专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110178283A1 Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes 有权
标题翻译：通过分析基因组的基因和内含子区域导致的核糖核酸干扰分子和结合位点
公开(公告)号：US20110178283A1
公开(公告)日：2011-07-21
申请号：US11408557
申请日：2006-04-21
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy
IPC分类号： C07H21/02
CPC分类号： G06F19/22 , G06F19/18
摘要： Sequences that can be used in the context of controlled gene regulation are provided. In one aspect, at least one sequence comprising at least one of one or more sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326 is provided. One or more of the provided sequences may be computationally predicted, e.g., from publicly available genomes, using a method based on pattern discovery. In another aspect, a method for regulating the expression of a transcript comprises the step of said transcript containing a region that corresponds to at least one of the provided sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326, the region being targeted either by a naturally occurring, or appropriately designed, interfering RNA molecule that regulates the expression of said transcript through post-transcriptional silencing. In a third aspect, a method for regulating the expression of a transcript comprises the step of at least one of the provided sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326 being used to design an interfering RNA molecule that contains a region that corresponds to the reverse complement of one or more of the one or more sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326, the interfering molecule regulating, through post-transcriptional silencing, one or more transcripts that contain said sequence of the one or more sequences having SEQ ID NO: 1 through SEQ ID NO: 747,326, or a substantial fraction thereof.
摘要翻译：提供了可在受控基因调控环境中使用的序列。在一个方面，提供至少一个包含具有SEQ ID NO：1至SEQ ID NO：747,326的一个或多个序列中的至少一个的序列。所提供的序列中的一个或多个可以使用基于模式发现的方法从计算上预测，例如来自公众可获得的基因组。在另一方面，调节转录物表达的方法包括所述转录物的步骤，所述转录物含有对应于至少一个所提供的具有SEQ ID NO：1至SEQ ID NO：747,326的序列的区域，所述区域被靶向通过天然存在或适当设计的干扰RNA分子，其通过转录后沉默调节所述转录物的表达。在第三方面，用于调节转录物表达的方法包括提供的具有SEQ ID NO：1至SEQ ID NO：747,326的序列中的至少一个的步骤用于设计干扰RNA分子，所述干扰RNA分子含有对应于具有SEQ ID NO：1至SEQ ID NO：747,326的一个或多个一个或多个序列的反向互补序列，干扰分子通过转录后沉默调节一个或多个含有所述序列的所述序列的转录本或更多的具有SEQ ID NO：1至SEQ ID NO：747,326的序列，或其相当一部分。

2. 发明授权

US08178503B2 Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes 有权
标题翻译：通过分析基因组的基因和内含子区域导致的核糖核酸干扰分子和结合位点
公开(公告)号：US08178503B2
公开(公告)日：2012-05-15
申请号：US11408557
申请日：2006-04-21
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy
IPC分类号： C12N15/11
CPC分类号： G06F19/22 , G06F19/18
摘要： In one aspect of the invention, a method for regulating the expression of a transcript comprises using at least one interfering RNA molecule that binds to an area of transcript containing a region that corresponds to at least one sequence having SEQ ID NO: 1, the interfering RNA molecule regulating the expression of the transcript through post-transcriptional silencing. In another aspect, a method for regulating the expression of a transcript comprises at least one of the provided sequences having SEQ ID NO: 1 being used to design an interfering RNA molecule that contains a region that corresponds to the reverse complement of one or more sequences having SEQ ID NO: 1, the interfering molecule regulating, through post-transcriptional silencing, transcripts that contain the sequence having SEQ ID NO: 1.
摘要翻译：在本发明的一个方面，用于调节转录物表达的方法包括使用至少一种干扰RNA分子，所述干扰RNA分子与含有对应于至少一个具有SEQ ID NO：1的序列的区域的转录物区域结合， RNA分子通过转录后沉默调节转录本的表达。另一方面，用于调节转录物表达的方法包括提供的具有SEQ ID NO：1的序列中的至少一个用于设计干扰RNA分子，其包含对应于一个或多个序列的反向互补序列的区域具有SEQ ID NO：1的干扰分子通过转录后沉默调节含有具有SEQ ID NO：1的序列的转录物。

