专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4476128A 2-Substituted thiazolyl-piperazine compounds, process for preparation thereof and utilizations thereof _ 失效
标题翻译： 2-取代的噻唑基 - 哌嗪化合物，其制备方法及其用途
公开(公告)号：US4476128A
公开(公告)日：1984-10-09
申请号：US458311
申请日：1983-01-13
申请人： Isao Sakano , Shiyoichiro Miyahara , Yoshitsugu Yamada , Yutaka Okazaki , Hiroshi Tokuda , Akira Awaya , Takuo Nakano
发明人： Isao Sakano , Shiyoichiro Miyahara , Yoshitsugu Yamada , Yutaka Okazaki , Hiroshi Tokuda , Akira Awaya , Takuo Nakano
IPC分类号： C07D277/20 , A61K31/495 , A61P29/00 , A61P35/00 , A61P37/04 , C07D277/42 , C07D417/04
CPC分类号： C07D277/42
摘要： The present invention relates to a piperazine compound represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom or a phenyl group, R.sup.1 stands for a hydrogen atom or an alkyl group, and R.sup.2 stands for a hydrogen atom or an alkyl group.These compounds are valuable as immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of the immune function.
摘要翻译：本发明涉及由以下通式（I）表示的哌嗪化合物：其中X代表氢原子或苯基，R1代表氢原子或烷基，R2代表对于氢原子或烷基。这些化合物作为免疫增强剂是有价值的，例如用于治疗慢性类风湿性关节炎和伴有免疫功能的减少或异常变化的其它疾病。

2. 发明授权

US4446133A 1-Phenyl-4-carbamoyl piperazine compounds, process for preparation thereof and utilizations thereof 失效
标题翻译： 1-苯基-4-氨基甲酰基哌嗪化合物，其制备方法及其用途
公开(公告)号：US4446133A
公开(公告)日：1984-05-01
申请号：US235112
申请日：1981-02-13
申请人： Yutaka Okazaki , Hiroshi Tokuda , Shiyoichiro Miyahara , Yoshitsugu Yamada
发明人： Yutaka Okazaki , Hiroshi Tokuda , Shiyoichiro Miyahara , Yoshitsugu Yamada
IPC分类号： C07D295/20 , A61K31/495 , A61P37/04 , C07D295/215 , C07D241/04
CPC分类号： C07D295/215 , Y10S514/825
摘要： The present invention relates to a novel piperazine compound represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen or halogen atom, an alkoxy, carboxy or alkoxycarbonyl group or a group R.sup.3 CO-- in which R.sup.3 stands for an alkyl group having 1 to 4 carbon atoms, R.sup.1 stands for a hydrogen atom or an alkyl group, and R.sup.2 stands for a hydrogen atom or an alkyl group.These compounds are valuable as immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of the immune function.
摘要翻译：本发明涉及由以下通式（I）表示的新型哌嗪化合物：其中X表示氢或卤素原子，烷氧基，羧基或烷氧基羰基或基团R 3 CO-，其中R 3 代表具有1至4个碳原子的烷基，R1代表氢原子或烷基，R2代表氢原子或烷基。这些化合物作为免疫增强剂是有价值的，例如用于治疗慢性类风湿性关节炎和伴有免疫功能的减少或异常变化的其它疾病。

3. 发明授权

US4420481A Use of piperazine compounds as immunopotentiating agents 失效
标题翻译：使用哌嗪化合物作为免疫增强剂
公开(公告)号：US4420481A
公开(公告)日：1983-12-13
申请号：US235992
申请日：1981-02-19
申请人： Yutaka Okazaki , Hiroshi Tokuda , Shiyoichiro Miyahara , Yoshitsugu Yamada
发明人： Yutaka Okazaki , Hiroshi Tokuda , Shiyoichiro Miyahara , Yoshitsugu Yamada
IPC分类号： C07D295/20 , A61K31/495 , A61P37/04 , C07D295/215 , C07D403/00 , C07D401/00
CPC分类号： C07D295/215 , Y10S514/825 , Y10S514/885
摘要： The present invention relates to a novel piperazine compound represented by the following general formula (I): ##STR1## wherein R stands for an alkyl or phenyl group, and n is a number of 4 or 5.These compounds are valuable as an immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of immune function.
摘要翻译：本发明涉及由以下通式（I）表示的新型哌嗪化合物：其中R代表烷基或苯基，n是4或5的数。这些化合物是有价值的免疫增强剂，例如用于治疗慢性类风湿性关节炎和伴随免疫功能的减少或异常变化的其它疾病。

