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1. 发明申请

US20080026040A1 Active agent-releasing dosage forms 审中-公开
标题翻译：活性剂释放剂型
公开(公告)号：US20080026040A1
公开(公告)日：2008-01-31
申请号：US11496770
申请日：2006-07-31
申请人： Isaac Farr , Leslie Rivera Guzman , Ricardo G. Diaz-Felipe , Javier Valentin-Sivico , Saul Tirado , Iddys D. Figueroa , Kevin Michael Kane , Mirayda Aponte
发明人： Isaac Farr , Leslie Rivera Guzman , Ricardo G. Diaz-Felipe , Javier Valentin-Sivico , Saul Tirado , Iddys D. Figueroa , Kevin Michael Kane , Mirayda Aponte
IPC分类号： A61K9/70 , A61K31/18 , A61P43/00
CPC分类号： A61K31/18 , A61K9/0056 , A61K9/209 , A61K9/2095 , A61K9/7007 , A61K9/7092
摘要： The present invention provides pharmaceutical compositions. In one aspect, a pharmaceutical composition is provided having a plurality of polymeric film layers heat sealed together as a multilayer structure and having an active agent dispersed within the multilayer structure. The multilayer structure is configured to release the active agent upon administration to a subject, either in a controlled release or immediate release manner.
摘要翻译：本发明提供药物组合物。在一个方面，提供了具有多个聚合物膜层的药物组合物，多个聚合物膜层作为多层结构热密封在一起并且具有分散在多层结构内的活性剂。多层结构被配置为在以受控释放或立即释放方式施用于受试者时释放活性剂。

2. 发明申请

US20080026062A1 Pharmaceutical compositions including nano-sized active agent 审中-公开
标题翻译：药物组合物，包括纳米级活性剂
公开(公告)号：US20080026062A1
公开(公告)日：2008-01-31
申请号：US11496873
申请日：2006-07-31
申请人： Isaac Farr , Leslie Rivera , Ricardo G. Diaz-Felipe , Javier Valentin-Sivico , Saul Tirado , Iddys D. Figueroa , Kevin Michael Kane , Mirayda Aponte
发明人： Isaac Farr , Leslie Rivera , Ricardo G. Diaz-Felipe , Javier Valentin-Sivico , Saul Tirado , Iddys D. Figueroa , Kevin Michael Kane , Mirayda Aponte
IPC分类号： A61K9/14
CPC分类号： A61K9/146
摘要： The present invention is directed to a particulate pharmaceutical composition. The particulate pharmaceutical composition can comprise a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix. The particulate pharmaceutical composition can be micronized or in the form of a film that can be rolled up. If micronized, the individual micron-sized particles can have a plurality of nano-sized particles present in the micron-sized particles.
摘要翻译：本发明涉及一种颗粒药物组合物。颗粒状药物组合物可以包含水溶性或部分水溶性聚合物基质; 以及分散在水溶性或部分水溶性聚合物基质中微溶于水不溶性的多种纳米尺寸的活性剂颗粒。颗粒状药物组合物可以是微粉化的或可以卷起的膜的形式。如果微粉化，单个微米尺寸的颗粒可以具有存在于微米级颗粒中的多个纳米尺寸的颗粒。

3. 发明授权

US08733274B2 Tube mounted inkjet printhead die 有权
标题翻译：管式喷墨打印头
公开(公告)号：US08733274B2
公开(公告)日：2014-05-27
申请号：US11551318
申请日：2006-10-20
申请人： David R. Otis, Jr. , Jeffrey A. Nielsen , Casey T. Miller , Gerald F. Meehan , Isaac Farr , Joseph W. Dody
发明人： David R. Otis, Jr. , Jeffrey A. Nielsen , Casey T. Miller , Gerald F. Meehan , Isaac Farr , Joseph W. Dody
IPC分类号： B05B7/06 , B05C11/00 , B41J29/38 , B41J2/045 , B41J2/41 , B05D1/02 , C23C28/00
CPC分类号： B41J2/17513 , B41J2/17553 , B41J3/4073 , B41J11/0015
摘要： Inkjet print head dies are directly seated upon an exterior of a tubular member so as to face different directions.
摘要翻译：喷墨打印头模具直接安置在管状构件的外部上，以面对不同的方向。

