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1. 发明申请

US20100069389A1 NOVEL FORMS OF REBOXETINE 审中-公开
标题翻译：新形式的复方
公开(公告)号：US20100069389A1
公开(公告)日：2010-03-18
申请号：US12553564
申请日：2009-09-03
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Wei Lai , David T. Jonaitis , A. Gracia Lityo
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Wei Lai , David T. Jonaitis , A. Gracia Lityo
IPC分类号： A61K31/5375 , C07D295/12 , A61P25/24 , A61P25/22
CPC分类号： C07D265/30
摘要： The invention relates to novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride. In various embodiments, the novel crystalline forms may be substantially enantiopure. The preparation and characterization of the novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride is also described. The invention also relates to pharmaceutical compositions containing novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride, which are useful to treat and/or prevent various conditions such as nervous system and pain disorders.
摘要翻译：本发明涉及（2R）-2 - [（R） - （2-乙氧基苯氧基） - 苯基甲基]吗啉盐酸盐的新结晶形式。在各种实施方案中，新的结晶形式可以是基本上对映体纯的。还描述了（2R）-2 - [（R） - （2-乙氧基苯氧基） - 苯基甲基]吗啉盐酸盐的新结晶形式的制备和表征。本发明还涉及包含（2R）-2 - [（R） - （2-乙氧基苯氧基） - 苯基甲基]吗啉盐酸盐的新结晶形式的药物组合物，其可用于治疗和/或预防各种病症如神经系统和疼痛障碍

2. 发明申请

US20120196895A1 NOVEL FORMS OF EPERISONE 审中-公开
标题翻译： EPERISONE的新形式
公开(公告)号：US20120196895A1
公开(公告)日：2012-08-02
申请号：US13144292
申请日：2010-01-11
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Jason A. Hanko
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Jason A. Hanko
IPC分类号： A61K31/4453 , A61P21/02 , A61P29/00 , A61P25/14 , A61P25/00 , C07D295/108 , A61P21/00
CPC分类号： C07D295/108 , A61K31/445
摘要： The invention relates to novel crystalline forms of (2RS)-1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline forms, which are useful to treat and/or prevent various conditions such as pathological muscle contracture, myotonic conditions, and spastic paralysis or spasticity caused by various neurologic conditions, and are also useful for the treatment and/or prevention of various types of pain and pathological muscle tension.
摘要翻译：本发明涉及（2RS）-1-（4-乙基苯基）-2-甲基-3-哌啶-1-基 - 丙-1-酮的新型结晶形式。描述根据本发明的各种实施方案的新型结晶形式的制备和表征。本发明还涉及含有新型结晶形式的药物组合物，其可用于治疗和/或预防各种病症如病理性肌肉挛缩，强直条件和由各种神经病症引起的痉挛性麻痹或痉挛状态，并且还可用于治疗和/或预防各种类型的疼痛和病理性肌肉紧张。

3. 发明申请

US20110275681A1 NOVEL SOLID FORMS OF EPALRESTAT 有权
标题翻译： EPALRESTAT的新型固体形式
公开(公告)号：US20110275681A1
公开(公告)日：2011-11-10
申请号：US13013786
申请日：2011-01-25
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
IPC分类号： A61K31/426 , A61P25/00 , A61P3/10 , C07D277/14 , A61P9/10
CPC分类号： C07D277/36 , A61K31/426
摘要： The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.
摘要翻译：本发明涉及5 - [（1Z，2E）-2-甲基-3-苯基亚丙基] -4-氧代-2-硫代-3-噻唑烷乙酸的新型结晶盐和5 - [（1Z， 2E）-2-甲基-3-苯基亚丙叉基] -4-氧代-2-硫代-3-噻唑烷乙酸。描述根据本发明的各种实施方案的新型结晶盐和共晶的制备和表征。本发明还涉及含有新结晶盐和共结晶的药物组合物以及新型结晶盐和共结晶治疗和/或预防各种病症的治疗用途，包括治疗和/或预防糖尿病并发症，抑制醛糖还原酶和提供心脏保护作用可能患有非糖尿病的患者。

4. 发明授权

US08906948B2 Choline cocrystal of epalrestat 有权
标题翻译：胆碱共同结晶
公开(公告)号：US08906948B2
公开(公告)日：2014-12-09
申请号：US13062644
申请日：2009-09-03
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
IPC分类号： A61K31/427 , A61P9/10 , A61P27/12 , C07D277/36
CPC分类号： C07D277/36 , A61K31/14 , A61K31/426 , A61K31/427 , C07B2200/13 , C07C215/40
摘要： The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.
摘要翻译：本发明涉及5 - [（1Z，2E）-2-甲基-3-苯基亚丙基] -4-氧代-2-硫代-3-噻唑烷乙酸的新型胆碱共结晶。描述了根据本发明的各种实施方案的新型胆碱共晶体的制备和表征。本发明还涉及含有新型胆碱共结晶的药物组合物和新型胆碱共结晶治疗和/或预防各种病症的治疗用途，包括治疗和/或预防糖尿病并发症，治疗和/或预防同型半胱氨酸的同型半胱氨酸降低水平血清，抑制醛糖还原酶，并在非糖尿病患者中提供心脏保护作用。

