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1. 发明授权

US4490393A Thiazolylurea derivatives, a process for preparing same and a pharmaceutical composition containing same 失效
标题翻译：噻唑基脲衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4490393A
公开(公告)日：1984-12-25
申请号：US420260
申请日：1982-09-17
申请人： Isao Sakano , Tatsuro Yokoyama , Seitaro Kajiya , Tamotsu Minami , Yutaka Okazaki , Hiroshi Tokuda , Hiroshi Kawazura , Mikio Kumakura , Takuo Nakano , Akira Awaya
发明人： Isao Sakano , Tatsuro Yokoyama , Seitaro Kajiya , Tamotsu Minami , Yutaka Okazaki , Hiroshi Tokuda , Hiroshi Kawazura , Mikio Kumakura , Takuo Nakano , Akira Awaya
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61K31/44 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , C07D277/48 , C07D277/54 , C07D417/12 , C07D277/46
CPC分类号： C07D417/12 , C07D277/48 , C07D277/54 , Y10S514/825
摘要： The present invention provides thiazolyl derivatives as new chemical substance represented by the general formula: ##STR1## wherein R.sup.1 stands for a lower alkyl group or a substituted or unsubstituted phenyl group, R.sup.2 for a hydrogen atom, a lower alkyl, lower alkoxy or lower alkylthio group, and R.sup.3 for a pyridyl or iso-oxazolyl group or a grouping of the general formula: ##STR2## processes for preparing same and pharmaceutical compositions containing the thiazolyl derivatives. More particularly, the present invention provides new thiazolyl derivatives which possess immuno-modulating activity and are thus therapeutically effective against immunodiseases such as chronic rheumatoid arthritis and also useful against viral diseases or for the immunotherapy of cancers and possess properties desirous as medicines with a slight toxicity, processes for preparing same and pharmaceutical compositions containing the new substance.
摘要翻译： PCT No.PCT / JP82 / 00021 Sec。 371日期1982年9月17日 102（e）1982年9月17日PCT申请日1982年1月21日PCT公布。公开号WO82 / 02553 日本1982年8月5日。本发明提供噻唑衍生物作为新化学物质，其通式如下：其中R1代表低级烷基或取代或未取代的苯基，R2表示氢原子，低级烷基，低级烷氧基或低级烷硫基，R3代表吡啶基或异恶唑基或下列通式的基团：其制备方法和含有噻唑衍生物的药物组合物。更具体地说，本发明提供了具有免疫调节活性的新的噻唑基衍生物，因此具有抗免疫性疾病如慢性类风湿性关节炎的治疗有效性，并且还可用于抗病毒疾病或癌症的免疫治疗，并具有希望作为具有轻微毒性的药物的性质，其制备方法和含有该新物质的药物组合物。

2. 发明授权

US5106585A Method and apparatus for cleaving deoxyribonucleic acid 失效
标题翻译：用于清除脱氧核糖酸的方法和装置
公开(公告)号：US5106585A
公开(公告)日：1992-04-21
申请号：US672253
申请日：1984-10-29
申请人： Tamotsu Minami , Nobumi Kusuhara , Mitsuio Onofusa , Toshihiro Sasaki
发明人： Tamotsu Minami , Nobumi Kusuhara , Mitsuio Onofusa , Toshihiro Sasaki
IPC分类号： C07H21/00 , C07H21/04
CPC分类号： C07H21/00
摘要： The invention relates to a procedure for chemically determining the base sequence of DNA and, in particular, its step of cleaving the labeled DNA having undergone a base-selective chemical modification at the position of the modified base. More particularly, it relates to a method for cleaving DNA which comprises modifying DNA base-selectively with chemical reagents, bringing the resulting reaction mixture into contact with an adsorbent to adsorb the chemically modified DNA on the adsorbent, washing the adsorbent with a washing fluid to remove any chemical modification reagents from the adsorbent, bringing the adsorbent into contact with an eluent to elute the chemically modified DNA adsorbed thereon, concentrating the resulting eluate and then heating it together with a cleavage reagent.This invention also relates to apparatus for carrying out the above-described method which comprises a reactor 1 for receiving the reaction mixture having undergone a chemical modification reaction of DNA, a transfer pump 4, an adsorber 2 containing an adsorbent, a three-way valve 5 and a concentrator 3, these units being interconnected by conduits in the order mentioned.
摘要翻译： PCT No.PCT / JP84 / 00074 Sec。 371日期1984年10月29日 102（e）日期1984年10月29日PCT提交1984年3月1日PCT公布。公开号WO84 / 0351200 日本1984年9月13日。本发明涉及化学测定DNA的碱基序列的方法，特别是涉及在经修饰的碱基位置切割经过碱选择性化学修饰的经标记的DNA的步骤。更具体地说，本发明涉及一种用于切割DNA的方法，其包括用化学试剂选择性地修饰DNA碱基，使得到的反应混合物与吸附剂接触以将化学修饰的DNA吸附在吸附剂上，用洗涤液洗涤吸附剂从吸附剂中除去任何化学修饰试剂，使吸附剂与洗脱液接触以洗脱其上吸附的化学修饰的DNA，浓缩所得洗脱液，然后与裂解试剂一起加热。本发明还涉及用于实施上述方法的装置，其包括用于接收已经经历DNA的化学改性反应的反应混合物的反应器1，转移泵4，含有吸附剂的吸附器2，三通阀 5和集中器3，这些单元通过导管以所述顺序互连。

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