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1. 发明授权

US4219730A Charge-particle energy analyzer 失效
标题翻译：电荷粒子能量分析仪
公开(公告)号：US4219730A
公开(公告)日：1980-08-26
申请号：US936928
申请日：1978-08-25
申请人： Isao Ishikawa , Yoshitaka Goto , Michiyasu Itoh
发明人： Isao Ishikawa , Yoshitaka Goto , Michiyasu Itoh
IPC分类号： G01N23/227 , G01N23/225 , G01Q30/02 , G01Q90/00 , G01T1/36 , G21K1/087 , H01J37/256 , H01J49/44 , H01J49/48 , H01J39/00
CPC分类号： H01J37/256 , G01N23/225 , G21K1/087 , H01J49/482
摘要： A charged-particle energy analyzer having means for irradiating a sample with a primary electron beam, deflecting electrode means which focus charged particle flux emitted from the sample onto a center axis of the primary electron beam or onto an identical circumference with its center on the axis, a slit disposed at the focus point of the charged particles, an energy analyzer whose object point lies at the focus point, a detector for detecting the charged particles analyzed by the energy analyzer, and charged particle flux deflecting means provided between the sample and the detector, for shielding by one part of the charged particle flux focused in a true circular form, to thereby make it possible not only to set a wide accepted solid angle for signals but also to get an information as to the concave or convex surface condition of the sample at the measured portion.
摘要翻译：一种带电粒子能量分析仪，其具有用于用一次电子束照射样品的装置，将从样品发射的带电粒子通量聚焦到一次电子束的中心轴上的偏转电极装置或与其一致的圆周上的中心在轴上的偏转电极装置设置在带电粒子的聚焦点的狭缝，物点在焦点处的能量分析器，用于检测由能量分析器分析的带电粒子的检测器，以及设置在样品和样品之间的带电粒子通量偏转装置检测器，用于通过以真圆形形式聚焦的一部分带电粒子通量进行屏蔽，从而不仅能够为信号设置广泛接受的立体角，而且可以获得关于凹面或凸面状况的信息在测量部分的样品。

2. 发明申请

US20110105940A1 METHOD FOR QUANTIFICATION OF TITER OF NEUTRALIZING ANTIBODY TO NEUROTOXIN 审中-公开
标题翻译：中性抗体对神经毒素的定量的方法
公开(公告)号：US20110105940A1
公开(公告)日：2011-05-05
申请号：US12673980
申请日：2008-08-20
申请人： Yasushi Torii , Tetsuhiro Harakawa , Yoshitaka Goto , Akihiro Ginnaga , Ryuji Kaji , Shunji Kozaki , Motohide Takahashi
发明人： Yasushi Torii , Tetsuhiro Harakawa , Yoshitaka Goto , Akihiro Ginnaga , Ryuji Kaji , Shunji Kozaki , Motohide Takahashi
IPC分类号： A61B5/0488
CPC分类号： G01N33/6854 , A61B5/0488 , G01N2333/33 , G01N2469/20
摘要： A method for quantification of a titer of a neutralizing antibody to a neurotoxin is disclosed. The method comprises the steps: (a) mixing a standard sample containing a fixed amount of a neurotoxin and a test sample containing a neutralizing antibody to said neurotoxin; (b) administering the mixture obtained in step (a) into the muscle of a non-human mammal; (c) applying electric stimulus to said non-human mammal; (d) measuring a compound muscle action potential (CMAP) due to contraction of the muscle of said mammal by application of electric stimulus with an electromyograph; and (e) analyzing CMAP amplitude data obtained in step (d) for an extent of decrease in amplitude by a non-neutralized neurotoxin to thereby quantify a titer of the neutralizing antibody contained in the test sample.
摘要翻译：公开了定量神经毒素中和抗体滴度的方法。该方法包括以下步骤：（a）将含有固定量的神经毒素的标准样品和含有中和抗体的测试样品与所述神经毒素混合; （b）将步骤（a）中获得的混合物给予非人哺乳动物的肌肉; （c）对所述非人哺乳动物施加电刺激; （d）通过用肌电图仪施加电刺激来测量由于所述哺乳动物的肌肉收缩引起的复合肌肉动作电位（CMAP）; 和（e）通过未中和的神经毒素分析在步骤（d）中获得的CMAP振幅数据的幅度减小，从而定量测试样品中所含的中和抗体的滴度。

