US4585591A 17.beta.-ethynylsteroids and process for preparing same 失效
标题翻译： 17β-乙炔基甾类化合物及其制备方法
公开(公告)号：US4585591A
公开(公告)日：1986-04-29
申请号：US325026
申请日：1981-11-25
申请人： Issei Nitta , Shinichiro Fujimori , Toshio Haruyama , Shinya Inoue
发明人： Issei Nitta , Shinichiro Fujimori , Toshio Haruyama , Shinya Inoue
IPC分类号： C07J7/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J1/00
CPC分类号： C07J41/0038 , C07J13/005 , C07J31/006 , C07J7/0005 , C07J7/0045
摘要： This is disclosed novel intermediates, i.e. 17.beta.-ethynylsteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for preparing the same.
摘要翻译：公开了可用于制备皮质激素例如氢化可的松和泼尼松龙的新型中间体，即17β-乙炔基甾类化合物及其制备方法。

2. 发明授权

US4440689A Acyloxysteroids and process for producing same 失效
标题翻译： Acyloxoidsoids及其生产方法
公开(公告)号：US4440689A
公开(公告)日：1984-04-03
申请号：US396447
申请日：1982-07-08
申请人： Issei Nitta , Shinichiro Fujimori , Toshio Haruyama , Shinya Inoue
发明人： Issei Nitta , Shinichiro Fujimori , Toshio Haruyama , Shinya Inoue
IPC分类号： C07J5/00 , C07J7/00 , C07J41/00 , C07J9/00
CPC分类号： C07J7/0085 , C07J41/0033 , C07J41/0038 , C07J5/0053 , C07J7/0005 , C07J7/0045
摘要： There is disclosed novel intermediates, i.e. acyloxysteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for producing the same.
摘要翻译：公开了可用于制备皮质激素例如氢化可的松和泼尼松龙的新颖中间体即辅助固醇类及其制备方法。

3. 发明授权

US4814507A Arylsulfone compounds as anti-ulcer agents 失效
标题翻译：芳砜化合物作为抗溃疡剂
公开(公告)号：US4814507A
公开(公告)日：1989-03-21
申请号：US95766
申请日：1987-09-14
申请人： Akihiro Tobe , Shinichiro Fujimori , Tomoshi Yamazaki , Mamoru Sugano , Ryoji Kikumoto , Issei Nitta
发明人： Akihiro Tobe , Shinichiro Fujimori , Tomoshi Yamazaki , Mamoru Sugano , Ryoji Kikumoto , Issei Nitta
IPC分类号： A61K31/135 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/495 , A61P1/04 , C07C47/11 , C07C67/00 , C07C313/00 , C07C317/22 , C07C317/32 , C07C317/44 , C07C317/46 , C07C317/48 , C07D295/08 , C07D295/092 , C07D295/096 , C07D333/76 , C07C87/28 , C07C147/00
CPC分类号： C07D295/096 , C07D295/088 , C07D333/76
摘要： A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylkene; Y is -(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.