4. 发明授权

US07435763B2 Solid freeform compositions, methods of application thereof, and systems for use thereof 有权
标题翻译：固体自由基组合物，其应用方法及其使用的系统
公开(公告)号：US07435763B2
公开(公告)日：2008-10-14
申请号：US10817038
申请日：2004-04-02
申请人： Isaac Farr , Terry M. Lambright , Vladek P Kasperchik , Christopher Oriakhi , David A Neel
发明人： Isaac Farr , Terry M. Lambright , Vladek P Kasperchik , Christopher Oriakhi , David A Neel
IPC分类号： G03C5/00 , G03C1/725 , B29C35/04
CPC分类号： G03F7/0047 , B29C64/165 , G03F7/0037
摘要： Compositions, methods of using the compositions, and solid freeform fabrication (SFF) systems for producing three-dimensional objects are disclosed. One exemplary composition, among others, includes a basic component, an acidic component, at least one monoacrylate component, a light sensitive initiator, and a polar binder. A polymerization reaction between the at least one monoacrylate component and the light sensitive initiator occurs upon exposure to optical energy. The polar binder includes a viscosity modifier and a surface tension modifier. The polar binder is capable of stimulating a crosslinking reaction between the basic component and the acidic component.
摘要翻译：公开了组合物，使用组合物的方法和用于生产三维物体的固体自由形成（SFF）系统。一个示例性组合物，其中包括碱性组分，酸性组分，至少一种单丙烯酸酯组分，光敏引发剂和极性粘合剂。在暴露于光能时，发生至少一种单丙烯酸酯组分和光敏引发剂之间的聚合反应。极性粘合剂包括粘度调节剂和表面张力调节剂。极性粘合剂能够刺激碱性组分和酸性组分之间的交联反应。

5. 发明申请

US20070166386A1 Nanoparticle formation of pharmaceutical ingredients 审中-公开
标题翻译：纳米颗粒形成药物成分
公开(公告)号：US20070166386A1
公开(公告)日：2007-07-19
申请号：US11332131
申请日：2006-01-13
申请人： Vanessa Chinea , Kevin Kane , Isaac Farr , Iddys Figueroa
发明人： Vanessa Chinea , Kevin Kane , Isaac Farr , Iddys Figueroa
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/5192 , A61K31/405 , A61K31/5415 , A61K31/57 , A61K31/64 , A61K31/704
摘要： A pharmaceutical ingredient is dissolved within a solvent. The solvent is evaporated until nanoparticles of the pharmaceutical ingredient are at least partially formed without employing a substrate for them. A portion of the solvent remains, within which the nanoparticles are located.
摘要翻译：将药物成分溶解在溶剂中。蒸发溶剂直到药物成分的纳米颗粒至少部分地形成，而不使用它们的底物。残留一部分溶剂，纳米颗粒位于其中。

6. 发明申请

US20070032865A1 Prosthesis having a coating and systems and methods of making the same 审中-公开
标题翻译：具有涂层的假体和系统及其制造方法
公开(公告)号：US20070032865A1
公开(公告)日：2007-02-08
申请号：US11197855
申请日：2005-08-05
申请人： David Otis , Hirdey Bhathal , Isaac Farr , N.K. Samuel , Bradley Bower
发明人： David Otis , Hirdey Bhathal , Isaac Farr , N.K. Samuel , Bradley Bower
IPC分类号： A61F2/06
CPC分类号： C09D11/30 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61L27/34 , A61L31/10 , B05B5/00 , B05B17/0607 , B05D1/02 , B41J3/4073
摘要： Implantable medical devices such as stents, methods of making medical devices, and systems for making medical devices are disclosed herein. In one exemplary embodiment, medical device includes a stent that is coated at least on a portion of one surface by an ink-jet device.
摘要翻译：本文公开了植入式医疗装置，例如支架，制造医疗装置的方法以及用于制造医疗装置的系统。在一个示例性实施例中，医疗装置包括通过喷墨装置至少在一个表面的一部分上涂覆的支架。