4. 发明授权

US06446629B1 Artificial respiration apparatus 有权
标题翻译：人造呼吸装置
公开(公告)号：US06446629B1
公开(公告)日：2002-09-10
申请号：US09363183
申请日：1999-07-29
申请人： Toshihisa Takaki , Masatake Saito , Mikio Yasukawa , Yasuhito Sugiura , Katsuyoshi Suzuki , Masahiro Kamada , Tomohisa Ohtake , Yoshitsugu Yamada , Kazufuku Nitta
发明人： Toshihisa Takaki , Masatake Saito , Mikio Yasukawa , Yasuhito Sugiura , Katsuyoshi Suzuki , Masahiro Kamada , Tomohisa Ohtake , Yoshitsugu Yamada , Kazufuku Nitta
IPC分类号： A61M1600
CPC分类号： A61M16/0096 , A61M16/0833 , A61M16/202 , A61M16/205 , A61M16/208
摘要： The present invention provides an artificial respiration apparatus 12 of a high oscillation type, in which oxygen supply to a patient P and exhaled gas discharge are urged by an oscillating gas having a higher frequency than the cycle of the patient respiration. The apparatus includes a discharge direction regulating mechanism 7 for regulating the exhaled gas to flow only in the discharge direction.
摘要翻译：本发明提供一种高振荡型人造呼吸装置12，其中向患者P供氧和呼出气体排出的振动气体的频率高于患者呼吸周期。该装置包括排出方向调节机构7，用于调节呼出气体仅沿排出方向流动。

5. 发明授权

US06644963B1 Batch-type kiln 有权
标题翻译：批式窑
公开(公告)号：US06644963B1
公开(公告)日：2003-11-11
申请号：US09625857
申请日：2000-07-26
申请人： Yoshitsugu Yamada
发明人： Yoshitsugu Yamada
IPC分类号： F27D900
CPC分类号： F27D9/00 , F27B17/0016 , F27D7/02 , F27D2003/0075 , F27D2009/0005 , F27D2099/0008
摘要： A novel batch-type kiln and a method of use thereof are provided. The kiln comprises a kiln body and a heating chamber disposed within the kiln body, which has a heater disposed therein. A table is disposed at the bottom of the heating chamber, the table having a peripheral portion and an upper surface for supporting an object to be treated. The peripheral portion of the table and a portion of the kiln body define a gap therebetween. This gap forms a gas-introducing path for introducing a gas into the heating chamber. The batch-type kiln is capable of preventing accumulation of a binder component in the gap between the table and the kiln wall.
摘要翻译：提供了一种新型的分批式窑及其使用方法。该窑炉包括窑体和设置在窑体内的加热室，其具有设置在其中的加热器。桌子设置在加热室的底部，桌子具有用于支撑待处理物体的周边部分和上表面。桌子的周边部分和窑体的一部分在它们之间限定了间隙。该间隙形成用于将气体引入加热室的气体导入路径。分批式窑能够防止粘结剂组分在工作台和窑壁之间的间隙中积聚。

6. 发明授权

US06319195B1 Endoscope 有权
标题翻译：内窥镜
公开(公告)号：US06319195B1
公开(公告)日：2001-11-20
申请号：US09421395
申请日：1999-10-20
申请人： Katsumi Nakaichi , Shinji Yamamori , Yoshitsugu Yamada
发明人： Katsumi Nakaichi , Shinji Yamamori , Yoshitsugu Yamada
IPC分类号： A61B100
CPC分类号： A61B1/267 , A61B1/0052
摘要： An endoscope for intubating an endotracheal tube includes an elongated insertion portion including at least an image transmitting optical fiber bundle, an illumination light transmitting optical fiber bundle, and a bendable element, an operation portion connected to the proximal end portion of the insertion portion, a bending operation mechanism provided in the operation portion, an endotracheal tube connection section provided in the vicinity of a joint between the insertion portion and the operation portion; and a bendable element for bending the insertion portion provided so as to extend from the inside of the insertion portion to the bending operation mechanism.
摘要翻译：插管气管内管的内窥镜包括至少包括图像传输光纤束，照明光传输光纤束和可弯曲元件的细长插入部，连接到插入部的基端部的操作部，设置在操作部中的弯曲操作机构，设置在插入部和操作部之间的接合部附近的气管内管连接部; 以及用于弯曲插入部的弯曲元件，其设置成从插入部分的内部延伸到弯曲操作机构。