4. 发明授权

US4734500A O-aminoalkylene (or aminoalkyleneoxy) phenylsulfone compounds having anti-ulcer effect 失效
标题翻译：具有抗溃疡作用的O-氨基亚烷基（或氨基亚烷氧基）苯基砜化合物
公开(公告)号：US4734500A
公开(公告)日：1988-03-29
申请号：US838569
申请日：1986-03-11
申请人： Akihiro Tobe , Shinichiro Fujimori , Tomoshi Yamazaki , Mamoru Sugano , Ryoji Kikumoto , Issei Nitta
发明人： Akihiro Tobe , Shinichiro Fujimori , Tomoshi Yamazaki , Mamoru Sugano , Ryoji Kikumoto , Issei Nitta
IPC分类号： A61K31/135 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/495 , A61P1/04 , C07C47/11 , C07C67/00 , C07C313/00 , C07C317/22 , C07C317/32 , C07C317/44 , C07C317/46 , C07C317/48 , C07D295/08 , C07D295/092 , C07D295/096 , C07D333/76 , C07D333/50
CPC分类号： C07D295/096 , C07D295/088 , C07D333/76
摘要： A novel sulfone compound represented by the general formula (I) ##STR1## wherein R.sup.1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R.sup.1 and R.sup.2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; X is oxygen or methylene; Y is --(CH.sub.2).sub.n --, wherein n is an integer of 0, 5 or 6, or ##STR2## wherein m is an integer 1-3; R.sup.6 is hydrogen, C.sub.1 -C.sub.3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R.sup.7 is hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sup.6 and R.sup.7 may form a ring together with N, or ##STR3## wherein R.sup.8 is hydrogen, C.sub.1 -C.sub.3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.
摘要翻译：由通式（I）表示的新型砜化合物其中R 1是环己基，苯基; 或被选自硝基，C 1 -C 3烷基，C 1 -C 3烷氧基和卤素的基团取代的苯基; R2，R3，R4和R5分别是氢，卤素，氰基或羰基，其中R1和R2可以形成被至少一个选自硝基C1-C3烷基，C1-C3烷氧基的基团取代的邻亚苯基或邻亚苯基和卤素; X是氧或亚甲基; Y是 - （CH 2）n - ，其中n是0或5或6的整数，或者其中m是整数1-3; R6是氢，C1-C3烷基，ω-烷基氨基烷基，其中每个烷基具有1-3个碳原子，或ω-二烷基氨基烷基，其中每个烷基具有1-3个碳原子; R7是氢或C1-C3烷基; 并且R 6和R 7可以与N或其中R 8是氢，C 1 -C 3羟基烷基或苯基形成环; 或其药学上可接受的盐。该化合物具有抗溃疡作用。

5. 发明授权

US4933344A Ethanone oximes and pharmaceutical compositions thereof 失效
公开(公告)号：US4933344A
公开(公告)日：1990-06-12
申请号：US239169
申请日：1988-08-31
申请人： Shinichiro Fujimori , Satoshi Yamazaki , Mamoru Sugano , Makoto Kawamura , Kunihiro Ninomiya , Akihiro Tobe , Issei Nitta
发明人： Shinichiro Fujimori , Satoshi Yamazaki , Mamoru Sugano , Makoto Kawamura , Kunihiro Ninomiya , Akihiro Tobe , Issei Nitta
IPC分类号： C07D295/12 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/54 , A61K31/5415 , A61P1/04 , C07D233/61 , C07D279/18 , C07D279/30 , C07D295/125 , C07D307/91 , C07D333/76 , C07D339/08 , C07D521/00
CPC分类号： C07D307/91 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/30 , C07D295/125 , C07D333/76 , C07D339/08
摘要： Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piparazino group, imidazolyl group, 4-alkyl substituted imidazolyl group or substituted amino group,R.sup.2 represents a hydrogen atom or an alkoxy group having 1 to 3 carbon atoms, andR.sup.3 represents a piperidino group, piperazino group or 4-alkyl substituted piperazino group, orR.sup.1 and R.sup.2 together with a phenyl group to which they are attached may form a phenothiazin-2-yl group, N-acetyl-phenothiazin-2-yl group, thianthren-2-yl group, dibenzothiophen-3-yl group, dibenzofuran-3-yl group or a group of the formula: ##STR2## wherein R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or a pharmaceutically acceptable acid addition salts thereof are disclosed. They are a potent antiulcer agent.

