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1. 发明申请

US20070274949A1 Cd25 Dna Vaccines for Treating and Preventing T-Cell Mediated Diseases 审中-公开
标题翻译：用于治疗和预防T细胞介导的疾病的Cd25 Dna疫苗
公开(公告)号：US20070274949A1
公开(公告)日：2007-11-29
申请号：US10591558
申请日：2007-06-08
申请人： Irun Cohen , Avishai Mimran , Francisco Quintana , Felix Mor , Pnina Carmi
发明人： Irun Cohen , Avishai Mimran , Francisco Quintana , Felix Mor , Pnina Carmi
IPC分类号： A61K48/00 , A61K9/127
CPC分类号： A61K39/0008 , A61K2039/53
摘要： Compositions comprising nucleic acids encoding the α chain of IL-2 receptor (IL-2Ra, CD25), homologs and fragment thereof, are effective in the treatment and prevention of T cell mediated pathologies. Methods are provided for enhancing anti-ergotypic T cell activity in a subject in need thereof, and for treating or preventing T cell mediated pathologies, such as autoimmune disease, inflammatory diseases and graft rejection.
摘要翻译：包含编码IL-2受体α链（IL-2Rα，CD25）的核酸，同系物及其片段的组合物在治疗和预防T细胞介导的病理方面是有效的。提供了用于在有需要的受试者中增强抗细胞型T细胞活性，以及用于治疗或预防T细胞介导的病症如自身免疫性疾病，炎性疾病和移植排斥反应的方法。

2. 发明申请

US20070238099A1 Antigen Receptor Variable Region Typing 审中-公开
标题翻译：抗原受体可变区域键入
公开(公告)号：US20070238099A1
公开(公告)日：2007-10-11
申请号：US10581913
申请日：2004-10-25
申请人： Irun Cohen , Daniel Douek , Avishai Mimran , Pnina Carmi , Francisco Quintana
发明人： Irun Cohen , Daniel Douek , Avishai Mimran , Pnina Carmi , Francisco Quintana
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12M1/00
CPC分类号： C12Q1/6883 , C07K14/7051 , C12Q1/6876 , C12Q2600/156
摘要： A method of typing a variable region of a specific variant of an antigen receptor chain is disclosed. The method comprises: (a) exposing a probe set to a sense or antisense strand of a polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, wherein the probe set includes a plurality of probe molecules, wherein each probe molecule of the plurality of probe molecules is substantially complementary to a sense or antisense strand of a nucleic acid sequence region of a specific polynucleotide encoding a variant of the antigen receptor chain, the nucleic acid sequence region encoding a specific combination of at least two variable region segments of the antigen receptor chain; and (b) measuring a hybridization of each probe molecule of the plurality of probe molecules with the sense or antisense strand of the nucleic acid sequence region of the polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, thereby typing the variable region of the specific variant of the antigen receptor chain.
摘要翻译：公开了一种对抗原受体链的特定变体的可变区进行分型的方法。该方法包括：（a）将探针组暴露于编码抗原受体链特异性变体的至少一部分可变区的多核苷酸的有义或反义链，其中探针组包括多个探针分子，其中所述多个探针分子中的每个探针分子基本上与编码抗原受体链变体的特异性多核苷酸的核酸序列区域的有义链或反义链互补，所述核酸序列区编码至少抗原受体链的两个可变区片段; 和（b）测量多个探针分子的每个探针分子与编码抗原受体链特异变体的可变区的至少一部分的核酸序列区的有义链或反义链的杂交，从而键入抗原受体链的特定变体的可变区。

3. 发明授权

US08067008B2 Peptide inhibitors for mediating stress responses 有权
标题翻译：用于介导应激反应的肽抑制剂
公开(公告)号：US08067008B2
公开(公告)日：2011-11-29
申请号：US11573707
申请日：2005-08-23
申请人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
发明人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
IPC分类号： A61K39/00 , A61K38/00 , A61K38/04 , C07K16/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/0005 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides.
摘要翻译：本发明涉及能够抑制真核细胞中的细胞和免疫应答反应的肽。本发明提供了利用这些肽治疗人退行性疾病和炎症的组合物和方法。

4. 发明授权

US08790653B2 Peptide inhibitors for mediating stress responses 有权
标题翻译：用于介导应激反应的肽抑制剂
公开(公告)号：US08790653B2
公开(公告)日：2014-07-29
申请号：US13287098
申请日：2011-11-01
申请人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
发明人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
IPC分类号： A61K39/00 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/18 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/0005 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides.
摘要翻译：本发明涉及能够抑制真核细胞中的细胞和免疫应答反应的肽。本发明提供了利用这些肽治疗人退行性疾病和炎症的组合物和方法。

5. 发明申请

US20120171233A1 PEPTIDE INHIBITORS FOR MEDIATING STRESS RESPONSES 有权
标题翻译：用于介导应激反应的肽抑制剂
公开(公告)号：US20120171233A1
公开(公告)日：2012-07-05
申请号：US13287098
申请日：2011-11-01
申请人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
发明人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
IPC分类号： A61K39/00 , A61P25/08 , A61P17/00 , A61P29/00 , A61P19/00 , A61P5/16 , A61P7/06 , A61P21/04 , A61P25/28 , A61P25/16 , A61P27/06 , A61P27/02 , A61P3/10 , A61P19/04 , A61P37/06 , A61P19/02 , A61P1/00 , A61P11/00 , A61P17/06 , A61P9/10 , A61P1/16 , A61P13/12 , A61P15/08 , A61P25/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/0005 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides.
摘要翻译：本发明涉及能够抑制真核细胞中的细胞和免疫应答反应的肽。本发明提供了利用这些肽治疗人退行性疾病和炎症的组合物和方法。

6. 发明申请

US20080267983A1 Peptide Inhibitors for Mediating Stress Responses 有权
标题翻译：用于中介应激反应的肽抑制剂
公开(公告)号：US20080267983A1
公开(公告)日：2008-10-30
申请号：US11573707
申请日：2005-08-23
申请人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
发明人： Johannes Herkel , Irun R. Cohen , Varda Rotter , Ansgar W. Lohse , Neta Erez , Avishai Mimran , Na'aman Kam
IPC分类号： A61K39/00 , C07K2/00 , C07K7/06 , A61P25/00 , A61P29/00 , C07K7/08 , C07K14/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/0005 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing peptides recognized by monoclonal anti-DNA antibodies, the peptides having anti-apoptotic and anti-inflammatory activity. The invention further provides antibody molecules and uses thereof for the isolation of such peptides.
摘要翻译：本发明涉及能够抑制真核细胞中的细胞和免疫应答反应的肽。本发明提供了使用由单克隆抗DNA抗体识别的肽，具有抗凋亡和抗炎活性的肽来治疗人退行性疾病和炎症的组合物和方法。本发明还提供抗体分子及其用于分离这些肽的用途。

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