7. 发明授权

US06439229B1 Pressure support ventilation control system and method 有权
标题翻译：压力支持通风控制系统及方法
公开(公告)号：US06439229B1
公开(公告)日：2002-08-27
申请号：US09634513
申请日：2000-08-08
申请人： Hong-Lin Du , Marcelo B. P. Amato , Yoshitsugu Yamada , Bich N. Nguyen
发明人： Hong-Lin Du , Marcelo B. P. Amato , Yoshitsugu Yamada , Bich N. Nguyen
IPC分类号： A61M1600
CPC分类号： A61M16/026 , A61M2016/0021 , A61M2016/0039 , A61M2016/0042 , A61M2205/3344 , A61M2230/42
摘要： A system and method of controlling the termination of the inhalation phase in a pressure support ventilation system is disclosed, in which an expiratory trigger sensitivity, or ratio of inspiratory flow rate to peak inspiratory flow rate at which the inspiration phase is terminated, is varied in proportion to variations in a calculated respiratory time constant. The system includes sensors for monitoring pressure and flow of gas during each breath, and, based on the sensor outputs, calculates the respiratory time constant for one breath or a series of breaths. The expiratory trigger sensitivity is automatically increased with increasing patient respiratory time constant, providing a closed loop control of expiratory trigger sensitivity. The expiratory trigger sensitivity may also be varied in response to changes in supra-plateau pressure.
摘要翻译：公开了一种在压力支持通气系统中控制吸入阶段终止的系统和方法，其中呼气触发灵敏度或吸气流速与吸气相终止时的吸气吸气流速之比在与计算的呼吸时间常数的变化成比例。该系统包括用于在每次呼吸期间监测气体的压力和流量的传感器，并且基于传感器输出，计算一次呼吸或一系列呼吸的呼吸时间常数。呼气触发灵敏度随着患者呼吸时间常数的增加而自动增加，提供呼气触发灵敏度的闭环控制。呼气触发灵敏度也可以响应于超平台压力的变化而变化。

8. 发明授权

US06209540B1 Artificial respiration apparatus 有权
标题翻译：人造呼吸装置
公开(公告)号：US06209540B1
公开(公告)日：2001-04-03
申请号：US09280973
申请日：1999-03-30
申请人： Yasuhito Sugiura , Mikio Yasukawa , Katsuyoshi Suzuki , Masahiro Kamada , Toshihisa Takaki , Kazufuku Nitta , Yoshitsugu Yamada
发明人： Yasuhito Sugiura , Mikio Yasukawa , Katsuyoshi Suzuki , Masahiro Kamada , Toshihisa Takaki , Kazufuku Nitta , Yoshitsugu Yamada
IPC分类号： A61M1600
CPC分类号： A61M16/202 , A61M16/0006 , A61M16/0009 , A61M16/0066 , A61M16/0081 , A61M16/024 , A61M16/0858 , A61M16/107 , A61M2016/0021 , A61M2205/42
摘要： The present invention provides a small-size, small-weight, low-cost artificial respiration apparatus which can easily be used in an ordinary hospital. The artificial respiration apparatus 10 includes: a positive blower 12p for generating a positive air pressure Ap; a negative blower 12n for generating a negative air pressure An; a rotary valve mechanism 54 for alternately selecting the positive pressure Ap generated by the positive blower 12p and the negative pressure An generated by the negative blower 12n and converting them into an oscillating air pressure Apn; and a diaphragm block 56 urged by the oscillating air pressure Apn from the rotary valve mechanism 54 to operate to supply air to a patient P. Use of the positive blower 12p and the negative blower 12n significantly reduces the load, enabling to use ones available on market, i.e., small-size, small-weight, low-consumption blowers.
摘要翻译：本发明提供一种小型，小型，低成本的人造呼吸装置，其可以容易地用于普通医院。人造呼吸装置10包括：用于产生正气压Ap的正鼓风机12p; 用于产生负气压An的负鼓风机12n; 用于交替选择由正鼓风机12p产生的正压Ap和由负鼓风机12n产生的负压力A并将其转换成振荡空气压力Apn的旋转阀机构54; 以及通过来自旋转阀机构54的振动空气压力Apn推动的隔膜块56来操作以向患者P供应空气。正鼓风机12p和负风机12n的使用显着地减小了负载，从而能够使用市场，即小型，小重量，低耗能鼓风机。