6. 发明授权

US4977151A Ethanone oximes and pharmaceutical compositions thereof 失效
标题翻译：乙酮肟及其药物组合物
公开(公告)号：US4977151A
公开(公告)日：1990-12-11
申请号：US501591
申请日：1990-03-29
申请人： Shinichiro Fujimori , Satoshi Yamazaki , Mamoru Sugano , Makoto Kawamura , Kunihiro Ninomiya , Akihiro Tobe , Issei Nitta
发明人： Shinichiro Fujimori , Satoshi Yamazaki , Mamoru Sugano , Makoto Kawamura , Kunihiro Ninomiya , Akihiro Tobe , Issei Nitta
IPC分类号： C07D295/12 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/54 , A61K31/5415 , A61P1/04 , C07D233/61 , C07D279/18 , C07D279/30 , C07D295/125 , C07D307/91 , C07D333/76 , C07D339/08 , C07D521/00
CPC分类号： C07D307/91 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/30 , C07D295/125 , C07D333/76 , C07D339/08
摘要： Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piperazino group, imidazolyl group 4-alkyl substituted imidazolyl group or substituted amino group,R.sup.2 represents a hydrogen atom or an alkoxy group having 1 to 3 carbon atoms, andR.sup.3 represents a piperidino group, piperazino group or 4-alkyl substituted piperazino group, orR.sup.1 and R.sup.2 together with a phenyl group to which they are attached may form a phenothiazin-2-yl group, N-acetyl-phenothiazin-2-yl group, thianthren-2-yl group, dibenzothiophen-3-yl group, dibenzofuran-3-yl group or a group of the formula: ##STR2## wherein R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or a pharmaceutically acceptable acid addition salts thereof are disclosed. They are a potent antiulcer agent.

7. 发明授权

US07986899B2 Development unit, process cartridge and image forming apparatus 有权
标题翻译：显影单元，处理盒和成像设备
公开(公告)号：US07986899B2
公开(公告)日：2011-07-26
申请号：US12417264
申请日：2009-04-02
申请人： Shinichi Kuramoto , Yoshifumi Ozaki , Takashi Ochi , Shinichiro Fujimori , Kenji Ogi , Akihiko Noda
发明人： Shinichi Kuramoto , Yoshifumi Ozaki , Takashi Ochi , Shinichiro Fujimori , Kenji Ogi , Akihiko Noda
IPC分类号： G03G15/08 , G03G15/09
CPC分类号： G03G15/0898 , G03G15/0855 , G03G15/0865 , G03G15/0889 , G03G2215/0802
摘要： A development unit includes a developer accommodating part that accommodates a developer therein, a developer stirring-transporting member that transports the developer in the developer accommodating part while stirring the developer, a bearing part that receives a rotating shaft of the developer stirring-transporting member, a magnetic member that is located between the bearing part and the developer accommodating part and fixed around the rotating shaft, and a stirring member that is spaced apart from the magnetic member so as to be opposed to the magnetic member and that is arranged at the rotating shaft of the developer stirring-transporting member.
摘要翻译：显影单元包括容纳其中的显影剂的显影剂容纳部分，在搅拌显影剂的同时将显影剂输送到显影剂容纳部分中的显影剂搅拌输送部件;接收显影剂搅拌输送部件的旋转轴的支承部件，位于所述支承部和所述显影剂容纳部之间并固定在所述旋转轴周围的磁性部件，以及搅拌部件，与所述磁性部件间隔开以与所述磁性部件相对并且配置在所述旋转体显影剂搅拌输送部件的轴。

8. 发明授权

US4265816A Process for preparing steroid-carboxylates 失效
标题翻译：类固醇羧酸盐的制备方法
公开(公告)号：US4265816A
公开(公告)日：1981-05-05
申请号：US145693
申请日：1980-05-01
申请人： Hiromi Okushima , Shinichiro Fujimori , Rikizo Furuya , Shuzo Hayakawa
发明人： Hiromi Okushima , Shinichiro Fujimori , Rikizo Furuya , Shuzo Hayakawa
IPC分类号： C07J21/00 , C07J31/00 , C07J51/00 , C07J9/00
CPC分类号： C07J21/003 , C07J51/00
摘要： An alkali metal salt of a 3-(17.beta.-hydroxyandrosten-3-one 3-acetal-17.alpha.-yl)propiolic acid which is useful as an intermediate in the preparation of 3-(3-oxo-7.alpha.-acetylthio-17.beta.-hydroxyandrost-4-en-17.alpha.-yl)-propiolactone (spironolactone) as antialdosteronic diuretics and hypotensive agents is prepared by reacting a 17.beta.-hydroxypregnen-20-yn-3-one 3-acetal (I) with an alkali metal dimsyl (II) to give an alkali metal salt of the 17.beta.-hydroxypregnen-20-yn-3-one 3-acetal (III), and reacting the compound (III) with carbon dioxide followed by hydrolysis.
摘要翻译： 3-（3-氧代-7α-乙酰基硫基）丙酸的3-（17β-羟基和3-酮-3-缩醛-17α-基）丙炔酸的碱金属盐，可用作中间体， 17β-羟基雄甾-4-烯-17α-基） - 丙内酯（螺内酯）作为抗增殖利尿剂和降血糖药是通过使17β-羟基孕烯-20-炔-3-酮3-缩醛（I）与碱金属二甲基（II），得到17β-羟基孕烯-20-炔-3-酮3-缩醛（III）的碱金属盐，并使化合物（III）与二氧化碳反应，然后水解。