3. 发明授权

US08065091B2 Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof 有权
标题翻译：用于连接非编码和基因编码脱氧核糖核酸序列的技术及其应用
公开(公告)号：US08065091B2
公开(公告)日：2011-11-22
申请号：US11928611
申请日：2007-10-30
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy , Kevin Charles Miranda
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy , Kevin Charles Miranda
IPC分类号： G01N33/48
CPC分类号： G06F19/22 , G06F19/18
摘要： Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.
摘要翻译：提供了用于连接基因组的非编码区和基因编码区的技术。一方面，确定生物体基因组中非编码序列与基因编码序列之间的关联的方法包括以下步骤。从一个或多个非编码序列鉴定至少一个保守区。保守区域的另外的实例位于正在考虑的生物体中的一个或多个基因的非翻译区或氨基酸编码区，并且保守区与这些一个或多个基因参与的一个或多个生物学过程相关。

4. 发明申请

US20090093624A1 Techniques for Linking Non-Coding and Gene-Coding Deoxyribonucleic Acid Sequences and Applications Thereof 审中-公开
标题翻译：用于连接非编码和基因编码脱氧核糖核酸序列的技术及其应用
公开(公告)号：US20090093624A1
公开(公告)日：2009-04-09
申请号：US11928523
申请日：2007-10-30
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy , Kevin Charles Miranda
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice Carolyn McHardy , Kevin Charles Miranda
IPC分类号： C07H21/02
CPC分类号： G16B30/00 , G16B20/00
摘要： Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.
摘要翻译：提供了用于连接基因组的非编码区和基因编码区的技术。一方面，确定生物体基因组中非编码序列与基因编码序列之间的关联的方法包括以下步骤。从一个或多个非编码序列鉴定至少一个保守区。保守区域的另外的实例位于正在考虑的生物体中的一个或多个基因的非翻译区或氨基酸编码区，并且保守区与这些一个或多个基因参与的一个或多个生物学过程相关。

5. 发明申请

US20080052008A1 Techniques for Linking Non-Coding and Gene-Coding Deoxyribonucleic Acid Sequences and Applications Thereof 有权
标题翻译：用于连接非编码和基因编码脱氧核糖核酸序列的技术及其应用
公开(公告)号：US20080052008A1
公开(公告)日：2008-02-28
申请号：US11928611
申请日：2007-10-30
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice McHardy , Kevin Miranda
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice McHardy , Kevin Miranda
IPC分类号： G06F19/00 , C07H21/04 , C12Q1/68
CPC分类号： G06F19/22 , G06F19/18
摘要： Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.
摘要翻译：提供了用于连接基因组的非编码区和基因编码区的技术。一方面，确定生物体基因组中非编码序列与基因编码序列之间的关联的方法包括以下步骤。从一个或多个非编码序列鉴定至少一个保守区。保守区域的另外的实例位于正在考虑的生物体中的一个或多个基因的非翻译区或氨基酸编码区，并且保守区与这些一个或多个基因参与的一个或多个生物学过程相关。

6. 发明申请

US20070042397A1 Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof 审中-公开
标题翻译：用于连接非编码和基因编码脱氧核糖核酸序列的技术及其应用
公开(公告)号：US20070042397A1
公开(公告)日：2007-02-22
申请号：US11367512
申请日：2006-03-03
申请人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice McHardy , Kevin Miranda
发明人： Isidore Rigoutsos , Tien Huynh , Aristotelis Tsirigos , Alice McHardy , Kevin Miranda
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B30/00 , G16B20/00
摘要： Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.
摘要翻译：提供了用于连接基因组的非编码区和基因编码区的技术。一方面，确定生物体基因组中非编码序列与基因编码序列之间的关联的方法包括以下步骤。从一个或多个非编码序列鉴定至少一个保守区。保守区域的另外的实例位于正在考虑的生物体中的一个或多个基因的非翻译区或氨基酸编码区，并且保守区与这些一个或多个基因参与的一个或多个生物学过程相关。

7. 发明申请

US20050267692A1 Method and system for the detection of atypical sequences via generalized compositional methods 失效
标题翻译：通过广义组成方法检测非典型序列的方法和系统
公开(公告)号：US20050267692A1
公开(公告)日：2005-12-01
申请号：US10855367
申请日：2004-05-28
申请人： Aristotelis Tsirigos , Isidore Rigoutsos
发明人： Aristotelis Tsirigos , Isidore Rigoutsos
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/22 , Y10S707/99936
摘要： A method and system for determining whether a sequence fragment g is atypical with respect to a reference sequence G using compositional methods and including constructing a template from G and g respectively containing a sequence of characters for a comparison with one another, wherein a number of characters contained in the template exceeds two. For the case where the sequences at hand are genetic, the atypicality detection can be used to determine whether a given sequence fragment g is the result of a horizontal transfer event.
摘要翻译：一种用于使用组合方法确定序列片段g是否不典型的方法和系统，并且包括构建分别包含用于彼此比较的字符序列的G和g的模板，其中多个字符包含在模板中超过两个。对于手头序列是遗传的情况，可以使用非典型性检测来确定给定的序列片段g是否是水平传递事件的结果。