7. 发明申请

US20060254467A1 Method for making spray-dried cement particles 审中-公开
标题翻译：制造喷雾干燥水泥颗粒的方法
公开(公告)号：US20060254467A1
公开(公告)日：2006-11-16
申请号：US11128681
申请日：2005-05-13
申请人： Isaac Farr , Daniel Kearl , William Carty , Hyojin Lee , Ungsoo Kim
发明人： Isaac Farr , Daniel Kearl , William Carty , Hyojin Lee , Ungsoo Kim
IPC分类号： C04B24/00 , C04B2/10
CPC分类号： B28B1/00 , B28B1/001 , B29C64/165 , C04B28/02 , C04B2111/00146 , C04B2111/00181 , C04B24/2641
摘要： A cement composition comprises free-flowing spray-dried unreacted cement particles and a liquid binder. The spray-dried particles may include a poly acid. A method for making a cement composition using spray dried cement particles comprises a) providing cement particles, b) milling or sieving said cement particles so as to produce cement particles having a desired average size, c) adding a liquid carrier to said particles before or after milling so as to form a slurry, d) adding a poly acid to said particles while maintaining the pH of the slurry above about 6, and e) spray-drying the slurry. The resulting particles can be used in conjunction with a liquid binder to form a monolith having a desired shape.
摘要翻译：水泥组合物包括自由流动的喷雾干燥的未反应水泥颗粒和液体粘合剂。喷雾干燥的颗粒可以包括多元酸。使用喷雾干燥的水泥颗粒制备水泥组合物的方法包括a）提供水泥颗粒，b）研磨或筛分所述水泥颗粒，以便生产具有所需平均尺寸的水泥颗粒，c）将液体载体添加到所述颗粒之前或在研磨之后以形成浆料，d）在保持浆料的pH高于约6的同时向所述颗粒中加入多元酸，以及e）喷雾干燥浆料。所得到的颗粒可以与液体粘合剂结合使用以形成具有期望形状的整料。

8. 发明申请

US20050093194A1 Solid free-form fabrication of three-dimensional objects 有权
标题翻译：固体自由形式制作三维物体
公开(公告)号：US20050093194A1
公开(公告)日：2005-05-05
申请号：US10700603
申请日：2003-11-03
申请人： Christopher Oriakhi , Isaac Farr
发明人： Christopher Oriakhi , Isaac Farr
IPC分类号： B28B1/00 , B29C67/00 , B29C67/24 , B29C35/02 , B32B5/16
CPC分类号： B28B1/001 , B28B1/00 , B29C64/165 , B33Y10/00 , B33Y70/00 , Y10T428/25 , Y10T428/254
摘要： The present invention is drawn toward compositions, methods, and systems for solid free-form fabrication of three-dimensional objects. In one embodiment, a system for solid free-form fabrication of three-dimensional objects can comprise a particulate composition, a substrate configured for supporting at least a layer of the particulate composition in a defined region, and a liquid phase binder configured for being jetted in the defined region to polymerize at least a portion of the particulate composition to form a polymeric cement. Using this system in a layer by layer deposition process, three-dimensional objects can be formed. The particulate composition can include from 70 wt % to 99.9 wt % of polymeric particulates, and from 0.1 wt % to 10 wt % of a polymerization initiator. The liquid phase binder can include from 70 wt % to 90 wt % of polymerizable monomers and from 0.1 wt % to 10 wt % of a polymerization accelerator.
摘要翻译：本发明涉及用于固体自由形成三维物体的组合物，方法和系统。在一个实施例中，用于固体自由形成三维物体的系统可以包括颗粒组合物，被配置用于在限定区域中至少支撑颗粒组合物层的基材和被配置为喷射的液相粘合剂在限定的区域中聚合至少一部分颗粒组合物以形成聚合物粘合剂。在逐层沉积工艺中使用该系统，可以形成三维物体。颗粒组合物可包含70重量％至99.9重量％的聚合物颗粒，和0.1重量％至10重量％的聚合引发剂。液相粘合剂可以包含70重量％至90重量％的可聚合单体和0.1重量％至10重量％的聚合促进剂。