9. 发明申请

US20100142983A1 IMAGE FORMING APPARATUS 有权
标题翻译：图像形成装置
公开(公告)号：US20100142983A1
公开(公告)日：2010-06-10
申请号：US12464460
申请日：2009-05-12
申请人： Yoshifumi Ozaki , Shinichiro Fujimori , Takashi Ochi , Akihiko Noda , Shinichi Kuramoto , Kenji Ogi
发明人： Yoshifumi Ozaki , Shinichiro Fujimori , Takashi Ochi , Akihiko Noda , Shinichi Kuramoto , Kenji Ogi
IPC分类号： G03G15/00
CPC分类号： G03G15/5062
摘要： There is provided an image forming apparatus. The image forming apparatus, after controlling so as to develop the developer image representing the predetermined image formed a plurality of times in the same location on an image carrier by an exposing component, controls such that without performing exposure with the exposing component, the developer image, developed on the image carrier by the developing component applying a biasing voltage to the developer so as to adhere the developer to the image carrier including to the same location on the image carrier, is transferred to the transfer component and detects whether or not a ghost image is generated by comparing the density detected by a detecting component at a position of a transfer body corresponding to the same location of the image carrier to a reference density.
摘要翻译：提供了一种图像形成装置。图像形成装置在通过曝光分量在图像载体上在相同位置上形成表示预定图像的显影剂图像的控制之后，控制使得不用曝光成分进行曝光，显影剂图像通过显影部件在显影部件上向显影剂施加偏置电压以将显影剂粘附到包括在图像载体上的相同位置的图像载体上的图像载体上被传送到传送部件并检测是否存在重影通过将与图像载体的相同位置对应的传送体的位置处的检测部件检测到的浓度与参考密度进行比较来生成图像。

10. 发明授权

US07680426B2 Image forming apparatus with air flow blocking mechanism 有权
标题翻译：具有气流阻塞机构的成像装置
公开(公告)号：US07680426B2
公开(公告)日：2010-03-16
申请号：US11955964
申请日：2007-12-13
申请人： Shinichiro Fujimori
发明人： Shinichiro Fujimori
IPC分类号： G03G15/08 , G03G15/09
CPC分类号： G03G15/0942
摘要： In a configuration with a plurality of developing units, an influx of air into one developing unit from another developing unit can be blocked with a simple configuration. An operation section for a developing unit that is not in operation rotates a developer roll in the reverse direction to move developer accumulated on a pickoff pole, and fills a clearance formed between a housing and the developer roll with the developer so that the air flow of the developing unit that is not in operation is blocked. Accordingly, even if a difference in pressure between a developing unit that is in operation and a developing unit that is not in operation occurs, an air flow from the developing unit in operation to the developing unit not in operation is not apt to be formed, and an influx of air into the developing unit that is not in operation is blocked.
摘要翻译：在具有多个显影单元的构造中，能够以简单的构造阻止从另一显影单元流入一个显影单元的空气。用于不操作的显影单元的操作部分使显影辊沿相反方向旋转，以移动积聚在拾取极上的显影剂，并且用显影剂填充形成在外壳和显影辊之间的间隙，使得空气流不工作的显影单元被阻挡。因此，即使在运转中的显影单元与未进行运转的显影单元之间的压力差发生的情况下，也不易形成来自显影单元的运转中的空气流向显影单元的运转，并且空气流入不在运行中的显影单元被阻挡。

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