3. 发明申请

US20110033431A1 TYPE A2 BOTULINUM TOXIN PREPARATION 审中-公开
标题翻译： A2型BOTULINUM毒素制剂
公开(公告)号：US20110033431A1
公开(公告)日：2011-02-10
申请号：US12935769
申请日：2009-03-31
申请人： Shinji Nakahira , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Satomi Munechika , Sachio Okuda , Shunji Kozaki
发明人： Shinji Nakahira , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Satomi Munechika , Sachio Okuda , Shunji Kozaki
IPC分类号： A61K35/74 , A61P21/00 , C12N1/20 , C07K14/33
CPC分类号： A61K38/164 , A61K38/4893 , Y02A50/469
摘要： A pharmaceutical preparation for use in a patient who has a neutralizing antibody to a botulinum toxin from type A1 Clostridium botulinum (type A1 botulinum toxin), said preparation comprising as an active ingredient 150 kDa type A neurotoxin from type A2 Clostridium botulinum (A2 NTX); a medicament for treating a disease with muscle overactivity for use in a patient who has a neutralizing antibody to a type A1 botulinum toxin, said medicament comprising as an active ingredient said A2 NTX; a method for treating a patient who has a neutralizing antibody to a type A1 botulinum toxin, said method comprising administering said A2 NTX to the patient; and a method for use of A2 NTX in a patient who has said neutralizing antibody. In accordance with the present invention, a problem can be solved of decrease in clinical response caused by a neutralizing antibody to a type A1 botulinum toxin produced when a patient is treated with a pharmaceutical preparation comprising a type A1 botulinum toxin.
摘要翻译：一种用于患有来自A1型肉毒毒素（A1型肉毒杆菌毒素）的肉毒毒素中和抗体的患者的药物制剂，所述制剂包含来自A2型肉毒毒素（A2NTX）的150kDa A型神经毒素作为活性成分， ; 用于治疗患有肌肉过度活动的疾病的药物，所述疾病用于患有A1型肉毒杆菌毒素的中和抗体的患者，所述药物包含所述A2NXX的活性成分; 用于治疗对A1型肉毒杆菌毒素具有中和抗体的患者的方法，所述方法包括向患者施用所述A2NXX; 以及在具有所述中和抗体的患者中使用A2NTX的方法。根据本发明，当患者用包含A1型肉毒杆菌毒素的药物制剂治疗时，可以解决由中和抗体对产生的A1型肉毒杆菌毒素引起的临床反应降低的问题。

4. 发明申请

US20100173841A1 Highly Purified Type A Botulinum Toxin Preparation From Infant Botulism Pathogen 有权
标题翻译：高纯度A型肉毒杆菌毒素从婴儿肉毒杆菌病原体制备
公开(公告)号：US20100173841A1
公开(公告)日：2010-07-08
申请号：US12447351
申请日：2007-10-26
申请人： Tetsuhiro Harakawa , Hirotoshi Nakano , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Sachio Okuda , Ryuji Kaji , Shunji Kosaki
发明人： Tetsuhiro Harakawa , Hirotoshi Nakano , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Sachio Okuda , Ryuji Kaji , Shunji Kosaki
IPC分类号： A61K38/16 , C07K14/33 , A61P25/06 , A61P13/10 , A61P25/14 , A61P25/00 , A61P21/00 , A61P29/00
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/19 , A61K38/4893 , Y02A50/469
摘要： A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.
摘要翻译：提供了一种新型的A型肉毒杆菌毒素制剂。一种包含作为活性成分的来自肉毒梭菌的高度纯化的A型肉毒杆菌毒素作为婴儿肉毒杆菌病原体的神经肌肉阻滞剂和用于治疗肌肉过度活动的疾病的药物，其包含所述毒素作为活性成分。特别地，与常规已知的肉毒杆菌毒素制剂相比，本发明的药物具有快速的潜力和较少的扩散作用，因此具有较宽的安全性，可用作减少局部，肌肉过度活动的治疗药物在肌肉过度活动的疾病中。