5. 发明授权

US08697735B2 Solid forms of epalrestat 有权
标题翻译： epalrestat的固体形式
公开(公告)号：US08697735B2
公开(公告)日：2014-04-15
申请号：US13013786
申请日：2011-01-25
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Travis L. Houston
IPC分类号： A61K31/426 , C07D277/36
CPC分类号： C07D277/36 , A61K31/426
摘要： The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.
摘要翻译：本发明涉及5 - [（1Z，2E）-2-甲基-3-苯基亚丙基] -4-氧代-2-硫代-3-噻唑烷乙酸的新型结晶盐和5 - [（1Z， 2E）-2-甲基-3-苯基亚丙叉基] -4-氧代-2-硫代-3-噻唑烷乙酸。描述根据本发明的各种实施方案的新型结晶盐和共晶的制备和表征。本发明还涉及含有新结晶盐和共结晶的药物组合物以及新型结晶盐和共结晶治疗和/或预防各种病症的治疗用途，包括治疗和/或预防糖尿病并发症，抑制醛糖还原酶和提供心脏保护作用可能患有非糖尿病的患者。

6. 发明申请

US20110281911A1 NOVEL FORMS OF EPERISONE 审中-公开
标题翻译： EPERISONE的新形式
公开(公告)号：US20110281911A1
公开(公告)日：2011-11-17
申请号：US13057542
申请日：2009-08-03
申请人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Jason A. Hanko , Jeffrey P. Kiplinger
发明人： Isabel Kalofonos , G. Patrick Stahly , William Martin-Doyle , Dimitris Kalofonos , Jeffrey S. Stults , Jason A. Hanko , Jeffrey P. Kiplinger
IPC分类号： A61K31/4453 , A61P21/00 , A61P25/00 , A61P29/00 , A61P25/14 , C07D295/108 , A61P21/02
CPC分类号： C07D295/108
摘要： The invention relates to substantially enantiopure crystalline salt forms of (2RS)-I-(4-Ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one. The preparation and characterization of the substantially enantiopure crystalline salt forms according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the substantially enantiopure crystalline salt forms, which are useful to treat and/or prevent various conditions such as pathological muscle contracture, myotome conditions, and spastic paralysis or spasticity caused by various neurologic conditions, and are also useful for the treatment and/or prevention of various types of pain and pathological muscle tension.
摘要翻译：本发明涉及（2RS）-1-（4-乙基苯基）-2-甲基-3-哌啶-1-基丙-1-酮的基本对映体纯的结晶盐形式。描述了根据本发明的各种实施方案的基本对映体纯的结晶盐形式的制备和表征。本发明还涉及含有基本上对映体纯的结晶盐形式的药物组合物，其可用于治疗和/或预防各种病症如病理性肌肉挛缩，肌肉破裂症状，以及由各种神经病症引起的痉挛性麻痹或痉挛状态，并且也是有用的用于治疗和/或预防各种类型的疼痛和病理性肌肉紧张。

7. 发明申请

US20110275679A1 FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL 审中-公开
标题翻译： FLUPIRTINE氢氯酸盐马来酸盐
公开(公告)号：US20110275679A1
公开(公告)日：2011-11-10
申请号：US13057560
申请日：2009-08-06
申请人： Isabel Kalofonos , Dimitris Kalofonos , Patrick G. Stahly , Jeffrey S. Stults , Jason A. Hanko , Rex A. Shipplett , William Martin-Doyle
发明人： Isabel Kalofonos , Dimitris Kalofonos , Patrick G. Stahly , Jeffrey S. Stults , Jason A. Hanko , Rex A. Shipplett , William Martin-Doyle
IPC分类号： A61K31/44 , A61P25/00 , A61P21/00 , A61P25/08 , A61P25/28 , A61P25/16 , A61P25/14 , A61P9/10 , A61P25/18 , A61P25/24 , A61P25/22 , A61P13/10 , A61P13/00 , A61P21/02 , A61P3/10 , A61P27/12 , C07D213/75
CPC分类号： C07D213/75
摘要： The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.
摘要翻译：本发明涉及氟吡汀的结晶形式，特别涉及1：1盐酸氟吡汀马来酸共结晶。描述了1：1盐酸氟吡汀马来酸共晶体的制备和表征。本发明还涉及氟吡汀盐酸马来酸共结晶治疗神经系统疾病，疼痛障碍和肌肉骨骼疾病以及含有共晶体的药物组合物的治疗用途。