9. 发明申请

US20050087903A1 System and method for fabricating three-dimensional objects using solid free-form fabrication 有权
标题翻译：使用固体自由形式制造制造三维物体的系统和方法
公开(公告)号：US20050087903A1
公开(公告)日：2005-04-28
申请号：US10696335
申请日：2003-10-28
申请人： Isaac Farr , Christopher Oriakhi , Terry Lambright
发明人： Isaac Farr , Christopher Oriakhi , Terry Lambright
IPC分类号： A61L27/12 , A61L27/42 , B28B1/00 , B29C67/00 , C04B28/34 , C04B35/447 , C04B35/634 , B29C41/02
CPC分类号： C04B35/634 , B28B1/001 , B28B7/465 , B29C64/165 , B33Y10/00 , B33Y40/00 , B33Y70/00 , C04B28/344 , C04B35/447 , C04B2111/00181 , C04B2235/3203 , C04B2235/3206 , C04B2235/3208 , C04B2235/3212 , C04B2235/3217 , C04B2235/3272 , C04B2235/3284 , C04B2235/6026 , C04B2235/94 , C04B22/06 , C04B40/0608 , C04B2103/10 , C04B2103/20 , C04B2103/40
摘要： A method for solid free-form fabrication of a three-dimensional object includes depositing a particulate blend in a defined region, the particulate blend including a calcium phosphate source, a reaction retardant, and a layered double hydroxide, and selectively ink-jetting a solubilizing binder onto a predetermined volume of the particulate blend to form a pre-ceramic object in the predetermined volume, wherein the solubilizing binder includes wetting agents, humectants, pH modifiers, and surfactants.
摘要翻译：用于固体自由形成三维物体的方法包括在限定区域中沉积颗粒混合物，所述颗粒混合物包括磷酸钙源，反应阻滞剂和层状双氢氧化物，并且选择性地喷射增溶的粘合剂到预定体积的颗粒混合物上以形成预定体积的预陶瓷物体，其中增溶粘合剂包括润湿剂，保湿剂，pH调节剂和表面活性剂。

10. 发明申请

US20050087902A1 Alginate-based materials, methods of application thereof, and systems for using the alginate-based materials 审中-公开
标题翻译：藻酸盐基材料，其应用方法和使用藻酸盐基材料的系统
公开(公告)号：US20050087902A1
公开(公告)日：2005-04-28
申请号：US10695565
申请日：2003-10-28
申请人： Isaac Farr , Howard Hovagimian , Terry Lambright
发明人： Isaac Farr , Howard Hovagimian , Terry Lambright
IPC分类号： B28B1/00 , B29C67/00 , C04B26/28 , B29C41/02
CPC分类号： C04B26/285 , B28B1/00 , B28B1/001 , B29C64/165 , C04B2111/00181 , C04B14/06 , C04B14/22 , C04B14/30 , C04B20/0048 , C04B2103/0079 , C04B2103/20
摘要： Solid freeform fabrication (SFF) systems for producing a three-dimensional object and methods of producing three-dimensional objects are disclosed. The SFF system includes a dispensing system including an alginate-based material that includes an alginate-based powder and a binder. The dispensing system is adapted to dispense the alginate-based material.
摘要翻译：公开了用于制造三维物体的固体自由形状制造（SFF）系统和制造三维物体的方法。 SFF系统包括包括基于藻酸盐的粉末和粘合剂的基于藻酸盐的材料的分配系统。分配系统适于分配基于藻酸盐的材料。

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