5. 发明授权

US06254973B1 Fluorine-containing polyfunctional (meth) acrylate, fluorine containing monomer composition, low refractivity material, and reflection reducing film 失效
$Fluorine-containing polyfunctional (meth) acrylate, fluorine containing monomer composition, low refractivity material, and reflection reducing film$
标题翻译：含氟多官能（甲基）丙烯酸酯，含氟单体组合物，低折射率材料和反射还原膜
公开(公告)号：US06254973B1
公开(公告)日：2001-07-03
申请号：US08945228
申请日：1997-10-10
申请人： Tatsurou Yoshida , Yasuhiro Kimura , Kenji Watanabe , Tomoyuki Ikeda , Tetsuya Itoh , Yoshitaka Goto
发明人： Tatsurou Yoshida , Yasuhiro Kimura , Kenji Watanabe , Tomoyuki Ikeda , Tetsuya Itoh , Yoshitaka Goto
IPC分类号： B32B2730
CPC分类号： C08F222/1006 , C07C69/653 , C08F22/105 , Y10T428/24942 , Y10T428/3154
摘要： Fluorine-containing polyfunctional (meth)acrylate represented by the formula (1), a monomer composition containing the (meth)acrylate, a low refractivity material prepared by curing the monomer composition, and a reflection reducing film provided with the low refractivity material. wherein R1, R2, R3, and R4 are the same or different groups, and each stands for a hydrogen atom, an acryloyl group, or a methacryloyl group, at least one of R1 and R2 and at least one of R3 and R4 stand for an acryloyl group or a methacryloyl group, R stands for a fluoroalkylene group having 2 to 12 carbon atoms and 2 or more fluorine atoms.
摘要翻译：由式（1）表示的含氟多官能（甲基）丙烯酸酯，含有（甲基）丙烯酸酯的单体组合物，通过固化单体组合物制备的低折射率材料和设置有低折射率材料的反射率降低膜。 R1，R2，R3和R4是相同或不同的基团，各自代表氢原子，丙烯酰基或甲基丙烯酰基，R 1和R 2中的至少一个和R 3和R 4中的至少一个代表丙烯酰基或甲基丙烯酰基，R表示碳原子数2〜12，氟原子数2以上的氟代亚烷基。

6. 发明授权

US6087010A Fluorine-containing polyfunctional (meth) acrylate composition low refractivity material and reflection reducing film 失效
$Fluorine-containing polyfunctional (meth) acrylate composition low refractivity material and reflection reducing film$
标题翻译：含氟多官能（甲基）丙烯酸酯组合物低折射率材料和反射降低膜
公开(公告)号：US6087010A
公开(公告)日：2000-07-11
申请号：US11812
申请日：1998-02-09
申请人： Tatsurou Yoshida , Yasuhiro Kimura , Kenji Watanabe , Tomoyuki Ikeda , Tetsuya Itoh , Yoshitaka Goto
发明人： Tatsurou Yoshida , Yasuhiro Kimura , Kenji Watanabe , Tomoyuki Ikeda , Tetsuya Itoh , Yoshitaka Goto
IPC分类号： B32B27/00 , C07C69/52 , C07C69/66 , C08F18/20
CPC分类号： B32B27/00 , C07C69/52 , C07C69/66 , C08F18/20
摘要： Fluorine-containing polyfunctional (meth)acrylate represented by the formula (1), as well as a composition, a low refractivity material and a reflection reducing film in which the (meth)acrylate is utilized: ##STR1## wherein X stands for a fluoroalkyl group of C1-14 having 3 or more F, or a fluorocycloalkyl group of C3-14 having 4 or more F; Y.sup.1, Y.sup.2, and Y.sup.3 stand for H, an acryloyl group or a methacryloyl group, and at least two of Y.sup.1, Y.sup.2, and Y.sup.3 stand for an acryloyl group or a methacryloyl group; Z stands for H or an alkyl group of C1-3; and n and m is an integer of 0 or 1, and n+m=1.
摘要翻译： PCT No.PCT / JP97 / 01952 Sec。 371日期：1998年2月9日 102（e）1998年2月9日PCT PCT 1997年6月9日PCT公布。第WO97 / 47585号公报日期：1997年12月18日由式（1）表示的含氟多官能（甲基）丙烯酸酯以及其中使用（甲基）丙烯酸酯的组合物，低折射率材料和反射还原膜：其中X代表具有3个或更多个F的C1-14的氟代烷基或具有4个或更多个F的C3-14的氟代环烷基; Y 1，Y 2和Y 3表示H，丙烯酰基或甲基丙烯酰基，Y1，Y2和Y3中的至少两个表示丙烯酰基或甲基丙烯酰基; Z代表H或C 1-3的烷基; n和m为0或1的整数，n + m = 1。