9. 发明授权

US5316009A Apparatus for monitoring respiratory muscle activity 失效
标题翻译：用于监测呼吸肌肉活动的装置
公开(公告)号：US5316009A
公开(公告)日：1994-05-31
申请号：US907399
申请日：1992-07-01
申请人： Yoshitsugu Yamada
发明人： Yoshitsugu Yamada
IPC分类号： A61B5/08 , A61B5/087 , A61M16/00
CPC分类号： A61B5/087
摘要： A respiratory muscle activity monitoring apparatus is provided with a pressure sensor for detecting pressure in an air passage connecting a lung ventilator and the airway system of a patient and a flow rate sensor for detecting flow rate in the air passage. An arithmetic constant detecting unit detects resistance Rrs and elastance Ers of the respiratory system including the airway and thorax beforehand by using detection signals from the pressure sensor and the flow rate sensor while the lung ventilator is supplying air to the patient whose spontaneous breathing is temporarily stopped. Using airway opening pressure Paw detected by the pressure sensor and flow rate dV/dt detected by the flow rate sensor, a developed pressure calculating unit calculates pressure Pmus developed by the respiratory muscles during mechanical ventilation as well as during spontaneous breathing from the expression: Pmus=-Paw+Rrs(dV/dt)+Ers .intg.(dV/dt)dt. An output unit displays and/or records the obtained Pmus together with waveform signal detected by the pressure sensor along a common time axis. Furthermore, by detecting a tidal volume VT from flow rate, work Wmus is calculated as follows: Wmus=-.intg.Paw(dV/dt)dt+.intg.Rrs(dV/dt).sup.2 dt+(1/2)Ers(VT).sup.2
摘要翻译：呼吸肌肉活动监测装置设置有用于检测连接肺通气机和患者气道系统的空气通道中的压力的压力传感器和用于检测空气通道中的流量的流量传感器。算术常数检测单元通过使用来自压力传感器和流量传感器的检测信号预先检测包括气道和胸部的呼吸系统的电阻Rrs和弹性Ers，同时肺呼吸机向自发呼吸临时停止的患者供应空气。使用气道打开压力由压力传感器检测到的气压Paw和由流量传感器检测的流量dV / dt，开发的压力计算单元计算机械通气期间以及在自发呼吸期间由呼吸肌发育的压力Pmus：表达：Pmus = -Paw + Rrs（dV / dt）+ Ers INTEGRAL（dV / dt）dt。输出单元沿着公共时间轴显示和/或记录所获得的Pmus以及由压力传感器检测的波形信号。此外，通过从流量检测潮气量VT，Wmus计算如下：Wmus = - INTEGRAL Paw（dV / dt）dt + INTEGRAL Rrs（dV / dt）2dt +（1/2）Ers（VT）2

10. 发明授权

US07938234B2 Multi-position brake lever system with a converter that converts a cable actuator to a hydraulic actuator 有权
标题翻译：具有转换器的多位制动杆系统将电缆执行器转换为液压执行器
公开(公告)号：US07938234B2
公开(公告)日：2011-05-10
申请号：US11772788
申请日：2007-07-02
申请人： Masahiko Jinbo , Takeshi Takachi , Satoshi Shahana , Yoshitsugu Yamada
发明人： Masahiko Jinbo , Takeshi Takachi , Satoshi Shahana , Yoshitsugu Yamada
IPC分类号： B62L3/00
CPC分类号： B60T11/18 , B60T11/046 , B60T11/10 , B60T13/588
摘要： A hydraulic assembly for a hydraulic disc brake system that includes a housing defining a cylinder, a piston received in and moveable within the cylinder, a first lever operatively associated with one of the piston or the cylinder, and a second lever operatively associated with the other of the piston or the cylinder. Moving the first lever pushes one of the piston or the cylinder in a first direction, and moving the second lever pulls the other of the cylinder or the piston in a second direction. In a preferred embodiment, the piston has a non-actuated position and a fully actuated position, and the piston is biased towards the non-actuated position, and wherein the cylinder has a non-actuated and a fully-actuated position, and the cylinder is biased towards the non-actuated position.
摘要翻译：一种用于液压盘式制动器系统的液压组件，其包括限定气缸的壳体，容纳在气缸内并在气缸内可移动的活塞，与活塞或气缸中的一个可操作地相关联的第一杆以及与另一个操作地相关联的第二杆的活塞或气缸。移动第一杠杆沿第一方向推动活塞或气缸中的一个，并且移动第二杠杆沿第二方向拉动气缸或活塞中的另一个。在优选实施例中，活塞具有非致动位置和完全致动位置，并且活塞朝向非致动位置偏置，并且其中气缸具有非致动位置和完全致动位置，并且气缸偏向非致动位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式