8. 发明申请

US20110275695A1 CRYSTALLINE FORMS OF ZOTEPINE HYDROCHLORIDE 审中-公开
标题翻译： ZOTEPINE HYDROCHLORIDE的结晶形式
公开(公告)号：US20110275695A1
公开(公告)日：2011-11-10
申请号：US12997499
申请日：2009-06-11
申请人： Isabel Kalofonos , Dimitris Kalofonos , William Martin-Doyle , Jason Hanko , Eric J. Hagen
发明人： Isabel Kalofonos , Dimitris Kalofonos , William Martin-Doyle , Jason Hanko , Eric J. Hagen
IPC分类号： A61K31/38 , A61P25/00 , A61P25/22 , A61P25/14 , A61P19/06 , C07D337/14 , A61P25/18
CPC分类号： C07D337/14
摘要： The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these crystalline forms of zotepine hydrochloride is described. The invention also relates to the therapeutic use of the crystalline forms of zotepine hydrochloride to treat central nervous system disorders and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及盐酸妥洛司定的结晶形式，包括zotepine的盐酸盐结晶盐酸盐和盐酸妥替托盐酸盐与苯甲酸两种共晶体。描述了盐酸替罗定的这些晶型的制备和表征。本发明还涉及盐酸替罗他宾的结晶形式治疗中枢神经系统疾病和含有它们的药物组合物的治疗用途。

9. 发明申请

US20110275682A1 NOVEL CHOLINE COCRYSTAL OF EPALRESTAT 有权
标题翻译： EPALRESTAT的新颖的椰子水晶
公开(公告)号：US20110275682A1
公开(公告)日：2011-11-10
申请号：US13062644
申请日：2009-09-03
申请人： Isabel Kalofonos , Patrick G. Stahly , William Martin-Doyle , Dimitris Kalofonos , Travis L. Houston , Jeffrey S. Stults
发明人： Isabel Kalofonos , Patrick G. Stahly , William Martin-Doyle , Dimitris Kalofonos , Travis L. Houston , Jeffrey S. Stults
IPC分类号： A61K31/426 , A61P9/10 , A61P25/00 , A61P25/28 , A61P27/12 , A61P1/04 , A61P7/00 , A61P1/00 , C07D277/36 , A61P9/00
CPC分类号： C07D277/36 , A61K31/14 , A61K31/426 , A61K31/427 , C07B2200/13 , C07C215/40
摘要： The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.
摘要翻译：本发明涉及5 - [（1Z，2E）-2-甲基-3-苯基亚丙基] -4-氧代-2-硫代-3-噻唑烷乙酸的新型胆碱共结晶。描述了根据本发明的各种实施方案的新型胆碱共晶体的制备和表征。本发明还涉及含有新型胆碱共结晶的药物组合物和新型胆碱共结晶治疗和/或预防各种病症的治疗用途，包括治疗和/或预防糖尿病并发症，治疗和/或预防同型半胱氨酸的同型半胱氨酸降低水平血清，抑制醛糖还原酶，并在非糖尿病患者中提供心脏保护作用。

10. 发明授权

US09032215B2 Management of access control in wireless networks 有权
标题翻译：无线网络中的访问控制管理
公开(公告)号：US09032215B2
公开(公告)日：2015-05-12
申请号：US11153307
申请日：2005-06-15
申请人： Dimitris Kalofonos , Saad Shakhshir
发明人： Dimitris Kalofonos , Saad Shakhshir
IPC分类号： G06F21/00 , H04L29/06 , H04L12/28 , H04W12/08
CPC分类号： H04L63/0428 , H04L12/2803 , H04L12/282 , H04L63/101 , H04L63/102 , H04L2012/285 , H04W12/08
摘要： Management of access control in wireless networks known as smart spaces includes a framework that presents non-expert users with a consistent and intuitive interaction mechanism to manage access to devices they own in the smart space without exposing to them the complexity of the underlying security infrastructure. Access control of devices in a network can include providing an interface between a user-level tool on a first device connected to a network and security components associated with the network, communicating a passlet between the user-level tool and the interface, verifying access permission at a second device on the network where access permissions are based on the passlet, and providing a response to the first device based on the verification of the access permission in the passlet. The passlet provides access permissions based on a particular user rather than a particular device.
摘要翻译：在被称为智能空间的无线网络中的访问控制管理包括一个框架，为非专家用户提供一致和直观的交互机制，以管理他们在智能空间中拥有的设备的访问，而不会暴露底层安全基础架构的复杂性。网络中设备的访问控制可以包括在连接到网络的第一设备上的用户级工具和与网络相关联的安全组件之间提供接口，在用户级工具和接口之间传递密码，验证访问权限在网络上的第二设备上，其中访问权限基于该密码，并且基于该密码中的访问许可的验证来向第一设备提供响应。该邮袋提供基于特定用户而不是特定设备的访问权限。

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