7. 发明授权

US09623075B2 Type A2 botulinum toxin preparation 有权
公开(公告)号：US09623075B2
公开(公告)日：2017-04-18
申请号：US13903731
申请日：2013-05-28
申请人： Shinji Nakahira , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Satomi Munechika , Sachio Okuda , Shunji Kozaki
发明人： Shinji Nakahira , Yasushi Torii , Yoshitaka Goto , Miho Shinmura , Satomi Munechika , Sachio Okuda , Shunji Kozaki
IPC分类号： A61K38/48 , A61K38/16
CPC分类号： A61K38/164 , A61K38/4893 , Y02A50/469
摘要： A method for treating a patient who has a neutralizing antibody to a type A1 botulinum toxin. The method includes administering 150 kDa type A neurotoxin from type A2 Clostridium botulinum (A2 NTX) to the patient. In accordance with the present invention, a problem can be solved of decrease in clinical response caused by a neutralizing antibody to a type A1 botulinum toxin produced when a patient is treated with a pharmaceutical preparation containing a type A1 botulinum toxin.

8. 发明授权

US06823694B2 Method of manufacturing glass optical elements 有权
标题翻译：制造玻璃光学元件的方法
公开(公告)号：US06823694B2
公开(公告)日：2004-11-30
申请号：US09942669
申请日：2001-08-31
申请人： Hiroyuki Sawada , Yoshitaka Goto , Yuka Miyashita
发明人： Hiroyuki Sawada , Yoshitaka Goto , Yuka Miyashita
IPC分类号： C03B1112
CPC分类号： C03B11/08 , C03B11/122 , C03B11/125 , C03B2215/47 , C03B2215/48
摘要： A method for manufacturing a glass optical element having at least one concave surface, including: softening a glass molding material by heating, molding the softened material with a first mold having a first molding surface and a second mold having a second molding surface by applying a pressure, the first molding surface including a first concave forming surface, the second molding surface including a convex forming surface, a planar forming surface or a second concave forming surface, the second concave forming surface having a curvature radius greater than that of the first concave forming surface, whereby the applying of the pressure starts when the first mold and the second mold are at temperatures above a glass transition temperature of said glass molding material, the glass material is cooled so that a temperature of the glass material reaches a temperature equal to or lower than a glass transition temperature (Tg) of the glass material, and the cooled glass material is removed from either of the first mold or the second mold. A second temperature of the second mold reaches the glass transition temperature prior to a time when a first temperature of first mold reaches the glass transition temperature in the cooling step.
摘要翻译：一种制造具有至少一个凹面的玻璃光学元件的方法，包括：通过加热软化玻璃成型材料，用具有第一成型面的第一模具和具有第二成型面的第二模具对软化材料进行成型，所述第一模制表面包括第一凹形成表面，所述第二模制表面包括凸形成表面，平面形成表面或第二凹形成表面，所述第二凹形成表面的曲率半径大于所述第一凹形形成表面的曲率半径从而当第一模具和第二模具处于高于所述玻璃成型材料的玻璃化转变温度的温度时开始施加压力，玻璃材料被冷却，使得玻璃材料的温度达到等于或低于玻璃材料的玻璃化转变温度（Tg），并且除去冷却的玻璃材料从第一模具或第二模具中的任一个。在第一模具的第一温度在冷却步骤中达到玻璃化转变温度的时间之前，第二模具的第二温度达到玻璃化转变温度。