8. 发明申请

US20090312191A1 METHOD AND SYSTEM FOR THE DETECTION OF ATYPICAL SEQUENCES VIA GENERALIZED COMPOSITIONAL METHODS 失效
标题翻译：通过一般化的组合方法检测原位序列的方法和系统
公开(公告)号：US20090312191A1
公开(公告)日：2009-12-17
申请号：US12545707
申请日：2009-08-21
申请人： Aristotelis Tsirigos , Isidore Rigoutsos
发明人： Aristotelis Tsirigos , Isidore Rigoutsos
IPC分类号： C40B30/02
CPC分类号： G06F19/22 , Y10S707/99936
摘要： A method and system for determining whether a sequence fragment g is atypical with respect to a reference sequence G using compositional methods and including constructing a template from G and g respectively containing a sequence of characters for a comparison with one another, wherein a number of characters contained in the template exceeds two. For the case where the sequences at hand are genetic, the atypicality detection can be used to determine whether a given sequence fragment g is the result of a horizontal transfer event.
摘要翻译：一种用于使用组合方法确定序列片段g是否不典型的方法和系统，并且包括构建分别包含用于彼此比较的字符序列的G和g的模板，其中多个字符包含在模板中超过两个。对于手头序列是遗传的情况，可以使用非典型性检测来确定给定的序列片段g是否是水平传递事件的结果。

9. 发明授权

US07613662B2 Apparatus, machine-readable medium, and system for the detection of atypical sequences via generalized compositional methods 失效
标题翻译：仪器，机器可读介质和用于通过广义组成方法检测非典型序列的系统
公开(公告)号：US07613662B2
公开(公告)日：2009-11-03
申请号：US10855367
申请日：2004-05-28
申请人： Aristotelis Tsirigos , Isidore Rigoutsos
发明人： Aristotelis Tsirigos , Isidore Rigoutsos
IPC分类号： G06N3/12
CPC分类号： G06F19/22 , Y10S707/99936
摘要： A method and system for determining whether a sequence fragment g is atypical with respect to a reference sequence G using compositional methods and including constructing a template from G and g respectively containing a sequence of characters for a comparison with one another, wherein a number of characters contained in the template exceeds two. For the case where the sequences at hand are genetic, the atypicality detection can be used to determine whether a given sequence fragment g is the result of a horizontal transfer event.
摘要翻译：一种用于使用组合方法确定序列片段g是否不典型的方法和系统，并且包括构建分别包含用于彼此比较的字符序列的G和g的模板，其中多个字符包含在模板中超过两个。对于手头序列是遗传的情况，可以使用非典型性检测来确定给定的序列片段g是否是水平传递事件的结果。

10. 发明授权

US07962427B2 Method for the detection of atypical sequences via generalized compositional methods 失效
标题翻译：通过广泛的组合方法检测非典型序列的方法
公开(公告)号：US07962427B2
公开(公告)日：2011-06-14
申请号：US12545707
申请日：2009-08-21
申请人： Aristotelis Tsirigos , Isidore Rigoutsos
发明人： Aristotelis Tsirigos , Isidore Rigoutsos
IPC分类号： G06N3/12
CPC分类号： G06F19/22 , Y10S707/99936
摘要： A method and system for determining whether a sequence fragment g is atypical with respect to a reference sequence G using compositional methods and including constructing a template from G and g respectively containing a sequence of characters for a comparison with one another, wherein a number of characters contained in the template exceeds two. For the case where the sequences at hand are genetic, the atypicality detection can be used to determine whether a given sequence fragment g is the result of a horizontal transfer event.
摘要翻译：一种用于使用组合方法确定序列片段g是否不典型的方法和系统，并且包括构建分别包含用于彼此比较的字符序列的来自G和g的模板，其中多个字符包含在模板中超过两个。对于手头序列是遗传的情况，可以使用非典型性检测来确定给定的序列片段g是否是水平传递事件的结果。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式