9. 发明授权

US5693447A Image forming material, method of preparing the same and image forming method employing the same 失效
标题翻译：成像材料，其制备方法以及使用其的成像方法
公开(公告)号：US5693447A
公开(公告)日：1997-12-02
申请号：US599152
申请日：1996-02-09
申请人： Toshihisa Takeyama , Ai Katsuda , Tomonori Kawamura , Masataka Takimoto , Yoshitaka Goto
发明人： Toshihisa Takeyama , Ai Katsuda , Tomonori Kawamura , Masataka Takimoto , Yoshitaka Goto
IPC分类号： B41M5/36 , B41M5/382 , G03F7/34 , G03F7/039
CPC分类号： B41M5/38207 , B41M5/368 , B41M5/382 , Y10S428/90 , Y10S428/913 , Y10S430/165 , Y10T428/24372 , Y10T428/31 , Y10T428/31504 , Y10T428/31551 , Y10T428/31935
摘要： An image forming material is disclosed which comprises a support and provided thereon, an image forming layer containing colorant particles and a binder, the image forming layer having an optical density of 3.0 or more per 1 .mu.m thickness of the image forming layer at .lambda.max which is a wavelength giving a maximum transparent density in the spectral absorption wavelength range of 350 to 1200 nm of the image forming layer, wherein an image is formed by removing exposed portions of the image forming layer of the image forming material.
摘要翻译：公开了一种图像形成材料，其包括载体并且设置在其上，包含着色剂颗粒和粘合剂的图像形成层，图像形成层的每1μm厚度的成像层的λ密度为3.0以上，λ最大其是在图像形成层的350至1200nm的光谱吸收波长范围内给出最大透明密度的波长，其中通过去除图像形成材料的图像形成层的暴露部分形成图像。

10. 发明授权

US4474868A Photo polymerization initiator compositions having high sensitivity 失效
标题翻译：具有高灵敏度的光聚合引发剂组合物
公开(公告)号：US4474868A
公开(公告)日：1984-10-02
申请号：US530168
申请日：1983-09-07
申请人： Tsuguo Yamaoka , Kenichi Koseki , Yoshitaka Goto
发明人： Tsuguo Yamaoka , Kenichi Koseki , Yoshitaka Goto
IPC分类号： C08F2/00 , C08F2/50 , C08F4/00 , C09D4/00 , C09D5/00 , C09D11/00 , C09D11/10 , C09J4/00 , G03F7/031 , G03C1/68
CPC分类号： G03F7/031 , Y10S430/114 , Y10S430/117 , Y10S430/122 , Y10S430/123
摘要： A photo polymerization initiator composition is disclosed. The composition is comprised of an organic peroxide and a salt selected from the group consisting of pyrylium salts, thiapyrylium salts and selenopyrylium salts represented by the general formula (I): ##STR1## the substituents are defined within the specification. By utilizing the disclosed photo polymerization initiator composition, it is possible to obtain high sensitivity even in the visible range of light.
摘要翻译：公开了一种光聚合引发剂组合物。该组合物由有机过氧化物和选自由通式（I）表示的吡喃鎓盐，硫代吡喃鎓盐和硒代吡喃鎓盐组成的组中的盐组成：取代基在本说明书中定义。通过利用所公开的光聚合引发剂组合物，即使在可见光范围内也可获得高灵敏度。

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